Coronaviruses

Chapter One: Supramolecular Architecture of the Coronavirus Particle

• Abstract
• 1 Introduction
• 2 Virion Structure and Durability
• 3 Viral Proteins in Assembly and Fusion
• 4 Evolution of the Structural Proteins

Chapter Two: Coronavirus Spike Protein and Tropism Changes

• Abstract
• 1 Introduction
• 2 Structure of the Coronavirus S Protein
• 3 Spike–Receptor Interactions
• 4 S Protein Proteolytic Cleavage and Conformational Changes
• 5 Tropism Changes Associated with S Protein Mutations
• 6 Concluding Remarks
• Acknowledgments

Chapter Three: The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing

• Abstract
• 1 Introduction
• 2 Coronavirus nsp7–10: Small but Critical Regulatory Subunits?
• 3 Coronavirus nsp12: A Multidomain RNA Polymerase
• 4 Coronavirus nsp13: A Multifunctional and Highly Conserved Helicase Subunit
• 5 The Coronavirus Capping Machinery: nsp10–13–14–16
• 6 Coronavirus nsp14 ExoN: Key to a Unique Mismatch Repair Mechanism That Promotes Fidelity
• 7 Coronavirus nsp15: A Remarkable Endoribonuclease with Elusive Functions
• 8 Summary and Future Perspectives
• Acknowledgments

Chapter Four: Coronavirus cis-Acting RNA Elements

• Abstract
• 1 Introduction
• 2 Coronavirus Genome Replication and Transcription
• 3 Coronavirus cis-Acting RNA Elements
• 4 RNA Elements Involved in Coronavirus Genome Packaging
• 5 Possible Roles of Cellular Proteins in Coronavirus Replication
• 6 Conclusions and Outlook
• Acknowledgments

Chapter Five: Viral and Cellular mRNA Translation in Coronavirus-Infected Cells

• Abstract
• 1 Introduction
• 2 Mechanisms and Control of Translation of Coronavirus mRNAs
• 3 Host and Viral Factors That Regulate Coronavirus mRNA Translation
• 4 Coronavirus-Mediated Control of Host Translation
• 5 Concluding Remarks
• Acknowledgments

Chapter Six: Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis

• Abstract
• 1 Feline Coronaviruses
• 2 Infection with Feline Coronaviruses
• 3 Molecular Pathogenesis of FIP
• 4 Reverse Genetics of Feline Coronaviruses
• 5 Perspectives

Chapter Seven: Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response

• Abstract
• 1 Introduction
• 2 The Coronavirus Genome
• 3 The Type I IFN System
• 4 Antiviral Action of IFNs Against Human Coronaviruses
• 5 Evasion Strategies of Coronaviruses
• 6 Conclusions and Outlook
• Acknowledgments

Chapter Eight: Molecular Basis of Coronavirus Virulence and Vaccine Development

• Abstract
• 1 Introduction
• 2 Subunit, Inactivated, and Vectored Vaccines
• 3 Live-Attenuated Vaccines
• 4 Vaccine Biosafety
• 5 Coronavirus Antiviral Selection
• 6 Conclusions
• Acknowledgments