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Elsevier

Libros en Ciencias de la Vida

  • RNA-binding Proteins Part C

    • 1 Edición
    • Volumen 745
    • Inglés

  • The Human Nervous System

    • 4 Edición
    • George Paxinos + 2 más
    • Inglés
    The 4th Edition of the classic book The Human Nervous System continues to assemble contributions from world leaders in research on the brain, spinal cord and peripheral nervous system. This book has been edited by the best-known team of brain cartographers, and it has been completely revised to present the cutting edge of human neuroscience. The structure, connections and function are explained in depth, making this book essential to any student or scientist interested in brain anatomy and function.

  • Food Packaging from Plant-Based By-products

    Sustainable Materials and Applications
    • 1 Edición
    • Preetam Sarkar + 3 más
    • Inglés
    Food Packaging from Plant-Based By-products: Sustainable Materials and Applications addresses the growing need for sustainable, eco-friendly packaging solutions derived from agricultural plant by-products. The book benefits its audience by delivering up-to-date scientific knowledge, practical case studies, and strategies to overcome technical challenges in the packaging industry. The book’s extensive table of contents covers extraction methods, characterization techniques, and applications of biopolymers from diverse plant by-products such as mango, grape, citrus, apple, tomato, wheat, rice, and legumes. It also explores advanced topics including nanocomposites, active and intelligent packaging, regulatory frameworks, consumer acceptance, and industrial scale-up processes. Each chapter is authored by experts from multiple countries, ensuring a global perspective on sustainable packaging innovations. Food Packaging from Plant-Based By-products: Sustainable Materials and Applications provides a comprehensive resource for researchers, industry professionals, and policymakers focused on developing innovative food packaging systems that improve food quality and safety while reducing environmental impact. It equips the readers with valuable insights to drive innovation, regulatory compliance, and consumer acceptance of sustainable packaging technologies worldwide.

  • Central Nervous System Viral Infections

    • 1 Edición
    • Karen L. Roos + 1 más
    • Inglés
    Central nervous system viral infections pose one of the greatest threats to humanity, as evidenced by recent history with SARS-CoV-2 (COVID 19), HIV, and others. Understanding their effects, therapeutics, and prevention are a top priority for all. "Central Nervous System Viral Infections" reviews the mechanisms of viral infections, current viruses of interest, diagnosis, course, and therapeutics, as well as prevention. Post infection syndromes and complications are also reviewed. Coverage includes Covid, HIV, Zika, EBOLA, Marburg, Herpes, Measles, Mumps, Polio, and more.

  • Molecular Mechanisms of Cancer Resistance

    Emerging Technologies and Therapeutic Strategies
    • 1 Edición
    • Ahmet Acar
    • Inglés
    Molecular Mechanisms of Cancer Resistance: Emerging Technologies and Therapeutic Strategies explores innovative tools and strategies designed to address the critical issue of drug resistance in cancer treatment. This comprehensive volume is tailored for researchers, clinicians, and students, offering insights into the latest advancements and methodologies in the field. The book covers essential topics such as molecular mechanisms of drug resistance, the tumor microenvironment, and emerging technologies like single-cell analysis and computational modeling. Each chapter features contributions from leading experts, providing a multi-dimensional perspective on both foundational concepts and cutting-edge research.By engaging with this book, the academic audience gains access to groundbreaking research and therapeutic strategies that enhance understanding and practice. The knowledge acquired will inspire collaboration and innovation, ultimately contributing to more effective and personalized cancer treatment approaches.

  • Euphorbiaceae Family Oriented Drug Discovery

    Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family
    • 1 Edición
    • Bingjie Li + 1 más
    • Inglés
    Euphorbiaceae Family Oriented Drug Discovery, Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family, a volume in the Drug Discovery Opinions series, aims to comprehensively explore the isolation, identification, synthesis, and drug discovery based on natural products derived from the Euphorbiaceae family. Focused on the isolation, identification, synthesis of bioactive compounds, and drug discovery techniques, the contents of the book are organized into ten chapters. The book opens with an introduction to the Euphorbiaceae family, its botanical overview, medicinal significance, and the importance of exploring its natural products for drug discovery.The next chapters focus on specific techniques for identification and synthesis of natural products, cover the antitumor activities and mechanisms of action of natural products, and discuss the specific antimicrobial properties and mechanisms of action. Final sections discuss anti-inflammatory properties, pharmacology, drug discovery processes for Euphorbiaceae Natural Products, and describe challenges and future directions in research. The final chapter presents final considerations, summarizing key findings and insights from the book.

  • Neurochemical Substrates of Addiction Medicine

    • 1 Edición
    • Mohammad Banazadeh + 2 más
    • Inglés
    Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction.Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating.

  • The Neurobiological Underpinnings of Addiction Medicine

    Focusing on Novel Approaches
    • 1 Edición
    • Mohammad Shabani + 3 más
    • Inglés
    The Neurobiological Underpinnings of Addiction Medicine: Focusing on Novel Approaches provides a comprehensive review of the biological mechanisms that drive addiction and innovative strategies for treatment. This book begins by examining the crucial role of the microbiome and the gut-brain axis in various substance use disorders, including opioid, alcohol, neurostimulant, and cannabis use disorders. It highlights how gut health can significantly influence addiction behaviors and treatment outcomes. Following this, the second section discusses the interplay between addiction and neuropsychiatric disorders such as depression, anxiety, schizophrenia, ADHD, bipolar disorder, PTSD, and OCD.This section emphasizes the impact of neurotransmitter systems and intracellular pathways on the development and persistence of these disorders. The final section introduces cutting-edge methodologies reshaping addiction research, including multi-OMICS approaches and the implications of CRISPR-Cas9 technology. By integrating these diverse topics, this book offers vital insights for clinicians and researchers alike.

  • High Amylose Cereals

    Impact of Starch Structure and Processing on Nutrition
    • 1 Edición
    • Nese Sreenivasulu + 2 más
    • Inglés
    High Amylose Cereals: Impact of Starch Structure and Processing on Nutrition provides a complete focused reference on resistant starch, its source and its efficient and effective use as part of a healthy diet. Moving the reader from the plant to the product, it guides the reader to greater understanding of the potential for these grains. High amylose starch provides a meaningful amount of dietary fiber through the delivery of starch resistant to digestion. This characteristic provides a mechanism to increase the global consumption of fiber. As high amylose grains are being developed and commercialized, a reference is needed describing the general background, nutritional benefits, underlying trait development, and product development. The scope of this book includes topics ranging from the genetics required for the plant to develop high amylose starch to the nuances of creating finished food products with high amylose grain ingredients, including post-harvest processing technologies, and potential for delivering health benefits to consumers. Edited and contributed by leading experts, the book will be valuable for those seeking to understand the role high amylose cereals can play in the global food supply.

  • A Comprehensive Guide to Surgical Oncology

    • 1 Edición
    • Aqeel Shakir Mahmood + 2 más
    • Inglés
    A Comprehensive Guide to Surgical Oncology is an authoritative reference that meticulously covers the surgical management of various cancers. Each section delves into the latest surgical techniques, treatment protocols, and post-operative care strategies, supported by up-to-date research and clinical evidence. Enriched with detailed illustrations, case studies, and expert insights, this book is an indispensable resource for professionals and students alike. The primary purpose of this book is to provide a comprehensive, up-to-date resource that addresses the current challenges and advancements in surgical oncology. As cancer treatment evolves rapidly with continuous improvements in surgical techniques and multidisciplinary care, there is a pressing need for a new resource that synthesizes these developments into a coherent guide. This book aims to fill that gap by offering a thorough overview of the latest surgical oncology practices, thereby enhancing the knowledge and skills of its readers. This book solves several key problems for its readers by bridging the gap between rapidly advancing research and clinical practice, ensuring access to the latest information. It consolidates a vast amount of information into one comprehensive volume, saving readers the time and effort of consulting multiple sources. Providing practical guidance on the surgical management of a wide range of cancers, it helps practitioners make informed decisions in clinical settings. For students and trainees, it serves as a valuable educational tool that covers both foundational knowledge and advanced concepts in surgical oncology, offering multidisciplinary insights that foster a better understanding of the collaborative efforts required in cancer treatment.

  • Pectin

    Sources, Technological Properties and Functional Applications
    • 1 Edición
    • F.A. Masoodi + 2 más
    • Inglés
    Pectin: Sources, Technological Properties, and Functional Applications provides a comprehensive overview of pectin, detailing its structure, chemistry, properties, functionality, and diverse applications. The book offers valuable insights into how pectin's intrinsic properties affect its functionality and suitability for various end uses. It also explores the sourcing of pectin from food and agro-industrial sources, with a comparative assessment of conventional and emerging extraction technologies, and emphasis on sustainability through waste valorisation. The book is organized into three sections: Pectin Chemistry and Functionality, Valorisation of Agro-Industrial Waste Streams for Sourcing Pectin, and Functional Applications of Pectin in the Food Industry and Allied Arenas. It serves as a valuable resource for academicians, scientists, researchers, industry professionals, and students in Food Science, Chemistry, Chemical Engineering, Material Science, Pharmaceutical Sciences and related fields. Being particularly relevant to those working with food by-product valorization, hydrocolloids, biopolymers, colloid chemistry, and materials science, the book provides insights into the applications of pectin in food packaging, emulsification, encapsulation, and drug delivery.

  • Artificial Intelligence in Immunoengineering

    Methods, Models, and Translational Applications
    • 1 Edición
    • Steven Zanganeh + 1 más
    • Inglés
    Artificial Intelligence in Immunoengineering: Methods, Models, and Translational Applications examines how AI reshapes immunoengineering to design immune-modulating biomaterials, imaging systems, and diagnostic tools. The book presents an integrated view of data-driven approaches that accelerate discovery and translation in biomedicine. It surveys biological data from single-cell to spatial omics and proteogenomics and offers practical machine learning frameworks, generative and mechanistic models, and multimodal integration strategies. Sections address bench-to-bedside translation, validation pipelines, and regulatory considerations for AI-enabled immunoengineering tools.The book highlights the rapid progress of multidisciplinary research within immunotherapy and immunoengineering. Looking forward, the prospects of immunoengineering appear promising, with further advancements in disease prevention, diagnostics, and treatment on the horizon. Graduate students, academic researchers, clinician-scientists... and computational biologists will gain standardized workflows, mechanism-aware modeling, and reproducible pipelines that advance immunotherapies and diagnostics from concept to clinical impact.

  • Evidence Based Diagnosis and Management of Testicular Tumors

    • 1 Edición
    • Axel Heidenreich
    • Inglés
    Evidence Based Diagnosis and Management of Testicular Tumors is a comprehensive reference that addresses the current needs of urologists, oncologists, and related specialists involved in testicular cancer care. This book synthesizes the latest research, clinical guidelines, and expert insights to facilitate accurate diagnosis, staging, and personalized treatment strategies. It emphasizes a multidisciplinary approach, integrating pathology, molecular genetics, imaging, and surgical techniques, to optimize patient outcomes and minimize long-term toxicity. The contents are organized into key sections covering epidemiology, pathology, staging, diagnostic evaluation, disease management, and follow-up. Each chapter begins with case scenarios and interactive questions, fostering active learning and decision-making skills. The book also dedicates sections to rare tumors and pediatric cases, ensuring broad applicability across age groups and tumor types. Visual content, including figures, flow charts, tables, and videos, enhances comprehension and procedural training. This reference aims to bridge the knowledge gap in current testicular cancer management, providing practitioners with practical, guideline-conforming advice. It supports clinicians in delivering individualized, risk-adapted care, ultimately improving survival rates and quality of life for patients. By combining expert perspectives with evidence-based protocols, this book serves as an essential resource for advancing clinical practice in testicular oncology.

  • Autophagy – Part D

    • 1 Edición
    • Volumen 407
    • Inglés
    Autophagy – Part D presents current methods and advances in the study of autophagy, covering experimental approaches, molecular mechanisms, and emerging applications across different biological and disease contexts. It serves as a useful resource for researchers investigating autophagy in cell biology, physiology, and translational research.

  • Remote Sensing and Machine Learning in Conservation

    Applications and Techniques
    • 1 Edición
    • Alireza Sharifi
    • Inglés
    In Remote Sensing and Machine Learning in Conservation: Applications and Techniques, readers will discover how cutting-edge technology is transforming our understanding of the natural world. This book explores how remote sensing and machine learning are being used to monitor wildlife populations, map critical habitats, predict the effects of climate change, and identify poaching hotspots. From the analysis of satellite imagery to the use of drones and artificial intelligence, this book provides a comprehensive overview of the latest tools and techniques available to conservationists. Written by a renowned expert in spatial information research, this book introduces readers to the exciting new possibilities opened by the combination of remote sensing and machine learning. Early chapters provide an overview of both emerging technologies and their integration into habitat mapping, species distribution, environmental monitoring, and climate change adaptation. Central chapters explore real-world applications and case studies for combating poaching, managing urban expansion, controlling invasive species, and more. Final chapters explore the funding and policy landscape and conclude with a reflection on the role of these technologies in transforming conservation practices. By equipping readers with an overview of these technologies, case studies of their real-world applications, and sample code, datasets, and open-source tools, Remote Sensing and Machine Learning in Conservation: Applications and Techniques promotes the innovative use of these technologies to address global environmental challenges. This is an essential resource for conservationists, resource managers, environmental scientists, and academics studying novel technological applications to conservation issues.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2 Edición
    • Joao L. de Quevedo + 2 más
    • Inglés
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition provides the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the novel optogenetic techniques revolutionizing depression research. This new edition aids advanced students and researchers in their understanding of MDD, presenting chapters that explore groundbreaking topics such as the neurobiology of treatment-resistant depression, the mechanisms that make ketamine a better antidepressant, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression.The book also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help provide a broader and more comprehensive understanding of depression and its treatment.

  • Food Bioactives and Their Role in Human Health and Nutrition

    • 1 Edición
    • Sajad Ahmad Wani
    • Inglés
    Food Bioactives and their Role in Human Health and Nutrition, is a comprehensive resource offering an in-depth look at essential bioactive compounds, such as polyphenols, flavonoids, plant sterols, omega-3 fatty acids, and probiotics, highlighting their importance in promoting health and preventing chronic diseases. Readers will gain insights into the chemical structures, sources, and bioavailability of these compounds, along with practical dietary recommendations tailored to address common lifestyle-related health challenges such as obesity, diabetes, and cardiovascular disease. Food Bioactives and their Role in Human Health and Nutrition, also addresses emerging trends and challenges in the field, including personalized nutrition approaches and the integration of functional foods and nutraceuticals. It examines the role of food processing on the stability of bioactives, ensuring that health professionals are equipped with the latest knowledge to optimize nutritional strategies.

  • Cell Death Part G

    • 1 Edición
    • Volumen 214
    • Inglés
    Cell Death Part G presents current methods and advances for studying the mechanisms, regulation, and biological significance of cell death. The volume covers experimental and analytical approaches relevant to apoptosis, necrosis, autophagy, and other cell death pathways in both basic and translational research.

  • Algal Bioprospecting and Bioprocessing

    Current Trends and Future Perspectives
    • 1 Edición
    • Nitin Trivedi + 1 más
    • Inglés
    Algal Bioprospecting and Bioprocessing: Current Trends and Future Perspectives explores the rapidly evolving field of algal biotechnology and emphasizes the increasing importance of marine and freshwater algae as sustainable sources of bioproducts. By highlighting recent advancements and industrial applications, it aims to promote translational research and promote a circular bioeconomy within the blue economy framework. The book covers a wide array of topics, including algal biomass processing, bioactive metabolites, proteins, pigments, and biorefinery strategies. Key chapters look into advanced extraction techniques, genetic engineering, and the development of high-value products such as omega-3 fatty acids, oligosaccharides, and biopolymers. The book also explores the role of algae in sustainable agriculture, aquaculture, biofuel production, and space missions, providing a holistic view of current research and future prospects. Algal Bioprospecting and Bioprocessing: Current Trends and Future Perspectives is primarily for university students, academics, researchers, and professionals interested in applied phycology and marine biotechnology. This book also appeals to aspiring algapreneurs, industry experts, and policymakers. It encourages a scientific approach to harnessing algae’s societal benefits and promotes understanding of innovative technologies transforming micro- and macroalgae into valuable industrial products within a sustainable, circular economy.

  • Primer on Cerebrovascular Research

    • 1 Edición
    • Dong-Eog Kim + 3 más
    • Inglés
    Primer on Cerebrovascular Research provides both clinical and basic cerebrovascular knowledge that is required for physicians, vascular researchers, biomedical students, and trainees to understand or conduct evidence-based clinical practice and cutting-edge experimental research. This book outlines how to a design experimental cerebrovascular research in the context of clinical relevance, conduct the study using proper methods, analyze the data accurately, and make conclusions in an unbiased and statistically correct way. Chapters will include representative examples and experimental protocols.

  • Avian Models of Development

    • 1 Edición
    • Volumen 173
    • Inglés
    Avian Models of Development provides practical and experimental approaches for using avian systems to study developmental processes. It covers key methods, model applications, and emerging techniques that support research in embryogenesis, tissue formation, gene function, and developmental mechanisms.

  • Advances in Animal Genomics

    • 2 Edición
    • Sukanta Mondal + 1 más
    • Inglés
    Advances in Animal Genomics, 2nd Edition offers a comprehensive exploration of the latest developments in animal genomics and biotechnology. This updated edition integrates traditional and cutting-edge omics approaches—including genomics, transcriptomics, epigenomics, and genome editing technologies—to advance sustainable livestock production and genetic improvement. Covering a wide range of topics from reproductive technologies, cloning, and stem cell applications to CRISPR/Cas9 genome editing, molecular markers, and nanobiotechnology, this volume delves into the molecular mechanisms underlying key traits such as yield, disease resistance, and stress tolerance. It also addresses emerging areas like microbial metagenomics, bioinformatics, gene therapy, and policy frameworks, providing readers with a holistic understanding of the scientific tools and ethical considerations shaping the future of animal biotechnology. Designed for scientists, researchers, students, educators, and professionals across agriculture, veterinary science, and biotechnology, Advances in Animal Genomics, 2nd Edition serves as an essential resource for those seeking to harness genomics for improving animal health, productivity, and sustainability. For those engaged in academic research, applied breeding programs, or policy development, this book offers the knowledge and insights needed to meet the global challenges of food security and environmental stewardship through innovative genomic solutions.

  • Animal Stress Biology

    Applications across Natural and Man-made Systems
    • 1 Edición
    • Edward Narayan
    • Inglés
    Animal Stress Biology: Applications across Natural and Man-made Systems provides the fundamental aspects of stress endocrinology with a major focus on the applications of stress research in animal welfare. Early sections introduce the basics of animal stress biology in major taxa. Latter sections explore how animal stress varies across species and settings and how this research can be applied to improve animal welfare. The book incorporates chapter summaries, key term definitions, global case studies, and discussion sections throughout, making it an indispensable resource to students and early career professionals, as well as specialists in agriculture, zoos, clinical research settings, and resource management.Stress plays an integral part in the maintenance of homeostasis in animals and is a useful measure of animal responses to management interventions across natural, agricultural, and clinical settings. Written by experts in the field of animal stress biology, this book is systematically structured for easy student navigation.

  • New Trends in Methodological Approaches for Fish Biology

    • 1 Edición
    • Ignacio Fernandez Monzón + 1 más
    • Inglés
    New Trends in Methodological Approaches for Fish Biology provides an extensive guide on the novel tools and methodologies that are available to fish biologists across diverse sectors. The book combines a historical overview of each research area with detailed descriptions of emerging cellular and molecular tools. Sections explore recent advances in fish genomics, nutrition, development, reproduction, health, and welfare. Given the breadth of subject matter, this is an essential resource for students, academic researchers, aquaculturists and fisheries biologists, and resource managers alike. Written by a globally diverse team of experts, it is systematically structured for easy navigation by technical and nontechnical audiences. As research in this area is growing exponentially, reflecting the global economic significance of fisheries and aquaculture industries, fish as model research organisms, and aquatic ecosystem health, this book is a welcomed resource.

  • Aquatic Biodiversity

    Theories, Approaches, and Future Directions
    • 1 Edición
    • Bryan L Brown + 1 más
    • Inglés
    Aquatic Biodiversity: Theories, Approaches, and Future Directions reviews the development of metacommunity ecology theory in aquatic systems. The book explores aquatic dispersal as a driver of community biodiversity, patterns, and processes. Considered a relatively new field, metacommunity ecology created a paradigm shift in the field of aquatic ecology by developing a novel, network-based theory that differences in connectivity throughout aquatic systems lead to predictable variations in the mechanisms of assembly for lentic and lotic communities. This book collates the cutting edge conceptual, theoretical, and empirical advancements of the field and its contributions to invasive species management, biomonitoring, and stream restoration. Written and edited by many of the key researchers contributing to the development of the field, this book is systematically structured for easy accessibility by diverse audiences. Introductory sections discuss the importance of spatial structure, dispersal dynamics in aquatic systems, the effects of disturbances, and eco-evolutionary dynamics. Latter chapters apply these theories by describing field experiments in lentic and lotic systems and highlighting the field's applications to stream restoration, invasive species monitoring, urban ecosystem management, and biomonitoring at varying spatial scales. As advancements and refinements to the field of metacommunity ecology develop, Aquatic Biodiversity presents the first compendium establishing its foundational theories and their applications in aquatic ecology. For this reason, it is an indispensable resource for students, researchers, community ecologists, and aquatic resource managers.

  • Insect Bioactives

    Innovations in Food, Feed, Pharma and Cosmetics
    • 1 Edición
    • Abdalbasit Adam Mariod + 2 más
    • Inglés
    Insect Bioactives: Innovations in Food, Feed, Pharma and Cosmetics serves as a comprehensive resource for researchers and professionals seeking to harness the power of insects as sustainable bioactive sources and beneficial health and wellness solutions. The book identifies the nutritional and chemical composition of insects, presenting them as versatile ingredients for the development of functional foods, nutraceuticals, animal feed and cosmetics. By examining how edible insects can be reared on agri-food by-products and organic waste, this volume illustrates how feeding strategies can influence their nutritional and bioactive profiles. The text also addresses potential allergenic risks and consumer behavior insights, equipping readers with strategies to promote acceptance of insect-based products in the market.Structured into eight sections, Insect Bioactives: Innovations in Food, Feed, Pharma and Cosmetics covers a wide array of topics essential for understanding insect bioactives. From the foundational overview of insect-based compounds to their applications in functional foods, animal feed, pharmaceuticals, and cosmetics, each section provides insights into the health benefits and technological innovations associated with insect bioactives. The text also discusses regulatory considerations and features case studies that showcase successful applications in various industries.

  • Medical and Health Genomics of South Asia

    • 1 Edición
    • Dhavendra Kumar + 1 más
    • Inglés
    Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region. Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

  • Inherited Metabolic Diseases and the Brain

    • 1 Edición
    • Fanny Mochel + 2 más
    • Inglés
    Inherited Metabolic Diseases and the Brain explores the latest research on the neurological aspects of inherited metabolic diseases such as epilepsy, encephalotomy and more. With a strong research driven foundation and clinical applications, this book provides a primer which will help practicing pediatric and adult neurologists recognize, diagnose and treat neurometabolic disorders. This volume will also present a number of more common disorders in more detail, describing the variability in clinical presentation, the life course of the disease and the intricacies of diagnosis and treatment.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1 Edición
    • Gary Tse + 3 más
    • Inglés
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Anorectal Malformations

    • 1 Edición
    • Ivo de Blaauw + 2 más
    • Inglés
    Anorectal Malformations is an essential resource for pediatric surgical specialists and caregivers, providing a comprehensive approach to the diagnosis, treatment, and follow-up of patients with anorectal malformations. This book not only covers the latest surgical techniques but also delves into the intricacies of the condition, offering structured advice from a trusted organization, ERN eUROGEN, and addressing the significant gaps in literature related to this rare disease. The handbook is meticulously organized, beginning with an introduction to the ERN eUROGEN and ARMnet networks, followed by an exploration of key topics such as anatomy, embryology, genetics, and epidemiology of anorectal malformations. It details surgical procedures, including colostomy and reconstruction techniques, as well as non-surgical treatments for common complications like constipation and incontinence. The book also emphasizes long-term outcomes, global care networks, and patient perspectives, ensuring a holistic understanding of the patient journey.Anorectal Malformations is invaluable for clinicians, researchers, and healthcare professionals, providing the necessary insights to make accurate diagnoses, perform effective surgeries, and ensure proper follow-up care. It serves as a critical reference guide for anyone involved in the care of patients with anorectal malformations, ultimately improving clinical outcomes and enhancing the quality of life for affected individuals and their families.

  • Biomechanics of the Heart

    From Model to Patient
    • 1 Edición
    • Patrick Clarysse + 3 más
    • Inglés
    Biomechanics of the Heart: From Model to Patient provides readers with a comprehensive overview of the modeling and assessment of the heart’s biomechanics. The book addresses topics such as the physiology of normal and diseased hearts, cardiovascular imaging, modeling of myocardial tissue in the passive and active states, as well as state-of-the-art approaches for patient specific modeling of the heart’s mechanical function. This is all augmented by case studies and examples of exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases. Readers are introduced to modeling of the heart’s anatomical and muscular structure, a review of imaging techniques to analyze the geometry, content and dynamics of the heart, as well as an in-depth look at the biomechanical properties of normal and diseased hearts. Finally, chapters cover modeling cardiac passive and contractile mechanics, biomechanical finite element simulations of the heart, patient-specific modeling of the heart and circulatory system, as well as the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases.

  • Self-Learning AI in Healthcare

    Agentic Systems for Smarter Medicine
    • 1 Edición
    • Rajesh Kumar Dhanaraj + 4 más
    • Inglés
    Self-Learning AI in Healthcare: Agentic Systems for Smarter Medicine covers the transformative potential of advanced artificial intelligence within modern medicine. The book addresses the critical need for self-learning and agentic AI systems that autonomously adapt, refine decision-making, and navigate complex clinical environments with minimal intervention. Chapters provide foundational insights into the rise of self-learning AI and neural networks tailored for adaptive medical systems. Subsequent chapters delve into unsupervised, semi-supervised, and reinforcement learning for autonomous healthcare decision-making, alongside decentralized edge AI approaches. Specialized sections cover personalized medicine, hospital workflow optimization, remote patient monitoring, early disease detection, federated learning for privacy preservation, and more.Further, this book explores AI applications in drug discovery, mental health support, radiology, digital twins, and medical robotics, culminating with an examination of future challenges, ethics, and regulatory frameworks shaping self-learning AI’s trajectory in healthcare. It is tailored to serve a diverse yet specialized audience spanning academic, professional, and research sectors. Healthcare IT professionals and clinical informatics specialists will gain practical guidance for implementing adaptive AI solutions within complex healthcare environments. AI researchers and data scientists focused on developing self-learning models will find cutting-edge methodologies and case studies that advance medical applications.

  • Propolis: Science, Innovation, and Healthcare Applications

    • 1 Edición
    • Jairo Kenupp Bastos
    • Inglés
    Propolis from Hive to Health: A Comprehensive Guide is a key reference for understanding the diverse applications of propolis in healthcare and industry. As a natural product derived from bees, propolis has a long history and notable potential in pharmacology and biotechnology. This book serves as a consolidated resource that brings together current knowledge, research, and developments related to propolis, including coverage of three types—Brazilian green propolis (BrGPs), red propolis (RP), and poplar propolis (PP)—making it valuable for both scholars and practitioners. The Table of Contents covers a broad range of topics, including the origin and formation of propolis, its chemical composition, and contemporary analytical methods. It also examines the biological properties of propolis, such as its antimicrobial, antiviral, and neuroprotective effects, along with information on regulatory standards and future research areas. Each chapter is structured to provide a balance of theoretical context and practical insights. Designed for academics, researchers, and industry professionals, the book offers detailed technical information and guidance on quality control and regulatory compliance. By addressing key issues in the commercialization of propolis-based products, this reference supports a deeper understanding and effective utilization of this natural substance.

  • SGLT2 Inhibitors in Cardiovascular Diseases

    Mechanisms, Clinical Impact, and Future Directions
    • 1 Edición
    • Tong Liu
    • Inglés
    SGLT2 Inhibitors in Cardiovascular Diseases: Mechanisms, Clinical Impact, and Future Directions reviews the impact of SGLT2 inhibitors on cardiovascular health in individuals with type 2 diabetes, chronic kidney disease, heart failure, and atherosclerosis. The book synthesizes preclinical and clinical evidence to highlight the cardiovascular benefits of these drugs, initially developed for hyperglycemia management. It details recent studies on SGLT2 inhibitors' effects on cognitive dysfunction, sudden death, ventricular arrhythmias, heart remodeling, and cancer risks in diabetic patients.In addition, it compares SGLT2 inhibitors with DPP4 inhibitors, emphasizing the efficacy of empagliflozin and dapagliflozin in reducing syncope and cardiovascular mortality, supported by trials like EMPA-REG OUTCOME and DECLARE-TIMI 58. Addressing a gap in literature, the book provides a comprehensive overview of SGLT2 inhibitors' cardiovascular benefits in high-risk populations, including atrial fibrillation and syncope. It offers valuable insights and recommendations for clinicians, researchers, and policymakers managing cardiovascular risk.

  • RNA-Binding Proteins Part B

    • 1 Edición
    • Volumen 744
    • Inglés
    Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Rare and Complex Liver Diseases

    • 1 Edición
    • Ansgar Wilhelm Lohse + 2 más
    • Inglés
    Rare and Complex Liver Diseases is a comprehensive guide that fills a critical gap in the literature, providing up-to-date, practical advice. The book is organized into distinct sections, each dedicated to a specific category of liver diseases. Topics covered include Autoimmune Liver Diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC); Cholestatic Liver Diseases including Biliary Atresia and Alagille Syndrome; Vascular Liver Diseases like Budd-Chiari Syndrome and Non-cirrhotic Portal Hypertension; Metabolic Liver Diseases such as Wilson Disease and Alpha-1 Antitrypsin Deficiency; Structural Liver Diseases including Polycystic Liver Disease; and Rare Liver Tumors like Cholangiocarcinoma and Hemangioendothelioma... chapters cover Liver Disease in Pregnancy and delve into Quality of Life issues, offering evidence-based insights and practical strategies for improving patient well-being. This book serves as an indispensable resource for gastroenterologists, hepatologists, internists, and researchers specializing in liver diseases. It equips these professionals with the knowledge and practical advice necessary to improve patient outcomes and advance their field of study.

  • Insights and Implications of Pseudo Esterase Activity of Human Serum Albumin in Diabetic Kidney Disease

    • 1 Edición
    • Dibyajyoti Banerjee
    • Inglés
    Insights and Implications of Pseudo Esterase Activity of Human Serum Albumin in Diabetic Kidney Disease provides a comprehensive exploration of diabetic nephropathy, emphasizing the critical need for early detection methods prior to the onset of microalbuminuria. The book's primary focus is on the study of pseudoesterase activity in urinary albumin and other proteins as a potential biomarker for early diagnosis of diabetic kidney disease. This resource bridges a significant gap in current literature by providing an in-depth analysis of how this enzymatic activity can inform the classification and management of diabetic nephropathy.Chapters cover foundational knowledge of diabetes and its complications, the mechanisms of diabetic nephropathy, and detailed discussions on human serum albumin and its enzymatic activities. Each chapter covers the biochemical characterization of pseudoesterase activity, methods for its detection, and the significance of urinary proteomic profiling. Final chapters highlight future research opportunities and the potential for developing point-of-care testing tools, positioning this work as a critical resource for advancing the field of diabetic kidney disease research and clinical practice.

  • Chronic Kidney Disease Management Through Herbal Phytoceuticals

    Mechanistic Findings and Phyto-Based Therapy for Chronic Kidney Disease Management
    • 1 Edición
    • Kalicharan Sharma
    • Inglés
    Chronic Kidney Disease Management Through Herbal Phytoceuticals: Mechanistic Findings and Phyto-Based Therapy for Chronic Kidney Disease Management examines chronic kidney disease (CKD) through the lens of plant-, marine-, and microbe-derived compounds. The field increasingly requires safer, non-invasive therapies that complement existing regimens while clarifying mechanisms of action. By combining ethnobotanical knowledge with contemporary computational methods, this work serves as a translational resource for researchers, clinicians, and students seeking evidence-based, mechanism-driven phytopharmaceutical approaches to nephroprotection and disease modification. Readers gain a framework for integrating traditional knowledge with modern drug discovery pipelines. The table of contents outlines a progression from foundational concepts to translational applications. Chapters 1–3 cover the global burden, pathophysiology, and current management of CKD. Chapter 4 identifies druggable molecular targets. Chapters 5–7 survey plant-based phytoceuticals for CKD management, marine natural products as emerging CKD therapies, and microbial-derived candidates as potential CKD agents, supported by efficacy and safety data. Chapters 8–9 apply molecular docking and docking-based mechanistic insights to plant, marine, and microbial compounds. Chapters 10–12 address clinically validated phytopharmaceuticals... formulation science, and global regulatory considerations. Chapter 13 presents clinical and preclinical case studies to illustrate practical applications. This book delivers clear benefits to end users by providing integrated, mechanism-driven insights that connect basic science to clinical decision-making. Readers gain access to curated data on plant-, marine-, and microbial-derived compounds along with their targets, efficacy, and safety, supported by docking-based mechanistic validation. It also addresses formulation challenges, regulatory pathways, and quality-control considerations essential for translating phytopharmaceuticals from bench to bedside, including safety assessment and scalable product development. This blend of theory and practical guidance supports researchers designing studies, clinicians implementing evidence-based phytotherapy, and educators teaching multidisciplinary approaches to CKD management across academic and clinical settings.

  • Practical Guide to Diagnosing and Treating Ocular Tumors

    • 1 Edición
    • Maura Di Nicola + 1 más
    • Inglés
    Practical Guide to Diagnosing and Treating Ocular Tumors provides practical guidance on the diagnosis and management of ocular tumors. This comprehensive guide highlights the strengths, limitations, and applications of all imaging modalities in ocular oncology. It not only discusses new treatments in ocular oncology (including belzupacap sarotalocan and darovasertib for uveal melanoma, mTOR inhibitors for retinal astrocytic hamartomas in patients with ocular involvement of tuberous sclerosis complex, and belzutifan for retinal hemangioblastomas in patients with Von Hippel Lindau disease), but also offers a comprehensive and practical review of the techniques, complications, and applications of well-established treatments.Ophthalmo... and ocular oncologists will find this to be a practical guide to diagnosing and treating surface and intraocular tumors using a novel approach that will instruct readers on how to utilize and interpret multimodal imaging correctly to diagnose ocular tumors. Readers will gain an understanding of the risks and benefits of different treatment modalities and the most appropriate use scenario in each tumor type.

  • Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

    • 1 Edición
    • Theresa Coetzer
    • Inglés
    Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolyti... Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

  • Understanding Mycotoxins

    Toxicity, Detection, Risk Assessment, and Prevention Strategies
    • 1 Edición
    • Vinay B. Raghavendra + 1 más
    • Inglés
    Understanding Mycotoxins: Toxicity, Detection, Risk Assessment, and Prevention Strategies offers an in-depth exploration of their toxicological impact, detection techniques, and strategies for prevention and risk management. It addresses the critical health risks associated with mycotoxin exposure, including acute poisoning, carcinogenicity, and neurotoxicity, emphasizing the importance of accurate detection and effective mitigation measures. The book provides evidence-based insights into the mechanisms of mycotoxin toxicity, emerging threats, and the latest technological advances in analysis and detection. The book is structured into three detailed sections. The first section covers the fundamental aspects of mycotoxins, including their structures, biosynthetic pathways, sources of contamination, and health risks, supported by discussions on sampling, analytical techniques such as chromatography and spectroscopy, and the link between mycotoxins and diseases like cancer and neurological disorders. The second section delves into modern detection methods, highlighting advanced electrochemical sensors, immunoassays, biosensors, and innovative approaches utilizing machine learning, artificial intelligence, and nanotechnology for rapid and accurate identification of mycotoxins in various food matrices. The final section focuses on prevention and risk management, exploring detoxification strategies, mitigation techniques—including physical, chemical, biological, and emerging plasma and nanotechnology-based methods—and the regulatory frameworks that underpin safe food production and handling practices, aiming to reduce exposure and protect vulnerable populations globally.

  • Crossing Viral Boundaries

    Zoonotic Infections and Strategies for Public Health Preparedness
    • 1 Edición
    • Zubaida Hassan + 1 más
    • Inglés
    Crossing Boundaries in Zoonotic Viral Infections and Strategies for Public Health Preparedness addresses the urgent need for a deeper understanding of zoonotic viruses, which pose significant public health threats and require improved preparedness. It provides up-to-date insights into the biology, transmission, and epidemiology of key zoonotic virus families, explores the associated human diseases, and discusses diagnostic and treatment strategies. This comprehensive book systematically explores major zoonotic virus families, beginning with an introductory overview of virology, zoonoses, and human-animal interactions, setting the stage for understanding virus transmission and public health challenges. Each subsequent chapter delves into a specific virus family—covering their discovery, biology, transmission routes, cellular targets, disease mechanisms, diagnostics, treatments, outbreak case studies, and surveillance strategies. Additionally, the book introduces simulation tools for modeling viral pathogenesis and predicting cross-species transmission. It concludes with a synthesis of key themes, emphasizing global health policies, preparedness, and future directions for managing zoonotic viral threats effectively equipping future scientists with essential knowledge and resources to combat emerging zoonotic infections.

  • Nanocarriers for Targeted Therapy and Management of Liver Cancer

    • 1 Edición
    • Devesh U. Kapoor + 2 más
    • Inglés
    Nanocarriers for Targeted Therapy and Management of Liver Cancer presents a comprehensive academic overview of nanocarrier‑based strategies for addressing the biological, pharmacological, and translational challenges of liver cancer. The book positions nanomedicine as a critical enabler of targeted, safer, and more effective therapies for hepatocellular carcinoma and related malignancies. The volume systematically covers major nanocarrier platforms alongside emerging approaches such as AI‑assisted design, pharmacokinetic modeling, nanotoxicology, clinical translation, and regulatory considerations. Each chapter integrates foundational concepts with current research, clinical trial insights, and future outlooks to ensure coherence and academic rigor. For researchers and graduate‑level learners, the book provides an authoritative reference that bridges nanocarrier design, liver‑specific biology, and translational feasibility. It supports advanced study, interdisciplinary research, and informed innovation in precision nanomedicine for liver cancer.

  • Advances in Food and Nutrition Research

    • 1 Edición
    • Volumen 123
    • Inglés
    Advances in Food and Nutrition Research provides the latest advances in the role of artificial intelligence in the precision nutrition and development of personalized foods, precision nutrition in autoimmune diseases, the need for vitamin D fortification in tropical regions, the health benefits of bioactive peptides, the factors affecting digestibility and glycemic index of rice, bio-based materials for intelligent sensing of food quality and safety, solid-state fermentation of cereal grains for modulating phenolic compounds, natural additives stabilized with nanoclays and the concomitant mycotoxin contamination in foods, especially on climate-related challenges for food safety.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 127
    • Inglés
    Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 137
    • Inglés
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Neuroinflammation and Biomarker Discovery

    From Mechanisms to Clinical Application
    • 1 Edición
    • Arun Kumar Singh + 1 más
    • Inglés
    Neuroinflammation and Biomarker Discovery: From Mechanisms to Clinical Application offers a detailed exploration of the molecular and cellular processes underlying neuroinflammatory conditions. This essential reference addresses the urgent need for advanced biomarkers that can facilitate early diagnosis, monitor disease progression, and guide personalized treatments in neurodegenerative and autoimmune disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. The book synthesizes current knowledge on neuroimmune interactions, glial cell activation, blood-brain barrier integrity, and innate immune signaling pathways, providing a comprehensive framework for understanding neuroinflammatory mechanisms. It also covers state-of-the-art platforms for biomarker discovery, including transcriptomics, proteomics, lipidomics, epigenomics, extracellular vesicles, and neuroimaging techniques, emphasizing their translational potential. The inclusion of disease-specific biomarker landscapes enhances its relevance for clinicians and researchers working in diagnostics and drug development. The final sections focus on translational applications, such as clinical trial design, biomarker validation, and the integration of AI-driven multi-omics data for personalized neuroimmunology. This volume is an indispensable resource for neuroscientists, clinicians, graduate students, biotech professionals, and data scientists seeking to advance understanding and innovation in neuroinflammatory research and clinical practice. By bridging basic science and clinical application, it aims to accelerate the development of targeted therapies and diagnostic tools, ultimately improving patient outcomes in neuroinflammatory diseases

  • Food Authentication and Future Challenges

    Ensuring Transparency in the Global Food Supply
    • 1 Edición
    • Shahzad Zafar Iqbal + 1 más
    • Inglés
    Food Authentication and Future Challenges: Ensuring Transparency in the Global Food Supply explores the vital role of verifying food origin, content, and quality to prevent fraud, ensure safety, and meet regulatory standards. As globalization, climate change, and shifting consumer demands increase the complexity of food integrity, this book offers essential insights into current methods and emerging technologies for safeguarding our food supply. The book is divided into clear sections, covering foundational concepts, advanced identification techniques like chromatography, spectroscopy, DNA, and sensor-based methods, as well as specific challenges related to seafood, meat, honey, oils, herbs, and GMOs. It also highlights innovative solutions such as AI, machine learning, NGS, and CRISPR, and discusses key issues like climate impacts, ethical concerns, and policy enforcement. By combining scientific advances with future perspectives, this book provides a comprehensive resource for researchers, industry professionals, and policymakers committed to protecting food integrity in a rapidly changing world.

  • Contemporary Challenges in Food Packaging

    Innovation, Consumer Acceptance, Sustainability, and Regulatory Considerations
    • 1 Edición
    • Sukvinder K. Jassi + 1 más
    • Inglés
    Contemporary Challenges in Food Packaging: Innovation, Consumer Acceptance, Sustainability, and Regulatory Considerations is an essential resource for academic and industry professionals that explores the complexities of creating innovative, sustainable, safe packaging that attracts consumers within the context of sustainability. This comprehensive text examines the misunderstandings that lead not only consumers but also scientists and industry professionals, to question the necessity and sustainability of packaging materials without fully grasping their essential roles in environmental safety, food preservation, and effective packaging waste management. By highlighting the vital role packaging plays in consumer acceptance, and the circular economy, this book serves as a bridge between academic research and practical application, and gives readers the knowledge to navigate existing challenges in the field. Organized into seven sections,Contemporar... Challenges in Food Packaging: Innovation, Consumer Acceptance, Sustainability, and Regulatory Considerations features 19 chapters that cover everything from the historical evolution of food packaging to the latest innovations in smart packaging technologies. Readers will explore the implications of environmental sustainability, the adaptation to a circular economy model, and the emerging solutions for effective waste management. With contributions from leading experts, the text identifies best practices and innovative strategies that address regulatory requirements, and consumer and industry needs.

  • Transesophageal Echocardiography

    Basic and Advanced Aspects and Clinical Field of Application
    • 1 Edición
    • Antonello D’Andrea
    • Inglés
    Transesophageal Echocardiography: Basic and Advanced Aspects and Clinical Field of Application provides clinicians and echocardiography professionals with a thorough and practical resource covering both the fundamental principles and advanced clinical uses of TEE. It benefits the audience by delivering step-by-step guidance on image acquisition, interpretation of valve and ventricular pathology, and real-world applications in perioperative, emergency, and interventional settings. Richly illustrated and supplemented by instructional videos, the book’s contents include diagnostic techniques, perioperative management, assessment of prosthetic and congenital heart conditions, and specialized topics such as TEE in sports cardiology and critical care—empowering readers to improve patient outcomes and master the latest advancements in cardiovascular imaging.

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