Advances in Immunology

Chapter One: NOD.H-2h4 Mice: An Important and Underutilized Animal Model of Autoimmune Thyroiditis and Sjogren's Syndrome

• Abstract
• 1 Introduction
• 2 Spontaneous Autoimmune Thyroiditis
• 3 TEC Hyperplasia/Proliferation
• 4 NOD.H-2h4 Mice Can Be Used as a Model of Experimentally Induced Autoimmune Thyroiditis
• 5 SS in NOD.H-2h4 Mice and NOD.H-2h4 Mutants
• 6 Concluding Remarks
• Acknowledgments

Chapter 2: Approaches for Analyzing the Roles of Mast Cells and Their Proteases In Vivo

• Abstract
• 1 Mast Cell Biology
• 2 Nongenetic Approaches for Analyzing the Functions of Mast Cells and Mast Cell-Associated Proteases In Vivo
• 3 Genetic Approaches for Analyzing the Functions of Mast Cells In Vivo
• 4 Genetic Approaches for Analyzing the Functions of Mast Cell-Associated Proteases In Vivo
• 5 Using Mast Cell-Deficient or Mast Cell-Associated Protease-Deficient Mice to Analyze Functions of Mast Cells or Their Proteases In Vivo
• 6 General Recommendations Regarding the Use of Mast Cell-Deficient or Mast Cell-Associated Protease-Deficient Mice to Analyze Biological Responses In Vivo
• 7 Perspective
• Acknowledgments

Chapter 3: Epithelial Cell Contributions to Intestinal Immunity

• Abstract
• 1 Introduction
• 2 Cellular Makeup of the Intestinal Epithelial Barrier
• 3 Epithelial Cell Sensing of Intestinal Microbes
• 4 Mucus Production by the Intestinal Epithelium
• 5 Epithelial Antimicrobial Proteins
• 6 Intestinal Epithelial Cell Autophagy
• 7 Epithelial Regulation of Adaptive Immunity
• 8 Bacterial Stimulation of Epithelial Cell Repair
• 9 Epithelial Dysfunction in Inflammatory Disease
• 10 Future Perspectives
• Acknowledgments

Chapter 4: Innate Memory T cells

• Abstract
• 1 Introduction
• 2 Innate Memory T Cells Produced Through Response to Lymphopenia
• 3 Innate Memory CD8+ T Cells Induced by IL-4
• 4 Innate Memory T Cells in Normal Homeostasis: “Virtual Memory” T Cells
• 5 The Role of Innate Memory T Cells in Immunity
• 6 Innate Memory Cells in Humans?