TDP-43 and Neurodegeneration
From Bench to Bedside
- 1 Edición - 23 de octubre de 2021
- Última edición
- Editores: Vijay Kumar, Manoj Kumar Jaiswal
- Idioma: Inglés
Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (F… Leer más
Descripción
Descripción
Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.
Puntos claves
Puntos claves
- Reviews TDP-43 structure, folding, function, and pathology
- Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases
- Presents a systems and precision biology perspective of TDP-43
- Discusses therapeutics of TDP-43 proteinopathies
- Translates bench research to application bedside
De interès para
De interès para
Researchers, advanced graduate students, and clinicians interested in translational neuroscience, neurobiology and neuropathology
Índice
Índice
2. Structural studies of TDP-43
3. TDP-43 mutations and Amyotrophic Lateral Sclerosis
4. Post translational modifications of TDP-43
5. TDP-43 and Autophagy
6. TDP-43 and Alzheimer Disease
7. TDP-43 and Stress granules
8. Repeat domains in TDP-43
8. Systems Biology of TDP-43
9. Animal models of TDP-43 in ALS
10. Therapeutic modulations of TDP-43
Detalles del producto
Detalles del producto
- Edición: 1
- Última edición
- Publicado: 23 de octubre de 2021
- Idioma: Inglés
Sobre los editores
Sobre los editores
VK
Vijay Kumar
Prof. Vijay Kumar is a distinguished faculty member and researcher specializing in Structural biology, Protein chemistry and neurosciences. He holds the position of Professor of the Department of Biotechnology, Anand School of Engineering and Technology, Sharda University, Agra. Prof. Kumar is internationally recognized and ranks among the top 2% of most cited scientists according to the STANFORD list. He earned his PhD in Biophysics from AIIMS, New Delhi, and completed a postdoctoral fellowship at UMass Medical School, focusing on folding and aggregation of proteins such as SOD1 and TDP-43 implicated in motor neuron disease, ALS, and FTD. He also served as Principal Investigator under the DST-SERB Young Scientist Scheme at Jamia Millia Islamia. His current research focuses on protein folding, misfolding, and aggregation, and the role of toxic RNA species in neurodegenerative diseases. He is a member of the Protein Society, Indian Biophysical Society, Indian Academy of Neurosciences, and the International Society for Neurochemistry. He has held fellowships from CSIR, India and a DAAD fellowship in Germany.
MJ