Molecular Chaperones in Neurodegenerative Diseases

1 Edición, Volumen 156 - 1 de abril de 2027
Última edición
Editores: Rossen Donev, Subashchandrabose Chinnathambi
Idioma: Inglés

Molecular Chaperones in Neurodegenerative Diseases explores the roles of molecular chaperones in maintaining protein homeostasis and their involvement in the onset and progre… Leer más

Descripción

Molecular Chaperones in Neurodegenerative Diseases explores the roles of molecular chaperones in maintaining protein homeostasis and their involvement in the onset and progression of neurodegenerative disorders. The book highlights current research on chaperone-mediated mechanisms, disease pathology, and emerging therapeutic approaches targeting protein misfolding and aggregation.

Puntos claves

Explores the role of molecular chaperones in the onset and progression of neurodegenerative diseases
Covers key mechanisms of protein folding, misfolding, aggregation, and proteostasis in the nervous system
Includes up-to-date experimental approaches and disease models used to study chaperone function in neurodegeneration

De interès para

Academic libraries, university libraries, biomedical research institutes, life science researchers, cell biologists, molecular biologists

Índice

1. Molecular Chaperones modulate the Amyloid- aggregates in Alzheimer's Disease
Subashchandrabose Chinnathambi

2. BAG Proteins: Proteostasis & Neurodegenerative Diseases
Amit Mishra

3. Heat shock proteins regulate Tau protein in Alzheimer’s disease
Subashchandrabose Chinnathambi and Nagaraj Rangappa

4. Small molecular chaperones regulate protein quality in neurodegenerative diseases
Subashchandrabose Chinnathambi, Nagaraj Rangappa and Amit Mishra

5. From Protein Synthesis to Synaptic Plasticity: The Role of Molecular Chaperones in Memory-Dependent Protein Homeostasis
Poornima Priyadarshini

6. Microbiome Modulated Molecular Chaperones: Gut-Brain Control of Proteostasis and Neurodegenerative Risk
Hem Chandra Jha

7. Cellular clearance mechanism in Neurodegenerative diseases
Subashchandrabose Chinnathambi and Gowshika Velmurugan

8. Molecular chaperone and chaperone-based therapeutic approaches for Alzheimer’s disease
Awanish Kumar Sr.

9. Proteostasis and Its dysregulation controlled by molecular chaperones in Alzheimer’s Disease
Subashchandrabose Chinnathambi

10. Marine-Derived Molecular Chaperones: Emerging Therapeutic Agents for Neurodegenerative Diseases
Selvaraj Chandrabose Sr.

11. Autophagy and Molecular chaperones
Subashchandrabose Chinnathambi, Nagaraj Rangappa, Murugan Sevanan and Riddhi Bharatkumar Upadhyay

12. Therapeutic Target in Neurodegeneration
Subashchandrabose Chinnathambi, Madhura Chandrashekar, Gowshika Velmurugan and Nagaraj Rangappa

13. Molecular signaling complexes in ND
Madhura Chandrashekar

14. Molecular Chaperones as Therapeutic Gatekeepers in Alzheimer’s Disease: Intersections with Tau Aggregation, Amyloid Burden, and Neuroinflammation
Vijay Kumar Prajapati

15. HSP90–CDC37–MAPT Axis in Alzheimer’s Disease: A Network-Based Analysis
George Priya Doss C

16. Chaperone-Mediated Protection in Parkinson's disease
Madhura Chandrashekar

Detalles del producto

Edición: 1
Última edición
Volumen: 156
Publicado: 1 de abril de 2027
Idioma: Inglés

Sobre los editores

Rossen Donev

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Afiliaciones y experiencia

Head of Research, MicroPharm Limited, UK

Subashchandrabose Chinnathambi

Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.