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Elsevier

Vitamin D Hormone

  • 1 Edición, Volumen 100 - 30 de enero de 2016
  • Última edición
  • Editor: Gerald Litwack
  • Idioma: Inglés

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Leer más

Descripción

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on vitamin D hormone.

Puntos claves

  • Expertise of the contributors
  • Coverage of a vast array of subjects
  • In depth current information at the molecular to the clinical levels

De interès para

Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.

Índice

  • Former Editors
  • Preface
  • Chapter One: Vitamin D: Historical Overview
    • Abstract
    • 1 The Discovery of Vitamin D
    • 2 The Discovery of the Physiological Functions of Vitamin D
    • 3 The Discovery of the Hormonal Form of Vitamin D
    • 4 The Isolation of the Final Active Form of Vitamin D
    • 5 Discovery of the Vitamin D Endocrine System (Fig. 5)
    • 6 Other Metabolism of Vitamin D
    • 7 Discovery of the Vitamin D Receptor
  • Chapter Two: Genomic Determinants of Vitamin D-Regulated Gene Expression
    • Abstract
    • 1 Introduction
    • 2 Genome-Wide Analysis Reveals New Concepts in Vitamin D Action
    • 3 Novel Principles of Vitamin D Action
    • 4 The Influence of Cellular Differentiation on Vitamin D Activity
    • 5 VDR Modulates Histone Acetylation at Target Genes
    • 6 Summary
    • Acknowledgments
  • Chapter Three: Inhibitors for the Vitamin D Receptor–Coregulator Interaction
    • Abstract
    • 1 Introduction
    • 2 Peptide-Based Inhibitors of the VDR–Coregulator Interaction
    • 3 Small-Molecule Inhibitors of the VDR–Coregulator Interaction
    • 4 VDR Antagonists or Allosteric Inhibition of the VDR–Coregulators Interaction
    • 5 Conclusion and Future Directions
    • Acknowledgments
  • Chapter Four: Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties
    • Abstract
    • 1 Introduction
    • 2 Crystal Structures of VDR LBD in Complex with 1,25(OH)2D3
    • 3 Secosteroidal Derivatives of 1,25(OH)2D3
    • 4 Synthetic Mimics of 1,25(OH)2D3
    • 5 Crystal Structures of VDR LBD with Lithocholic Acid
    • 6 Crystal Structures of HVDRR-Associated VDR Mutants
    • 7 Dynamic Process of Ligand Binding
    • 8 Conclusion and Perspectives
    • Acknowledgments
  • Chapter Five: Crystal Structure of the Vitamin D Receptor Ligand-Binding Domain with Lithocholic Acids
    • Abstract
    • 1 Introduction
    • 2 Lithocholic Acids
    • 3 Structures of the VDR LBD with LCAs
    • 4 Mechanism of Agonist Activities of LCA to VDR
    • 5 Conclusions and Future Directions
  • Chapter Six: 25-Hydroxyvitamin D3 24-Hydroxylase: A Key Regulator of 1,25(OH)2D3 Catabolism and Calcium Homeostasis
    • Abstract
    • 1 Introduction and Catalytic Properties
    • 2 CYP24A1 Gene and Crystal Structure of CYP24A1
    • 3 Cyp24a1-Null Mice
    • 4 Genetic Defect in CYP24A1: A Cause of Idiopathic Infantile Hypercalcemia
    • 5 Regulation of CYP24A1
    • 6 Aging and CYP24A1
    • 7 Placental CYP24A1
    • 8 Genomic Mechanisms Mediating 1,25(OH)2D3 Regulation of CYP24A1
    • 9 Conclusion and Future Directions
    • Acknowledgment
  • Chapter Seven: Analogs of 1α,25-Dihydroxyvitamin D3 in Clinical Use
    • Abstract
    • 1 Discovery of the Vitamin D Endocrine System
    • 2 Vitamin D Metabolites
    • 3 Precursors to 1,25-Dihydroxyvitamin D3
    • 4 Analogs of 1,25-Dihydroxyvitamin D3
    • 5 Functions of Vitamin D Beyond Bone, Parathyroid, Calcium, and Phosphorus
  • Chapter Eight: 1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age
    • Abstract
    • 1 Introduction
    • 2 1,25-Dihydroxyvitamin D
    • 3 Klotho
    • 4 Conclusion and Future Directions
    • Acknowledgments
  • Chapter Nine: Hedgehog and Vitamin D Signaling Pathways in Development and Disease
    • Abstract
    • 1 The Hedgehog Signaling Pathway
    • 2 Vitamin D Metabolism and Regulation
    • 3 Vitamin D/Hh Pathway Regulation in the Skin
    • 4 Inhibition of Hh Signaling by Vitamin D-Based Small Molecules
    • 5 Discussion and Conclusions
  • Chapter Ten: Molecular Approaches for Optimizing Vitamin D Supplementation
    • Abstract
    • 1 Introduction
    • 2 A View from Evolution
    • 3 Vitamin D and the Epigenome
    • 4 Molecular Insight from Vitamin D Intervention Trials
    • 5 Consequences for Vitamin D Supplementation
    • 6 Conclusion and Future Directions
    • Acknowledgments
  • Chapter Eleven: The Role of Vitamin D3 in the Development and Neuroprotection of Midbrain Dopamine Neurons
    • Abstract
    • 1 Introduction
    • 2 Biosynthesis and Metabolism of Vitamin D3
    • 3 Vitamin D3 and Health
    • 4 Vitamin D3 in the Central Nervous System
    • 5 Vitamin D and Neuroprotection in Parkinson's Disease
    • 6 Future Developments and Applications to Parkinson's Disease
  • Chapter Twelve: Vitamin D and Cardiac Differentiation
    • Abstract
    • 1 Introduction
    • 2 Calcitriol and CVD
    • 3 Calcitriol Is Critical in the Modulation and Maintenance of Heart Cell Structure and Function
    • 4 Noncanonical Wnt11 Signaling and Cardiogenesis
    • 5 1,25-Vitamin D3 Promotes Cardiac Differentiation Through Modulation of the Wnt Signaling Pathway
    • 6 Regulation of Cardiac Function Through Inhibition of Wnt Signaling Pathway
    • 7 Conclusion and Future Directions
  • Chapter Thirteen: Vitamin D in Prostate Cancer
    • Abstract
    • 1 Introduction
    • 2 Vitamin D Metabolism: Synthesis, Degradation, Relevance to Prostate Cancer
    • 3 VDR-Regulated Gene Transcription: Ligand Specificity, DNA Response Elements, Domain-Induced Allostery
    • 4 Inhibition of Prostate Cancer by Vitamin D: Insights from Cell Culture and Preclinical Studies, and Clinical Trials
    • 5 Functional Interplay of AR and VDR in Prostate Cancer: Impact on Cell Growth and Intracrine Androgen Biosynthesis
    • 6 Summary and Future Possibilities
    • Acknowledgments
  • Chapter Fourteen: Metabolism and Action of 25-Hydroxy-19-nor-Vitamin D3 in Human Prostate Cells
    • Abstract
    • 1 Introduction
    • 2 The Chemistry and Synthetic Schemes for 25-Hydroxy-19-nor-Vitamin D3
    • 3 19-nor-Vitamin D3 Analogs as Therapeutic Agent for Human Prostate Cancer
    • 4 The Biological Activities of 25-Hydroxy-19-nor-Vitamin D3
    • 5 The Metabolism of 25-Hydroxy-19-nor-Vitamin D3 in Prostate Cells
    • 6 Novel Mechanism of Action of 25-Hydroxy-19-nor-Vitamin D3
    • 7 Conclusions and Future Directions
  • Chapter Fifteen: Vitamin D Analogs with Nitrogen Atom at C2 Substitution and Effect on Bone Formation
    • Abstract
    • 1 Introduction
    • 2 Synthesis of New VDR Ligands: (Heteroaryl)ethyl Group at C2α
    • 3 Synthesis of New VDR Ligands: Cyanoalkyl or Cyanoalkoxy Group at C2α and C2β
    • 4 Biological Activity of New VDR Ligands
    • 5 New Ligands Bound to hVDR: X-Ray Cocrystallographic Analyses
    • 6 Summary
    • Acknowledgments
  • Chapter Sixteen: Mechanistic Insights of Vitamin D Anticancer Effects
    • Abstract
    • 1 Overview of Vitamin D Anticancer Effects
    • 2 Epidemiological Studies
    • 3 Experimental Studies
    • 4 Conclusions
    • Acknowledgments
  • Chapter Seventeen: Vitamin D Signaling Modulators in Cancer Therapy
    • Abstract
    • 1 Introduction
    • 2 Vitamin D Receptor and 1,25D3 Signaling
    • 3 Glucocorticoid, 1,25D3-Mediated Antitumor Effect and Hypercalcemia
    • 4 GR and VDR Signaling
    • 5 Regulation of CYP24A1 Expression
    • 6 CYP24A1 Expression in Cancer
    • 7 CYP24A1 Inhibitors
    • 8 Vitamin D Analogs
    • 9 Conclusions
  • Index

Detalles del producto

  • Edición: 1
  • Última edición
  • Volumen: 100
  • Publicado: 30 de enero de 2016
  • Idioma: Inglés

Sobre el editor

GL

Gerald Litwack

Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)

Afiliaciones y experiencia
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States Emeritus Professor, Rutgers University, United States

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