Genetic Dissection of Complex Traits

I OVERVIEW AND FUNDAMENTALS


1 An Overview of Genetic Dissection of Complex Traits
D. C. Rao

2 Familial Resemblance and Heritability
Treva K. Rice

3 Linkage and Association: Basic Concepts
Ingrid B. Borecki and Micheal A. Province

4 Definition of Phenotype
Mary K. Wojczynski and Hemant K.
Tiwari


5 Genotyping Platforms for Mass Throughput Genotyping with SNPs, including Human Genome-Wide Scans
Karen Maresso and Ulrich Broeckel


6 Genotyping Errors and their Impact on Genetic Analysis
Michael B. Miller, Karen Schwander, and D.C. Rao


II LINKAGE AND ASSOCIATION ANALYSIS


7 Model-Based Methods for Linkage Analysis
John P. Rice, Nancy L. Saccone and Jonathan Corbett


8 Contemporary Model-Free Methods for Linkage Analysis
Laura Almasy and John Blangero


9 DNA Sequence-Based Phenotypic Association Analysis
Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo


10 Family-Based Methods for Linkage and Association Analysis
Nan M. Laird and Christoph Lange


11 Searching for Additional Disease Loci in a Genomic Region
Glenys Thomson and Lisa F. Barcellos


12 Methods for Handling Multiple Testing
Treva Rice, Nicholas J. Schork and D.C. Rao


III SPECIAL TOPICS


13 Meta-analysis Methods
Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, and John P.A. Ioannidis


14 Haplotype Association Analysis
Nianjun Liu, Kui Zhang, and Hongyu Zhao


15 Characterization of LD Structures and the Utility of HapMap in Genetic Association Studies
C. Charles Gu, Kai Yu, and D.C. Rao


16 Associations among Multiple Markers and Complex Disease: Models, Algorithms, and Applications
Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan and Richard A. Olshen


17 Optimum Study Designs for Genome-Wide Association Studies
Peter Kraft and David G. Cox


18 Ethical, Legal, and Social Implications of Biobanks for Genetics Research
Susanne B. Haga and Laura M. Beskow


IV PROMISING TOPICS




19 Admixture Mapping and the Role of Population Structure for Localizing Disease Genes
Xiaofeng Zhu, Hua Tang, and Neil Risch


20 Integrating Global Gene Expression Analysis and Genetics
Charles R. Farber and Aldons J. Lusis


21 A Systems Biology Approach to Drug Discovery
Jun Zhu, Bin Zhang, and Eric E. Schadt


22 The Promise of Composite Likelihood Methods for Addressing Computationally Intensive Challenges
Na Li


23 Comparative Genomics for Detecting Human Disease Genes
Carol Moreno, Jozef Lazar, Howard J. Jacob and Anne E. Kwitek



V OUTSTANDING CHALLENGES


24 From Genetics to Mechanism of Disease Liability
Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel


25 Into the Post-HapMap Era
Newton E. Morton