Current Approaches to Cryo-electron Microscopy
- 1 Edición, Volumen 223 - 1 de junio de 2026
- Última edición
- Editor: David B. Teplow
- Idioma: Inglés
Current Approaches to Cryo-electron Microscopy, Volume 223 provides a comprehensive overview of the field, tracing its evolution from early structural studies to modern pipeli… Leer más
Descripción
Descripción
Additional chapters cover Cryo-EM of Amyloid Fibrils: Advances, Challenges, and Translational Applications, Computational Approaches for Protein Complex Modeling for Intermediate Resolution Cryo-EM Maps, Calcium-sensing receptor, involved in the oral perception of the kokumi substances, Insights into the Structure and Diversity of the Bacterial Flagellum from cryo-EM studies, Overview and future potential in structural studies of bacteriophages by cryo-electron microscopy, and more.
Puntos claves
Puntos claves
- Reviews cryo-EM yields near-atomic structures that advance neurodegenerative/metabolic disease understanding and enable drug design
- Provides information on deep-learning AI accelerates structure determination through image processing, map enhancement, and model building
- Assesses key challenges and opportunities including sample prep bottlenecks, polymorphism, and using high-res maps to design inhibitors that disaggregate fibrils
De interès para
De interès para
Índice
Índice
Jaekyung Hyun and Seu-Na Lee
2. TBD
Salvador Ventura
3. Pursuing the physics of cryoEM image formation
Duane Loh and Joel Yeo
4. AI Tools for Cryo-EM: Protein Particle Picking, Density Map Enhancement, and Atomic Model Building
Janlin Cheng, Ashwin Dhakal, Rajan Gyawali and Joel Selvaraj
5. Cryo-EM of Amyloid Fibrils: Advances, Challenges, and Translational Applications
Michal Maj and Dylan Valli
6. TBD
Alex de Marco
7. Computational Approaches for Protein Complex Modeling for Intermediate Resolution Cryo-EM Maps
Kihara Daisuke
8. Calcium-sensing receptor, involved in the oral perception of the kokumi substances
Hiroki Yamaguchi and Seiji Kitajima
9. Insights into the Structure and Diversity of the Bacterial Flagellum from cryo-EM studies
Julien Bergeron, Matias R. Iglesias Rando and Kailin Qin
10. TBD
Toshio Moriya
11. TBD
Brent Nannenga
12. Overview and future potential in structural studies of bacteriophages by cryo-electron microscopy
Michael Sherman and Elena Orlova
13. TBA
Seth Darst
Detalles del producto
Detalles del producto
- Edición: 1
- Última edición
- Volumen: 223
- Publicado: 1 de junio de 2026
- Idioma: Inglés
Sobre el editor
Sobre el editor
DT
David B. Teplow
David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid β-protein (Alzheimer's disease) and α-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.