Modern Approaches in Drug Discovery

1. Risk Management in Early Discovery Medicinal Chemistry
Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters

2. Target Identification Using Chemical Probes
Moses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan

3. Mining the Microbiome for Drug Targets
Qi Wang, Fangming Yang and Huijue Jia

4. Screening Library Design
Stephanie Kay Ashenden

5. Design of a Fragment Screening Library
Ashley Taylor, Bradley C. Doak and Martin J. Scanlon

6. Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond
Jacob Valentine and Ali Tavassoli

7. A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays
Christian Bergsdorf and Kirk Wright

8. Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening
Tracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky

9. An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives
Becky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler

10. High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary Neurons
Miklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis

11. Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening
Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft

12. Hit-to-Lead: Hit Validation and Assessment
Kirk E. Hevener, JinHong Ren, Russell Pesavento, Kiira Ratia, Hyun Lee and Michael E. Johnson

13. Knowledge-Based Approaches to Off-Target Screening
Daniel R. McMasters