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Elsevier

α-Tertiary Amines en Route to Natural Products

  • 1 Edición - 14 de enero de 2021
  • Última edición
  • Autores: Abdul Hameed, Mariya Al-Rashida, Muhammad Raza Shah
  • Idioma: Inglés

α-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review… Leer más

Descripción

α-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the α,α-disubstituted α-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A,C), Neooxazolomycin, Sphingofungins (E,F), (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid (ACPD), Total synthesis of cephalotaxine and related molecules, α-amino acids based natural products, α amino acid based natural products and Tetrodotoxin.

This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.

Puntos claves

  • Outlines synthetic strategies for natural products bearing α-tertiary amines and α,α-disubstituted α-amino acid motif
  • Describes multistep synthetic routes that highlight key steps
  • Covers asymmetric and diastereoselective synthetic approaches towards targeted natural products
  • Illustrates multistep synthetic routes related to -amino acids based natural products and -amino acids based natural products

De interès para

Researchers working in the area of organic synthesis and natural products, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis

Índice

1. Introduction: α,α-Disubsituted α-Amino Acids

2. Altemicidin

3. Amathaspiramide(A-F)

4. Kaitocephalin

5. Lactacystin

6. Salinosporamide

7. Manzacidins (A, C)

8. Sphingofungins (E, F) Synthesis

9. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid)

10. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin

11. Introduction: α,α-Disubsituted α-Amino Acids

12. Altemicidin

13. Amathaspiramide(A-F)

14. Kaitocephalin

15. Lactacystin

16. Salinosporamide

17. Manzacidins (A, C)

18. Sphingofungins (E, F) Synthesis

19. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid)

20. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin

Detalles del producto

  • Edición: 1
  • Última edición
  • Publicado: 21 de enero de 2021
  • Idioma: Inglés

Sobre los autores

AH

Abdul Hameed

Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential.
Afiliaciones y experiencia
Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

MA

Mariya Al-Rashida

Dr. Mariya al-Rashida is a synthetic chemist and has expertise in the area of organic synthesis. She completed Ph.D. in chemistry from the Institute of Chemistry, University of the Punjab, Lahore, Pakistan in 2011. Her area of expertise is synthetic and computational medicinal chemistry. She is currently working towards the synthesis of metalloenzyme inhibitors (carbonic anhydrase, and ecto-nucleotidases). She is an Associate Professor and Chairperson of the Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. She has published more than 60 research articles with a cumulative Impact Factor > 150 in various peer review international journals. She has been the recipient of many awards including the prestigious CSP Gold Medal Award for Chemist Under 40.
Afiliaciones y experiencia
Department of Chemistry, Forman Christian College, Lahore, Pakistan

MS

Muhammad Raza Shah

Prof. Muhammad Raza Shah is Professor at the International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan. His research focuses on nanotechnology, materials science, supramolecular chemistry, nanomedicine, and advanced drug delivery systems, with particular emphasis on nanocarriers for targeted therapeutic applications. He has made significant contributions to the development of novel biomedical and pharmaceutical technologies and holds multiple national and international patents. Prof. Shah has authored and edited several scholarly books and contributed extensively to the scientific literature. He has supervised a large number of postgraduate researchers and maintains active international research collaborations. He is a Fellow of the Pakistan Academy of Sciences and the Islamic World Academy of Sciences and has received national recognition for his contributions to chemical sciences.
Afiliaciones y experiencia
Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

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