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Elsevier

New Targeting in The Reversal of Resistant Glioblastomas

  • 1 Edición, Volumen 14 - 5 de marzo de 2021
  • Última edición
  • Editor: Ali Syed Arbab
  • Idioma: Inglés

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microe… Leer más

Descripción

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field.

Puntos claves

  • Explains the effect of bone marrow derived cells on the development of resistance to clinically practiced therapies
  • Provides information on the availability of alternate therapies for recurrent glioblastoma when standard practices have failed
  • Discusses targeting tumor microenvironment using available FDA approved drugs as an alternative treatment strategy for glioblastoma

De interès para

Cancer researchers, medical scientists, clinicians, graduate students

Índice

1. Current status of recurrent glioblastoma therapies

2. Imaging of glioblastoma recurrence

3. Overarching therapeutic challenges and arachidonic acid metabolism as a novel target in glioblastoma

4. The intervention of IL-8-CXCR2 axis to reverse the resistance to GBM therapies

5. Targeting Glioma Stem Cell Metabolism to Enhance Therapy Responses and Minimize Resistance

6. Targeting Tumor Microenvironment Associated Cells to Reverse Therapy Resistance

7. Recent Progress in Immunotherapy for Glioblastoma

8. The Role of Convection Enhanced Deliver in the Treatment of GBM

9. TBA Sensitization of Resistant GBM to Radiation

Reseñas

"New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field."—Anticancer Research

Detalles del producto

  • Edición: 1
  • Última edición
  • Volumen: 14
  • Publicado: 10 de marzo de 2021
  • Idioma: Inglés

Sobre el editor

AA

Ali Syed Arbab

Ali Syed Arbab, MD PHD, is Leader of Tumor Angiogenesis Initiative and Director, Core Imaging Facilities for Small Animals, both at Augusta University. Dr. Arbab’s laboratory is devoted to determining the mechanisms of therapy resistance by focusing on the involvement of bone marrow derived cells in modulating the tumor microenvironment and initiating tumor neovascularization in glioblastoma models. To understand the involvement of bone marrow cells in developing resistance to antiangiogenic therapies (AAT), his group has developed chimeric animal models where bone marrow of the recipient animal is replaced with GFP+ bone marrow. Dr. Arbab’s group documented that tumor-recruited bone marrow cells are a predominantly heterogeneous myeloid cell population that can predict therapeutic response in cancer, and they are using several strategies to target bone marrow or tumor-promoting myeloid cells to potentiate the anti-tumor effect of FDA-approved drugs in preclinical models of glioblastoma.
Afiliaciones y experiencia
Leader of Tumor Angiogenesis Initiative and Director, Core Imaging Facilities for Small Animals, Augusta University, Georgia

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