Brain Energy Metabolism in Alzheimers Disease - Part A

Brain Energy Metabolism in Alzheimer’s Disease – Part A, published as Volume 186 of the serial International Review of Neurobiology, provides a comprehensive and up‑to‑date synthesis of molecular, cellular, and systemic mechanisms underpinning energy dysregulation in neurodegeneration, with a primary focus on Alzheimer’s disease. This volume assembles expert-led reviews exploring key metabolic pathways—from glutamate–glutamine cycling and mitochondrial bioenergetics to neurovascular coupling, circadian regulation, and gut–brain axis interactions—while also examining emerging contributors such as environmental toxins, PFAS exposure, and microplastic-induced neurotoxicity. Together, these chapters illuminate how disrupted energy homeostasis intersects with oxidative stress, inflammation, and neuronal senescence, offering new insights into disease pathophysiology and therapeutic targeting.