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Elsevier

Nitric Oxide

  • 1 Edición, Volumen 96 - 12 de agosto de 2014
  • Última edición
  • Editor: Gerald Litwack
  • Idioma: Inglés

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Leer más

Descripción

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on nitric oxide.

Puntos claves

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels
  • Three-dimensional structures in color
  • Elaborate signaling pathways

De interès para

Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested

Índice

  • Former Editors
  • Preface
  • Chapter One: Regulation of Nociceptive Transduction and Transmission by Nitric Oxide
    • Abstract
    • 1 Introduction
    • 2 Role of NO in Nociceptive Transduction at the Periphery
    • 3 Diverse Effects of NO on Ion Channels Expressed on Primary Sensory Neurons
    • 4 Role of NO in Regulating Nociceptive Transmission at the Spinal Cord Level
    • 5 NO Reduces Excitatory, But Potentiates Inhibitory, Synaptic Transmission in Spinal Cords
    • 6 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Two: microRNA and Human Inducible Nitric Oxide Synthase
    • Abstract
    • 1 Introduction
    • 2 Regulation of Human iNOS Gene
    • 3 miRNAs Regulation
    • 4 Conclusion
  • Chapter Three: Heart Mitochondrial Nitric Oxide Synthase: A Strategic Enzyme in the Regulation of Cellular Bioenergetics
    • Abstract
    • 1 Introduction
    • 2 Heart Mitochondrial NO Production
    • 3 Regulation of Heart mtNOS
    • 4 Effects of NO on Heart Mitochondrial Function
    • 5 Physiopathological Regulation of Heart mtNOS
    • 6 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Four: Nitric Oxide Regulation of Adult Neurogenesis
    • Abstract
    • 1 Introduction
    • 2 Adult Neurogenesis
    • 3 Expression of NOS in Neurogenic Regions
    • 4 Pharmacological Studies of NO on Adult Neurogenesis In Vivo
    • 5 NOS Knockout Animals and Adult Neurogenesis
    • 6 Neuropeptide Y and NO
    • 7 The Dual Role of NO in Adult Neurogenesis
    • 8 Concentration-Dependent Effects of NO
    • 9 Conclusions
  • Chapter Five: Nitric Oxide in the Nervous System: Biochemical, Developmental, and Neurobiological Aspects
    • Abstract
    • 1 Introduction
    • 2 NO Signaling Pathways
    • 3 NO and Neuronal Viability
    • 4 NO and Neurotransmitters Release
    • 5 NO and Neuroplasticity
  • Chapter Six: Hippocampus and Nitric Oxide
    • Abstract
    • 1 Introduction
    • 2 Profiles of NO in the CNS
    • 3 NO and Hippocampal Plasticity
    • 4 NO and the Related CNS Disorders
    • 5 Conclusion
  • Chapter Seven: Nitric Oxide and Hypoxia Signaling
    • Abstract
    • 1 Introduction
    • 2 Part 1: NO Biology in Normoxia, Hypoxia, and Anemia
    • 3 Part 2: Effects of Hypoxia on NOSs
    • 4 Summary
  • Chapter Eight: NO Binding to the Proapoptotic Cytochrome c–Cardiolipin Complex
    • Abstract
    • 1 Introduction
    • 2 The cyt c–CL Complex
    • 3 Ligand Binding to the cyt c/CL Complex
    • 4 Insights into the Nature and Formation of the Proximal NO Complex in cyt c–CL
    • 5 Conclusions
  • Chapter Nine: The Nitric Oxide-Mediated Regulation of Prostaglandin Signaling in Medicine
    • Abstract
    • 1 Introduction
    • 2 NOS and NO Production
    • 3 COX and Prostaglandin in Biology
    • 4 The Role of Nitric Oxide in Prostaglandin Regulation
    • 5 Perspective/conclusion
  • Chapter Ten: Nitric Oxide as a Mediator of Estrogen Effects in Osteocytes
    • Abstract
    • 1 Introduction
    • 2 Bone-Protective Effects of Estrogen
    • 3 Induction of NO Synthesis by Estrogen
    • 4 NO/cGMP Signaling in Bone Cells
    • 5 Bone-Anabolic Effects of NO in Humans—Lessons from Clinical Trials
    • 6 Estrogen Promotion of Osteocyte Survival via the NO/cGMP/PKG Pathway
    • Acknowledgment
  • Chapter Eleven: Insights into the Diverse Effects of Nitric Oxide on Tumor Biology
    • Abstract
    • 1 Introduction
    • 2 Cellular Reactions of NO
    • 3 Conclusion/Discussion
  • Chapter Twelve: Dual Effect of Interferon (IFNγ)-Induced Nitric Oxide on Tumorigenesis and Intracellular Bacteria
    • Abstract
    • 1 Introduction
    • 2 Interferon γ
    • 3 NOS2/NO
    • 4 L-Arg Metabolism
    • 5 NOS2/NO in Disease
    • 6 IFNγ-Induced NO as a Mechanism to Inhibit Renal Cancer Growth
    • 7 Conclusions and Future Directions
    • Acknowledgments
  • Chapter Thirteen: Antiobesogenic Role of Endothelial Nitric Oxide Synthase
    • Abstract
    • 1 Introduction
    • 2 eNOS is Important for Regulating Vascular and Metabolic Function
    • 3 NO Bioavailability is Decreased in Obese and Diabetic States
    • 4 Regulation of Obesity and Insulin Resistance by eNOS
    • 5 Synopsis
    • Acknowledgments
  • Chapter Fourteen: Nitric Oxide and Cerebrovascular Regulation
    • Abstract
    • 1 Introduction
    • 2 Sources of NO in the Neurovascular Unit
    • 3 Resting CBF
    • 4 Autoregulation
    • 5 Neurovascular Coupling (Fig. 14.1)
    • 6 Conclusion
    • Acknowledgments
  • Chapter Fifteen: Endothelial Nitric Oxide Synthase Gene Polymorphisms in Cardiovascular Disease
    • Abstract
    • 1 Introduction
    • 2 Genetic Variants
    • 3 eNOS Polymorphisms in CVD
    • 4 eNOS Polymorphisms in Other Diseases
    • 5 Conclusion
  • Chapter Sixteen: Role of Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension
    • Abstract
    • 1 Role of NO in Vasorelaxation and Proliferation in PH
    • 2 Endothelial Nitric Oxide Synthase Expression and its Activity in Relationship to the Vasoreactivity
    • 3 Physiological Role of NO in Pulmonary Hypertension
    • 4 Use of NO in Patients with PH in Clinical Practice
    • 5 Clinical Application of NO Inhalation in Patients with Pulmonary Hypertension
  • Index

Detalles del producto

  • Edición: 1
  • Última edición
  • Volumen: 96
  • Publicado: 12 de agosto de 2014
  • Idioma: Inglés

Sobre el editor

GL

Gerald Litwack

Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)

Afiliaciones y experiencia
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States Emeritus Professor, Rutgers University, United States

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