Drug-Biomembrane Interaction Studies

Dedication

Figures

Tables

List of abbreviations

Preface

About the editor and contributors

Chapter 1: Biological membranes and their role in physio-pathological conditions

Abstract:

1.1 Importance of drug-biomembrane interactions in biomedical and pharmaceutical research

1.2 The structure of cell membranes

1.3 Properties of plasma membranes

1.4 Movement of molecules across the plasma membrane

1.5 Functions of cell membranes

1.6 Conclusion

Chapter 2: Biomembrane models

Abstract:

2.1 Introduction

2.2 The fluid mosaic model of a biological membrane

2.3 Lipid phases and lipid phase transitions

2.4 Models of biological membranes and their applications

2.5 Conclusion

Chapter 3: Analytical methods for studying drug–biomembrane interactions

Abstract:

3.1 Introduction

3.2 Spectroscopic techniques

3.3 Chromatographic methods

3.4 Zeta potential measurement

3.5 Microscopy techniques

3.6 The Langmuir–Blodgett (LB) film balance technique

3.7 Other techniques and mixed techniques

3.8 Conclusions

Chapter 4: Differential scanning calorimetry (DSC): theoretical fundamentals

Abstract:

4.1 Introduction

4.2 Brief survey of the main thermodynamic techniques

4.3 Application to lipid systems

4.4 Membrane partitioning and binding of additives

4.5 The effects of additives on membrane properties

4.6 Kinetic phenomena

Chapter 5: DSC: history, instruments and devices

Abstract:

5.1 Introduction

5.2 History

5.3 Instruments

5.4 Special devices

Chapter 6: DSC in drug–biomembrane interaction studies

Abstract:

6.1 Introduction

6.2 Aims and advantages of DSC

6.3 Drug–biomembrane interactions

6.4 Surfactants

6.5 Genetic materials

6.6 Polymers

6.7 Drug delivery systems (DDSs)

6.8 Toxicity of biomolecules

6.9 Conclusion

Chapter 7: DSC applications: macromolecules

Abstract:

7.1 Introduction

7.2 Proteins

7.3 Nucleic acids

7.4 Polysaccharides

7.5 Biopolymers

7.6 Conclusion

Chapter 8: DSC applications: nucleic acids and membrane interactions

Abstract:

8.1 Introduction

8.2 DNA–membrane interaction studies with DSC

8.3 RNA–membrane interaction studies with DSC

8.4 Conclusions

Chapter 9: Non-steroidal anti-inflammatory drugs

Abstract:

9.1 Introduction to anti-inflammatory drugs

9.2 The interaction of NSAIDs with biomembrane models

9.3 NSAID-loaded DDSs

9.4 Conclusion

Chapter 10: Antimicrobial agents

Abstract:

10.1 Introduction

10.2 What are the appropriate biomembrane models for antimicrobial agents?

10.3 Antivirals, virus envelopes, and biomembrane models

10.4 Antifungals and biomembrane models

10.5 Conclusion

Chapter 11: Drug delivery systems: drug nanocarriers

Abstract:

11.1 Introduction

11.2 Drug delivery systems

11.3 Experimental protocols

11.4 Applications

Appendix 1: General experimental set-up of liposomal systems for DSC

Appendix 2: Journals

Index