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Elsevier

Libros en Ciencias Farmacéuticas

  • Theranostics in Cancer Management

    Integrating Diagnostics and Therapeutic Strategies
    • 1 Edición
    • Kuttiappan Anitha + 2 más
    • Inglés
    Theranostics in Cancer Management: Integrating Diagnostics and Therapeutic Strategies introduces a transformative paradigm in clinical oncology, heralding a new era of precision and personalized cancer care. This comprehensive guide empowers clinicians by seamlessly integrating advanced diagnostics with targeted therapeutic approaches. The book provides an extensive exploration of theranostics across diverse clinical scenarios, ensuring that healthcare professionals are equipped with the knowledge to navigate the complexities of cancer management effectively. Beyond the introductory insights, the book delves into several types of cancer and the utilization of Artificial Intelligence in cancer detection tools.Comprising 15 chapters, it offers an invaluable resource for health professionals, scientists, researchers, practitioners, and students who seek to expand their understanding in this evolving field. The emphasis on practical applications and emerging technologies makes it a timely addition to the field of oncology.

  • Strategies to Modify the Drug Release from Pharmaceutical Systems

    • 2 Edición
    • Marcos Luciano Bruschi
    • Inglés
    Strategies to Modify the Drug Release from Pharmaceutical Systems, Second Edition serves as a vital reference on contemporary models aimed at achieving the precise therapeutic dosage and timing of drug release. The book provides updated strategies, mathematical models, routes of administration, and technologies, all presented succinctly and objectively. This six-chapter guide covers general concepts of drug release modification and classification of therapeutic systems, including passive versus active targeting. It delves into mechanisms to control drug release, discussing materials and technologies, and introduces mathematical and physicochemical models of drug release.Furthermore, it reviews drug delivery systems like 3D printing, nose-to-brain delivery, environmentally responsive systems, and new lipid systems, making it indispensable for pharmaceutical scientists, graduate students, materials scientists, and chemists.

  • Bioprospecting of Natural Pigments in Human Health

    • 1 Edición
    • Siva Ramamoorthy + 1 más
    • Inglés
    Bioprospecting of Natural Pigments in Human Health provides a comprehensive overview of the therapeutic potential of these compounds. Covering the main pigment classes sourced from plants, algae, and microbes, the book is organized around the applications to specific diseases and conditions. With chapters on the anti-cancer, antidiabetic, anti-microbial, anti-inflammatory, anti-aging effects, cardioprotective and neuroprotective agents, the book covers the molecular biology principles of action, as well as bioavailability and structure. This is the ideal reference for academic researchers interested in natural products pharmacology. It is also beneficial for the academic and corporate researchers in food sciences and the nutraceutical industries.

  • Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals

    Technology, Validation and Current Regulations
    • 2 Edición
    • Tim Sandle
    • Inglés
    Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals: Technology, Validation and Current Regulations, Second Edition is an in-depth guide to the world of pharmaceutical sterilization. This new edition has been updated to reflect the latest standards and regulations, ensuring alignment with current practices. It explores emerging methods and techniques, complemented by new case studies that provide practical examples. Readers will gain comprehensive knowledge about sterilization’s critical role in healthcare and pharmaceutical manufacturing, highlighting the importance of controlling microbial challenges to ensure product safety and patient well-being.The book discusses sterility, sterilization methods such as gamma radiation, e-beam, dry heat, steam, gas, vapor, filtration, and new techniques like X-ray sterilization, liquid-phase sterilization, ultraviolet light, supercritical gases, and sterilization assurance governance. It covers biopharmaceutical manufacturing processes, including aseptic filling, container and packaging design, and cleanroom environments. This edition is essential for professionals in pharmaceuticals, healthcare, and medical device manufacturing, providing the knowledge needed to comply with current standards and regulations.

  • Formulating and Implementing Pharmaceutical Pricing Policies

    Challenges, Case Studies and Lessons Learned from Medicine Price Control
    • 1 Edición
    • Zaheer-Ud-Din Babar
    • Inglés
    Provides readers with a framework to understand and analyze several medicine pricing policies. Through case studies from countries across geographies and income tiers, this book explores the challenges and opportunities related to price control experiences. Studying global policies this book discusses approaches, strategies, and the underlying pharmaceutical pricing practices used to provide advice for formulating highly effective policies. Alongside the cases, this book covers appropriate research methods for pricing analysis, the essential components of pricing policy, data quality, and the generic structure of a pharmaceutical pricing policy.

  • Sustainability in the Manufacturing of Pharmaceuticals

    • 1 Edición
    • Dimitrios A. Lamprou
    • Inglés
    Sustainability in Pharmaceutical Manufacturing is a groundbreaking reference for the pharmaceutical industry. Currently lagging behind other manufacturing sectors, pharmaceutical production requires significant changes in areas such as manufacturing methods, waste management, packaging, and supply chain. This book compiles cutting-edge research from leading global experts, offering scientific insights and innovative strategies to revolutionize sustainability in pharmaceuticals. It explores the transformative potential of the circular economy, lifecycle management, and resource optimization for maximum efficiency and minimal environmental impact.The book delves into green chemistry, highlighting alternative solvents and methods for drug production. It emphasizes novel microfluidic and additive manufacturing techniques, utilizing bio-based sustainable polymers and materials. Chapters on greener drug discovery, development, and scaling processes provide the most current research at each production stage. This invaluable resource enables researchers in academia and industry to make informed choices, enhancing their manufacturing practices and shaping the future of sustainability in the pharmaceutical sector.

  • Advances in Probiotic Delivery Systems

    Strategies for Enhanced Viability, Targeted Delivery and Efficacy
    • 1 Edición
    • Tanmay Sarkar + 2 más
    • Inglés
    Advances in Probiotic Delivery Systems: Strategies for Enhanced Viability, Targeted Delivery and Efficacy covers the complex world of probiotics, offering a comprehensive exploration of innovative delivery mechanisms designed to overcome challenges of stability and efficacy. From oral administration to alternative delivery routes, each chapter provides insights into cutting-edge formulation strategies, encapsulation techniques, and emerging technologies, equipping readers with the knowledge to explore the full potential of probiotics for health and wellness. Bridging the gap between theory and practice in probiotic delivery systems, this book delivers insights into the most effective delivery strategies.Despite the growing interest in probiotics and their potential health benefits, challenges such as poor stability and limited efficacy hinder their widespread application. This book fills this critical gap by providing readers with a thorough understanding of the underlying principles, latest advancements, and practical solutions in probiotic delivery. By consolidating the expertise of leading researchers and practitioners, the book empowers professionals across various industries to develop and implement effective probiotic formulations that make a difference in health outcomes.

  • Ligands for Targeted Drug Delivery

    Basic Fundamentals and Applications
    • 1 Edición
    • Vikas Pandey + 3 más
    • Inglés
    Ligands for Targeted Drug Delivery: Basic Fundamentals and Applications is a comprehensive reference focused on the many ways drug carriers can be functionalized to target specific organs, tissues, cells, and sub-cellular compartments. Chapters cover the basic concepts of targeted drug delivery, describing multiple levels of targets and challenges, along with approaches for target-specific drug delivery and a thorough overview of the challenges in design and application of ligands. Following sections discuss nanoparticles and the main ligand classes with their respective applications. The final chapters discuss future prospects of the technology and clinical aspects of ligand modified drug delivery systems.This is a key reference to drug delivery researchers dealing with the application of ligands to overcome challenges in delivering their active principles to the target structure. Biomedical engineers, materials scientists, and chemists can also benefit from the through description of ligand classes and their potential to improve drug delivery efficiency.

  • Emerging Paradigms in Delivery Systems for Antitubercular Therapy

    • 1 Edición
    • Rajeev Sharma + 3 más
    • Inglés
    Emerging Paradigms in Delivery Systems for Antitubercular Therapy provides an up-to-date and thorough overview of the state-of-the-art of concepts, design, and recent advances in nanomedicines and nanobiotechnology-ba... strategies for the treatment of tuberculosis. The book enables researchers to prepare a variety of nanotechnology-based strategies, investigate their properties, and discover their uses and applications in antitubercular therapy, focusing on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccination.This book covers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of Nanotechnology based treatment innovation. It will be a welcomed resource for researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for the effective therapy of tuberculosis.

  • Nanocarriers Based Colon Targeting

    Design, Development, Mechanism and Case Studies
    • 1 Edición
    • Lalit Kumar + 1 más
    • Inglés
    Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-base... nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.

  • Intelligent Nanobiosystems in Medicine and Healthcare, Volume 2

    Applications of Intelligent Nanobiosystems
    • 1 Edición
    • Vijay Mishra + 2 más
    • Inglés
    Intelligent Nanobiosystems in Medicine and Healthcare, Volume 2: Applications of Intelligent Nanobiosystems provides recent progress in the nanobiosystems arena, helping readers better design and develop novel drug delivery systems and devices that take advantage of recent advances in nanomedical technologies. The book explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advancements in cutting-edge nanomedical technologies. This updated volume includes chapters by experts in the field, featuring an exploration of targeted therapy and drug delivery systems, analytical and imaging tools, theranostics, tissue engineering and regenerative medicines, dentistry tools and modern developments.This book will be a useful resource for researchers and postgraduate students in pharmaceutical sciences and biotechnology industries as well as medical professionals, biologists, chemists, materials scientists, clinical researchers, and biochemical and biomedical engineers working both in industry and academia.

  • Intelligent Nanobiosystems in Medicine and Healthcare, Volume 1

    Fundamentals, Fabrication and Commercialization
    • 1 Edición
    • Vijay Mishra + 2 más
    • Inglés
    Intelligent Nanobiosystems in Medicine and Healthcare, Volume One: Fundamentals, Fabrication and Commercialization provides an overview of recent progress in the nanobiosystems arena, helping readers design and develop novel drug delivery systems and devices that take advantage of recent advances in nanomedical technologies. The book explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advancement in cutting-edge nanomedical technologies. It highlights established research and technology on intelligent nanobiosystems, their rapidly emerging aspects, and future research directions. Sections cover nanobiosystems, explore nano candidates and fabrication aspects, and delve into the challenges of commercialization.Th... book will be a useful resource for researchers and postgraduate students in pharmaceutical sciences and biotechnology as well as medical professionals, biologists, chemists, materials scientists, clinical researchers, biochemical and biomedical engineers working both in academia and industry.

  • An Overview of FDA Regulated Products

    From Drugs and Cosmetics to Food and Tobacco
    • 2 Edición
    • Eunjoo Pacifici + 1 más
    • Inglés
    An Overview of FDA Regulated Products: From Drugs and Cosmetics to Food and Tobacco, Second Edition is fully updated to reflect recent advances in science and technology and new laws and regulations. Breakthroughs in cellular and gene therapy, immunotherapy, precision medicine, and digital health are changing the face of healthcare and regulation. The updates brought about by the 21st Century Cures Act and subsequent PDUFA Reauthorizations, as well as signing into law the “Modernization of Cosmetic Regulation Act of 2022,” which will transform FDA’s oversight of cosmetics, are fully reflected in all chapters of the book.This book provides graduate students and industry professionals with comprehensive information on approval processes with the FDA and other country regulation organizations. Regulatory science professionals working with not only drugs, but biologics, medical devices, food and additives, cosmetics, veterinary products, and tobacco will benefit from this comprehensive overview of the regulatory environment.

  • Lipid-Drug Conjugates

    Innovation and Applications
    • 1 Edición
    • Malay K. Das
    • Inglés
    Lipid-Drug Conjugates: Innovation and Applications highlights the most recent advances and clinical applications of nano lipid-drug conjugates for enhanced drug delivery and targeting in the treatment of cancer, glioblastoma, Alzheimer’s, AIDS, and bacterial diseases. In addition, various conjugation methods to prepare lipid-drug conjugates and their pharmacokinetics in vivo are explored, together with the production and characterization of various delivery carriers for lipid-drug conjugates. The contents of this book provide pharmaceutical science researchers with the tools to explore targeted drug delivery leveraging the unique characteristics of lipid conjugates. Scientists in the corporate setting can benefit of the cases and techniques presented in developing new formulations and products.

  • Natural Biopolymers for Drug Delivery

    • 1 Edición
    • Amit Kumar Nayak + 2 más
    • Inglés
    Natural Biopolymers for Drug Delivery thoroughly details the properties, benefits and challenges of using these biomaterials in drug delivery, with a strong focus on biocompatibility and reduction of unwanted interactions. An extensive range of natural biopolymers are explored, such as cellulose, chitosan, casein, gelatin, cashew gum, and many more. Biocompatibility, toxicity and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science and pharmacology, chemical engineering and clinical science.

  • Challenges in Delivery of Therapeutic Genomics and Proteomics

    • 2 Edición
    • Aliasgar Shahiwala + 1 más
    • Inglés
    Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics.After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented.

  • Lipids in Pulmonary Drug Delivery

    • 1 Edición
    • Md Faiyazuddin + 3 más
    • Inglés
    Lipid in Pulmonary Drug Delivery explores the most recent advancements, strategies, and state-of-the-art technological progress in the development of lipid-based nanocarriers for pulmonary administration. The book presents wide coverage of various lipid-based nano-drug carriers such as liposomes, solid lipid nanoparticles, and nanoemulsions intended for the administration of drugs through the pulmonary route to treat different conditions. It also includes a general description of the formulation aspects of various lipid-based drug delivery vehicles, post-production processing, and biofate aspects with special emphasis on the pulmonary microenvironment.In addition, the authors include an update on the clinical status of the potential lipid nanocarriers used for effective management of the pulmonary related diseases. Written in a technical way covering the latest advancements in lipid-based drug delivery for pulmonary administration, this book is a useful reference for researchers, scientists, and graduate and postgraduate students working on, or planning, research in the field of lipid-based nano-drug pulmonary delivery platforms.

  • Introduction to Pharmaceutical Technology Development

    Journey from Lab to Shelf of Commercial Pharmaceutical Drugs
    • 1 Edición
    • Yaser Dahman
    • Inglés
    Introduction to Pharmaceutical Technology Development: Journey from Lab to Shelf of Commercial Pharmaceutical Drugs is a complete reference and learning resource for those working in pharmaceutics or aspiring to join the industry. The book provides a comprehensive view into all aspects of drug discovery, approval, and production. Using examples of well-known drugs and their journeys from lab to market, the book provides a comprehensive overview of all steps involved in bringing new drugs, including biologics, to the shelves.Topics covered include Drug Discovery, Pharmaceutical Formulations of Different Dose Form, Analytical Testing and Development, Unit Operations and Design for Major Equipment, Basics of Analytics and Process Validations and Protocols (DQ, IQ, OQ, PQ) in FDA-Regulated Industries.This book provides graduate students from several areas with a solid foundation of the Pharmaceutic industry across key stages on new drug lifecycle.

  • Recent Advances in Nanomedicines Mediated Wound Healing

    • 1 Edición
    • Prashant Kesharwani
    • Inglés
    Recent Advances in Nanomedicines Mediated Wound Healing presents an overview of various nanotechnology-based drug delivery systems explored widely for wound healing. The book provides a comprehensive review of thriving strategies used for wound healing and thoroughly describes the most recent developments in emerging modern drug delivery systems with a focus on nanotechnology. It serves as a complete package for a holistic understanding of molecular pathways, conventional therapy, and novel nanocarrier-mediated drug delivery for wound healing while also exploring advanced strategies like siRNA and aptamer mediated approaches and nanomedicines to treat diabetic and full thickness wounds.This book will help researchers, undergraduates, graduate students, and experts in nanotechnology drug delivery and pharmaceutical related disciplines design and develop novel drug delivery systems and devices for wound healing that take advantage of recent advances in nanomedical technologies.

  • Navigating Endophytic Research for Next-Generation Therapeutics

    • 1 Edición
    • Vagish Dwibedi + 3 más
    • Inglés
    Navigating Endophytic Research for Next-Generation Therapeutics explores the evolving field of endophytic fungal research and applications in combating diseases, addressing environmental challenges, and in shaping the future of therapeutics. The book starts off with a discussion on the biodiversity and biogeography of endophytic fungal communities and describes the bioprospecting of endophytes for drug discovery. In addition, it covers the therapeutic application of endophytic fungi to treat and manage specific diseases and investigates the innovative use of technologies such as genome editing, genetic engineering for enhanced bioactivity, multi-omics-based exploration, and the use of big data and machine learning in endophytic drug discovery.Featuring contributions from experts across fields like mycology, pharmacology, biotechnology, and environment science, this comprehensive, practical, and insightful resource guides those engaged in endophytic fungal research and its transformative potential in next-generation therapeutics.

  • Workbook and Lab Manual for Mosby's Pharmacy Technician

    Principles and Practice
    • 7 Edición
    • Elsevier Inc + 2 más
    • Inglés
    This easy-to-use, chapter-by-chapter companion to Mosby's Pharmacy Technician: Principles and Practice, Seventh Edition, helps you solidify your understanding and mastery of key skills and concepts. Each chapter of this combination workbook and lab manual contains a wide variety of review questions, exercises, and experiential lab activities to reinforce key concepts, encourage you to reflect critically, and relate to practice for success on the job. Combined with the core textbook, this learning package takes you from day one through graduation and certification!

  • Health Literacy in Medicines Use and Pharmacy

    A Definitive Guide
    • 1 Edición
    • Ahmed Awaisu + 4 más
    • Inglés
    Health Literacy in Medicines Use and Pharmacy: A Definitive Guide highlights issues related to medication literacy from the context of the pharmacist and other healthcare professionals. This definitive guide will undoubtedly serve as an invaluable resource for healthcare professionals in training and practice, fostering excellence in patient care globally. The book provides a clear explanation of medication literacy, presents different tools to assess health and medication literacy, readability, and comprehensibility of written medicine information (WMI), and elaborates on different approaches to develop customized and patient-friendly WMI. The book also covers health and medication literacy in special populations, including geriatrics, pediatrics, and pregnant/lactating patients. Written by experts in health communication, this book will help pharmacists, other health professionals, educators, students, and regulators, who need to develop customized educational materials that can be understood by a broad range of patients, especially those with low health literacy.

  • Bacterial Enzymes as Targets for Drug Discovery

    Meeting the Challenges of Antibiotic Resistance
    • 1 Edición
    • Punit Kaur + 1 más
    • Inglés
    Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The contents cover the foundations of the antibiotic drug discovery process and focus on bacterial enzymes as drug targets, building across these disciplines to provide a comprehensive resource in bacterial structural biology and genomics. This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books’ content.

  • Drug Delivery Systems for Wound Healing

    • 1 Edición
    • Pedro Fonte + 1 más
    • Inglés
    Drug Delivery Systems for Wound Healing explores the different delivery systems and drugs used in wound healing, outlining the many pharmaceutical approaches in wound healing and management. Bringing together interdisciplinary research on wound healing and management, this book offers the theory behind wound healing, but also has a strong focus on the practical approach where scientists involved in medication development can find suggestions. Where appropriate, clinical outcomes are given so the book can be useful as a guide for the choice by medication prescription or use.Topics in the book include types of drugs used in wound healing; types of carriers used in wound healing; clinical outcomes; biocompatibility and toxicity problems, and pipeline products. Researchers working in the pharmaceutical sciences, biomedical sciences and engineering fields will find this a useful resource.

  • Fundamentals and Future Trends of 3D Printing in Drug Delivery

    • 1 Edición
    • Dimitrios A. Lamprou + 1 más
    • Inglés
    Fundamentals and Future Trends of 3D Printing in Drug Delivery provides readers with all needed information for their journey from ideation to approval of innovative drug delivery devices produced through additive manufacturing.This book provides an in-depth discussion on key factors affecting the printing process such as different printer technologies, materials selection, resolutions, temperatures and speeds. Dedicated chapters include specific drug delivery devices in the form of oral solid dosage, implants, catheters and vascular grafts, and microneedles. The prospects of 3D printing associated with personalized medicine are covered in a full chapter.Fundamentals and Future Trends of 3D Printing in Drug Delivery is the perfect reference for any researcher or professional embarking on a 3D printing process for drug delivery devices. The regulatory aspects included are of particular interest to companies entering this promising market.

  • Side Effects of Drugs Annual

    • 1 Edición
    • Volumen 46
    • Inglés
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 46, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered include ADRs, ADEs and SEDs: A Bird’s Eye View, Lithium, Drugs of abuse, Side effects of drugs used in the treatment of Alzheimer's disease, Sedatives and hypnotics, Antipsychotic agents, Anti-epileptic Medications, Side effects of opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, Side effects of local anesthetics and therapeutic gases, and more.Other sections covered include Antihistamines (H1 receptor antagonists), Drugs that act on the respiratory tract, Positive inotropic drugs and drugs used in dysrhythmias, Beta adrenergic antagonists and antianginal drugs, Drugs acting on the cerebral and peripheral circulations, Antihypertensive drugs, and much much more.

  • Nonclinical Development of Biologics, Vaccines and Specialty Biologics

    • 2 Edición
    • Lisa M. Plitnick + 1 más
    • Inglés
    Nonclinical Development of Biologics, Vaccines and Specialty Biologics, Second Edition, is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, vaccines, cell and gene therapies, and oncology therapeutics. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. This book discusses the different types of biologics, as well as early characterization strategies, principles of study design, nonclinical pharmacokinetics and pharmacodynamics, nonclinical assays, and regulatory guidelines. A coedited book with chapters authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics.

  • Drug Delivery

    Advances and Emerging Strategies
    • 1 Edición
    • Kevin Ita
    • Inglés
    Drug Delivery: Advances and Emerging Strategies begins with an overview on drug delivery, setting the stage for detailed discussions on oral, pulmonary, vaginal, ocular, and nasal dedicated sections. Chapters cover colonic, transdermal, transungual, brain, and nose-to-brain delivery, but also focus on vaccine delivery and organ specific delivery routes via the myocardium, kidney, liver, pancreas, buccal, sublingual, and injectable drug delivery systems. The book offers an integrated, up-to-date overview of drug delivery methods, technologies, and approaches, targeting body systems and organs. Researchers and advanced students in pharmaceutical science will benefit from this consolidated outlook.

  • Migraine Pain Management

    Current Pharmacological and Non-pharmacological Options
    • 1 Edición
    • Stephen B. Shrewsbury
    • Inglés
    Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It will also be a perfect reference for physicians and care professionals involved in the well-being of migraine patients.

  • Mosby's Pharmacy Technician

    Principles and Practice
    • 7 Edición
    • Karen Davis + 1 más
    • Inglés
    Get everything you need to prepare for a successful career as a pharmacy technician in one easy-to-read textbook! Useful from day one through graduation, Mosby's Pharmacy Technician: Principles and Practice, 7th Edition, includes comprehensive information on pharmacy practice, anatomy and physiology, math calculation, and pharmacology. Built from the ground up to map directly to American Society for Health-System Pharmacists (ASHP) accreditation competencies and to the accepted certification exams, this approachable text covers everything from processing and handling of medications and medication orders to patient safety, quality assurance, and regulation and compliance. It also features a rich art program with equipment close-ups, clinical procedures and processes, and body system illustrations that bring the content to life and visually reinforce your understanding of key concepts. With its clear writing, expert insight, and engaging study tools, this text will help you develop a solid foundation in the pharmacy content you need to pass the board examination and launch a successful and rewarding career.

  • Green Analytical Methods and Miniaturized Sample Preparation techniques for Forensic Drug Analysis

    • 1 Edición
    • Rajeev Jain + 1 más
    • Inglés
    Green Analytical Methods and Miniaturized Sample Preparation techniques for Forensic Drug Analysis provides a comprehensive overview of GAMs in forensic drug analysis, including green sample preparation techniques, in-situ analytical platforms (such as DIC and µPADs), and on-site sample preparation. The book discusses not only eco-friendly GAM’s, but also methods which provide high sample throughput and cost-effective analysis, and are therefore of immense use in resource limited laboratories of developing countries. This is a comprehensive source of literature for analytical scientists in this developing area of sustainable and affordable analytical methods.

  • Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders

    • 1 Edición
    • Gabriele De Rubis + 5 más
    • Inglés
    Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders focuses on 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling. The book, written by a team of leading experts in the field, is an essential resource for anyone interested in the future of CRD treatment. Chapters discuss the emerging therapeutic approaches for CRDs, including biologicals and phytoceuticals. Core chapters of the book then cover the application of 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling to different CRDs. The book concludes with a discussion of the current clinical trials and future prospects for the management of CRDs.This is a valuable resource for researchers, clinicians, and other healthcare professionals who are interested in the latest technological advances in the field of CRDs. It will also be of interest to students and scientists working in the fields of pharmaceutical sciences, microfluidics, bioinformatics, drug design, drug delivery, and 3D printing.

  • Drug Discovery Stories

    From Bench to Bedside
    • 1 Edición
    • Bin Yu + 1 más
    • Inglés
    Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The book covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds.The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology.

  • Theranostics Nanomaterials in Drug Delivery

    • 1 Edición
    • Prashant Kesharwani + 1 más
    • Inglés
    Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages.Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems.

  • Polymers for Oral Drug Delivery Technologies

    • 1 Edición
    • Anilkumar Parambath
    • Inglés
    Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.

  • Novel Drug Delivery Systems in the management of CNS Disorders

    • 1 Edición
    • Pooja A Chawla + 4 más
    • Inglés
    Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others.The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies.This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system.

  • Artificial Intelligence for Drug Product Lifecycle Applications

    • 1 Edición
    • Alberto Pais + 3 más
    • Inglés
    Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments.Accelerat... pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications.

  • Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics

    Recent and Future Trends in Pharmaceutics, Volume 2
    • 1 Edición
    • Amit Kumar Nayak + 1 más
    • Inglés
    Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics: Recent and Future Trends in Pharmaceutics, Volume Two explores aspects of pharmaceutics with an original approach that focuses on technology, novelties and future trends. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. Readers will find practical information for conducting research in pharmaceutics that is ideal for researchers in academia and industry as well as advanced graduate students in pharmaceutics.In addition, the book discusses the most recent developments in biopharmaceutics, including important and exciting areas such as solubility of drugs, pharmaceutical granulation, routes of drug administration, drug absorption, bioavailability and bioequivalence.

  • Design and Applications of Microneedles in Drug Delivery and Therapeutics

    • 1 Edición
    • Prashant Kesharwani
    • Inglés
    Design and Applications of Microneedles in Drug Delivery and Therapeutics details the design, characterization, and applications of this novel drug delivery system. Microneedles offer several advantages over traditional oral and parenteral approaches due to their ability to be fabricated and altered in shape, size and material type, and their convenience to be matched to specific treatment needs. This book covers the materials selection, design and fabrication approaches, and clinical translation of microneedles for a range of therapeutic applications, including cancer therapy, gene and vaccine delivery, wound healing, and more.This book is a forward-thinking resource for those working in the development of materials and devices for novel drug delivery.

  • Biochemical and Molecular Pharmacology in Drug Discovery

    • 1 Edición
    • Mithun Rudrapal + 2 más
    • Inglés
    Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches, along with certain key topics related to molecular pharmacology of drugs and therapeutics. The book explains the phenomena of drug-target interactions, considering different biochemical systems and cellular strategies. With the advent of technologies, current advances, and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology in a comprehensive and systematic manner.Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology.

  • Therapeutic Monoclonal Antibodies: From Lot Release to Stability Testing

    • 1 Edición
    • Harleen Kaur
    • Inglés
    Therapeutic Monoclonal Antibodies: From Lot Release to Stability Testing is a highly topical resource on a subject of interest for scientists and researchers working on monoclonal antibodies' characterization, release testing, stability testing and similarity assessments of monoclonal antibodies in the biopharmaceutical industry. Monoclonal antibodies (mAbs) are large, extremely complex and dynamic biomolecules, so it can be challenging to develop well-characterized therapeutic antibodies that meet regulatory expectations that are also in-line with commercialized standards for different drug markets.Lot release testing and understanding the stability of the mAb over a period of time, and in different environmental conditions, is an indispensable aspect of mAb physicochemical characterization. This book covers the process, including extensive analysis that starts with quantifying the purity attribute to glycan profiling and identifying the mAb primary structure. The book has a primary purpose of focusing on both Lot release testing and stability testing of monoclonal antibodies (subjects not covered in any great detail in other books).

  • Cancer Therapy

    Potential Applications of Nanotechnology
    • 1 Edición
    • Surendra Nimesh + 2 más
    • Inglés
    Cancer Therapy: Potential Applications of Nanotechnology provides readers with a compendium of all the latest research work in cancer therapeutics, including an emphasis on work in nanotechnology and polymeric nanoparticles. While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology, especially those with an emphasis on polymeric nanoparticles in cancer therapy. This title enlightens researchers and students and provides exhaustive knowledge on the topics covered.

  • An Integrated Guide to Human Drug Metabolism

    From Basic Chemical Transformations to Drug-Drug Interactions
    • 1 Edición
    • Mark Ashton + 3 más
    • Inglés
    An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines, and other drugs. Each of the human metabolic processes are covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, this book is for students and researchers needing a reference for interdisciplinary research in drug interactions.Metabol... is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects.

  • Reproducibility in Biomedical Research

    Epistemological and Statistical Problems and the Future
    • 2 Edición
    • Erwin B. Montgomery Jr.
    • Inglés
    Reproducibility in Biomedical Research: Epistemological and Statistical Problems, Second Edition explores the ideas and conundrums inherent in scientific research. This second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters are expanded to cover advances in the topics previously addressed. This book provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area.

  • Liposomes in Drug Delivery

    What, Where, How and When to deliver
    • 1 Edición
    • Sophia G. Antimisiaris
    • Inglés
    Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/chara... liposome properties for a particular application.The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvant... and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/techno... for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.

  • Novel Formulations and Future Trends

    Recent and Future Trends in Pharmaceutics, Volume 3
    • 1 Edición
    • Amit Kumar Nayak + 1 más
    • Inglés
    Novel Formulations and Future Trends, Volume Three in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics with an original approach focused on technology, novelties and future trends. It discusses the most important developments in drug delivery, including important and exciting areas such as mucosal, implantable, transdermal, gastroretentive, vaccine and targeted drug delivery systems. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students.New technologies are also explored including 3D printing and computational pharmaceutics.

  • Concepts and Models for Drug Permeability Studies

    Cell and Tissue based In Vitro Culture Models
    • 2 Edición
    • Bruno Sarmento + 2 más
    • Inglés
    Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-deriv... tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

  • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

    • 3 Edición
    • Ali S. Faqi
    • Inglés
    **Selected for 2025 Doody’s Core Titles® in Toxicology**A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

  • Biocontamination Control for Pharmaceuticals and Healthcare

    • 2 Edición
    • Tim Sandle
    • Inglés
    Biocontamination Control for Pharmaceuticals and Healthcare, Second Edition outlines a biocontamination strategy that tracks bio-burden control and reduction at each transition in classified areas of a facility. The first edition of the book covers many of the aspects of the strategy, but the new official guidance signals that a roadmap is required to fully comply with its requirements. Completely updated with the newest version of the EU-GPM (EN17141), this new edition expands coverage of quality risk management and contains completely new examples to help professionals bridge the gap between regulation and implementation. This book offers professionals in pharma quality control and related areas guidance on building a complete biocontamination strategy.

  • Pharmacology for Pharmacy Technicians

    • 4 Edición
    • Kathy Moscou + 1 más
    • Inglés
    Build a solid foundation in pharmacology with this all-in-one resource! Combining a comprehensive textbook with workbook exercises, Pharmacology for Pharmacy Technicians, 4th Edition helps you understand the principles of pharmacology and apply them to the daily activities and challenges seen in the practice setting. Full-color photos and illustrations make it easier to master concepts, and an in-depth review designed specifically for pharmacy technicians meets the requirements of the American Society of Health-System Pharmacists (ASHP) for anatomy and physiology and pharmacology. Written by a pharmacist and a pharmacy technician, Kathy Moscou and Karen Snipe — each with extensive experience in the field — this book helps you master the expanding role of the pharmacy technician and launch a successful and rewarding career in Pharmacy Technology.

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