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Elsevier

Libros en Microbiología y Virología

  • Biomedical Applications of Microprobe Analysis

    • 1 Edición
    • Peter Ingram + 3 más
    • Inglés
    Biomedical Applications of Microprobe Analysis is a combination reference/laboratory manual for the use of microprobe analysis in both clinical diagnostic and research settings. Also called microchemical microscopy, microprobe analysis uses high-energy bombardment of cells and tissue, in combination with high resolution EM or confocal microscopy to provide a profile of the ion, metal, and mineral concentrations present in a sample. This allows insight into the physiology and pathophysiology of a wide variety of cells and tissues.This book describes methods for obtaining detailed information about the identity and composition of particles too small to be seen with the naked eye and describes how this information can be useful in diagnostic and biomedical research.

  • Biofilms

    • 1 Edición
    • Volumen 310
    • John N. Abelson + 1 más
    • Inglés
    Volume 310 of Methods in Enzymology is the first volume devoted solely to biofilm research methods. It provides a contemporary source book for virtually any kind of experimental approach involving biofilms. It includes bioengineering, molecular, genetic, microscopic, chemical, continuous culture, and physical methods. This volume will serve as a starting point for future developments.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 54
    • Inglés

  • Advances in Virus Research

    • 1 Edición
    • Volumen 53
    • Inglés

  • Veterinary Virology

    • 3 Edición
    • Frederick A. Murphy + 3 más
    • Inglés
    Completely rewritten, this edition has expanded coverage of zoonotic viruses and the diseases they cause, and viruses and viral diseases of laboratory animals, poultry, fish, and wildlife. The concept of new emerging and reemerging viral diseases reflects the new perspective this concept has brought to veterinary and zoonotic virology and related fields.Part I presents fundamental principles of virology related to animal infection and disease. Part II details the properties and clinical features of the viruses that afflict animals and describes their treatment and control.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 44
    • Inglés
    There are currently 3-5 million cases of leishmaniasis in the world and the prevalence is rising. The first chapter in this volume reviews the cell biology of the parasite and its transmission and survival. The second review addresses the apicomplexan protozoan parasites Theileria anulaga, T. parva and T. sergenti which globally cost agriculture over one billion US dollars annually. Current research in this area aims to produce effective, stable and cheap subunit viruses requiring only a single application and the authors predict that success will eventually be achieved with 'naked DNA' vaccines containing cytokine genes as immunopotentiators.T... next review is the first in over 30 years to discuss the larva of the class Monogenea.The authors cover morphology, behaviour and structure of many examples providing a detailed reference for researchers. The penultimate chapter discusses the distribution of Schistosoma bovis and considers the reported interactions occurring between parasites and snails. The final chapter reviews one of the most serious parasitic diseases in salmonid aquaculture - sealice. In 1998 the costs due to sealice damage in Scotland alone were estimated at 15-30 million pounds. Discussion of biology and control of these ectoparasites emphasizes the need to understand the basic biology of the parasite.This volume will be essential reading for parasitologists in many branches of the subject.

  • Encyclopedia of Food Microbiology

    • 1 Edición
    • Richard K. Robinson + 1 más
    • Inglés
    The Encyclopedia of Food Microbiology, Three-Volume Set is the largest comprehensive reference source of current knowledge available in the field of food microbiology. Consisting of nearly 400 articles, in three volumes, written by the world's leading scientists, the Encyclopedia presents a highly structured distillation of the whole field--from Acetobacter to Zymomonas. Each article in the Encyclopedia is approximately 4000 words in length and contains tables, line drawings, black-and-white photographs, or electron micrographs, where appropriate. The articles critically review the current state of knowledge of the topic in question. A list of suggested further reading is provided at the end of each article allowing the interested reader to research the subject more closely. The Encyclopedia is written at the research/technician level and could be used as a coursebook. Practitioners in industry, analysts, and similar professionals will especially be interested in the methodologies and techniques theme.

  • Advances in Microbial Physiology

    • 1 Edición
    • Volumen 41
    • Inglés
    This volume contains advances in microbial physiology, particularly: factors affecting the production of l-phenylacetylcarbin... by yeast.

  • Origin and Evolution of Viruses

    • 1 Edición
    • Esteban Domingo + 2 más
    • Inglés
    Are infectious diseases caused by novel entities, viruses that have rapidly evolved into more pathogenic forms, or viruses that have crossed species divides and become more virulent in their alternative host? These questions and how new diseases such as AIDS emerged have prompted renewed interest in the ways viruses originated and co-evolved with their hosts.Origin and Evolution of Viruses presents a full and clear description of general viral concepts and specific viral systems, and provides an excellent foundation to our understanding of how viruses emerged.This unique and comprehensive work is essential reading for all researchers in virology, molecular biology and related areas, as well as evolutionary biologists interested in phylogenetic approaches to molecular evolution. The reader is taken on an illumination journey--in time and concepts--from the first primitive replicons to their present-day complex viral counterparts. Apart from the obvious interest, as humans are potential hosts for these viruses, there is also a great deal of academic interest in the evolutionary aspects of this simple group of organisms, since information can be gained about the origin of stains/species and evolutionary patterns that might be applicable to higher species.

  • Of Mice, Men, and Microbes

    Hantavirus
    • 1 Edición
    • David R. Harper + 1 más
    • Inglés
    In May 1993, a cluster of cases of a lethal disease among healthy young people brought the attention of the world to the southwestern deserts. A previously unknown disease was killing up to 80% of the people it infected. The reaction in the area and across the nation mixed fear, lack of information, and the struggles of doctors to save the victims of an unknown killer with hard science and the age old rhythmns of the desert. What came out was the story of a virus that had been killing since man arrived in the American continents, Hantavirus, with deadly relatives across the Americas and across the world. This book explains why and how the virus kills, and why it is still killing today. Why all of the science aimed at a virus identified back in 1993 has not brought a vaccine or a cure is part of the story, as is how that killer virus fits into the story of "new" diseases across the world. The story of hantavirus disease, what has happened since that first outbreak, and what the real risks are is laid out by an experienced scientist and an award winning journalist living and working in the area of the 1993 outbreak.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 52
    • Inglés

  • Genetic Methods for Diverse Prokaryotes

    • 1 Edición
    • Volumen 29
    • Inglés
    This new volume presents overviews of the very latest genetic approaches in a diverse range of prokaryotes. Divided into three sections, the topics include essential techniques for genetic analysis, case studies in which genetic methods in carefully chosen genera are described and approaches are used in the elucidation of specific phenomena.

  • Handbook of Animal Models of Infection

    Experimental Models in Antimicrobial Chemotherapy
    • 1 Edición
    • Merle A. Sande
    • Oto Zak
    • Inglés
    Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 43
    • Inglés
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomeiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • HIV and the New Viruses

    • 2 Edición
    • Angus G. Dalgleish + 1 más
    • Inglés
    HIV and the New Viruses presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time. These cover recently discovered viruses such as HHV-6, HHV-8 and HCV, as well as the latest research on HIV. This comprehensive and updated reference includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses and management of conditions associated with those viruses. Information on new pharmaceuticals and vaccine developments is also included. Edited by the leading experts in the field, HIV and the New Viruses will be essential reading for postgraduates, clinicians and researchers in virology, immunology, cancer, molecular biology and the pharmaceutical industry.

  • Automation: Genomic and Functional Analyses

    • 1 Edición
    • Volumen 28
    • Inglés
    Automation is the major future trend for many areas in microbiology, molecular biology, and biochemistry, among other disciplines. It is an enormously exciting area, where techniques and assays that were once repetitive, tedious, and time consuming can be performed robotically, liberating the time of researchers and hospital laboratory workers for more interesting work. Many techniques have now been automated and often miniaturized, including PCR analysis, DNA/RNA preparation, diagnostic test (e.g., Pap tests), compound screening, and of course, sequencing. Some major advances, notably in Professor Leroy Hood's group, have resulted in the ability to perform thousands of assays simultaneously on a normal microscope slide. Automation, edited by two of the leading experts in the field, presents the very latest experimental techniques explained in detail. This book has succeeded in bringing together researchers at the forefront of clone library construction, genome analysis, sequencing, computational data evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 42
    • Inglés
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • Advances in Microbial Physiology

    • 1 Edición
    • Volumen 40
    • Inglés

  • Advances in Virus Research

    • 1 Edición
    • Volumen 51
    • Inglés

  • Advances in Parasitology

    • 1 Edición
    • Volumen 41
    • Inglés
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • Nonhuman Primates in Biomedical Research

    Diseases
    • 1 Edición
    • Inglés
    This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.

  • Advances in Immunology

    • 1 Edición
    • Volumen 69
    • Inglés

  • Advances in Virus Research

    • 1 Edición
    • Volumen 50
    • Inglés

  • Advances in Immunology

    • 1 Edición
    • Volumen 68
    • Inglés

  • The Yeasts - A Taxonomic Study

    • 4 Edición
    • Cletus Kurtzman + 1 más
    • Inglés
    The yeasts are a phylogenetically diverse group of fungi characterized by unicellular growth. Yeasts have been used for bread making and brewing beverages for millennia, and have become increasingly important in biotechnology for production of fuel alcohol, organic acids, enzymes, and various pharmacologically important chemicals. Other species are serious human, animal, and plant pathogens. Since publication of the 3rd edition of this book in 1984, numerous new species and genera have been described, many because of the application of new molecular biological methods. Molecular comparisons have now provided a phylogenetic distinction between the yeasts and other fungi, some of which have a unicellular growth phase.This book is the most definitive treatment of taxonomy and systematics of yeasts available and has been prepared by an international team of experts and is directed at taxonomists, ecologists, mycologists, microbiologists, clinicians, molecular geneticists, and biotechnologists.

  • Opportunistic Protozoa in Humans

    • 1 Edición
    • Volumen 40
    • Inglés
    Due to the advent of AIDS, there is currently great interest in opportunistic infections in people with compromised immune systems. This special volume of Advances in Parasitology provides a detailed account ofthe pathogens associated with human enteric diseases, Cryptosporidium parvum, Enterocytozoon bieneusi and Cyclospora cayetanensis. This volume is essential for all parasitologists working on opportunistic protozoa.

  • Microbiology

    • 1 Edición
    • Volumen 9A
    • Edward Bittar
    • Inglés
    There is a need in small group teaching for a readable module that provides a balanced treatment of the four main areas of medical microbiology-bacteri... mycology, virology and parasistology. It need not be encyclopedic in scope nor didactic, but it should emphasise principles and concepts. Any existing gaps in this type of presentation are, of course, left for the student to fill.Some subject material has been excluded. An example is a chapter on laboratory procedures including PCR for rapid bacterial and viral diagnosis. The discussion of bacterial sexually transmitted diseases does not cover goncoccal infections. This is not a serious matter because the tutor can assign the topic to the students. Moreover, we have reluctantly omitted a separate chapter on anaerobic bacteria. The subject of nosocomial pathogens is touched upon but not in sufficient detail (e.g., control). These bacteria (e.g., S. aureus, E. coli and pseudomonas) are found in hospitals and are resistant to disinfectants and antibiotics. A new but serious problem is the emergence of resistance to antiviral agents.Without question, molecular biology owes more to the study of viruses than bacteria. The fact remains, however, that effective therapy against most viral diseases is not yet available. Perhaps one of the most dramatic examples of this situation is the fight against the AIDS virus and the search for a vaccine. The public health challenge of AIDS remains formidable in spite of the recent encouraging results obtained with protease inhibitor therapy. At the moment at least six receptors for HIV are known to be present in human cells. One of them is the CCR5 receptor in the absence of which cells fail to get infected with the virus. Drugs that can interrupt CCR5 binding sites on the virus envelope are being vigorously sought. Thus, Volume 9B gives a large place to HIV disease.The last group of chapters highlight several features of microbiology which are also of clinical importance and heuristic value. The chapter on fever of unknown origin provides fertile soil for problem based learning.

  • Emerging Infections

    • 1 Edición
    • Volumen 1
    • Inglés
    Emerging Infections is the first volume of the new Biomedical Research Reports Series, which will provide annual updates on hot topics of interest to a broad spectrum of the biomedical research community. This book provides state-of-the-art reviews of new and reemerging bacterial, viral, and parasitic infections, their life cycles, host defense evasion strategies, and clinical features. It includes the history of infectious disease outbreaks, population and evolutionary biology of human pathogens, and current epidemiological models that describe how ecological and demographic changes produce new epidemics.

  • Advances in Immunology

    • 1 Edición
    • Volumen 66
    • Inglés

  • Advances in Immunology

    Cumulative Subject Index, Volumes 37-65
    • 1 Edición
    • Volumen 67
    • Inglés

  • Cumulative Subject Index

    • 1 Edición
    • Volumen 49
    • Inglés
    This volume gives the index of Volumes 25-47 as a handy reference to the contents. The series is aimed at virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 45
    • Inglés
    This text provides information on advances in microbiology, covering such topics as: the role of norsolorinic acid in aflatoxin research; flavour compounds in cheese; the role of micro-organisms in soy sauce production; and gene transfer among bacteria in natural environments.

  • Advances in Applied Microbiology

    Cumulative Subject Index, Volumes 22-42
    • 1 Edición
    • Volumen 46
    • Inglés
    A cumulative subject index to volumes 22 through 24 of Advances in Applied Microbiology.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 44
    • Inglés
    Praise for the Series"No laboratory scientist, field worker or technical administrator can afford to pass it up."--ASM News"The topics are well supported by an extensive bibliography and provide a rich source of current information."--Bioph...

  • Advances in Virus Research

    • 1 Edición
    • Volumen 48
    • Inglés
    Praise for the Series"This serial...is well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology...Timely, informative, and useful to the student, teacher, and research scientist."--America... Scientist"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in doing research in the field of virology."--Military Medicine

  • Approaches to Design and Synthesis of Antiparasitic Drugs

    • 1 Edición
    • Volumen 25
    • N. Anand + 1 más
    • Inglés
    This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 39
    • Inglés
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • The Clostridia

    Molecular Biology and Pathogenesis
    • 1 Edición
    • Julian I. Rood + 3 más
    • Inglés
    The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans.The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together the results from some of the most innovative and exciting research in the past decade. Using a principle-oriented rather than taxonomic approach, the results from molecular biology research are placed in the context of their clinical significance, and the disease process as a whole.This state-of-the-art work is truly comprehensive, covering and integrating the diverse topics of genetics, physiology, pathogenesis and cell biology.Written and edited by world-renowned authorities, material is presented to give the reader an up-to-date knowledge of the pathogenic species of this important genus. Background information is followed by details of the genetics, molecular biology, biochemistry and disease mechanisms. The structure, function and mode of action of toxins and other virulence determinants is clearly presented. As such, this work will prove essential for students, teachers, research microbiologists, infectious disease clinicians, toxin specialists, and all those working in medical or veterinary bacteriology, microbial genetics and the pharmaceutical industries.

  • Advances in Cancer Research

    • 1 Edición
    • Volumen 71
    • Inglés
    Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok et all. Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 43
    • Inglés
    Discusses various advances in applied microbiology, including: production of acetic acid by Clostridium thermoaceticum; marine microorganisms as a source of new natural products; and stereoselective biotransformations for synthesis of some pharmaceutical intermediates.

  • Manual of Techniques in Insect Pathology

    • 1 Edición
    • Lawrence A. Lacey
    • Inglés
    Biological Techniques is a series of volumes aimed at introducing to a wide audience the latest advances in methodology. The pitfalls and problems of new techniques are given due consideration, as are those small but vital details not always explicit in the methods sections of journal papers.In recent years, most biological laboratories have been invaded by computers and a wealth of new DNA technology and this will be reflected in many of the titles appearing in the series.The books will be of value to advances researches and graduate students seeking to learn and apply new techniques, and will be useful to teachers of advanced undergraduate courses involving practical or project work.This manual describes the broad array of techniques that are used in insect pathology. It will provide biologists, insect pathologists, entomologists, and those interested in biological control, with the necessary information to work on a variety of pathogen groups.This book will be an essential laboratory reference for insect pathologists.

  • Advances in Cancer Research

    • 1 Edición
    • Volumen 70
    • Inglés
    Volume 70 begins with two "Foundations in Cancer Research" articles, a staple of the Advances in Cancer Research series. The first article by Michael Stoker presents a review of some of the early advances made by cancer cell biology researchers. The second article by Emmanuel Farber describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes to prevent or delay carcinomas. Chidambaram and Dean illustrate the tumors and associated malformations of nevoid basal cell carcinoma. Koli and Keski-Oja review the effects of how transforming growth factor-b regulates cell proliferation, differentiation, and morphogenesis and its regulation by the steroid hormone superfamily. Jean-Marc Lemaitre and colleagues discuss the involvement of protooncogenes in the control of the cell cycle and embryonic development with specific attention paid to c-Myc expression and c-Myc function. A review of the various studies involving tumor-infiltrating lymphocytes and their possible role in cancer prevention is presented by Steven Rosenberg and co-workers. Finally, Bruce Ponder and Darrin Smith review the genetic and biological aspects of multiple endocrine neoplasia type-2 syndromes and the phenotypes associated with ret mutations.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 47
    • Inglés
    Praise for the Series:"This serial... is well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology... Timely, informative, and useful to student, teacher, and research scientist."--America... Scientist"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in or doing research in the field of virology."--Military Medicine

  • Nonmammalian Genomic Analysis

    A Practical Guide
    • 1 Edición
    • Bruce Birren + 1 más
    • Inglés
    Offering detailed protocols for those needing to construct a variety of maps and isolate genes, this unique book is intended to popularize the new techniques of genome analysis derived from the Human Genome Project. The power of these new methods is often most striking when applied to problems outside of human genetics, particularly the nonmammalian systems on which many researchers focus. Many of these organisms are economically important and biologically rich.Nonmammalian Genomic Analysis: A Practical Guide covers the "how to" aspects of preparation, handling, cloning, and analysis of large DNA and the creation of chromosome and genome maps. This lab manual facilitates the transfer of these technologies to small "low tech" environments and allows them to be used by those with no background in genome mapping or large-fragment cloning. Like having a local expert, this collection provides procedures for anyone, anywhere, and allows the replication of others' success.

  • Computer Applications in Food Technology

    Use of Spreadsheets in Graphical, Statistical, And Process Analysis
    • 1 Edición
    • R. Paul Singh
    • Inglés
    The Institute of Food Technologists (IFT) recently endorsed the use of computers in food science education. The minimum standards for degrees in food science, as suggested by IFT,"require the students to use computers in the solution of problems, the collection and analysis of data, the control processes, in addition to word processing."Because they are widely used in business, allow statistical and graphical of experimental data, and can mimic laboratory experimentation, spreadsheets provide an ideal tool for learning the important features of computers and programming. In addition, they are ideally suited for food science students, who usually do not have an extensive mathematical background.Drawing from the many courses he has taught at UC Davis, Dr. Singh covers the general basics of spreadsheets using examples specific to food science. He includes more than 50 solved problems drawn from key areas of food science, namely food microbiology, food chemistry, sensory evaluation, statistical quality control, and food engineering. Each problem is presented with the required equations and detailed steps necessary for programming the spreadsheet. Helpful hints in using the spreadsheets are also provided throughout the text.

  • Advances in Cancer Research

    • 1 Edición
    • Volumen 68
    • Inglés
    Volume 68 of Advances in Cancer Research continues the tradition of publishing up-to-date reviews and "hot" topics in cancer research. This volume begins with a "Foundations in Cancer Research" article by Harald zur Hausen that reviews his years of research on the idea that cancer can be triggered by infection. The structure and function of the cytokine receptor superfamily and its association with leukemias are discussed in depth by James Ihle. Marcia Hall and Gordon Peters review the evidence indicating that genetic abnormalities hinder the function of certain cyclins and their inhibitors. The most widely studied protooncogene, c-myc, is reviewed by Marie Henriksson and Bernhard Lüscher; the chapter focuses on the function of c-myc as a transcription factor rather than on the effects of gene translocation and activation on malignancies. Ham Werner and Derek LeRoith present data on the role that insulin-like growth factors play on cell growth and regulation. In the final chapter, Olli-P. Kallioniemi and Tapio Visakorpi investigate the field of prostate cancer and, more importantly, the biological reason and natural history behind the growth of this cancer.

  • Advances in Antiviral Drug Design

    • 1 Edición
    • Volumen 2
    • E. De Clercq
    • Inglés
    The purpose of the series on Advances in Antiviral Drug Design is to regularly review the "state of the art" on emerging new developments in the antiviral drug research field, thereby spanning the conceptual design and chemical synthesis of new antiviral compounds, their structure-activity relationship, mechanism and target(s) of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use. Volume 2 begins with a description of the antiviral potential of antisense oligonucleotides by J. Temsamani and S. Agrawal. According to the aims of the anitsense technology, these oligonucleotides should be targeted at specific viral antisense technology, these oligonucleotides should be targeted at specific viral mRNA sequences so that translation to the virus-specified proteins is blocked; this has been achieved for a number of oligomers, some of which are now in clinical trials for the treatment of HIV, HCMV, and human papilloma virus (HPV) infections. Then C.-S. Yuan, S. Liu, S.F. Wnuk, M.J. Robins and R.T. Borchardt assess the role of S-adenosylhornocyste... (AdoHcy) hydrolase as target for the design of antiviral agents with broad-spectrum antiviral activity. This is followed by an in-depth account on the design and synthesis of a number of first-, second- and third-generation AdoHcy hydrolase inhibitors and their mode of action at the enzyme level.V.E. Marquez provides a comprehensive description of the various carbocyclic (carba) nucleosides that have been synthesized and evaluated for antiviral activity. Although the number and diversity of the carba-nucleosides that have been found to be antivirally active (or inactive) is astonishingly high, there is no limit to further expansion of this fascinating class of molecules. For the various nucleoside analogues that have to be intracellularly phosphorylated to the 5'-triphosphate stage, to interact with their target enzyme (i.e., herpesviral DNA polymerase or retroviral revers transcriptase) the first phosphorylation step is often the rate-limiting step, and thus various strategies are envisaged by C. Perigoud, J.-L. Girardet, G. Gosselin and J.-L. Bach on how to bypass this initial phosphorylation and to deliver the nucleoside 5'-monophophate directly inside the cells.The HIV protease has been considered as a paradigm for rational drug design. The enzyme is among the best understood in terms of both structure and action, and because of its crucial role in the maturation of HIV, it has been vigorously pursued as a target for anti-HIV chemotherapy. In their comprehensive review of the multidisciplinary approach towards the development of HIV protease inhibitors A.G. Tomasselli, S. Thaisrivongs and R.L. Heinrikson highlight those protease inhibitors which have been brought forward to clinical trials.

  • Virology Methods Manual

    • 1 Edición
    • Hillar O. Kangro + 1 más
    • Inglés
    The Virology Methods Manual is a comprehensive source of methods for the study, manipulation, and detection of viruses. Edited by Brian Mahy and Hillar Kangro, this work describes the most up-to-date, definitive techniques, provided by experts in each area, and presented with easy-to-use, step-by-step protocols. This new manual will satisfy the needs of virologists and all those working with viruses who need a practical guide to methods that work!

  • The Chaperonins

    • 1 Edición
    • Robert L. Ellis
    • Inglés
    The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 37
    • Inglés
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

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