Peptide-Derived Drug Discovery
Design Strategies, Discovery Methods and Applications in Therapeutic Challenges
- 1 Edición - 1 de marzo de 2027
- Última edición
- Editor: Jian Zhang
- Idioma: Inglés
Peptide-Derived Drug Discovery: Design Strategies, Discovery Methods and Applications in Therapeutic Challenges provides a comprehensive exploration of peptide-like drugs, detail… Leer más
Descripción
Descripción
Peptide-Derived Drug Discovery: Design Strategies, Discovery Methods and Applications in Therapeutic Challenges provides a comprehensive exploration of peptide-like drugs, detailing their structural features and physico-chemical properties while demonstrating their application in the rational design of drug-like peptides. The book also highlights the latest advancements in peptide science, focusing on innovative technologies such as high-throughput screening methods for the macrocyclic peptide-based drug discovery. By showcasing novel approaches and offering step-by-step strategies to overcome key development challenges, this book delivers cutting-edge knowledge to advance the development of next-generation peptide therapeutics
Puntos claves
Puntos claves
- Peptide-Derived Drug Discovery offers a clear understanding of why peptides are a promising drug modality
- Provides practical solutions for overcoming drug development barriers, including in-depth discussions on solving development barriers of peptide drugs
- Covers cutting-edge screening and discovery technologies, including valuable insights into novel high throughput screening methodologies
- Presents detailed examples of successful peptide-based drugs, providing a roadmap for practical applications and future research
De interès para
De interès para
Professionals and researchers in the filed of chemical biology and medicinal chemistry who are dedicated to advancing peptide-based therapeutics through innovative strategies that overcome the inherent limitations of peptide drugs. It also serves as a comprehensive resource for scientists specializing in peptide science, including peptide synthesis, peptide drug design and discovery, offering valuable insights for the biological and medicinal study of peptides and peptide-like molecules. Also, the book will be an ideal resource for postgraduate students majoring in chemical biology, medicinal chemistry, and chemistry
Índice
Índice
Section 1: Introduction
1. Peptide-Derived Drug Discovery: Challenges and Solutions
Section 2: Innovative Methodologies in Peptide Chemistry
2. Macrocyclic Peptides: Advantages and Future Perspectives
3. Fast-flow Technology based Rapid Peptide Synthesis.
4. Chemoselective Ligation-Mediated Peptide Drug Discovery
5. Structure-based Rational Design Strategies in Peptide Drug Discovery
6. Carbohydrates in Peptide Drug
7. Phage Display-Based Discovery of Bicyclic Peptide Drugs
8. mRNA-Display based Nonstandard Peptide Drug Discovery
9. Enzymatic Macrocyclization and Peptide Biosynthesis
10. Peptide-based PROTAC Durg Discovery
Section 3. Peptide Therapeutics for Challenging and "Undruggable" Targets
11. Targeting "Undruggable" protein with Peptide-Based Molecules
12. Insights into Peptide Drug Discovery for G-Protein Coupled Receptors (GPCRs)
13. Cyclic Cell-Penetrating Peptides for Targeting p53/MDM2 Interactions
14. Recent Advances in Targeting KRas
15. Cell-Penetrating Bicyclic Peptide Targeting SARS-CoV‑2
Section 4. Recent Advances in Approved Peptide Therapeutics
16. Recently Approved Peptide Therapeutics
17. Peptide Drug: From Discovery to Approval Index
1. Peptide-Derived Drug Discovery: Challenges and Solutions
Section 2: Innovative Methodologies in Peptide Chemistry
2. Macrocyclic Peptides: Advantages and Future Perspectives
3. Fast-flow Technology based Rapid Peptide Synthesis.
4. Chemoselective Ligation-Mediated Peptide Drug Discovery
5. Structure-based Rational Design Strategies in Peptide Drug Discovery
6. Carbohydrates in Peptide Drug
7. Phage Display-Based Discovery of Bicyclic Peptide Drugs
8. mRNA-Display based Nonstandard Peptide Drug Discovery
9. Enzymatic Macrocyclization and Peptide Biosynthesis
10. Peptide-based PROTAC Durg Discovery
Section 3. Peptide Therapeutics for Challenging and "Undruggable" Targets
11. Targeting "Undruggable" protein with Peptide-Based Molecules
12. Insights into Peptide Drug Discovery for G-Protein Coupled Receptors (GPCRs)
13. Cyclic Cell-Penetrating Peptides for Targeting p53/MDM2 Interactions
14. Recent Advances in Targeting KRas
15. Cell-Penetrating Bicyclic Peptide Targeting SARS-CoV‑2
Section 4. Recent Advances in Approved Peptide Therapeutics
16. Recently Approved Peptide Therapeutics
17. Peptide Drug: From Discovery to Approval Index
Detalles del producto
Detalles del producto
- Edición: 1
- Última edición
- Publicado: 1 de marzo de 2027
- Idioma: Inglés
Sobre el editor
Sobre el editor
JZ
Jian Zhang
Professor Jian Zhang is the director of the Center for Medicinal Chemistry and Bioinformatics at Shanghai JiaoTong University School of Medicine in China. His research focuses on drug design, medicinal chemistry, and chemical biology, with groundbreaking achievements in precise target identification and first-in-class drug discovery. He has published more than 150 high-impact journal articles
Afiliaciones y experiencia
Director of the Center for Medicinal Chemistry and Bioinformatics, Shanghai JiaoTong University School of Medicine, China