Saltar al contenido principal
Elsevier

Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels

  • 1 Edición, Volumen 123 - 23 de septiembre de 2015
  • Última edición
  • Editores: Paul A. Slesinger, Kevin Wickman
  • Idioma: Inglés

This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current k… Leer más

Descripción

This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field.

Puntos claves

  • Presents a comprehensive overview of the latest research into GIRK potassium channels
  • Serves as a perfect starting point for researchers and practitioners entering the field
  • Expands the literature and field of neurobiology

De interès para

People working in basic neuroscience, neurology and psychiatry; medical doctors and care givers.

Índice

  • Preface
  • Chapter One: Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides
    • Abstract
    • 1 Introduction
    • 2 Regulation of KACh by G Proteins
    • 3 Molecular Constituents of Kir3 Channels and Physiological Roles
    • 4 Dependence of KACh Channel Activity on PIPs
    • 5 Physiological Significance of Distinct Membrane-Delimited Signaling Mechanisms
    • 6 Molecular Mechanism of PIP2 Control of Kir Channel Gating
    • 7 Posttranslational Modification Can Control Activity Through Changes in Channel–PIP2 Interactions
    • 8 The Kir3 Channel Site of Gβγ Action
  • Chapter Two: The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels
    • Abstract
    • 1 Introduction
    • 2 Interaction of Gα and Gβγ With GIRK
    • 3 Roles of Gβγ and Gα in GIRK's Evoked and Basal Activity
    • 4 Basal Activity of GIRKs
    • 5 Multimolecular Signaling Complex and the Mechanism of GIRK Activation
    • Acknowledgments
  • Chapter Three: RGS Redundancy and Implications in GPCR–GIRK Signaling
    • Abstract
    • 1 RGS Proteins—Background and Significance
    • 2 Direct “Membrane-Delimited” GPCR-to-Ion Channel Signaling
    • 3 RGS Actions on GPCR–GIRK Channel Gating Kinetics
    • 4 RGS Functional Redundancy—Emerging Evidence from Retinal Neurons
    • 5 RGS Functional Redundancy in Neuronal GPCR–GIRK Channel Signaling
    • 6 RGS Functional Redundancy in Cardiac GPCR-GIRK Channel Signaling
    • 7 RGS Actions on Gq-Mediated Changes in GIRK Channel Activity
    • 8 Conclusions
  • Chapter Four: Structural Insights into GIRK Channel Function
    • Abstract
    • 1 Introduction
    • 2 Selectivity and Permeation
    • 3 Rectification
    • 4 Gating
    • 5 Conclusions
    • Acknowledgments
  • Chapter Five: Localization and Targeting of GIRK Channels in Mammalian Central Neurons
    • Abstract
    • 1 Introduction
    • 2 Molecular Organization and Heterogeneity of GIRK Channels
    • 3 Neuroanatomical Approaches to the Study of GIRK Channel Distribution
    • 4 Regional Distribution of GIRK Channel Subunits in the CNS
    • 5 Cellular Distribution of GIRK Channel Subunits
    • 6 Subcellular Distribution of GIRK Channel Subunits
    • 7 Developmental Aspects of GIRK Channel Distribution
    • 8 Conclusions and Future Perspectives
    • Acknowledgments
  • Chapter Six: GIRK Channel Plasticity and Implications for Drug Addiction
    • Abstract
    • 1 Introduction
    • 2 GIRK Channels in the Mesocorticolimbic System
    • 3 Drug-Dependent Plasticity of GIRK Channel-Dependent Signaling
    • 4 Mechanisms Underlying the Plasticity of GIRK Channel-Dependent Signaling
    • 5 Concluding Thoughts and Future Directions
    • Acknowledgments
  • Chapter Seven: GIRK Channels: A Potential Link Between Learning and Addiction
    • Abstract
    • 1 Introduction
    • 2 GIRK Channels
    • 3 GIRK Channel Modulation by Drugs of Abuse
    • 4 Neuronal Plasticity
    • 5 Summary and Future Directions
  • Chapter Eight: Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction
    • Abstract
    • 1 Introduction
    • 2 GIRK Channels in CNS Disorders
    • 3 GIRK Channels in Addiction
    • 4 Therapeutic Potential of GIRK Channel Modulators
    • 5 Concluding Remarks and Future Directions
    • Acknowledgments
  • Index
  • Contents of recent volumes

Detalles del producto

  • Edición: 1
  • Última edición
  • Volumen: 123
  • Publicado: 23 de septiembre de 2015
  • Idioma: Inglés

Sobre los editores

PS

Paul A. Slesinger

Afiliaciones y experiencia
Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY

KW

Kevin Wickman

Afiliaciones y experiencia
University of Minnesota, MN, USA

Ver libro en ScienceDirect

Lee Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels en ScienceDirect