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Elsevier

Libros en Neurociencia

  • Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology

    • 1 Edición
    • Varun Sasidharan Nair + 1 más
    • Inglés
    Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology offers an in-depth exploration of how epigenetic mechanisms shape neural development, immune interactions, and disease progression in the central nervous system. This interdisciplinary volume synthesizes current knowledge across neuroscience, immunology, and pathology, addressing the critical need for integrated frameworks that connect molecular regulation with clinical outcomes. The book covers foundational epigenetic processes such as DNA methylation, histone modifications, and non-coding RNAs, illustrating their roles in neural differentiation, circuit formation, and brain plasticity.It further examines how environmental factors influence epigenetic landscapes, impacting resilience and vulnerability to neuropsychiatric and neurodegenerative disorders. The volume also delves into the epigenetic drivers of neuropathologies including glioblastoma, neuroinflammation, and neurodegeneration, highlighting emerging therapeutic strategies. With contributions from leading international experts, this resource bridges basic science and translational research, providing valuable insights for researchers, clinicians, and advanced students seeking to understand and target complex CNS disorders.

  • Endovascular Therapy for Intracranial Atherosclerotic Stenosis

    • 1 Edición
    • Ning Ma + 1 más
    • Inglés
    Endovascular Therapy for Intracranial Atherosclerotic Stenosis presents selected cases of endovascular treatment for intracranial atherosclerotic stenosis (ICAS), providing detailed information on periprocedural medical management, endovascular strategies, device selection, and follow-up outcomes. The book serves to improve understanding of ICAS and share clinical experiences from high-volume stroke intervention centres with neuro-interventional... The book reviews recent developments in ICAS management and presents evidence that appropriate patient selection and peri-operative planning may contribute to the effectiveness of endovascular therapy for ICAS

  • Cognitive Remediation in Psychiatric Disorders Part B

    Other Conditions, Contexts and Considerations
    • 1 Edición
    • Volumen 307
    • Inglés
    Cognitive Remediation in Psychiatric Disorders is a two-volume work comprising Part A: Core Psychiatric Conditions (Volume 306) and Part B: Other Conditions, Contexts and Considerations (Volume 307). Together, the volumes provide a comprehensive, contemporary account of cognitive remediation and related cognition-oriented interventions across psychiatric, neurodevelopmental, lifespan, and other clinical contexts. Part A establishes the historical, conceptual, and practical foundations of cognitive remediation and examines its application across psychosis, serious mental illness, depression, bipolar disorder, obsessive-compulsive disorder, substance use disorders, and trauma-related disorders. Part B extends the discussion to personality disorders, eating disorders, behavioral addictions, ADHD, autism spectrum disorder, intellectual and developmental disabilities, cognitive concerns in older adults, HIV-associated neurocognitive disorders, multiple sclerosis, cognitive difficulties following electroconvulsive therapy, and emerging technology-enabled approaches. Across both volumes, contributors address intervention principles and mechanisms, clinical integration, adaptation and accessibility, metacognition and subjective cognition, memory, real-world skill acquisition, and functional and vocational outcomes. Together, the volumes provide a broad, integrated framework for understanding how cognition-oriented interventions can support recovery, participation, and everyday functioning across diverse clinical populations.

  • Reasoning

    An Integrative Approach
    • 2 Edición
    • Daniel Krawczyk
    • Inglés
    Reasoning: An Integrative Approach, Second Edition provides an overview, summary, and synthesis of research approaches to the psychology of reasoning. Representing historical perspectives, state-of-the art research, and coverage of upcoming future directions, this volume offers an integrative approach including research on animal behavior, neuroscience, cognitive psychology, AI, development, medicine, and philosophy. The contents range from animal studies through applied situations, and present historical perspectives, discussion of both animal reasoning and human reasoning to provide a cross-species context, and an examination of human reasoning across the lifespan. Though intended primarily for neuroscientists, the book will provide an interdisciplinary examination of reasoning, synthesizing perspectives from neuroscience, cognitive psychology, animal behavior, development, and philosophy, to provide readers with a well-rounded understanding of what reasoning is, various types of reasoning, and its role in decision making and social interactions. New to this edition is research on the influence of technology throughout the book, as well as a greater emphasis on the way that cultural backgrounds and variations in our exposure to information influence our thinking. This will enhance the scope, relatability, and diversity of the book, making it more applicable to future practices and research.

  • Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part B

    • 1 Edición
    • Volumen 193
    • Inglés
    Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part B, published as Volume 193 of the serial International Review of Neurobiology, provides a comprehensive examination of emerging blood-based biomarkers and related biological mechanisms relevant to Alzheimer's disease, Parkinson's disease, vascular cognitive impairment, stroke, and other neuropsychiatric disorders. The volume highlights advances in biomarker discovery, genetic and epigenetic determinants of neurodegeneration, extracellular vesicles and exosomes, protein misfolding, microRNA dysregulation, blood-brain barrier dysfunction, and biofluid-based biosensing technologies. It also explores the integration of artificial intelligence with multimodal biomarker datasets to improve diagnosis, prognosis, and precision medicine approaches. Bringing together contributions from international experts, this volume offers researchers and clinicians an up-to-date resource on translational developments that are shaping the future of neurodegenerative disease detection and management.

  • The Brain Histaminergic System in Health and Disease

    • 1 Edición
    • Zhong Chen + 2 más
    • Inglés
    Histamines in Neurology and Psychiatry summarizes histamines and their impact on neuroinflammation and brain development in key neural circuits. This book presents the latest research on the physiological regulation of a neuroendocrine responses and releases, broadly discussing histamine receptor modulators and histamine effects in neurology and psychiatry, and also including clinical applications that will be of interest to practitioners.

  • Adult Hydrocephalus and Disorders of CSF Dynamics

    • 1 Edición
    • Benjamin D. Elder + 1 más
    • Inglés
    Adult Hydrocephalus and Disorders of CSF Dynamics reviews the pathophysiology, evaluation, differential diagnosis, management and treatment of adult hydrocephalus and disorders of cerebrospinal fluid (CSF). The introductory section begins with the anatomy and physiology of the cerebrospinal fluid system, with a review of adult hydrocephalus management, including longitudinal care and management of comorbidities. The following technical section devoted to shunt design and development, and then management of patients with idiopathic normal pressure hydrocephalus (iNPH). Coverage includes differential diagnosis and treatment of iNPH, as well as common presentations, neuroimaging, genetic studies, CSF biomarkers, and using artificial intelligence. Confirmatory testing discusses high volume lumbar punctures, lumbar drainage trials, and CSF infusion testing. Medical and surgical treatments are reviewed with expected functional outcomes. A subsequent section discusses secondary normal pressure hydrocephalus, caused by other etiologies such as hemorrhage, tumors, or infection, and covers longstanding overt ventriculomegaly (LOVA), management of adult patients who were shunted as children, and Chiari malformations. The book concludes with high and low pressure CSF dynamics disorders, including idiopathic intracranial hypertension and secondary intracranial hypertension, followed by a review of the medical, surgical, and ophthalmological management of these disorders.

  • Bacterial Infections of the Central Nervous System

    • 1 Edición
    • Karen L. Roos + 1 más
    • Inglés
    "Bacterial Infections of the Central Nervous System" consolidates recent discoveries and best practices on diagnosis and treating infection to minimize morbidity and mortality. The book discusses advancements in neuroimaging techniques, diagnostic studies performed on cerebrospinal fluid, adjunctive therapy, and antimicrobial therapy. Beginning with pathogenesis and pathophysiology of bacterial CNS infections, the book reviews when to suspect a bacterial infection of the central nervous system. The majority of the chapters review specific disease entities, including meningitis, focal CNS infections (e. g., brain abscess, subdural empyema and epidural abscess), CNS diseases caused by selected infectious pathogens (Mycobacteria, Rickettsiae, Anaplasmataceae, Treponema pallidum, Borrelia burgdorferi and other Borrelia species), the neurological complications of infective endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, bacterial etiologies of movement disorders, Guillain-Barre syndrome, toxin-mediated syndromes of the nervous system and infectious encephalopathy.

  • The Zebrafish Model of Neurodegenerative Disorders

    Knowing the Unknown
    • 1 Edición
    • Wael Mohamed
    • Inglés
    The Zebrafish Model of Neurodegenerative Disorders: Knowing the Unknown reveals a ground-breaking method for decoding neurodegenerative disorders such as Parkinson's, Alzheimer's, ALS, and Huntington's through the lens of the zebrafish. This volume bridges the divide between fundamental science and clinical innovation, demonstrating how the genetic malleability, transparent embryos, and conserved neural pathways of zebrafish provide unparalleled insights into neurodegeneration. It illustrates the potential to uncover concealed pathological mechanisms, expedite drug discovery, and surmount the translational failings that impede current research using this gold-standard model species. Featuring contributions from global experts, this volume is systematically structured into five topical sections for ease of navigation. These sections explore the role of cutting-edge tools such as CRISPR-Cas9, AI-driven phenotyping, and high-throughput drug screening in the study of α-synuclein aggregation in Parkinson's Disease and amyloid-β toxicity in Alzheimer's Disease. The volume offers real-world applications, comparative analyses of zebrafish and mammalian models, and actionable protocols that translate zebrafish discoveries to clinical trials. The Zebrafish Model of Neurodegenerative Disorders is designed to empower researchers, clinicians, and healthcare professionals by addressing existing gaps in knowledge, particularly fragmentation in protocols and the translational disconnect between preclinical models and human trials. By fostering an integrated understanding of zebrafish as a model for neurodegeneration, it enhances research reproducibility, accelerates drug discovery, and promotes ethical, scalable research practices. Whether used as a teaching resource or a reference for experimental design, this volume offers invaluable insights to advance the understanding and treatment of devastating neurodegenerative diseases.

  • Sleep Neurology

    • 1 Edición
    • Anne Marie Morse
    • Inglés
    Sleep Neurology explores the intricate relationship between sleep and neurological health, bridging the gap between theoretical knowledge and practical application. This comprehensive reference highlights the role of sleep in overall health and provides an examination of how sleep influences a wide range of neurological disorders. From neurodevelopmental issues to neurodegenerative diseases, this book offers a detailed review of how sleep science can be applied to improve patient outcomes in various neurological conditions. Structured around key neurological topics, the book offers insights into conditions such as epilepsy, stroke, and traumatic brain injury, emphasizing the importance of sleep management in their treatment. Each chapter not only discusses the scientific underpinnings of sleep but also provides tangible strategies for integrating sleep health into primary neurological care.

  • Roles of the Cerebellum in Motor Control

    Foundations, Experimental Approaches and Clinical Applications
    • 1 Edición
    • Mario Manto + 2 más
    • Inglés
    Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease.From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.

  • The Human Nervous System

    • 4 Edición
    • George Paxinos + 2 más
    • Inglés
    The 4th Edition of the classic book The Human Nervous System continues to assemble contributions from world leaders in research on the brain, spinal cord and peripheral nervous system. This book has been edited by the best-known team of brain cartographers, and it has been completely revised to present the cutting edge of human neuroscience. The structure, connections and function are explained in depth, making this book essential to any student or scientist interested in brain anatomy and function.

  • Gold Nanoparticle Therapeutics in Alzheimer's Disease

    Revolutionizing Diagnosis and Treatment
    • 1 Edición
    • Arun Kumar Singh + 2 más
    • Inglés
    Gold Nanoparticle Therapeutics in Alzheimer's Disease: Revolutionizing Diagnosis and Treatment is an essential resource that delves into the groundbreaking use of nanotechnology in the fight against one of the most challenging neurodegenerative disorders. This volume offers an in-depth exploration on how gold nanoparticles can be used to enhance the diagnosis, treatment, and overall understanding of Alzheimer's disease. By examining the molecular mechanisms that enable nanoparticles to cross the blood-brain barrier, the book highlights their role in inhibiting amyloid fibrils and their potential as precise diagnostic tools.Covering a wide range of topics, this comprehensive guide serves as an invaluable reference for researchers, clinicians, and industry professionals at the forefront of Alzheimer's research and nanomedicine.

  • Protein Misfolding

    • 1 Edición
    • Timir Tripathi
    • Inglés
    Protein Misfolding explores the structural and biochemical foundations of protein misfolding, highlighting its wide-reaching implications for cellular function, disease progression, and biomedical innovation. This book provides a comprehensive understanding of how proteins deviate from their native conformations and the resulting biological consequences. Focusing on both physiological and pathological misfolding, the volume covers essential topics such as folding quality control, molecular chaperones, degradation pathways, and proteostasis. It presents in-depth analyses of protein aggregation mechanisms, amyloid formation, and misfolding-associate... diseases including Alzheimer's, Parkinson's, and prion-related disorders. Additional chapters explore structural approaches to understanding misfolded states, computational modeling of aggregation kinetics, and current efforts to design therapeutics that restore folding homeostasis or prevent toxic accumulation. The book also addresses the cellular response to misfolding stress and the integration of folding dynamics with cellular signaling pathways.This book is a valuable resource for researchers, educators, and professionals in biochemistry, structural biology, molecular medicine, biotechnology, and related disciplines. It supports efforts to understand the fundamental principles of protein structure and function, while offering insight into emerging therapeutic strategies and future research directions in disease-focused protein science.

  • Central Nervous System Viral Infections

    • 1 Edición
    • Karen L. Roos + 1 más
    • Inglés
    Central nervous system viral infections pose one of the greatest threats to humanity, as evidenced by recent history with SARS-CoV-2 (COVID 19), HIV, and others. Understanding their effects, therapeutics, and prevention are a top priority for all. "Central Nervous System Viral Infections" reviews the mechanisms of viral infections, current viruses of interest, diagnosis, course, and therapeutics, as well as prevention. Post infection syndromes and complications are also reviewed. Coverage includes Covid, HIV, Zika, EBOLA, Marburg, Herpes, Measles, Mumps, Polio, and more.

  • The Neurobiological Underpinnings of Addiction Medicine

    Focusing on Novel Approaches
    • 1 Edición
    • Mohammad Shabani + 3 más
    • Inglés
    The Neurobiological Underpinnings of Addiction Medicine: Focusing on Novel Approaches provides a comprehensive review of the biological mechanisms that drive addiction and innovative strategies for treatment. This book begins by examining the crucial role of the microbiome and the gut-brain axis in various substance use disorders, including opioid, alcohol, neurostimulant, and cannabis use disorders. It highlights how gut health can significantly influence addiction behaviors and treatment outcomes. Following this, the second section discusses the interplay between addiction and neuropsychiatric disorders such as depression, anxiety, schizophrenia, ADHD, bipolar disorder, PTSD, and OCD.This section emphasizes the impact of neurotransmitter systems and intracellular pathways on the development and persistence of these disorders. The final section introduces cutting-edge methodologies reshaping addiction research, including multi-OMICS approaches and the implications of CRISPR-Cas9 technology. By integrating these diverse topics, this book offers vital insights for clinicians and researchers alike.

  • Basic Neurochemistry

    Principles of Molecular, Cellular, and Medical Neurobiology
    • 9 Edición
    • Scott Brady + 1 más
    • Inglés
    Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, Ninth Edition is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions).This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.

  • Tourette Syndrome and Other Tic Disorders

    • 1 Edición
    • Mariam Hull
    • Inglés
    The Neuroscience of Tourette's Syndrome and Other Tic Disorders provides a foundation of the latest research into tic disorders and the brain, as well as including a comprehensive framework for the evaluation of tics. Authors across multiple specialties present the most thorough and latest knowledge of Tourette syndrome to include underlying pathophysiology, clinical presentation, how to differentiate it from other tic disorders, particularly functional tics. Clinical case studies will also feature throughout to outline challenging cases with expert commentary on evaluation and management strategies.

  • Neurochemical Substrates of Addiction Medicine

    • 1 Edición
    • Mohammad Banazadeh + 2 más
    • Inglés
    Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction.Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2 Edición
    • João L. de Quevedo + 2 más
    • Inglés
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition follows the success of the first edition, synthesizing the basic neurobiology of major depressive disorder (MDD) with discussions on the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and novel optogenetic techniques revolutionizing depression research. This new edition includes comprehensive foundational understandings of the disorder and highlights recent advances, aiding advanced students and researchers in their understanding of MDD. The book introduces new chapters exploring groundbreaking topics such as the neurobiology of treatment-resistant depression, the antidepressant mechanisms of ketamine, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression. This edition also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help to provide a broader and more comprehensive understanding of depression and its treatment.

  • Primer on Cerebrovascular Research

    • 1 Edición
    • Dong-Eog Kim + 3 más
    • Inglés
    Primer on Cerebrovascular Research provides both clinical and basic cerebrovascular knowledge that is required for physicians, vascular researchers, biomedical students, and trainees to understand or conduct evidence-based clinical practice and cutting-edge experimental research. This book outlines how to a design experimental cerebrovascular research in the context of clinical relevance, conduct the study using proper methods, analyze the data accurately, and make conclusions in an unbiased and statistically correct way. Chapters will include representative examples and experimental protocols.

  • Neuroinflammation and Biomarker Discovery

    From Mechanisms to Clinical Application
    • 1 Edición
    • Arun Kumar Singh + 1 más
    • Inglés
    Neuroinflammation and Biomarker Discovery: From Mechanisms to Clinical Application offers a detailed exploration of the molecular and cellular processes underlying neuroinflammatory conditions. This essential reference addresses the urgent need for advanced biomarkers that can facilitate early diagnosis, monitor disease progression, and guide personalized treatments in neurodegenerative and autoimmune disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. The book synthesizes current knowledge on neuroimmune interactions, glial cell activation, blood-brain barrier integrity, and innate immune signaling pathways, providing a comprehensive framework for understanding neuroinflammatory mechanisms. It also covers state-of-the-art platforms for biomarker discovery, including transcriptomics, proteomics, lipidomics, epigenomics, extracellular vesicles, and neuroimaging techniques, emphasizing their translational potential. The inclusion of disease-specific biomarker landscapes enhances its relevance for clinicians and researchers working in diagnostics and drug development. The final sections focus on translational applications, such as clinical trial design, biomarker validation, and the integration of AI-driven multi-omics data for personalized neuroimmunology. This volume is an indispensable resource for neuroscientists, clinicians, graduate students, biotech professionals, and data scientists seeking to advance understanding and innovation in neuroinflammatory research and clinical practice. By bridging basic science and clinical application, it aims to accelerate the development of targeted therapies and diagnostic tools, ultimately improving patient outcomes in neuroinflammatory diseases

  • Inherited Metabolic Diseases and the Brain

    • 1 Edición
    • Fanny Mochel + 2 más
    • Inglés
    Inherited Metabolic Diseases and the Brain explores the latest research on the neurological aspects of inherited metabolic diseases such as epilepsy, encephalotomy and more. With a strong research driven foundation and clinical applications, this book provides a primer which will help practicing pediatric and adult neurologists recognize, diagnose and treat neurometabolic disorders. This volume will also present a number of more common disorders in more detail, describing the variability in clinical presentation, the life course of the disease and the intricacies of diagnosis and treatment.

  • Neurosurgical Neuropsychology

    The Practical Application of Neuropsychology in the Neurosurgical Practice
    • 2 Edición
    • Caleb M. Pearson + 2 más
    • Inglés
    The second edition of Neurosurgical Neuropsychology: The Practical Application of Neuropsychology in the Neurosurgical Practice offers an in-depth review of the critical role neuropsychology plays in neurosurgical settings. This comprehensive resource covers essential preoperative techniques, including advanced functional neuroimaging methods such as fMRI and connectivity-based imaging, alongside traditional approaches like neurocognitive testing and the Wada procedure. This book highlights the significant contributions of neuropsychologists to the neurosurgical team, emphasizing their value in managing diverse patient populations, from candidates for Deep Brain Stimulation to those undergoing adult and pediatric epilepsy surgeries and neuro-oncology interventions. New chapters in this edition address contemporary topics such as the cognitive impact of epilepsy and epilepsy surgery, concussion, neuroplasticity, and the future role of artificial intelligence in neurosurgery. By updating existing content and incorporating fresh insights, this book serves as an essential guide for neurosurgeons, neuropsychologists, neuro-oncologists, epileptologists, and general neurologists who wish to enhance their understanding of neuropsychology's application in both preoperative and postoperative care.

  • Neurobiology of Psychiatric Disorders: New Perspectives on Mental Illness Associated with High Penetrance Genetic Variants

    New Perspectives on Mental Illness Associated with High Penetrance Genetic Variants
    • 1 Edición
    • Noboru Hiroi
    • Inglés
    "The Neurobiology of Psychiatric Disorders" provides a conceptually innovative framework to understand psychiatric disorders including autism spectrum disorders, schizophrenia, intellectual disability, bipolar disorder, and ADHD. This book will allow readers to learn diverse mechanistic bases of psychiatric disorders causally associated with genetic variants. Because rare genetic variants have unprecedentedly high levels of penetrance for psychiatric disorders, this book provides reliable genetic links and their mechanistic substrates, thereby providing the starting points of precision medicine.

  • Non-Invasive Brain Stimulation and Modulation of Auditory Processing

    Basic Principles and Clinical Application
    • 1 Edición
    • Jos J. Eggermont
    • Inglés
    Non-invasive Brain Stimulation and Modulation of Auditory Processing: Basic Principles and Clinical Application provides a comprehensive overview of innovative techniques designed to address auditory processing disorders while highlighting their underlying mechanisms and clinical applications. This book addresses the distinction between hearing loss and hearing impairment, emphasizing the need for interventions that target the brain's neural processes. With a focus on both transcranial and transcutaneous stimulation methods, including transcranial magnetic stimulation (TMS) and transcutaneous electrical stimulation (TES), it explores their effects on auditory functions, cognitive processes, and long-term conditions such as tinnitus and developmental disorders. Each chapter investigates the biophysical mechanisms, therapeutic applications, and potential limitations of these non-invasive techniques, while also discussing their role in enhancing auditory attention, speech processing, and cognitive function in aging populations. By integrating neuroimaging techniques and addressing the importance of brain state, this book serves as an essential resource for researchers and clinicians seeking to understand and apply non-invasive brain stimulation methods to improve auditory processing and overall cognitive health.

  • Epigenetics and miRNA in Neurodegenerative Diseases

    From Molecular Mechanisms to Clinical Applications
    • 1 Edición
    • Lance R. McMahon + 2 más
    • Inglés
    Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatment

  • The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care

    • 1 Edición
    • Volumen 192
    • Inglés
    The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care, published as Volume 192 of the serial International Review of Neurobiology, provides a comprehensive and multidisciplinary examination of Alzheimer’s disease (AD) across its biological, psychological, and technological dimensions. This volume integrates current research on neuropsychiatric factors such as depression, stress, and anxiety with advances in neuroanatomy, systems neuroscience, and emerging AI-driven diagnostic and therapeutic approaches. Chapters explore key brain regions and circuits implicated in AD—including the thalamus, prefrontal cortex, hippocampus, and memory-emotion networks—while also addressing comorbidities, extracellular vesicles as biomarkers, and innovative treatment strategies. The inclusion of computational approaches, model organisms, and novel therapeutic avenues reflects a strong translational focus, bridging mechanistic understanding with clinical and digital health applications. Collectively, this volume serves as an authoritative resource for understanding the Alzheimer’s continuum from early cognitive impairment to advanced disease and care optimisation.

  • Algorithmic Approaches for the Diagnosis of Common Neurological Emergencies

    • 1 Edición
    • Gentle Sunder Shrestha + 3 más
    • Inglés
    Algorithmic Approaches for the Diagnosis of Common Neurological Emergencies is a practical resource aimed at clinicians working in the field of neurology. By providing an algorithmic approach to diagnosing patients, this volume helps clinicians quickly and systematically approach patients, minimizing the risk of missing common neurological emergencies. Offering case studies and various common neurological scenarios, readers will be able to pick up on warning signs of serious neurological emergencies and treat patients effectively. Users will find this to be a valuable guide to help manage patients with neurological emergencies with limited resources.

  • The NeuroComplex Interaction of Appetite Regulation

    Brain, Body and Environment
    • 1 Edición
    • Nasrollah Moradikor + 1 más
    • Inglés
    The NeuroComplex Interaction of Appetite Regulation: Brain, Body and Environment presents the latest research on why we eat, what makes us hungry, and how our brain controls our cravings. The book covers the data for how the brain, hormones, and different factors such as stress, the environment, and even food itself affects our desire to eat. Written for academics and researchers, this book helps facilitate a comprehensive understanding on how the brain influences appetite regulation, allowing readers to understand how neurobiological mechanisms can help treat patients involved with obesity, eating disorders, or other related conditions.Readers will find this to be a reliable resource that connects current neuroscience research with practical applications in appetite and behavior.

  • Lysosomal Pathophysiology of Parkinson’s Disease

    • 1 Edición
    • Mattia Volta + 1 más
    • Inglés
    Lysosomal Pathophysiology of Parkinson’s Disease delves into the genetic and genomic revelations that have transformed our understanding of Parkinson’s Disease at the molecular level. The book highlights the critical role of the autophagy-lysosome pathway in the disease's pathogenic processes, drawing a comprehensive timeline of disease onset and progression. It offers a detailed examination of how disruptions in this pathway contribute to the hallmarks of Parkinson’s Disease, providing invaluable insights for researchers and clinicians alike. Subsequent chapters extend these insights by comparing Parkinson’s Disease to other neurodegenerative disorders such as Alzheimer’s Disease and Frontotemporal Dementia. By exploring protein pathology and synaptic alterations, the book underscores the broader implications of autophagy-lysosome dysfunction. Additionally, it discusses how the molecular perspectives gleaned from Parkinson’s Disease can inform our understanding of these other conditions, presenting a unified approach to studying neurodegeneration.

  • Precision Functional Mapping

    From Human Neuroscience to Engineering
    • 1 Edición
    • Prantik Kundu
    • Inglés
    Precision Functional Mapping explores next-generation functional neuroimaging techniques, focusing on the pursuit of accuracy and scalability in understanding the human brain, to the extent of enabling individual-subject level insights on brain function. Precision Functional Mapping: From Neuroscience to Engineering provides a clear and practical guide to implementing precision functional mapping. It uniquely balances the theoretical foundations of advanced functional neuroimaging with actionable strategies for implementation. With an emphasis on precision, scalability, and practical relevance, it addresses both current limitations and future possibilities in the field. By focusing on underexplored areas such as sparsity, temporal precision, and regulatory considerations, it offers a fresh perspective. Readers interested in neuroscience research, clinical applications, or technology development will find this book gives them tools and insights to push the boundaries of what is possible with functional neuroimaging.

  • Neuroreceptors

    Physiology, Pathology, and Therapeutic Targeting
    • 1 Edición
    • Deepa S. Mandlik + 1 más
    • Inglés
    Neuroreceptors: Physiology, Pathology, and Therapeutic Targeting offers an in-depth exploration of the cellular and molecular mechanisms underlying brain receptor function and their critical roles in health and disease. This authoritative reference addresses ionotropic, metabotropic, receptor tyrosine kinases, and nuclear receptors, detailing their structures, signaling pathways, and physiological functions. The book emphasizes how receptor malfunctions contribute to neurological and psychiatric conditions such as Parkinson’s disease, Alzheimer’s, schizophrenia, and epilepsy, bridging fundamental biology with clinical relevance. Through comprehensive coverage of experimental methodologies—includ... imaging, electrophysiology, and molecular pharmacology—it equips researchers and clinicians with practical insights for investigating receptor dynamics and developing targeted therapies. The final sections focus on innovative therapeutic strategies, including gene editing, receptor modulation, and personalized medicine approaches, reflecting current advances in translational neuroscience. This resource is designed to serve as a vital tool for scientists, healthcare professionals, and students seeking a cohesive understanding of receptor biology and its therapeutic potential, fostering progress in neuropharmacology and neurotherapeutics

  • A Guide to Brief Clinical Interventions in Inpatient and Abbreviated Settings

    • 1 Edición
    • Elaheh Ashtari + 3 más
    • Inglés
    There are many resources available for evidence-based psychotherapies in outpatient and other long-term settings, but limited resources are available for inpatient and other brief settings. A Guide to Brief Clinical Interventions in Inpatient and Abbreviated Settings offers a problem-focused psychotherapeutic approach applicable to brief and long-term care settings. The text will this text will include explicit cultural considerations when applying brief treatment, and promote cultural responsiveness across treatment providers and care settings. This multimodal, evidence-informed handbook is intended for behavioral health and mental health practitioners alike who desire to deliver high quality interventions in time limited settings, such as acute and subacute inpatient units.

  • Rhythmic Regulation in Neuroscience and Clinical Practice

    • 1 Edición
    • Barbara Minton + 2 más
    • Inglés
    Rhythm and Entrainment in Neuromodulation covers cutting-edge and up-to-date information on currently available rhythm-related treatment procedures, as well as the interplay between music and cognition. The book contains contributions from leading experts in the across several fields, exploring the ways in which rhythmic stimulation serves as a powerful neuromodulator, enhancing cognitive function and promoting healing. Best suited for clinicians and researchers interested in neuromodulation, this volume offers profound insights into how rhythm shapes our cognition, influences our well-being, and paves the way for innovative therapeutic practices.

  • Biomarkers in Neurological Disorders and Treatment

    • 1 Edición
    • Arun Kumar Singh + 3 más
    • Inglés
    Decoding the Brain: Biomarkers in Neurological Disorders and Treatment provides a comprehensive exploration of the latest advances in neurological biomarkers, detailing their discovery, validation, and application in clinical practice. By offering insights into the biological underpinnings of various neurological disorders, this book aims to bridge the gap between cutting-edge biomarker research and its practical implementation in patient care.

  • Nanomedicine for Neurological Disorders

    Design, Delivery, and Clinical Perspectives
    • 1 Edición
    • Malik Zainul Abdin + 4 más
    • Inglés
    Nanomedicine for Neurological Disorders: Design, Delivery, and Clinical Perspectives addresses the urgent need for innovative solutions in treating complex neurological and neurodegenerative diseases. As the global burden of conditions such as Alzheimer's, Parkinson's, multiple sclerosis, and brain tumors continues to rise, the scientific community faces the critical challenge of safely and effectively delivering therapeutics across the blood-brain barrier. This reference meets the needs of neuroscientists, clinicians, pharmaceutical scientists, and biomedical engineers seeking advanced strategies and translational insights in neuro-nanomedicine. The contents are structured to provide a comprehensive, interdisciplinary exploration of the field. Chapters cover the anatomy and connectivity of the human brain, the global burden and mechanisms of neurological disorders, conventional and nanomedicine-based drug delivery systems, and the intricacies of the blood-brain barrier. Readers will benefit from detailed analyses of nanocarrier engineering, stability, analytical techniques, toxicological safety, regulatory challenges, and artificial intelligence-driven drug design. Real-world case studies, clinical trial data, and future outlooks are presented alongside ethical and patient-centric considerations, ensuring a holistic perspective on the evolving landscape of neuro-nanomedicine. Nanomedicine for Neurological Disorders delivers essential benefits by bridging the gap between laboratory innovation and clinical practice. It equips readers with practical knowledge, foundational advances, and visionary insights to inspire new research directions, inform better decision-making, and accelerate the development of safer, more precise treatments for brain-related disorders. This reference is an indispensable resource for researchers, clinicians, and innovators at the forefront of neurological therapeutics.

  • Complications in Neuroanesthesia

    • 2 Edición
    • Hemanshu Prabhakar
    • Inglés
    Complications in Neuroanesthesia, Second Edition offers an extensive examination of the complications associated with neuroanesthesia practice, emphasizing both new and existing challenges in the field. This updated edition introduces critical topics such as locked-in syndrome, cerebellar mutism syndrome, delirium, awareness, memory loss, perioperative stroke, and coma, alongside established complications like brain herniation, hydrocephalus, and seizures. Each complication is meticulously examined in separate chapters, detailing the pathophysiology, mechanisms, diagnosis, treatment, and prevention strategies. This book also addresses cardiovascular issues, including stunned myocardium, as well as fluid and electrolyte disturbances like glucose dysregulation and conditions like post-dural puncture headache, malignant hyperthermia and reperfusion injury. Written in an accessible format for quick navigation, this resource provides invaluable insights into the perioperative management of neurosurgical and neurologic patients. This book is a practical tool for trainees, clinicians, and researchers in anesthesia, neuroanesthesia, neurosurgery, neurocritical care, and neurology. By highlighting preventable mishaps, this edition aims to enhance the safety and efficacy of neuroanesthesia and neurocritical care practice.

  • Neuroscience-Informed Psychoeducation (NIPE) for Brain and Mental Health

    Part D
    • 1 Edición
    • Volumen 305
    • Inglés
    Neuroscience-Informe... Psychoeducation (NIPE) for Brain and Mental Health series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Neurogynecology and Associated Neurological Disorders

    • 1 Edición
    • Vishal K. Chavda + 2 más
    • Inglés
    Neurogynecology and Associated Neurological Disorders addresses the emerging interdisciplinary field linking neurology and gynecology, focusing on how neurological disorders impact female reproductive health throughout the lifespan. The book covers foundational neuroanatomy, hormonal influences on neurological function, and specific disorders including headaches, epilepsy, pelvic neuropathies, and mental health conditions related to reproductive stages. It includes clinical guidelines, case studies, diagnostic tools, and treatment protocols tailored to hormonal phases and life stages. The integration of neurobiological mechanisms with gynecological considerations offers readers a robust framework for interdisciplinary collaboration.Reader... will find this to be a great reference that responds to the growing clinical need for integrated understanding and management of conditions such as menstrual migraines, pregnancy-related neuropathies, and menopausal neurological changes.

  • Neuroscience-Informed Psychoeducation (NIPE) for Brain and Mental Health

    Part C
    • 1 Edición
    • Volumen 304
    • Inglés
    Neuroscience-Informe... Psychoeducation (NIPE) for Brain and Mental Health, Part B, Volume 300 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics such as Neuroscience-informe... Psychoeducation for Functional Neurological Disorder, Neuroscience-informe... Psychoeducation for Multiple Sclerosis, Neuroscience-informe... Psychoeducation for Neurodegenerative Disorders (Alz & PD) / Dementia, Neuroscience-informe... Psychoeducation for Traumatic Brain Injury, Neuroscience-informe... Psychoeducation for Epilepsy, Neuroscience-informe... Psychoeducation for Stroke, Neuroscience-informe... Psychoeducation for Movement Disorders, and much more.Additional chapters cover Neuroscience-informe... Psychoeducation for Therapy, Neuroscience-informe... Psychoeducation for Pharmacotherapy, Neuroscience-informe... Psychoeducation for Brain Stimulation, Neuroscience-informe... Psychoeducation for Cognitive Rehabilitation, Neuroscience-Informe... Psychoeducation as a Digital Neurotechnology Platform, Neuroscience-informe... Psychoeducation for Policy Making (Neurolaw), Neuroscience-informe... Psychoeducation to Promote Community Engagement, and more.

  • Motor Control Methods and Clinical Applications

    • 1 Edición
    • Volumen 220
    • Robert Chen + 1 más
    • Inglés
    Motor Control Methods and Clinical Applications provides a detailed review on the use of non-invasive brain stimulation to study motor control. Split into two distinct parts, this new volume covers the latest research in motor control, including real examples of these methods in a clinical setting. The first part covers advanced methods such as transcranial magnetic, electrical and ultrasound stimulation, long latency, spinal reflexes, multichannel EMG, and EEG-EMG analyses that can be used to examine and modulate the motor system. The second part of the book addresses the clinical applications of these methods.

  • Neuroscience-Informed Psychoeducation (NIPE) for Brain and Mental Health

    Part B
    • 1 Edición
    • Volumen 303
    • Inglés
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Diagnostic Application of Blood-based Biomarkers for Neurodegenerative Diseases

    • 1 Edición
    • Meenakshi Dhanawat + 4 más
    • Inglés
    Diagnostic Application of Blood-based Biomarkers for Neurodegenerative Diseases is a comprehensive exploration of the pivotal role blood-based biomarkers play in diagnosing and managing neurological disorders. This comprehensive guide emphasizes the need for early detection and intervention in conditions such as Alzheimer’s disease, Parkinson’s disease, and neuroinflammation. Each chapter delves into specific biomarkers, including glial fibrillary acidic protein and neurofilaments, elucidating their diagnostic potential. This book highlights recent advancements in the application of blood biomarkers across various neurodegenerative diseases, underscoring the integration of artificial intelligence in biomarker discovery. By bridging research and clinical practice, it serves as an essential resource for professionals in diagnostic sciences, pharmaceutical research, and clinical pharmacology. Ultimately, this volume aims to reshape the landscape of early diagnosis, offering insights that promise to enhance personalized treatment strategies and improve patient outcomes in the fight against debilitating neurological disorders.

  • Epigenetic Mechanisms in Brain Physiology and Disorders

    • 1 Edición
    • Volumen 219
    • Moshe Szyf + 1 más
    • Inglés
    Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.

  • Practice of Neurocritical Care in Resource Limited Countries

    • 1 Edición
    • Hemanshu Prabhakar + 2 más
    • Inglés
    Practice of Neurocritical Care in Resource Limited Countries offers a comprehensive examination of the unique challenges and practical strategies for delivering neurocritical care in low- and middle-income countries (LMICs). As the prevalence of neurological emergencies continues to rise in these regions, this book addresses the critical need for effective management in resource constrained environments. It begins by exploring the landscape of neurocritical care, including common neurological emergencies and their epidemiology in LMICs. The content outlines foundational principles of patient assessment and monitoring, as well as advanced management strategies for conditions such as traumatic brain injury, stroke, and spinal cord injury. Special attention is given to the nuances of caring for diverse patient populations, including pediatric and geriatric patients. Additionally, this book highlights the essential role of pain management, and nutritional support, in neurocritical settings. With contributions from experts across various LMICs, this resource emphasizes innovative approaches to training and capacity building, empowering healthcare professionals to provide high-quality neurocritical care despite the challenges of limited resources. This book is an invaluable tool for clinicians and educators dedicated to improving outcomes for neurologically ill patients in lesser-resourced healthcare systems.

  • Disorders of Memory

    • 1 Edición
    • Andrew E. Budson + 1 más
    • Inglés
    Disorders of Memory provides a new update on research pertaining to memory disorders, with a central focus on differing components of memory processes, as well as clinical conditions affecting memory. The book covers methods of assessment and clinical treatment, management, and rehabilitation of these disorders. With chapters written by leading international experts, it provides an overview of our current knowledge on memory disorders that will be of benefit to both researchers and practitioners interested in neurology.

  • Neuroscience of Social Behavior

    Bridging the Mind and Society
    • 1 Edición
    • Mikhail Votinov
    • Inglés
    Social behavior is fundamental to human experience, yet the neural mechanisms that govern how individuals perceive, interpret, and respond to one another are only beginning to be understood. Neuroscience of Social Behavior: Bridging the Mind and Society offers a rigorous and integrative examination of the biological foundations of social interaction, synthesizing current knowledge from neuroscience, psychology, sociology, and anthropology into a coherent framework.The book addresses the full scope of social neuroscience, from the evolutionary origins of the social brain to the challenges posed by digital communication and artificial intelligence. Core topics include social perception, language and communication, empathy, mentalizing, moral cognition, decision-making, and the neural basis of both prosocial and antisocial behavior. The text further explores how hormones and neurochemistry modulate social bonds, how social reward and pain systems shape motivation, and how clinical conditions disrupt social functioning. Computational and translational perspectives are integrated throughout, connecting laboratory findings to real-world implications.By bridging multiple levels of analysis, from neural circuits and neurochemistry to behavior and societal context, this volume equips readers with a comprehensive understanding of how the brain supports, and sometimes undermines, our capacity for social life.

  • Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management

    • 1 Edición
    • Wael Mohamed
    • Inglés
    Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management offers a comprehensive exploration of the latest innovations and multidisciplinary approaches in Parkinson’s Disease treatment. The volume is organized into sections covering genetic therapies, gut microbiota, artificial intelligence, virtual reality, neuroprotective strategies, polypharmacy, and combination therapies. It addresses the integration of personalized medicine, neuroprotective diets, natural products, cognitive enhancers, and ethical considerations. Additional chapters introduce traditional medicine, music therapy, and the synergy between pharmacotherapy and complementary modalities. The book equips readers with the knowledge to implement innovative therapies, navigate complex ethical landscapes, and integrate multidisciplinary and complementary approaches.This reference is essential for those seeking to advance clinical practice and research in Parkinson’s Disease through the adoption of cutting-edge strategies.

  • Pediatric Deep Brain Stimulation

    • 1 Edición
    • George M. Ibrahim + 1 más
    • Inglés
    Pediatric Deep Brain Stimulation offers the first comprehensive, multi-disciplinary exploration of this rapidly advancing field, providing clinicians with an authoritative guide to the science, practice, and future of pediatric neuromodulation.Orga... into four integrated sections, the book begins with the essentials of a pediatric DBS program—including state-of-the-art imaging, peri-operative management, complication avoidance, and ethical considerations unique to the developing brain. Subsequent chapters examine the use of DBS across the spectrum of childhood movement disorders, from monogenic and acquired dystonias to non-dystonic conditions. A dedicated section addresses neuromodulation for pediatric epilepsy, with a focus on emerging technologies. The book concludes with cutting-edge applications of DBS in neurodevelopmental and neuropsychiatric disorders and a view toward the integration of neuroengineering to expand the reach and future potential of circuit-based interventions in children.Edited by a pediatric movement disorders neurologist and a pediatric functional neurosurgeon who together direct an integrative, comprehensive pediatric DBS program, this volume brings a uniquely collaborative perspective and deep clinical expertise. It is an essential resource for neurosurgeons, neurologists, epileptologists, pediatric specialists, and researchers committed to advancing care for children with severe neurological disease.

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