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Elsevier

Epigenetics in Human Disease

  • 3 Edición - 9 de octubre de 2023
  • Última edición
  • Editor: Trygve O. Tollefsbol
  • Idioma: Inglés

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders… Leer más

Descripción

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice.

Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.

Puntos claves

  • Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications
  • Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs
  • Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways
  • Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding
  • Features step-by-step methods and disease research case studies to put book concepts into practice

De interès para

Researchers and graduate students working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies. Advanced undergraduate; clinicians

Índice

Section I: Introduction

1. Epigenetics of Human Disease: An Overview

Section II: Methodology

2. Methods and Strategies to Determine Epigenetic Variation in Human Disease

3. DNA Methylation–Based Measures of Biological Aging

4. Bioinformatics of Epigenomic Data Generated From Next-Generation Sequencing

Section III: Human Cancer

5. DNA Methylation Alterations in Human Cancer

6. Alterations of Histone Modifications in Cancer

7. MicroRNA in Cancer

8. Epigenetic Approaches to Cancer Therapy

Section IV: Neurological Disease

9. Epigenetics in Neurobehavioral Disease

10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders

11. The Epigenetics of Alzheimer's and Other Neurodegenerative Disorders

12. Epigenetic Modulation of Human Neurobiological Disorders

Section V: Autoimmune Disease

13. Epigenetic Basis of Autoimmune Disorders in Humans

14. Approaches to Autoimmune Diseases Using Epigenetic Therapy

Section VI: Metabolic Disorders

15. Epigenomics and Human Obesity

16. Epigenetic Approaches to Control Obesity

17. Early-Life Nutrition, Epigenetics and Prevention of Obesity

18. Epigenetics of Diabetes in Humans

19. The Potential of Epigenetic Compounds in Treating Diabetes

Section VII: Other Disorders/Diseases

20. Epigenetic-Processes Driven Disorders and Therapeutics

21. Epigenetics of Allergic Diseases Allergies, Eczema, Asthma, and Rhinitis

22. Therapy of Airway Disease: Epigenetic Potential

23. The Role of Epigenetics in Cardiovascular Disease

24. Epigenetic Treatment Approaches to Cardiovascular Disease

25. Epigenetics and Human Infectious Diseases

26. Therapy of Infectious Diseases Using Epigenetic Approaches

27. Translational Aspects of the Endometriosis Epigenome

28. Aberrant DNA Methylation Patterns in Gynecologic Cancers: Implications for Prevention and Therapy

29. Epigenetics in Human Reproduction and Gynecologic Diseases

Section VIII: Development, Aging and Transgenerational Effects

30. Epigenetics of Transgenerational Inheritance of Disease

31. Epigenomic Mechanisms of Human Developmental Disorders

32. Therapeutic Approaches to Imprinting Diseases

33. Stem Cell Epigenetics and Human Disease

34. Noncoding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy

35. Aging and Disease: The Epigenetic Bridge

36. Epigenetic Programming of Human Disease and Aging

Section IX: Future Research

37. Epigenetic Prospects in Epidemiology and Public Health

Detalles del producto

  • Edición: 3
  • Última edición
  • Publicado: 10 de octubre de 2023
  • Idioma: Inglés

Sobre el editor

TO

Trygve O. Tollefsbol

Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
Afiliaciones y experiencia
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA

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