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Elsevier

Libros en Neurobiología

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2 Edición
    • Joao L. de Quevedo + 2 más
    • Inglés
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition provides the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the novel optogenetic techniques revolutionizing depression research. This new edition aids advanced students and researchers in their understanding of MDD, presenting chapters that explore groundbreaking topics such as the neurobiology of treatment-resistant depression, the mechanisms that make ketamine a better antidepressant, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression.The book also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help provide a broader and more comprehensive understanding of depression and its treatment.

  • Neurobiology of Obsessive-Compulsive Disorder

    • 1 Edición
    • Eric A. Storch + 2 más
    • Inglés
    Neurobiology of Obsessive-Compulsive Disorder provides a comprehensive review of obsessive-compulsive disorder through a neurobiological lens, offering invaluable insights for researchers and clinicians alike. The book begins with a comprehensive introduction to OCD, detailing its definition, historical perspectives, prevalence, and symptomatology, alongside its comorbidities and associated disorders. Delving into the genetic and familial aspects, the book examines genetic predispositions, heritability, and significant genome-wide association studies. In addition, it addresses neuropsychological findings, cognitive dysfunctions, and implications for treatment, alongside neurodevelopmental factors, including early life stress, immune system dysregulation, and environmental risk factors.Special attention is given to PANDAS/PANS as mechanisms of OCD pathogenesis and the insights gained from animal models. Subsequent chapters cover diagnosis, pharmacological treatments, and a range of psychotherapeutic and behavioral interventions, including CBT, ERP, and ACT, as well as neuromodulation techniques. Finally, the book presents neurobiology-informe... treatment approaches, personalized medicine, and integrative strategies, concluding with discussions on current challenges, ethical considerations, and future research directions.

  • The Rat Nervous System

    • 5 Edición
    • George Paxinos + 1 más
    • Inglés
    The Rat Nervous System, Fifth Edition is an indispensable guide for researchers and students in neuroscience who are working on the rat and mouse as experimental models. The new edition provides thorough updates throughout, including the latest information in an active field of research on the brain, spinal cord, and peripheral nervous system and their unique functions. Readers will learn how to formulate sound hypotheses as well as carry out accurate research models.

  • Neurobiology of Type 2 Diabetes

    • 1 Edición
    • Shovit Ranjan + 2 más
    • Inglés
    The "Neurobiology of Type 2 Diabetes" delves into the intricate interplay between the nervous system and the development, progression, and management of Type 2 Diabetes. This comprehensive volume explores the often-overlooked neurological aspects of diabetes, offering a unique perspective on the disease. The purpose of this book is to bridge the gap between neuroscience and diabetes research, providing a consolidated resource that elucidates the complex relationship between the brain and metabolic regulation. By synthesizing the latest scientific findings, the book aims to offer researchers, clinicians, and students a deep understanding of how neural pathways influence glucose homeostasis, insulin sensitivity, and the emergence of diabetic complications.

  • Neurobiology and Artificial Intelligence

    Medical, Social and Ethical Implications
    • 1 Edición
    • Luca Saba
    • Inglés
    Neurobiology and Artificial Intelligence: Medical, Social, and Ethical Implicationsexplores the dynamic intersection of neurobiology and artificial intelligence (AI),investigating the scientific, philosophical, and ethical implications of these rapidlyevolving fields. By blending cutting-edge research with thought-provoking discussions,this book aims to make complex topics accessible to an interdisciplinary audience,from researchers and upper graduate students eager to understand how AI andneuroscience shape our understanding of intelligence, creativity, learning, and thehuman condition.

  • Neurobiology of Aging

    Exploring Cognitive Decline and Neurodegeneration
    • 1 Edición
    • Sachchida Nand Rai
    • Inglés
    Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration is a comprehensive reference exploring the complexities of the aging brain. This book examines the intricate processes driving cognitive decline and neurodegeneration. From the gradual loss of neurons and synapses to the formation of protein aggregates characteristic of Alzheimer's disease, each chapter reviews key aspects of brain aging. Chapters dissect the mechanisms driving neuronal loss, synaptic dysfunction, and protein misfolding, shedding light on the intricate interplay of oxidative stress, inflammation, and mitochondrial dysfunction. This book also navigates through strategies for healthy brain aging, from the impact of diet and exercise to the role of cognitive stimulation.

  • Nervonic Acid and Brain Health

    • 1 Edición
    • Xianyang Chen + 2 más
    • Inglés
    Nervonic Acid and Brain Health is a comprehensive guide for professionals and researchers seeking in-depth knowledge about nervonic acid. This book meticulously delves into its functions, sources, synthesis, and therapeutic applications. Readers will find valuable information on the connections between nervonic acid, brain health, and neurological conditions, presenting data that is currently scarce in other publications. The book emphasizes evidence-based research findings, making it an essential resource for understanding the impact of nervonic acid on cognitive development and its potential therapeutic benefits.In addition to exploring nervonic acid's role in brain health, the book addresses its significance in infant and toddler brain development, the consequences of deficiency during pregnancy, and its inclusion in infant formula and cognitive health products. The association with neurological conditions such as Alzheimer's disease, multiple sclerosis, and cerebral ischemia is thoroughly examined, providing practical insights for medical professionals and caregivers. This text bridges the gap between scientific research and consumer interests, offering real-world relevance and application.

  • Music and Dementia

    Theory and Implications for Music Use in Dementia Care
    • 1 Edición
    • Sandra Garrido
    • Inglés
    Music and Dementia: Theory and Implications for Music Use in Dementia Care presents research on the effect of music on the brain for neurodegenerative diseases and care. This volume examines the neurological impact of music from research to clinical application, offering case studies and practical steps. This book will be of interest to researchers in dementia and neurodegeneration, as well as practitioners and clinicians interested in the therapeutic application of music in dementia care.

  • Modern Intervention Tools for Rehabilitation

    • 1 Edición
    • Meena Gupta + 2 más
    • Inglés
    Modern Intervention Tools for Rehabilitation addresses current advancements in rehabilitation to better equip clinicians and researchers in the field. This resource will equip professionals for better patient outcomes and improve future rehabilitation research quality. An interdisciplinary understanding of the rehabilitation field is crucial for improved patient care and outcomes, with relevance to patient care in other disciplines as well. With chapters dedicated to diagnostics, choosing appropriate techniques, managing medical treatment, and proper equipment care, readers will be well-equipped to decide on protocols, increase patient outcomes, and improve quality of life.

  • Determinants of Addiction

    Neurobiological, Behavioral, Cognitive, and Sociocultural Factors
    • 1 Edición
    • Justin R. Yates
    • Inglés
    Why can two people use a drug and one person becomes addicted while the other does not? Determinants of Addiction: Neurobiological, Behavioral, Cognitive, and Sociocultural Factors unravels the complexities underlying addiction to understand how individual factors at the genetic, cellular, anatomical, cognitive–behavioral... and sociocultural level can influence susceptibility to substance use disorders. The first section reviews the neurobiological determinants of addiction and examines how drugs hijack the reward pathway and alter numerous neurotransmitter systems such as dopamine. The second section covers the behavioral–cognitive determinants of addiction such a conditioning, memory processes, and decision-making. The final section examines individual differences in addiction vulnerability, with a focus on personality factors, sociocultural factors, sex/gender, and stress. The book references commonly used drugs such as nicotine, ethanol (alcohol), opioids, and cocaine.

  • Plant Extracts in Neurodegenerative Diseases

    • 1 Edición
    • Magisetty Obulesu
    • Inglés
    Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease.

  • Arrestins

    Structure and Function in Vision and Beyond
    • 1 Edición
    • Vsevolod V. Gurevich
    • Inglés
    Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

  • Neurological Complications of Systemic Cancer and Antineoplastic Therapy

    • 2 Edición
    • Herbert B. Newton + 1 más
    • Inglés
    Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist. Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more.

  • Biomarkers in Bipolar Disorders

    • 1 Edición
    • Rodrigo Machado-Vieira + 1 más
    • Inglés
    Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes... prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder.

  • Body, Brain, Behavior

    Three Views and a Conversation
    • 1 Edición
    • Tamas L. Horvath + 2 más
    • Inglés
    Body, Brain, Behavior: Three Views and a Conversation describes brain research on the frontiers, with a particular emphasis on the relationship between the brain　and its development and evolution, peripheral organs, and other brains in communication. The book expands current views of neuroscience by illustrating the integration of these disciplines. By using a novel method of conversations between 3 scientists of different disciplines, cellular, endocrine, developmental, and social processes are seamlessly woven into topics that relate to　contemporary　livi... in health and disease. This book is a critical read for anyone who wants to become familiar with the inner workings of the nervous system and its intimate connections to the universe of contemporary life issues.

  • Year One of Practice Transition

    The Necessary Guide to Success
    • 1 Edición
    • Jason E. Pope + 1 más
    • Inglés
    Year One of Practice Transition: The Necessary Guide to Success is a practical guide for both established physicians transitioning from one practice opportunity to another, and those transitioning from formal residency or fellowship training. This book is an up-to-date look at how to achieve a successful practice, offering insights from top experts who have navigated transition through various phases and circumstances.

  • Methodological Approaches for Sleep and Vigilance Research

    • 1 Edición
    • Eric Murillo-Rodriguez
    • Inglés
    Methodological Approaches for Sleep and Vigilance Research examines experimental procedures used to study the sleep-wake cycle, with topics covered by world leaders in the field. The book focuses on techniques commonly used in the sleep field, including polysomnography, electrophysiology, single- and multi-unit spiking activity recording, brain stimulation, EEG power spectra, optogenetics, telemetry, and wearable and non-wearable tracking devices. Further chapters on imaging techniques, questionnaires for sleep assessment, genome-wide association studies, artificial intelligence and big data are also featured. This discussion of significant conceptual advances into experimental procedures is suitable for anyone interested in the neurobiology of sleep.

  • The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

    • 1 Edición
    • Elizabeth Head + 1 más
    • Inglés
    The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.

  • Stereotaxic Brain Atlas of the Egyptian Fruit Bat

    • 1 Edición
    • Raya Eilam-Altstadter + 3 más
    • Inglés
    The Stereotaxic Brain Atlas of the Egyptian Fruit Bat provides the first stereotaxic atlas of the brain of the Egyptian fruit bat (Rousettus aegyptiacus), an emerging model in neuroscience. This atlas contains coronal brain sections stained with cresyl violet (Nissl), AChE, and Parvalbumin – all stereotaxically calibrated. It will serve the needs of any neuroscientist who wishes to work with these bats – allowing to precisely target specific brain areas for electrophysiology, optogenetics, pharmacology, and lesioning. More broadly, this atlas will be useful to all neuroscientists working with bats, as it delineates many brain regions that were not delineated so far in any bat species. Finally, this atlas will provide a useful resource for researchers interested in comparative neuroanatomy of the mammalian brain.

  • Problems of Living

    Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science
    • 1 Edición
    • Dan J. Stein
    • Inglés
    Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.

  • Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

    • 1 Edición
    • Moyra Smith
    • Inglés
    Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

  • An AGI Brain for a Robot

    • 1 Edición
    • John H. Andreae
    • Inglés
    An AGI Brain for a Robot is the first and only book to give a detailed account and practical demonstration of an Artificial General Intelligence (AGI). The brain is to be implemented in fast parallel hardware and embodied in the head of a robot moving in the real world. Associative learning is shown to be a powerful technique for novelty seeking, language learning, and planning. This book is for neuroscientists, robot designers, psychologists, philosophers and anyone curious about the evolution of the human brain and its specialized functions. The overarching message of this book is that an AGI, as the brain of a robot, is within our grasp and would work like our own brains. The featured brain, called PP, is not a computer program. Instead, PP is a collection of networks of associations built from J. A. Fodor’s modules and the author’s groups. The associations are acquired by intimate interaction between PP in its robot body and the real world. Simulations of PP in one of two robots in a simple world demonstrate PP learning from the second robot, which is under human control. "Both Professor Daniel C. Dennett and Professor Michael A. Arbib independently likened the book　‘An AGI Brain for a Robot’　to Valentino Braitenberg’s 1984 book　‘Vehicles: Experiments in Synthetic Psychology’." Daniel C. Dennett, Professor of Philosophy and Director of Center for Cognitive Studies, Tufts University. Author of "From Bacteria to Bach and Back: The Evolution of Minds."　 "Michael Arbib, a long time expert in brain modeling, observed that sometimes a small book can catch the interest of readers where a large book can overwhelm and turn them away. He noted, in particular, the success of Valentino Braitenberg’s ‘Vehicles’ (for which he wrote the foreword). At a time of explosive interest in AI, he suggests that PP and its antics may be just the right way to ease a larger audience into thinking about the technicalities of creating general artificial intelligence." Michael A Arbib, Professor Emeritus of Computer Science, Biomedical Engineering, Biological Sciences and Psychology, University of Southern California. Author of "How the Brain Got Language". "Robots seem to increasingly invade our lives, to the point that sometimes seems threatening and other-worldly. In this small book, John Andreae shows some of the basic principles of robotics in ways that are entertaining and easily understood, and touch on some of the basic questions of how the mind works." Michael C. Corballis, Professor of Psychology, University of Auckland. Author of "The Recursive Mind". "A little book that punches far beyond its weight." Nicholas Humphrey, Emeritus Professor of Psychology, London School of Economics. Author of "Soul Dust: The Magic of Consciousness". "A bold and rich approach to one of the major challenges for neuroscience, robotics and philosophy. Who will take up Andreae’s challenge and implement his model?" Matthew Cobb, Professor of Zoology, University of Manchester. Author of "The Idea of the Brain". "Here is a book that could change the direction of research into artificial general intelligence in a very productive and profitable way. It describes a radical new theory of the brain that goes some way towards answering many difficult questions concerning learning, planning, language, and even consciousness. Almost incredibly, the theory is operational, and expressed in a form that could—and should—inspire future, novel, research in AI that transcends existing paradigms." Ian H. Witten, Professor of Computer Science, Waikato University. Author with Eibe Frank of "Data Mining: Practical Machine Learning Tools and Techniques".

  • Origins of Human Socialization

    • 1 Edición
    • Donald W. Pfaff
    • Inglés
    Origins of Human Socialization introduces a new concept on the origins of basic human instinct. The book combines the three disciplinary approaches, including neuroscience, paleoanthropology and developmental psychology as an intertwined foundation for prosocial behavior. It argues that humans have the basic brain mechanisms for prosocial activity, offering new insights into more sophisticated social behavior. It also examines both visual and auditory systems in both humans and animals to explain the evolution of social interactions. Written by world-renowned researcher Dr. Donald Pfaff, this book is the first to explore why we have basic social instinct and how it works. For centuries, researchers have argued over the foundations of human behavior in society. Anthropologists point to transitions from hunter/gathers to urban dwellers leading to human domestication. Developmental psychologists highlight social competences in babies. Neuroscientists focus on specific genetic and neurochemical mechanisms that attribute to social behavior. This book brings all of these important areas together in an interdisciplinary approach that helps readers understand how they are linked.

  • Ketamine for Treatment-Resistant Depression

    Neurobiology and Applications
    • 1 Edición
    • Gustavo H. Vazquez + 2 más
    • Inglés
    Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics.

  • Genetics, Neurology, Behavior, and Diet in Dementia

    The Neuroscience of Dementia, Volume 2
    • 1 Edición
    • Colin R. Martin + 1 más
    • Inglés
    Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

  • Biometals in Autism Spectrum Disorders

    • 1 Edición
    • Andreas Grabrucker
    • Inglés
    Biometals in Autism Spectrum Disorders focuses on trace metals and autism. Compared to other references examining ASDs or metallomics, this book presents findings of abnormal metal homeostasis in ASD, providing an overview of current findings on trace metal biology, its role in ASD etiology, and how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs that were once considered unrelated. This comprehensive resource opens new vistas for the development of new therapies based on the targeted manipulation of trace metal homeostasis that will generate new awareness surrounding trace metal levels during pregnancy.

  • Patterning and Cell Type Specification in the Developing CNS and PNS

    Comprehensive Developmental Neuroscience
    • 2 Edición
    • John Rubenstein + 3 más
    • Inglés
    Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems.

  • Omega Fatty Acids in Brain and Neurological Health

    • 2 Edición
    • Ronald Ross Watson + 1 más
    • Inglés
    Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases.

  • Introduction to Addiction

    Addiction, Animal Models, and Theories
    • 1 Edición
    • Volumen 1
    • George F. Koob + 3 más
    • Inglés
    Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 1 Edición
    • Joao L. de Quevedo + 2 más
    • Inglés
    Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.

  • The Molecular and Cellular Basis of Neurodegenerative Diseases

    Underlying Mechanisms
    • 1 Edición
    • Michael S. Wolfe
    • Inglés
    The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

  • Clinical Informatics Literacy

    5000 Concepts That Every Informatician Should Know
    • 1 Edición
    • Dean F. Sittig
    • Inglés
    Clinical Informatics Literacy: 5000 Concepts That Every Informatician Should Know is about all aspects of clinical informatics, a subset of the larger field of biomedical informatics. Clinical Informatics is an applied field that exists at the intersection of the fields of medicine, computer science, information science, anthropology, human factors engineering, cognitive psychology and health services research. As such informaticians are required to have an extremely broad understanding of a considerable swath of the fields at the heart of the health-oriented knowledge economy. The author has collected and explained each one of the relevant concepts during his experience of 27 years working with many of the leaders in the field of clinical informatics at several of the leading academic healthcare institutions around the USA. The author’s experience and his didactic approach make this book an essential source of information for all participants in the clinical informatics field.

  • Essentials of Noncoding RNA in Neuroscience

    Ontogenetics, Plasticity of the Vertebrate Brain
    • 1 Edición
    • Davide De Pietri Tonelli
    • Inglés
    Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differ... neuronal plasticity, and learning and memory.

  • Motivation

    Theory, Neurobiology and Applications
    • 1 Edición
    • Volumen 229
    • Inglés
    Motivation: Theory, Neurobiology and Applications is inspired by a question central to health care professionals, teachers, parents, and coaches alike, "How can an individual be motivated to perform a given activity or training?" It presents novel measurements of motivation developed in psychology and economics, recent insights into the neurobiology of motivation, and current research on applications designed to boost motivation in neurorehabilitation, education, and sports. In addition, tactics on how to connect these different research and knowledge fields within a common (theoretical) framework of motivation is discussed. Thus, in short, the book provides an integrative, interdisciplinary, up-to-date accounting on the neurobiology of motivation and how it might be boosted.

  • Gut Microbiome and Behavior

    • 1 Edición
    • Volumen 131
    • Inglés
    Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications.

  • Nanotechnology and the Brain

    • 1 Edición
    • Volumen 130
    • Inglés
    Nanotechnology and the Brain, the latest edition in the International Review of Neurobiology series is well-known for its appeal to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Written by an internationally renowned expert in the field, this volume focuses on the application of nanotechnology in the brain, covering blood brain barrier biology and how nanoparticles should be engineered to tackle this barrier.

  • The Neurobiology of Schizophrenia

    • 1 Edición
    • Ted Abel + 1 más
    • Inglés
    The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance.

  • Neurobiology of Epilepsy

    From Genes to Networks
    • 1 Edición
    • Volumen 226
    • Inglés
    Neurobiology of Epilepsy: From Genes to Networks is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields.

  • Animal Models for Medications Screening to Treat Addiction

    • 1 Edición
    • Volumen 126
    • Richard L Bell + 1 más
    • Inglés
    Animal Models for Medications Screening to Treat Addiction, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

  • Fundamental Statistical Principles for the Neurobiologist

    A Survival Guide
    • 1 Edición
    • Stephen W. Scheff
    • Inglés
    Fundamental Statistical Principles for Neurobiologists introduces readers to basic experimental design and statistical thinking in a comprehensive, relevant manner. This book is an introductory statistics book that covers fundamental principles written by a neuroscientist who understands the plight of the neuroscience graduate student and the senior investigator. It summarizes the fundamental concepts associated with statistical analysis that are useful for the neuroscientist, and provides understanding of a particular test in language that is more understandable to this specific audience, with the overall purpose of explaining which statistical technique should be used in which situation. Different types of data are discussed such as how to formulate a research hypothesis, the primary types of statistical errors and statistical power, followed by how to actually graph data and what kinds of mistakes to avoid. Chapters discuss variance, standard deviation, standard error, mean, confidence intervals, correlation, regression, parametric vs. nonparametric statistical tests, ANOVA, and post hoc analyses. Finally, there is a discussion on how to deal with data points that appear to be "outliers" and what to do when there is missing data, an issue that has not sufficiently been covered in literature.

  • Insights to Neuroimmune Biology

    • 2 Edición
    • Istvan Berczi
    • Inglés
    Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms.

  • The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon

    • 1 Edición
    • Volumen 131
    • Inglés
    The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport.

  • Endocannabinoids

    • 1 Edición
    • Volumen 125
    • Inglés
    Endocannabinoids, the latest volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into the neurobiology of migraines. It reviews the current knowledge and understanding in the field, and provides a starting point for researchers and practitioners entering the field.

  • Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels

    • 1 Edición
    • Volumen 123
    • Inglés
    This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field.

  • Neurobiology of Language

    • 1 Edición
    • Gregory Hickok + 1 más
    • Inglés
    Neurobiology of Language explores the study of language, a field that has seen tremendous progress in the last two decades. Key to this progress is the accelerating trend toward integration of neurobiological approaches with the more established understanding of language within cognitive psychology, computer science, and linguistics. This volume serves as the definitive reference on the neurobiology of language, bringing these various advances together into a single volume of 100 concise entries. The organization includes sections on the field's major subfields, with each section covering both empirical data and theoretical perspectives. "Foundational" neurobiological coverage is also provided, including neuroanatomy, neurophysiology, genetics, linguistic, and psycholinguistic data, and models.

  • Headache and Migraine Biology and Management

    • 1 Edición
    • Seymour Diamond + 4 más
    • Inglés
    There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field.

  • Epigenetics and Neuroplasticity - Evidence and Debate

    • 1 Edición
    • Volumen 128
    • Inglés
    The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—includ... DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease.

  • Neurobiology of Social Behavior

    Toward an Understanding of the Prosocial and Antisocial Brain
    • 1 Edición
    • Michael Numan
    • Inglés
    Social neuroscience is a rapidly growing, interdisciplinary field which is devoted to understanding how social behavior is regulated by the brain, and how such behaviors in turn influence brain and biology. Existing volumes either fail to take a neurobiological approach or focus on one particular type of behavior, so the field is ripe for a comprehensive reference which draws cross-behavioral conclusions. This authored work will serve as the market’s most comprehensive reference on the neurobiology of social behavior. The volume will offer an introduction to neural systems and genetics/epigenetics... followed by detailed study of a wide range of behaviors – aggression, sex and sexual differentiation, mating, parenting, social attachments, monogamy, empathy, cooperation, and altruism. Research findings on the neural basis of social behavior will be integrated across different levels of analysis, from molecular neurobiology to neural systems/behavioral neuroscience to fMRI imaging data on human social behavior. Chapters will cover research on both normal and abnormal behaviors, as well as developmental aspects.

  • Artificial Neural Networks, 2

    Proceedings of the 1992 International Conference on Artificial Neural Networks (ICANN-92) Brighton, United Kingdom, 4-7 September, 1992
    • 1 Edición
    • I. Aleksander + 1 más
    • Inglés
    This two-volume proceedings compilation is a selection of research papers presented at the ICANN-92. The scope of the volumes is interdisciplinary, ranging from the minutiae of VLSI hardware, to new discoveries in neurobiology, through to the workings of the human mind. USA and European research is well represented, including not only new thoughts from old masters but also a large number of first-time authors who are ensuring the continued development of the field.

  • Neurobiology of Alcohol Dependence

    • 1 Edición
    • Antonio Noronha + 3 más
    • Inglés
    Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence.