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Elsevier

Libros en Farmacología Bioquímica

  • Drug Metabolism in Diseases

    Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development
    • 2 Edición
    • Wen Xie
    • Inglés
    Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, Second Edition provides essential knowledge for pharmaceutical scientists and biologists to understand the interplay between diseases and physiological conditions, impacting drug metabolism and its implications in personalized treatment. Expanded with six new chapters since the first edition, this updated book covers the latest scientific findings. Other important points include the book’s comprehensive reference on mutual effects between drug metabolism and diseases, implications in precision medicine, and therapeutic development. Pharmaceutical scientists, drug metabolism researchers, and research physicians will benefit from the expert insights provided.

  • Pharmacological Targets in Metabolic Diseases

    Challenges and Opportunities
    • 1 Edición
    • Marcos Roberto de Oliveira
    • Inglés
    Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities is a complete reference on possible drug development targets to be leveraged in therapeutic developments. Covering both signaling pathways and specific proteins, the book presents ways to modulate the molecular and cellular alterations observed in metabolic diseases and disorders through the application of new or classical drugs. The comprehensive coverage starts by providing an overview of metabolic diseases and disorders, biological alterations, and pharmacological targets. This section covers targets at both molecular, and subcellular and cellular levels. The next section in the book is focused on pharmaceutical targeting of organs, including a dedicated chapter to the gut-brain axis. Next comes a thorough review of the current advances in metabolic syndrome research. Section VI is focused on inborn errors of metabolism and is followed by a section devoted to natural molecules and their pharmacological potential to treat these conditions. The Editor introduces next a whole section dedicated to the role of the microbiota in metabolic diseases therapeutics. The following sections cover the impact of aging, nanotechnology, the environment, and finally diagnostic techniques in metabolic diseases and disorders. Pharmacological Targets in Metabolic Diseases: Challenges and Opportunities meet the needs of pharmacology researchers looking for a comprehensive and authoritative source of information on possible therapeutic targets to treat these conditions. Research physicians, nutritionists, pharmacists, and biologists can benefit from the detailed information provided at the different levels of targets identified to treat metabolic diseases and conditions.

  • Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

    • 2 Edición
    • Mahendra Rai
    • Inglés
    Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, Second Edition offers pharmaceutical and life sciences researchers an overview on the most relevant studies for fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses, and fungi using natural products. This new edition expands the coverage of uses of traditional medicinal plants to against MDR, includes new chapters on the potential of plant-derived bioactive compounds for reversal of multidrug resistances, covers the use of flavonoids to combat microbes and cancer, and the use of nanoparticles as drug delivery vehicle.The need to combat multidrug-resistant microorganisms is an urgent one. This book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components, and more, to aid researchers in effective antimicrobial drug discovery.

  • Exosome Communication

    Advances in Research and Therapeutics for Health and Disease
    • 1 Edición
    • Dalapathi Gugulothu + 3 más
    • Inglés
    Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing.

  • TRP Channels as Therapeutic Targets

    Advances in Basic Science and Clinical Use
    • 2 Edición
    • Arpad Szallasi
    • Inglés
    TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

  • Advancement of Phenolic Acids in Drug Discovery

    Fundamentals and Applications
    • 1 Edición
    • Naresh Kumar + 2 más
    • Inglés
    Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book’s final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.

  • Progress and Prospect of Nanocarriers

    Design, Concept, and Recent Advances
    • 1 Edición
    • Sushil K. Kashaw + 2 más
    • Inglés
    Progress and Prospect of Nanocarriers: Design, Concept, and Recent Advances examines the different nanocarriers that are currently being developed for specific applications in biomedical drug delivery, disease management, diagnosis and therapy. Nanosized drug delivery systems have gained tremendous amounts of clinical interest due to their effective bio-distribution and enhanced pharmacokinetic and selective targeting capability which results in high therapeutic potential, low side effects, and the generation of cost-effective drug delivery systems. Numerous effective nanocarriers have been evolving, including polymeric nanoparticles, liposomes, microspheres, dendrimers, and carbon nanotubes.This book is a helpful reference for scientists and students in the fields of drug delivery, biomaterials and nanomedicine, as well as scientists and engineers in industrial disciplines of drug delivery and drug formulation.

  • Modulation of Oxidative Stress

    Biochemical, Physiological and Pharmacological Aspects
    • 1 Edición
    • Luciano Saso + 3 más
    • Inglés
    Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

  • Discoveries in Pharmacology - Volume 1 - Nervous System and Hormones

    • 2 Edición
    • Clive Page + 2 más
    • Inglés
    Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

  • Allosteric Modulation of G Protein-Coupled Receptors

    • 1 Edición
    • Robert Laprairie
    • Inglés
    Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies.

  • The Pharmacological Potential of Cyanobacteria

    • 1 Edición
    • Graciliana Lopes + 2 más
    • Inglés
    The Pharmacological Potential of Cyanobacteria explores the bioactive compounds isolated from cyanobacteria and their relationship to human health and biotechnological applications. The book presents an overview of the chemistry and ecology of cyanobacteria, focusing on culture needs and techniques of biomass production. It is organized according to the different biological activities and biotechnological applications of compounds discovered in recent years. Besides biological activity, the mechanism of action of compounds is explained, along with molecular structure. Finally, compounds already used in therapeutics and biotechnology, as well as those in phases of approval or clinical trials are explored. Each chapter is written by a different research group with expertise in the field and publications in peer reviewed journals. Researchers and students in pharmaceutical academic research, pharmaceutical industrial sector personnel, health professionals, and nutritionists will find this book to be very useful.

  • Tamoxifen Tales

    Suggestions for Scientific Survival
    • 1 Edición
    • V. Craig Jordan
    • Inglés
    Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan’s 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women’s healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 2 Edición
    • Paul I. Dargan + 1 más
    • Inglés
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology, Second Edition provides readers with a comprehensive examination on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." The book covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance and a discussion of their associated acute and chronic harm and toxicity. This second edition addresses drugs new to the scene, with completely updated and revised chapters. Written by international experts in the field, this multi-authored book is an essential reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

  • Serum Pharmacochemistry of Traditional Chinese Medicine

    Technologies, Strategies and Applications
    • 1 Edición
    • Xijun Wang + 2 más
    • Inglés
    Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development.

  • Biomarkers and Biosensors

    Detection and Binding to Biosensor Surfaces and Biomarkers Applications
    • 1 Edición
    • Ajit Sadana + 1 más
    • Inglés
    Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market.

  • Pharmacology and Therapeutics of Constitutively Active Receptors

    • 1 Edición
    • Volumen 70
    • Ya-Xiong Tao
    • Inglés
    Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental.

  • The Alkaloids

    Chemistry and Physiology
    • 1 Edición
    • R. H. F. Manske
    • Inglés
    The Alkaloids: Chemistry and Physiology, Volume V: Pharmacology deals with the chemistry and pharmacology of the alkaloids. This book discusses the general pharmacology of morphine, cryptopine-like compounds, toad poisons, and respiratory stimulants. The appraisal of the utility of alkaloids as antimalarials, uterine stimulants, metabolism of cocaine, and optical isomerism-activity relationship are also elaborated. This publication likewise covers the parasympathetic blocking agents as mydriatics, methods of measuring mydriatic activity, alkaloids exhibiting curariform activity, and minor alkaloids of unknown structure. Other topics include the fate of morphine, tropane group, factors affecting cocaine anesthesia, and sympathomimetic mydriatics. This volume is intended for chemists and pharmacologists concerned with alkaloids.

  • The Alkaloids

    Chemistry and Physiology
    • 1 Edición
    • R. H. F. Manske
    • Inglés
    The Alkaloids: Chemistry and Physiology, Volume VI: Supplement to Volumes I and II updates the chemistry of the alkaloids by linking developments to the content of earlier volumes. This book discusses the taxonomic position of the alkaloids in plants, external factors governing alkaloid formation, pyrrolidine alkaloids, and structure of the necines. The alkaloids of the pomegranate root bark, alkaloids of Sedum spp, structure of dioscorine, and reactions of morphine and codeine are also elaborated. This publication likewise covers the chemistry of colchicine, alkaloids derived from dibenzofuran, and biological effects of the amaryllidaceae alkaloids. This volume is a good reference for chemists and specialists conducting work on alkaloids.

  • The Alkaloids

    Chemistry and Physiology
    • 1 Edición
    • R. H. F. Manske
    • Inglés
    The Alkaloids: Chemistry and Physiology, Volume X focuses on the structure of alkaloids. This book discusses the occurrence of glycoalkaloids and alkamines, jerveratrum alkaloids, and erythrophleum alkaloids containing a C-4 carbomethoxy group. The mass spectra of lycopodium alkaloids, alkaloids of the Calabar bean, and benzyltetrahydroisoq... alkaloids with three oxygenated substituents are also elaborated. This publication likewise covers the biogenesis of benzylisoquinoline alkaloids, simple indole bases, biogenesis of the picralima alkaloids, and stereochemistry of the uncarines. Other topics include plants and their contained alkaloids, lycodine and related alkaloids, and a-naphthaphenanthrid... alkaloids. This volume is suitable for chemists and specialists working in the field of alkaloid chemistry.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 1 Edición
    • Paul I. Dargan + 1 más
    • Inglés
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

  • Elsevier's Dictionary of Vitamins and Pharmacochemistry

    • 1 Edición
    • Henry Philippsborn
    • Inglés
    The dictionary will contain terms covering the following fields and subfields: Vitamin Technology: Vitamin biochemistry / Physiology; Origin of vitamins: natural, synthetic; Fat-soluble vitamins; Water-soluble vitamins; Vitamins as antioxidants; Vitamin deficiencies / Hypervitaminosis - Enzymes/Proteins: Biotechnology as applied biological science aimed at industrial exploitation - Hormones: Biochemistry; Physiology - Pharmaceutical Chemistry / Pharmaceutical Technology / Pharmaceutical Processes: Conception of the active principles; Structural analysis; Antibiotics and their way of action; Biochemistry; The Drug / The Medicament: Definition, origin, way of action; Biochemistry - Medical Aspects in the languages English, German, French and Portuguese.