Hematopathology

**Selected for 2025 Doody’s Core Titles® with "Essential Purchase" designation in Surgical Pathology**

Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your #1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.

PART I Technical Aspects

1. Processing of the Lymph Node Biopsy Specimen

2. Fine-Needle Aspiration of Lymph Nodes

3. Immunohistochemistry for the Hematopathology Laboratory

4. Flow Cytometry

5. Molecular Pathology of Hematologic Neoplasms

6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them

PART II Normal and Reactive Conditions of Hematopoietic Tissues

7. Normal Lymphoid Organs and Tissues

8. Reactive Lymphadenopathies

9. The Normal Bone Marrow

10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia

11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders

PART III Lymphoid Neoplasms

12. Principles of Classification of Lymphoid Neoplasms

SECTION 1 • MATURE B-CELL NEOPLASMS

13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia

14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia

15. Hairy Cell Leukemia

16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen

17. Follicular Lymphoma

18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma

19. Primary Cutaneous B-Cell Lymphomas

20. Nodal Marginal Zone Lymphoma

21. Mantle Cell Lymphoma

22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas

23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements

24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma

25. Plasma Cell Neoplasms

26. Nodular Lymphocyte-Predominant B-Cell Lymphoma

27. Classic Hodgkin Lymphoma

28. Virally Associated B-Cell Lymphoproliferative Disease

SECTION 2 • MATURE T-CELL AND NK-CELL NEOPLASMS

29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders

30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations

31. T-Cell Prolymphocytic Leukemia

32. Adult T-Cell Leukemia/Lymphoma

33. Hepatosplenic T-Cell Lymphoma

34. Peripheral T-Cell Lymphoma, Not Otherwise Specified

35. Follicular Helper T-Cell Lymphoma

36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative

37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas

38. Mycosis Fungoides and Sézary Syndrome

39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders

40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes

SECTION 3 • PRECURSOR B- AND T-CELL NEOPLASMS

41. Precursor B-Cell and T-Cell Neoplasms

42. Acute Leukemias of Ambiguous Lineage

PART IV Myeloid, Histiocytic, and Related Proliferations

43. Principles of Classification of Myeloid Neoplasms

44. The Myelodysplastic Syndromes

45. Myeloid and Hematologic Neoplasms With Germline Predisposition

46. Acute Myeloid Leukemia

47. Myeloproliferative Neoplasms

48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions

49. Mastocytosis

50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions

51. Blastic Plasmacytoid Dendritic Cell Neoplasm

52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic

PART V Immunodeficiency Disorders

53. The Pathology of Primary Immunodeficiencies

54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders

PART VI Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia

55. Bone Marrow Evaluation for Lymphoma

56. Evaluation of the Bone Marrow After Therapy

57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes

58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions

59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

APPENDIX A: THE INTERNATIONAL CONSENSUS CLASSIFICATION OF MYELOID, LYMPHOID, AND HISTIOCYTIC NEOPLASMS

EJ

Elaine Sarkin Jaffe

Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard.

Afiliaciones y experiencia

Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland, USA

DA

Daniel A. Arber

Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen.

Afiliaciones y experiencia

Professor and Chair of Pathology, University of Chicago School of Medicine, USA

EC

Elias Campo

the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium.

Afiliaciones y experiencia

Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain

LQ

Leticia Quintanilla-Fend

Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks.

Afiliaciones y experiencia

Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, Germany

AO

Attilio Orazi

Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.

Afiliaciones y experiencia

Chair, Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA

LR

Lisa M. Rimsza

Afiliaciones y experiencia

Department of Pathology, Mayo Clinic, USA

SS

Steven H. Swerdlow

Afiliaciones y experiencia

Professor of Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

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Hematopathology

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Sobre los autores

Elaine Sarkin Jaffe

Daniel A. Arber

Elias Campo

Leticia Quintanilla-Fend

Attilio Orazi

Lisa M. Rimsza

Steven H. Swerdlow