Radiation Biology
Molecular Foundations and Clinical Applications
- 1 Edición - 19 de octubre de 2026
- Última edición
- Autores: Barry S. Rosenstein, Jerome M. Karp
- Idioma: Inglés
Radiation Biology: Molecular Foundations and Clinical Applications explores the effects of ionizing radiation on a molecular scale, with a focus on radiobiological principle… Leer más
Descripción
Descripción
Radiation Biology: Molecular Foundations and Clinical Applications explores the effects of ionizing radiation on a molecular scale, with a focus on radiobiological principles relevant to cancer radiotherapy.
The book starts at the subcellular level, elucidating the interactions between radiation and important cellular macromolecules, then gradually moves toward larger scales, demonstrating how the effects of radiation on macromolecules result in changes to the cell, which in turn lead to either cure or control of a cancer, or alternatively injury to normal tissues and organs. Topics covered include radiation-induced DNA damage and repair; effects of radiation on cellular signaling and cell death; quantification of cell kill and the effects of oxygen, linear energy transfer, radiosensitizers, and radioprotectors; models of radiation-induced tissue damage; the role of fractionation and dose rate; radiation-induced mutagenesis; and whole-body effects of radiation. Active areas of current research in radiation biology are discussed, including the use of radiation with immune-modulating agents, bystander effects, novel mechanisms of radiation-induced cell death, FLASH radiotherapy, personalized assays for prediction of radiation effects, nanoparticle delivery of radiosensitizers, and GRID/LATTICE radiotherapy. The last section of the book provides a review of cancer biology, discussing cancer genetics and epigenetics, the role of the tumor microenvironment, tumor metabolism, chemotherapy, and immunotherapy.
Puntos claves
Puntos claves
- Focuses on radiation biology at the molecular, cellular, tissue/organ, and individual level
- Addresses each topic from fundamentals through to clinical applications
- Considers the latest advances in the field of radiation biology and radiation oncology
- Includes a chapter summary and multiple-choice questions at the end of each chapter to review the material and assist in preparing for board examinations
De interès para
De interès para
Índice
Índice
1. Radiation Physics and Chemistry
Part II: Effects of Radiation at the Molecular Level
2. Deoxyribonucleic Acid Damage
3. DNA Repair
Part III: Effects of Radiation at the Cellular Level
4. Proliferative Cell Signaling
5. The Cell Cycle
6. Cell Death
7. Mathematical Models of Cell Survival
8. Modifiers of the Radiation Dose-Response Curve
9. The Oxygen Effect
Part IV: Effects of Radiation at the Tissue and Organ Level
10. Principles of Tissue Radiobiology
11. Fractionation and Dose Rate
12. Normal Tissue Toxicity
Part V: Effects of Radiation on the Human Body
13. Human Radiation Exposure
14. Whole-body Radiation
15. Mutagenic Effects of Radiation
Part VI: Cancer Biology
16. Carcinogenesis
17. Tumor Growth
18. Biomarkers in Cancer
19. Chemotherapy and Targeted Agents
20. The Immune System and Cancer
Detalles del producto
Detalles del producto
- Edición: 1
- Última edición
- Publicado: 30 de octubre de 2026
- Idioma: Inglés
Sobre los autores
Sobre los autores
Barry S. Rosenstein
Dr. Rosenstein is a Professor of Radiation Oncology and a Professor of Genetics & Genomic Sciences at the Icahn School of Medicine at Mount Sinai. He is a renowned educator who has received numerous teaching awards. More than 600 trainees from multiple radiation oncology and medical physics residency programs have taken Dr. Rosenstein’s 60-hour course in radiation and cancer biology. He also provides lectures in radiation biology and radiation safety for radiology residents. Dr. Rosenstein has served as a member of the Radiation Oncology Radiation/Cancer Biology Committee and the Radiology Physics Committee of the American Board of Radiology. He created and was the editor-in-chief of the widely used American Society for Radiation Oncology (ASTRO) Radiation and Cancer Biology Practice Examination and Study Guide. The focus of Dr. Rosenstein’s research program has been the identification of genetic/genomic markers associated with the development of adverse effects resulting from radiotherapy.
Jerome M. Karp
Dr. Karp is a radiation oncologist at Sheba Medical Center, and a research instructor at NYU Grossman School of Medicine, specializing in the treatment of patients with central nervous system malignancies. His research interests include bioinformatic analysis of brain tumors and liquid biopsies, effects of radiation on cells of the nervous system, and radiation-induced malignancies. Dr. Karp lectures radiation oncology and physics residents internationally on radiobiology, clinical oncology, and radiosurgery, and has served as a member of the American Society for Radiation Oncology (ASTRO) Education Committee.