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Elsevier

Hormones and Transport Systems

  • 1 Edición, Volumen 98 - 25 de marzo de 2015
  • Última edición
  • Editor: Gerald Litwack
  • Idioma: Inglés

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Leer más

Descripción

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on hormone and transport systems.

Puntos claves

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels

De interès para

Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.

Índice

  • Former Editors
  • Preface
  • Chapter One: Dietary I− Absorption: Expression and Regulation of the Na+/I− Symporter in the Intestine
    • Abstract
    • 1 The Importance of Iodide in Human Health
    • 2 The Na+/I− Symporter
    • 3 NIS Expression Beyond the Thyroid
    • 4 Targeting of NIS to the Plasma Membrane
    • 5 Hormonal Regulation of NIS Expression
    • 6 Dietary I− Absorption
    • 7 Regulation of Intestinal NIS Expression
    • 8 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Two: Apical Iodide Efflux in Thyroid
    • Abstract
    • 1 Introduction
    • 2 Iodide and Thyroid Hormone Synthesis
    • 3 Vectorial Transport Processes in Epithelia and Thyroid I− Accumulation
    • 4 Chloride Transport Proteins and Luminal I− Translocation
    • 5 Conclusions
    • Acknowledgment
  • Chapter Three: The Sodium/Multivitamin Transporter: A Multipotent System with Therapeutic Implications
    • Abstract
    • 1 Introduction
    • 2 “Active” Transport
    • 3 Identification of the Multivitamin Transporter
    • 4 The hSMVT Gene
    • 5 From Gene to Protein
    • 6 Family Ties
    • 7 The Predicted Structure of hSMVT
    • 8 The (Co)Substrates of hSMVT
    • 9 The Characterization of the Cloned hSMVT
    • 10 Medical Implications
    • 11 Conclusion and Future Directions
    • Acknowledgments
  • Chapter Four: Regulation of αENaC Transcription
    • Abstract
    • 1 Introduction
    • 2 Dot1a–Af9 Complex Mediates Repression of αENaC
    • 3 Dot1a–Af9-Mediated αENaC Repression is Relieved by Multiple Mechanisms
    • 4 Transcriptional Changes in ENaC Genes are Translated into Changes in ENaC Activity
    • 5 Mouse Models with Genetic Defects in ENaC Regulators
    • 6 Regulation of ENaC Activity by Other Regulatory Proteins
    • 7 Conclusion and Future Directions
    • Acknowledgment
  • Chapter Five: Control of ENaC-Mediated Sodium Reabsorption in the Distal Nephron by Bradykinin
    • Abstract
    • 1 Introduction
    • 2 KKS Components
    • 3 KKS Expression in the Kidney
    • 4 Molecular Mechanisms of the Distal Nephron Sodium Reabsorption
    • 5 Regulation of Distal Nephron Sodium Reabsorption by BK: A Role for ENaC
    • 6 Signaling Pathways Mediating BK Actions on ENaC
    • 7 Salt Sensitivity of BK Actions on Distal Nephron Sodium Reabsorption
    • 8 Inhibition of ENaC by BK Promotes ACE-Dependent Natriuresis
    • 9 Conclusions
    • Acknowledgments
  • Chapter Six: Inhibition of ENaC by Endothelin-1
    • Abstract
    • 1 Introduction
    • 2 Regulation of Sodium Reabsorption: The Role of ENaC
    • 3 Endothelin Signaling and Control of Blood Pressure
    • 4 Collecting Duct: ET-1 and ENaC
    • 5 Lung, Smooth Muscle, and Distal Colon: ET-1 and ENaC
    • 6 Molecular Mechanisms of Inhibition of ENaC by ET-1
    • 7 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Seven: Pharmacological Regulation of the Cholesterol Transport Machinery in Steroidogenic Cells of the Testis
    • Abstract
    • 1 Introduction
    • 2 Role of T in Health and Well-Being
    • 3 T-Replacement Therapy
    • 4 Steroid Biosynthesis
    • 5 Can Serum Testosterone Levels Be Increased by Stimulating the Leydig Cells Themselves?
    • 6 Conclusion
    • Acknowledgments
  • Chapter Eight: Insulin Transport into the Brain and Cerebrospinal Fluid
    • Abstract
    • 1 Introduction
    • 2 Insulin Synthesis, Secretion, and Action
    • 3 Transport of Insulin into the CNS
    • 4 The Effects of Insulin on the CNS
    • 5 Central Insulin and Leptin as Adiposity Signals
    • 6 Conclusion and Future Directions
  • Chapter Nine: Regulation of Hormone-Sensitive Renal Phosphate Transport
    • Abstract
    • 1 Introduction
    • 2 Biological Forms of Phosphate
    • 3 Renal Phosphate Transporters
    • 4 Hormone Regulation of Renal Phosphate Transport
    • 5 Other Hormones
    • 6 Adapter Proteins Modifying Hormone-Dependent Phosphate Transport
    • 7 Genetic Disorders of Renal Phosphate Transport Due to Hormonal Dysregulation
    • 8 Regulation of Phosphate in CKD and End Stage Renal Disease
  • Chapter Ten: Regulation of Aquaporins by Vasopressin in the Kidney
    • Abstract
    • 1 Introduction
    • 2 Aquaporins in the Kidney
    • 3 Vasopressin Signaling
    • 4 Aquaporins Regulated by Vasopressin (General Aspects)
    • 5 Short-Term Regulation of Aquaporin-2 by Vasopressin
    • 6 Long-Term Regulation of Aquaporin-2 by Vasopressin
    • 7 Disorders Due to Abnormalities of the Vasopressin–Aquaporin-2 Axis
    • 8 Conclusion and Future Directions
    • Acknowledgments
  • Chapter Eleven: The Structure and Function of the Dopamine Transporter and its Role in CNS Diseases
    • Abstract
    • 1 Introduction
    • 2 The Dopaminergic System
    • 3 The Dopamine Transporter
    • 4 The Dopamine Transporter and Disease
    • 5 Pharmacological Targeting of the DAT
    • 6 Conclusion
    • Acknowledgments
  • Chapter Twelve: Regulation of the Norepinephrine Transporter by Endothelins: A Potential Therapeutic Target
    • Abstract
    • 1 Introduction
    • 2 Neuronal NE Uptake
    • 3 Endothelins
    • 4 ET and NE Neuronal Uptake Interaction
    • 5 Conclusion
    • Acknowledgments
  • Chapter Thirteen: Vitamin D-Enhanced Duodenal Calcium Transport
    • Abstract
    • 1 Introduction
    • 2 Sources of 1,25(OH)2D3 for Stimulation of Duodenal Calcium Transport
    • 3 Vitamin D-Enhanced Transcellular Calcium Transport
    • 4 Vitamin D-Enhanced Paracellular Calcium Transport
    • 5 Regulation of Calcium Transport by the Parathyroid–Kidney–Intestinal Axis
    • 6 Novel Concept of the Bone–Kidney–Intestinal Axis of Calcium Regulation
    • 7 Vitamin D-Independent Intestinal Calcium Transport
    • 8 Conclusion and Perspectives
    • Acknowledgments
  • Chapter Fourteen: Endocannabinoid Transport Revisited
    • Abstract
    • 1 The Endocannabinoid System
    • 2 AEA Cellular Uptake and Intracellular Transport—A Primer
    • 3 AEA and 2-AG Transport at the Synapse
    • 4 Transport of 2-AG and Other Suggested Endocannabinoids
    • 5 Conclusions
    • Acknowledgments
  • Chapter Fifteen: Adenosine Transporters and Receptors: Key Elements for Retinal Function and Neuroprotection
    • Abstract
    • 1 Introduction
    • 2 The Nucleoside Adenosine in the CNS
    • 3 Neuromodulatory Actions of Adenosine in the Retina
    • 4 Nucleoside Transporters
    • 5 Adenosine and Neuroprotection in the Retina
    • 6 Concluding Remarks
  • Index

Detalles del producto

  • Edición: 1
  • Última edición
  • Volumen: 98
  • Publicado: 25 de marzo de 2015
  • Idioma: Inglés

Sobre el editor

GL

Gerald Litwack

Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)

Afiliaciones y experiencia
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States Emeritus Professor, Rutgers University, United States

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