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Elsevier

Libros en Farmacología

  • Molecular Mechanisms of Cancer Resistance

    Emerging Technologies and Therapeutic Strategies
    • 1 Edición
    • Ahmet Acar
    • Inglés
    Molecular Mechanisms of Cancer Resistance: Emerging Technologies and Therapeutic Strategies explores innovative tools and strategies designed to address the critical issue of drug resistance in cancer treatment. This comprehensive volume is tailored for researchers, clinicians, and students, offering insights into the latest advancements and methodologies in the field. The book covers essential topics such as molecular mechanisms of drug resistance, the tumor microenvironment, and emerging technologies like single-cell analysis and computational modeling. Each chapter features contributions from leading experts, providing a multi-dimensional perspective on both foundational concepts and cutting-edge research.By engaging with this book, the academic audience gains access to groundbreaking research and therapeutic strategies that enhance understanding and practice. The knowledge acquired will inspire collaboration and innovation, ultimately contributing to more effective and personalized cancer treatment approaches.

  • Principles of Antiviral Drug Development

    Rapid Discovery Technologies and Practical Applications
    • 1 Edición
    • Ailin Liu
    • Inglés
    Principles of Antiviral Drug Development: Rapid Discovery Technologies and Practical Applications systematically integrates the major experimental techniques and virtual drug screening methods involved in the discovery of antiviral drugs, and provides a detailed discussion of their applications: among them, the combination of virtual drug screening technologies coupled with experimental methods offers strong potential for the rapid discovery of antiviral agents. The book also discusses activity-guided extraction, isolation, and activity evaluation of active components in order to reveal the material basis of antiviral activity and preliminary mechanisms of action. The book also discusses: drug repurposing of approved medicines; and an analysis of the discovery and mechanistic studies of a series of antiviral natural products which offer important information on the needs of future research, development, together with the clinical application of new antiviral drugs.

  • Annual Reports in Medicinal Chemistry

    • 1 Edición
    • Volumen 67
    • Inglés
    Annual Reports in Medicinal Chemistry, Volume 67 presents authoritative and forward‑looking reviews that capture current advances in medicinal chemistry, with a strong emphasis on molecular conjugates, hybrid therapeutics, and precision drug design. Contributions from leading international researchers examine emerging strategies for antiviral, antifungal, and antimicrobial drug development, including small‑molecule conjugates, aptamer–RNA platforms, terpene‑derived hybrids, and intracellular targeting approaches.The volume highlights how chemical innovation is being leveraged to address drug resistance, emerging viral threats, and unmet clinical needs, while also reflecting broader methodological advances in conjugate design, carrier systems, and structure–activity relationships. As with previous volumes in the series, ARMC 67 serves as both a critical reference and a forward‑looking guide for medicinal chemists in academia and industry.

  • Encyclopedia of Pharmacy Practice and Clinical Pharmacy

    • 2 Edición
    • Zaheer-Ud-Din Babar
    • Inglés
    Encyclopedia of Pharmacy Practice and Clinical Pharmacy, Second Edition, Three-Volume Set is a comprehensive reflection of the transformative shifts in pharmaceutical policy, practice, and research. Covering a wide range of subjects, including clinical pharmacy, socio-administrative and behavioral pharmacy, and the critical field of pharmacovigilance, this new edition is hailed as the most comprehensive reference resource in the field. With a collection of over 210 chapters contributed by field experts, the book seamlessly bridges the gap between foundational principles and emerging trends, providing readers with a rich understanding of the multifaceted aspects of pharmacy practice and clinical pharmacy.Readers will find this an indispensable tool that allows practitioners, researchers, and students alike to easily navigate the ever-changing landscape of pharmacy in the 21st century.

  • Analytical Pharmacology

    • 1 Edición
    • Su Zeng + 1 más
    • Inglés
    Analytical Pharmacology covers a wide range of analytical methods, including PCR, flow cytometry, molecular imaging, and gene editing, in the context of mechanistic studies, target discovery, biomarker development, drug metabolism, and clinical evaluation. The comprehensive scope and emphasis on emerging technologies make it a valuable resource for researchers seeking to understand how analytical tools are applied to solve key scientific problems in pharmacology and toxicology. Pharmaceutical industry specialists, including quality control analysts, regulatory affairs specialists and pharmaceutical technicians, will find value in understanding how modern analytical techniques can enhance drug quality assessment and compliance with regulatory requirements. For all readers interested in practical applications there are detailed descriptions of analytical techniques and validation methods. Case studies are used throughout to enrich theory and practical application.The book offers research and academic readers detailed information on the emerging technologies of spatial transcriptomics and spatial omics, supporting their application in research studies and teaching

  • Pharmaceutical Hot Melt Extrusion

    From Materials Selection to Commercial Production
    • 1 Edición
    • Purnima D. Amin
    • Inglés
    Pharmaceutical Hot Melt Extrusion: From Materials Selection to Commercial Production is an authoritative resource on the evolving landscape of HME technology. The book explores the core principles of formulation development, equipment design, process scaling, and regulatory considerations, providing essential knowledge for researchers and industry professionals. It emphasizes innovative, green manufacturing practices, solvent-free processes, and patient-centric delivery systems, making it a vital guide for advancing pharmaceutical and nutraceutical formulations. This reference enhances understanding of cutting-edge HME applications, supporting environmentally sustainable practices and innovative product development for both academia and industry.It equips formulation scientists, R&D professionals, and students with the knowledge to accelerate research, improve efficiency, and translate laboratory innovations into market-ready solutions.

  • Anti-Obesity Drug Development

    Physiology, Pharmacology and Drug Delivery
    • 1 Edición
    • Fadia Salah Youssef + 1 más
    • Inglés
    Anti-Obesity Drug Development: Physiology, Pharmacology and Drug Delivery is a complete reference for pharmaceutical researchers in this key area of research and clinical development. The contents of the book are organized in four parts. The first provides an overview of the foundations and historical development of anti-obesity drugs, including extensive discussion of comorbidities and how they impact drug activity and efficacy. Part two is dedicated to the drug targets involved in the progression of obesity treatment. These include GLPRI and GIPR agonists, Incretin/Glucagon, RM-493 and Liraglutide, Pramlintide and metreleptin, Growth Hormone, FXR and GPR131, and the Gut Microbiota. Part three discusses the most common drugs available in the market and their pharmacological parameters. The final part of the book covers all natural products known to have scientific evidence on the treatment of obesity.Anti-Obesity Drug Development: Physiology, Pharmacology and Drug Delivery is the perfect reference for pharmacology researchers and those involved in new drug development both in academic and corporate environments. Research-physicians, endocrinologists, and nutritionists will also benefit from the comprehensive overview of treatments covered in this book.

  • Integrating Artificial Intelligence with Virtual Screening

    A New Era in Drug Discovery
    • 1 Edición
    • Vivek Asati + 1 más
    • Inglés
    Integrating Artificial Intelligence with Virtual Screening: A New Era in Drug Discovery addresses the evolving landscape of drug discovery by combining traditional virtual screening with cutting-edge artificial intelligence technologies. This volume offers an interdisciplinary guide to AI-driven ligand and structure-based screening methods, including machine learning, deep learning, and generative models, thus enabling faster and more accurate identification of drug candidates. It covers mathematical models, computational workflows, and optimization strategies such as Pareto-based and physics-based approaches.Sections also discuss challenges in navigating ultra-large chemical libraries and present practical case studies that demonstrate real-world applications. Edited by leading researchers, the book provides authoritative insights suited for graduate students, researchers, and industry professionals. Users will be empowered by the latest tools and knowledge to innovate drug discovery pipelines and support the development of precision medicines and foster advancements in pharmaceutical sciences.

  • Medicines Safety and Pharmacovigilance

    Introduction, Concepts, and Applications
    • 1 Edición
    • Rabia Hussain
    • Inglés
    Medicines Safety and Pharmacovigilance: Introduction, Concepts, and Applications provides a comprehensive guide for pharmaceutical professionals navigating the complex landscape of medicine safety and vigilance. Designed to support strategic decision-making, this reference draws on industry expertise to uphold the highest standards of patient care. The book addresses essential regulatory requirements, reporting obligations, and ethical considerations, offering practical guidance for implementing effective pharmacovigilance systems. Covering the latest technological advancements, it ensures readers are equipped to meet the modern challenges faced by healthcare and pharmaceutical sectors in monitoring the safety and efficacy of medicines for diverse populations worldwide.Beyond the foundational concepts, the book presents detailed insights into signal detection, risk management plans, and the real-world application of pharmacovigilance through case studies from both high- and low-middle-income countries. It examines the pivotal role of pharmacists and the importance of tailored approaches for special populations, while emphasizing effective communication of medicines safety.

  • Nonclinical Evaluation Studies of Cellular and Gene Therapy Products

    Strategies, Models, and Regulatory Frameworks
    • 1 Edición
    • Quanjun Wang + 2 más
    • Inglés
    Nonclinical Evaluation Studies of Cellular and Gene Therapy Products: Strategies, Models, and Regulatory Frameworks systematically explores the nonclinical evaluation of Cell and Gene Therapies (CGT) products, emphasizing risk mitigation and innovation. The book provides comprehensive coverage, including 20+ chapters spanning preclinical toxicology, pharmacokinetics, and novel evaluation models. It is the first book to integrate organ-on-chip models into CGT evaluation, reflecting FDA/NMPA modernization initiatives. It includes practical guidance on addressing CRISPR off-target effects, immunogenicity, and long-term carcinogenicity risks.

  • Annual Reports on Medicinal Chemistry

    • 1 Edición
    • Volumen 66
    • Inglés
    Annual Reports in Medicinal Chemistry Volume 66 provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Focus in this new release is on The anti-inflammatory and immunological properties of GLP-1R and How to reduce side effects of GLP-1 based obesity medications.

  • Recent Advances in Molecular Docking

    Methods, Tools, and Applications
    • 1 Edición
    • Khalid Raza
    • Inglés
    Recent Advances in Molecular Docking: Methods, Tools, and Applications offers an authoritative guide to modern molecular docking techniques, emphasizing the integration of artificial intelligence and machine learning. The volume covers foundational principles, computational workflows, and advanced scoring functions, providing researchers and practitioners with practical tools to improve drug-target interaction predictions. It highlights applications across pharmaceuticals, including cancer, neurological disorders, and infectious diseases, which are all supported by real-world case studies. Challenges in docking accuracy, reproducibility, validation, and ethical and regulatory considerations are also covered.Authored by international experts, it bridges theoretical knowledge with practical applications, making it an essential resource for computational biologists, pharmacologists, and drug developers aiming to leverage AI-driven docking in precision medicine.

  • The Science of Pharmacology

    • 1 Edición
    • Jahangir Moini + 3 más
    • Inglés
    The Science of Pharmacology offers a detailed and contemporary exploration of medications, delving into the scientific principles behind drug actions and their therapeutic applications. It is an essential resource for students in pharmacology and pharmaceutical sciences, providing foundational knowledge on a wide range of topics. The book addresses the effects of drugs on various bodily systems, such as the nervous, respiratory, and cardiovascular systems, and also covers their impact on mental health and behavior. Beyond the core topics, the book also discusses special subjects like herbal medications and drug interactions.It includes valuable teaching materials, including test banks and quizzes, and offers comprehensive insights into toxicological treatments, making it an invaluable tool for both learning and teaching in the field.

  • Biofunctional Cosmetics for Health

    Exploring Nature’s Ingredients for Safety, Efficacy, and Sustainability
    • 1 Edición
    • Alexandros Tsoupras + 1 más
    • Inglés
    Bio-functional Cosmetics for Health: Exploring Nature’s Ingredients for Safety, Efficacy, and Sustainability bridges the gap between cosmetics, nutraceuticals, and pharmaceuticals, providing the latest research for developing health-promoting cosmeceuticals and nutricosmetics from various food sources and food waste. From medicinal plants, teas, cacao, coffee, fruits, vegetables, plant oils, nuts, and cereals to marine microorganisms, fungi, insects, crustaceans, and more, this book takes a close look into the safety, efficacy and sourcing of bioactives from these food sources and how they can be sustainably used as ingredients to create bio-functional cosmetics, cosmeceuticals and nutricosmetics.Reade... will gain insight on the anti-inflammatory, antioxidant, anti-aging, and anti-cancer properties of bioactive ingredients in cosmetics and will also be informed on the latest regulatory and safety issues and R&D trends for the application of bioactives in functional cosmetics and cosmeceutical products.

  • The Pharmacology of Obesity

    • 1 Edición
    • Volumen 107
    • Inglés
    The Pharmacology of Obesity, Volume 107 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Obesity Therapeutic Landscape, Challenges, and Unmet Needs, Diagnosis and Evaluation of Obesity for Therapeutic Selection, When to use First-Generation Anti-Obesity Medications?, GLP-1 Receptor Agonists in our Clinics, Future Directions in Obesity Pharmacotherapy: Novel Targets and Pipeline Therapies, Destigmatizing Obesity: from language to the clinical environment, and much more.Additional chapters cover Role of Nutrition and physical Activity in the Therapy of Obesity, Behavioral and Lifestyle Strategies in Obesity Management and Post-Bariatric Follow-Up, The interpretation of Body-composition Metrics in Obesity, Digital Health, Technology, Artificial Intelligence, and Wearables in Obesity Care, Metabolic Aging and Obesity: how Physiology Changes with Age, Endoscopic Bariatric and Metabolic Therapies, and What Patients Could Benefit from Bariatric Surgery?

  • Toxicological Survey of African Medicinal Plants

    • 2 Edición
    • Victor Kuete
    • Inglés
    Toxicological Survey of African Medicinal Plants, Second Edition bridges traditional knowledge with modern science, providing a comprehensive and detailed overview of toxicological studies related to traditionally used African medicinal plants with special emphasis on practical insights and scientifically validated methodologies, and tools used for data collection and interpretation. Completely revised and updated, the book considers the physical parameters of novel plants and their effect on specific areas of the body and overall human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.The new edition also considers advances in omics approaches and the increased use of advanced analytical techniques to understand plant toxicity and improved the identification of toxic compounds in medicinal plants. With contributions from a distinguished team of researchers in the field, this book is an invaluable resource for researchers, advanced students and postgraduates, industry professionals, and policymakers who require an integrated understanding of toxicology, pharmacology, ethnopharmacology, as well as regulatory and policy frameworks for African medicinal plants.

  • Pharmacology of T-Cell Therapies

    • 1 Edición
    • Volumen 106
    • Inglés
    Pharmacology of T-Cell Therapies, Volume 106 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this new release include Enhancing persistence of therapeutic T cells, T cell manufacturing impacts on in vivo function, Transient T cell therapies, In vivo T cell therapies, T cell subsets for therapy, Engineering T cell metabolism to enhance therapeutic efficacy, and Tracking Therapeutic T cells In Vivo contacts.

  • A Comprehensive Guide for the Novice Researcher in Clinical Trials

    • 1 Edición
    • Miltiadis Lytras + 2 más
    • Inglés
    A Comprehensive Guide for Novice Researcher in Clinical Trials is a must-have resource for individuals embarking on the journey of clinical research. This book is tailored for beginners, offering a clear and structured introduction to the vital principles, methodologies, and skills required to design and conduct robust clinical trials. Spanning 13 chapters, it meticulously covers the entire clinical trial process, emphasizing Good Clinical Practice (GCP) standards. From foundational research concepts to advanced trial strategies, the guide empowers readers to confidently navigate the complexities of clinical trials and contribute meaningfully to the field of healthcare.In addition to its foundational content, the book addresses a variety of important topics, such as ethical considerations, regulatory compliance, and the development of trial protocols. It explores different trial designs, types of bias, and the historical evolution of clinical research. Practical sections on data management, monitoring, statistical analysis, and project management offer readers hands-on guidance for real-world application. Notably, the book includes a dedicated focus on regulatory affairs in Saudi Arabia, making it particularly valuable for health professionals in that region.

  • Lo esencial en farmacología. Cursos Crash

    • 6 Edición
    • Catrin Page
    • Español
    Con una fórmula que ha demostrado su éxito a lo largo de los últimos 25 años, cada volumen de la serie se ha actualizado por completo para facilitar el estudio. La serie está escrita por estudiantes de últimos cursos y recién graduados que acaban de superar sus exámenes, y toda la información ha sido cuidadosamente revisada por profesores universitarios. Este volumen de la serie se ha mejorado para satisfacer las necesidades de los estudiantes de Medicina actuales, y las de los estudiantes y profesionales de otras disciplinas sanitarias que requieran un acceso rápido a los aspectos esenciales de la farmacología. Cada capítulo guía de forma sucinta por todos los temas curriculares, integrando los aspectos clínicos con la ciencia básica relevante y evitando los detalles innecesarios o confusos. Los cuadros destacados a lo largo del texto ofrecen los apuntes, las sugerencias y los puntos clave esenciales. Se incluye una sección de autoevaluación totalmente revisada y adaptada a los últimos formatos de exámenes para comprobar los conocimientos y para ayudar en la preparación de las pruebas. Completamente revisada y actualizada, esta sexta edición ofrece un recurso accesible de aprendizaje y repaso que facilite la compresión de los principios y las aplicaciones de la farmacología en todas las áreas de la medicina y la cirugía. Comienza con un capítulo introductorio sobre los principios básicos de la farmacología. En el resto de los capítulos, se describen los efectos de los fármacos en los distintos sistemas orgánicos y se incluyen actualizaciones sobre los avances farmacológicos más recientes en medicina (p. ej., las nuevas terapias dirigidas en oncología y enfermedades inflamatorias, así como los nuevos tratamientos utilizados en el manejo de la diabetes y la insuficiencia cardíaca). La sección de autoevaluación se ha actualizado para reflejar el contenido y el estilo de varios exámenes de pre- y posgrado. Las preguntas de autoevaluación se centran en la farmacología clínica y su aplicación a casos reales de la práctica clínica.

  • Capsaicin, the Pungent Principle in Hot Pepper

    From Basic Pharmacology to Therapeutic Applications
    • 1 Edición
    • Arpad Szallasi
    • Inglés
    Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications explores capsaicin's biological and pharmacological characteristics, from its discovery and isolation to its receptor identification and antagonists. The book's structure is divided into three sections, starting with the historical development of research on capsaicin. This foundational section provides a thorough understanding of the compound's journey from a simple pungent ingredient to a significant element in pharmacological studies. The second part of the book delves into capsaicin’s biological effects and pharmacology, covering areas such as nociception, pain, salivary secretion, body temperature regulation, and blood pressure regulation.Finally, the book examines the clinical applications of capsaicin, discussing potential future developments in desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. This book is invaluable for pharmacology researchers and clinicians in pain management and cancer, offering insights into the unique characteristics and therapeutic potential of capsaicin.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 2 Edición
    • Rebecca Sheets + 6 más
    • Inglés
    This second edition of Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. In this new edition the book provides more in-depth coverage of Quality by Design, Combination Products, Quality Target Product Profiles, Risk Management Plans and REMS, and switching from reliance on in vivo to in vitro analytical methods. This new edition also reflects the new developments and processes accelerated by the COVID-19 vaccine experience, including emergency use authorizations and conditional marking authorizations. New pedagogic elements and case studies have been added to improve learning outcomes for students. This book provides multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions with emphasis on the European Medicines Agency and the U.S. Food and Drug Administration. Graduate students will benefit from the new pedagogic features. Regulatory professionals will have in Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines a complete guide to navigate through the approval process.

  • Brain Shuttle Peptides: Development and Applications

    • 1 Edición
    • Volumen 105
    • Inglés
    Advances in Pharmacology, Volume 105, a new volume in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Introduction to brain shuttle peptides, In silico optimization of brain shuttle properties for passive diffusion, Shuttles derived from natural proteins, Shuttles derived from phage display, Chemically enhanced brain shuttle peptides, Brain delivery of gold nanoparticles, Brain delivery of lipid nanoparticles, Brain delivery of therapeutic proteins, In vitro BBB models for the study of brain shuttle transport, Physiological strategies for delivery across the BBB, and Polymeric Nanoparticles.

  • Emerging Trends in Cancer Pharmacology

    From Molecular Targets to Personalized Medicine
    • 1 Edición
    • Tapan Behl + 4 más
    • Inglés
    Emerging Trends in Cancer Pharmacology: From Molecular Targets to Personalized Medicine gives readers a comprehensive and up-to-date resource on the latest developments and trends in the field of cancer pharmacology. It serves as a valuable reference for researchers, scientists, clinicians, and other professionals involved in cancer research, pharmacology, oncology, and personalized medicine. In recent years, there have been significant breakthroughs in understanding the molecular mechanisms of cancer and the development of targeted therapies. Additionally, personalized medicine has emerged as a promising approach to tailor treatments based on an individual's genetic profile, tumor characteristics, and other factors. These developments have the potential to revolutionize cancer treatment and improve patient outcomes. This book covers such developments.

  • Medicinal Plants

    Chemistry, Biology and Omics
    • 2 Edición
    • Da-Cheng Hao + 1 más
    • Inglés
    Medicinal Plants: Chemistry, Biology, and Omics, Second Edition is a reference to help researchers identify and master the patterns in the distribution of medicinal compounds on the phylogenetic tree to explore new drug resources and develop novel therapies against different diseases. The book provides a deeper understanding of how the interrelationship between phytometabolites, bioactivities and omics techniques facilitates sustainable conservation and application of phytomedicine resources. Now in 2nd edition, the contents have been updated to include topics as machine learning applications, geographic distribution of phytometabolites, comparative analysis of alkaloids, expanded coverage of selected taxa, and conditions like cardiovascular disease and cancer. The book is structured around chemotaxonomy. After an introduction and review of taxonomy, chemistry, biology and omics, the authors dive into a taxon-guided exploration of medicinal resources for Fritillaria, Chelidoniae, Dichocarpum, Aconitum, Cimicifugeae, Clematis, Potentilla, Rubus, Cannabis, and other taxa. All chapters follow a similar and consistent structure, offering detailed information on each of them. Researchers in phytopharmacology can acquire in-depth understanding of the interrelationships between chemistry, biology and omics, as well as the implications of the link between phylogeny, phytometabolites and bioactivities in medical biotechnology and sustainability. Clinicians can better understand the principles of mutual interactions between phytometabolites and drug efficacy.

  • Drug Metabolism in Diseases

    Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development
    • 2 Edición
    • Wen Xie
    • Inglés
    Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharmaceutical scientists and biologists to understand the interplay between diseases and physiological conditions, impacting drug metabolism and its implications in personalized treatment. Expanded with six new chapters since the first edition, this updated book covers the latest scientific findings. Other important points include the book’s comprehensive reference on mutual effects between drug metabolism and diseases, implications in precision medicine, and therapeutic development. Pharmaceutical scientists, drug metabolism researchers, and research physicians will benefit from the expert insights provided.

  • Machine Learning in Drug Development: Part 2

    • 1 Edición
    • Volumen 65
    • Inglés
    Machine Learning in Drug Development: Part Two, Volume 65 in the Annual Reports on Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume explore Transforming Modern Drug Discovery with Machine Learning – Applications in Ligand-based Drug Design, Optimizing Multi-Modal Drug Design Through Computational Pocket Mapping and Data Integration, Harnessing AI for Nucleic Acid Drug Discovery: Small Molecule Targeting DNA and RNA, AI-aided Drug Development for Protein Degraders: Design, Lead Identification, and Optimization, and more.Additional section delve into Artificial Intelligence in the Development of Antiviral Drugs – Progress and Applications, Artificial Intelligence for Drug Target Identification, and Machine Learning in Proteomic Biomarker Discovery

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 64
    • Inglés
    Progress in Medicinal Chemistry, Volume 64 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Machine Learning in Drug Development: Part 1

    • 1 Edición
    • Volumen 64
    • Inglés
    Machine Learning in Drug Development: Part One, Volume 64 in the Annual Reports on Medicinal Chemistry series, highlights new advances in the field. Chapters in this release include Artificial Intelligence in Small Molecule and Nucleic Acid Research: A Review, AI-aided Drug Development for Protein Degraders: Design, Lead Identification, and Optimization, AI-aided Drug Development for Protein Degraders: Biology Validation, Disease-association, Drug Repurposing, Transforming Modern Drug Discovery with Machine Learning, Artificial Intelligence in the Development of Antiviral Drugs: Progress and Applications, Artificial Intelligence for Drug Target Identification, and Machine Learning in Proteomic Biomarker Discovery.

  • Handbook of Melatonin-Based Therapy and its Applications

    • 1 Edición
    • Alejandro Romero Martínez + 2 más
    • Inglés
    Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melatonin in the therapeutic setting. Succinct, meticulously organized, and expertly written, this book addresses all essential aspects. It starts with an overview of safe use of melatonin, translational aspects, and its prospection. The next section of the book covers a variety of clinical applications, including dosage, pharmacokinetics and pharmacodynamic profiles, toxicity, and principles of action. The chapters in this section cover applications to both adults and pediatric patients suffering from conditions like skin cancers, GI issues, psychiatric, hepatic and ocular conditions.This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.

  • Ketamine

    Fundamentals, Applications, Pharmacology, and Clinical Aspects
    • 1 Edición
    • Albert Dahan + 1 más
    • Inglés
    Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.

  • Comprehensive Toxicology

    • 4 Edición
    • Charlene McQueen
    • Inglés
    Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies.

  • Massachusetts General Hospital. Psicofarmacología y Neuroterapéutica

    • 2 Edición
    • Theodore A. Stern + 2 más
    • Español
    Información práctica y específica de uno de los principales hospitales y departamentos de psiquiatría del mundo. La segunda edición de Massachusetts General Hospital. Psicofarmacología y Neuroterapéutica es la guía ideal sobre los más actuales tratamientos psicofarmacológicos y somáticos para enfermedades psiquiátricas y neurológicas. Compuesta por capítulos extraídos principalmente de la tercera edición de Massachusetts General Hospital. Tratado de Psiquiatría Clínica, de Stern et al., la presente obra, exhaustivamente revisada, se centra en los tratamientos psicotrópicos actuales, la terapia electroconvulsiva y la neuroterapéutica, lo que la convierte en una herramienta de ágil consulta, ideal para psiquiatras, psicólogos, internistas y enfermeras.

  • Handbook of Intervention Science

    From Design to Implementation
    • 1 Edición
    • Laura N.Gitlin + 1 más
    • Inglés
    Handbook of Intervention Science: From Design to Implementation discusses multiple approaches for developing and advancing interventions at the individual, family, community, health system, and policy level. The book focuses on creating interventions suitable for diverse populations from racial, ethnical, geographical, and socioeconomical perspectives. Combining best practices with a practical approach, the book enables readers to advance their intervention research. It covers intervention design, data capture in trials, and evaluation. Decision trees help illustrate when to move forward with an implementation relative to the need for further work.

  • Pharmacological Targets in Metabolic Diseases

    Challenges and Opportunities
    • 1 Edición
    • Marcos Roberto de Oliveira
    • Inglés
    Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities is a complete reference on possible drug development targets to be leveraged in therapeutic developments. Covering both signaling pathways and specific proteins, the book presents ways to modulate the molecular and cellular alterations observed in metabolic diseases and disorders through the application of new or classical drugs. The comprehensive coverage starts by providing an overview of metabolic diseases and disorders, biological alterations, and pharmacological targets. This section covers targets at both molecular, and subcellular and cellular levels. The next section in the book is focused on pharmaceutical targeting of organs, including a dedicated chapter to the gut-brain axis. Next comes a thorough review of the current advances in metabolic syndrome research. Section VI is focused on inborn errors of metabolism and is followed by a section devoted to natural molecules and their pharmacological potential to treat these conditions. The Editor introduces next a whole section dedicated to the role of the microbiota in metabolic diseases therapeutics. The following sections cover the impact of aging, nanotechnology, the environment, and finally diagnostic techniques in metabolic diseases and disorders. Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities meet the needs of pharmacology researchers looking for a comprehensive and authoritative source of information on possible therapeutic targets to treat these conditions. Research physicians, nutritionists, pharmacists, and biologists can benefit from the detailed information provided at the different levels of targets identified to treat metabolic diseases and conditions.

  • Curcumin Bioavailability and Sustainability as Therapeutic Agent

    Strategies for Sustained Release Curcumin
    • 1 Edición
    • Mahmood Ahmed + 1 más
    • Inglés
    Curcumin Bioavailability and Sustainability as Therapeutic Agent: Strategies for Sustained Release Curcumin is a comprehensive reference on techniques to enhance the bioavailability of curcumin, while also covering sustainability aspects across its production cycle. This book focuses on the information needs of pharmaceutical scientists aiming at developing drug delivery systems and formulations that can maximize the therapeutic impact of curcumin drugs. After an introduction to curcumin therapeutic properties, the authors delve into the bioavailability challenges confronted by curcumin, discussing influencing factors, pharmacokinetic pathways, and formulations to augment its bioaccessibility. Chapter 3 explores innovative formulation paradigms, encompassing nanoparticle-based delivery systems and lipidic matrices, tailored to overcome solubility limitations and increase absorptive efficacy. Chapter 4 covers delivery systems, encompassing prodrug strategies, encapsulation modalities, and nanocarrier technologies. Chapter 5 investigates sustainable sourcing and production, raising awareness to ethical cultivation practices, eco-friendly extraction methodologies, and proficient waste management techniques within curcumin production processes. In Chapter 6 discusses balancing bioavailability augmentation with sustainability principles including case studies. Chapter 7 navigates the domain of pharmacokinetic studies and clinical trials, providing an overview of bioaccessibility and bioavailable formulations. Chapter 8 explores safety profiles, regulatory requirements, and quality benchmarks, encompassing product labeling and claims concerning curcumin's bioavailability and sustainability. Chapter 9 casts a future view contemplating nascent technologies for bioavailability and sustainability optimization. The final chapter concludes the book with the author's observations on its central themes. Curcumin Bioavailability and Sustainability as Therapeutic Agent: Strategies for Sustained Release Curcumin provides practical strategies to be explored by pharmaceutical scientists in increasing bioavailability of curcumin formulations. Research physicians and nutritionists may also benefit from the evidence-based information on curcumin's therapeutic activities provided across the book.

  • ​Theoretical and Clinical Geropharmacology​

    • 1 Edición
    • Volumen 104
    • Inglés
    ​Theoretical and Clinical Geropharmacology​, explores the emerging field of senotherapeutics, which focuses on targeting cellular senescence to reduce age-related diseases and promote healthy aging. Chapters in this new release include Senotherapeutics: Milestones, innovations, and future prospects, Game Changer: Navigating between challenges and hopes in Geropharmacology, Next-Gen Senotherapeutics: AI/ML-driven strategies for aging and age-related disorders, Pharmacological frontiers in senescence: Transforming senescence with drug repurposing, Pharmacological potential of calorie restriction mimetics in mitigating brain aging, Isothiocyanates from cruciferous plants as geroprotectors, and much more.Other chapters cover Cellular parabiosis as a senotherapeutic approach, Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases, Mitochondria-associa... membranes (MAMs) in age-related heart diseases, role of endoplasmic reticulum stress, Cellular senescence and senotherapeutics in cardiovascular diseases, Risk of senescence, polypharmacy, and their outcomes in elderly cardiovascular disease patients, Geropharmacology and gastrointestinal surgery, Oxygen-ozone adjunct therapy in aging and senescence-related disorders, and more.

  • Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology

    • 1 Edición
    • Muhammad Ishfaq
    • Inglés
    Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology is a comprehensive resource that offers an advanced overview of computational techniques employed in drug discovery, design, and toxicity prediction. The book discusses various topics, including molecular modeling, virtual screening, machine learning, and network pharmacology. It serves as an essential guide for researchers, practitioners, and students in pharmacology, toxicology, medicinal chemistry, bioinformatics, and systems biology fields, showcasing practical applications and future perspectives on new technologies. In addition to covering computational approaches, the book provides real-world examples of drug discovery, candidate optimization, and safety assessment.Other sections explore computer applications in pharmacology and toxicology and discusses the importance of these methods in advancing medicinal research.

  • Farmacología humana

    • 7 Edición
    • Jesús Flórez Beledo + 2 más
    • Español
    La séptima edición de "Farmacología humana", obra de referencia de la especialidad en habla hispana, ofrece un texto exhaustivo y plenamente actualizado, guiado por la claridad expositiva y combinando el conocimiento teórico con la práctica clínica. Se han mantenido y reforzado los capítulos que abordan los principios básicos de la ciencia farmacológica y se han reflejado todas las novedades acontecidas desde la última edición y se ha incluido un nuevo capítulo dedicado a las "Terapias antoneoplásicas dirigidas". Otra novedad a destacar es la incorporación de nuevos colaboradores que junto con los ya tradicionales aúnan experiencia y frescura a esta magnífica obra.

  • Medicinal Plant Research in Africa

    Advances in Pharmacology and Chemistry
    • 2 Edición
    • Victor Kuete
    • Inglés
    Medicinal Plant Research in Africa, second edition is an updated and complete reference on the pharmacology of most relevant African species and their phytochemical properties. Although pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes, however there was no global standard book on the nature and specificity of chemicals isolated in African medicinal plants. This book has set the standard when it first published in 2013 and now is updated with novel phytochemicals belonging to diverse classes of terpenoids, phenolics, and alkaloids. The first chapter cover monoterpenes and related phytochemicals and is followed by sesquiterpenes on chapter two. Chapter tri reviews diterpenoids and chapter four provides an overview of triterpenes and steroids. Essential oils, simple phenols, phenolic acids and related esters come next in chapters five and six, respectively. The following chapters cover coumarins, flavonoids, quinones, xanthones, lignans and stilbenes. Tannins, alkaloids, and ceramides. Chapters 15 to 20 focus on specific health conditions starting with antibiotic infection, antimalarial and other antiprotozoal diseases, cytotoxic and anticancer activity, anti-inflammatory and analgesic action, antidiabetic botanicals and the applications of African plant phytochemicals on reproductive, cardiovascular, and central nervous systems conditions. The final chapter covers the market and industry updates since the first edition published. "Medicinal Plant Research in Africa, 2 Ed." provides a complete overview of the main phytochemical principles present in the African flora and their pharmaceutical use. Pharmaceutical scientists, Ethnopharmacists, botanists, and medicinal chemists will benefit from the content organization and the inclusion of the most recent methods for structural identification of phytochemicals, pharmacological techniques, and data interpretation.

  • Revolutionizing Drug Discovery: Cutting-Edge Computational Techniques

    • 1 Edición
    • Volumen 103
    • Inglés
    Revolutionizing Drug Discovery: Cutting-Edge Computational Techniques is an essential guide for professionals, researchers, and students in the pharmaceutical and biotech industries, providing an in-depth look at how computational methods transform drug development. This book explores advanced tools like molecular modeling, machine learning, and AI-driven design, which accelerate drug discovery, enhance target identification, and improve clinical outcome predictions. Through real-world applications and case studies, readers gain practical insights into the benefits of computational approaches in managing data, optimizing leads, and predicting drug efficacy and safety. Emphasizing a multidisciplinary approach, it bridges chemistry, biology, and informatics, addressing both the technical and ethical dimensions of these innovations. This book is a roadmap to the future of medicine, revealing how computational advancements are reshaping the landscape of drug discovery.

  • Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

    • 2 Edición
    • Mahendra Rai
    • Inglés
    Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, Second Edition offers pharmaceutical and life sciences researchers an overview on the most relevant studies for fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses, and fungi using natural products. This new edition expands the coverage of uses of traditional medicinal plants to against MDR, includes new chapters on the potential of plant-derived bioactive compounds for reversal of multidrug resistances, covers the use of flavonoids to combat microbes and cancer, and the use of nanoparticles as drug delivery vehicle.The need to combat multidrug-resistant microorganisms is an urgent one. This book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components, and more, to aid researchers in effective antimicrobial drug discovery.

  • Biofarmacia y farmacocinética

    • 3 Edición
    • Antonio Aguilar Ros + 3 más
    • Español
    Esta nueva edición actualiza plenamente contenidos y conceptos, abordando los principales modelos de cálculo de la Biofarmacia y Farmacocinética a través de la resolución de problemas, todo ello en un estilo riguroso y con una perspectiva eminentemente práctica. Incorpora nuevos capítulos sobre ajuste posológico en insuficiencia renal, y sobre modelos farmacocinéticos/far... (PK/PD), así como un capítulo final consistente en 50 cuestiones tipo test para estudio y repaso. Para esta edición se han incorporado además nuevos autores.Los capítulos comienzan con un breve repaso del esquema del modelo y de las ecuaciones que posteriormente se utilizan en los problemas, que se resuelven paso a paso a continuación. La obra está dirigida tanto a los estudiantes de la materia como a los profesionales de distintos ámbitos que deseen profundizar y ampliar sus conocimientos en Biofarmacia y Farmacocinética. Se ofrece acceso a la versión electrónica completa del libro a través de la plataforma VitalSource. Esta versión incluye los siguientes contenidos complementarios: Problemas extra por capítulo, con sus soluciones; Enlaces a archivos para la impresión de papel milimetrado y semilogarítmico para la elaboración de gráficas, Enlaces a archivos Excel (con complemento SOLVER) para el cálculo y elaboración de gráficas, mediante regresión no lineal de los distintos modelos de biofarmacia y farmacocinética que se desarrollan en el libro.

  • Targeting Enzymes in the Brain

    • 1 Edición
    • Volumen 102
    • Inglés
    Targeting Enzymes in the Brain series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Pharmacovigilance

    A Practical Approach
    • 2 Edición
    • Thao Doan + 4 más
    • Inglés
    **Selected for 2026 Doody's Core Titles in Pharmacy**Written by multidisciplinary experts in the fields of pharmaceutical and patient safety, Pharmacovigilance: A Practical Approach, Second Edition, provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. From cover to cover, this concise resource offers essential information for physicians and other health care professionals, clinical researchers, and regulators who need a comprehensive, up-to-date source of information on the principles and practice of pharmacovigilance.

  • PROTAC and similar technologies

    • 1 Edición
    • Volumen 63
    • Inglés
    Annual Reports on Medicinal Chemistry: PROTAC and similar technologies Volume 63 in this series Annual Reports on Medicinal Chemistry, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Exosome Communication

    Advances in Research and Therapeutics for Health and Disease
    • 1 Edición
    • Dalapathi Gugulothu + 3 más
    • Inglés
    Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing.

  • Emerging Therapeutic Targets and Drug Delivery Approaches in IBD

    • 1 Edición
    • Volumen 101
    • Inglés
    Emerging Therapeutic Targets and Drug Delivery Approaches in IBD, Volume 101 in this ongoing series, highlights new advances, with this volume presenting interesting chapters on timely topics, including Fibrosis in IBD – AXL as a Promising Therapeutic Target, Developing a pathway to test anti-fibrotic drugs in Crohn’s disease, Emerging therapeutics for the management of intestinal fibrosis and strictures, GCPII for IBD, Fistulas/stem cell products for IBD/Crohn’s, The landscape of new therapeutic opportunities for IBD, TL1A : A Model For The Use Of Precision Medicine For The Treatment of Crohn’s Disease and Ulcerative Colitis, Dectin-1 as a therapeutic target for IBD, and more.Additional sections cover BRD4 as an Emerging Epigenetic Therapeutic Target for Inflammatory Bowel Diseases, Scripps - S1P, The potential of targeting TREM-1 in Inflammatory Bowel Disease, and Microbiome therapies.

  • Traditional Medicines and Natural Products as Preventive and Therapeutic Agents Against COVID-19

    A Promising Response to the Global Unprecedented Pandemic
    • 1 Edición
    • Nabeelah Bibi Sadeer + 1 más
    • Inglés
    Traditional Medicines and Natural Products as Preventive and Therapeutic Agents Against COVID-19: A Promising Response to the Global Unprecedented Pandemic presents comprehensive coverage of the pharmacological effects of natural products on the prevention and treatment of COVID-19. Sections provide traditional medicine approaches and their potential to prevent and treat COVID-19 infection, including traditional Chinese, Ayurvedic, Persian, and Kampo medicine, alongside an overview of nutritional regimens and their therapeutic potential. Other sections cover natural molecules such as flavonoids, saponins, coumarins, alkaloids, terpenes, polysaccharides, and several microbial natural products of relevant action against viruses. Final chapters cover nanotherapeutic approaches.This is a valuable resource for researchers and academics in the fields of herbal medicine, pharmacology, pharmacognosy and for professionals in the pharmaceutical industries and anyone interested in natural products and their application for therapeutic purposes.

  • Annual Reports in Medicinal Chemistry: Roadmaps

    • 1 Edición
    • Volumen 62
    • Inglés
    Annual Reports in Medicinal Chemistry: Roadmaps, Volume 62 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. This release provides a compendium of information on newly approved drugs and compounds entering late-stage clinical trials, making it a valuable resource for graduate students pursuing research in medicinal chemistry

  • Quinone-Based Compounds in Drug Discovery

    Trends and Applications
    • 1 Edición
    • Umar Ali Dar + 2 más
    • Inglés
    Quinone-Based Compounds in Drug Discovery: Trends and Applications provides a comprehensive and up-to-date overview of the latest advances in the field of drug discovery using quinone-based materials. The book covers various aspects of quinone-based materials such as their synthesis, characterization, and applications in drug discovery, consolidating current research. It introduces quinones in the pharmacology context and then describes current developments in drugs for key diseases and conditions. Final chapters deal with the regulatory and commercial framework to take quinone-based drugs to the market.This book will benefit a wide range of readers, including researchers, scientists, and graduate students in the field of drug discovery. Chemists and biochemists will also benefit from the contents of this book.

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