Saltar al contenido principal
Elsevier

Libros en Toxicología

  • Drugs During Pregnancy and Lactation

    Treatment Options and Risk Assessment
    • 3 Edición
    • Christof Schaefer + 2 más
    • Inglés
    Drugs During Pregnancy and Lactation, Third Edition is a quick and reliable reference for all those working in disciplines related to fertility, pregnancy, lactation, child health and human genetics who prescribe or deliver medicinal products, and to those who evaluate health and safety risks. Each chapter contains twofold information regarding drugs that are appropriate for prescription during pregnancy and an assessment of the risk of a drug when exposure during pregnancy has already occurred. Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and pregnancy.

  • Heart and Toxins

    • 1 Edición
    • Dr. Meenakshisundaram Sundaram Ramachandran
    • Inglés
    The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity.

  • Handbook on the Toxicology of Metals

    • 4 Edición
    • Gunnar F. Nordberg + 2 más
    • Inglés
    Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations” and Volume II is devoted to “Specific Metals.” A multidisciplinary resource with contributions from internationally-reco... experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

  • Applied Dermatotoxicology

    Clinical Aspects
    • 1 Edición
    • Howard I. Maibach + 1 más
    • Inglés
    Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

  • Toxicological Survey of African Medicinal Plants

    • 1 Edición
    • Victor Kuete
    • Inglés
    Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology.

  • History of Toxicology and Environmental Health

    Toxicology in Antiquity Volume I
    • 1 Edición
    • Inglés
    Toxicology in Antiquity is the first in a series of short format works covering key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents.

  • Introduction to Biostatistics

    A Guide to Design, Analysis and Discovery.
    • 1 Edición
    • Ronald N. Forthofer + 1 más
    • Inglés
    The Biostatistics course is often found in the schools of public Health, medical schools, and, occasionally, in statistics and biology departments. The population of students in these courses is a diverse one, with varying preparedness. The book assumes the reader has at least two years of high school algebra, but no previous exposure to statistics is required.Written for individuals who might be fearful of mathematics, this book minimizes the technical difficulties and emphasizes the importance of statistics in scientific investigation. An understanding of underlying design and analysis is stressed. The limitations of the research, design and analytical techniques are discussed, allowing the reader to accurately interpret results. Real data, both processed and raw, are used extensively in examples and exercises. Statistical computing packages - MINITAB, SAS and Stata - are integrated. The use of the computer and software allows a sharper focus on the concepts, letting the computer do the necessary number-crunching.

  • Alcohol and Aldehyde Metabolizing Systems

    Intermediary Metabolism and Neurochemistry
    • 1 Edición
    • Ronald G. Thurman + 2 más
    • Inglés
    Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoli... derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.

  • Toxicological Aspects of Drug-Facilitated Crimes

    • 1 Edición
    • Pascal Kintz
    • Inglés
    Toxicological Aspects of Drug-Facilitated Crimes provides readers with an overview of the field of DFC: its history, toxicological effects, analysis, interpretation of results, the roles that age, gender and race may play, and clinical presentations of these drugs. The most commonly used drugs in DFC are addressed (alcohol, cannabis, MDMA, and cocaine), as well as an emerging range of pharmaceuticals (benzodiazepines, hypnotics, sedatives, neuroleptics, histamine H1-antagonists, or anesthetics), which are becoming more widely used, but are more difficult to detect. Edited by a world-renowned expert in the field of Forensic and Analytical Toxicology, Pascal Kintz, this book investigates toxicants of emerging concern and brings together a number of experts in the field to address the most recent discoveries on DFC toxicology.

  • Therapeutic Risk Management of Medicines

    • 1 Edición
    • Stephen J. Mayall + 1 más
    • Inglés
    Therapeutic risk management of medicines is an authoritative and practical guide on developing, implementing and evaluating risk management plans for medicines globally. It explains how to assess risks and benefit-risk balance, design and roll out risk minimisation and pharmacovigilance activities, and interact effectively with key stakeholders.A more systematic approach for managing the risks of medicines arose following a number of high-profile drug safety incidents and a need for better access to effective but potentially risky treatments. Regulatory requirements have evolved rapidly over the past decade. Risk management plans (RMPs) are mandatory for new medicinal products in the EU and a Risk Evaluation and Mitigation Strategy (REMS) is needed for certain drugs in the US.This book is an easy-to-read resource that complements current regulatory guidance, by exploring key areas and practical implications in greater detail. It is structured into chapters encompassing a background to therapeutic risk management, strategies for developing RMPs, implementation of RMPs, and the continuing evolution of the risk management field.The topic is of critical importance not only to the pharmaceutical and biotechnology industries, but also regulators and healthcare policymakers.Some chapters feature contributions from selected industry experts.

  • Biomarkers in Toxicology

    • 1 Edición
    • Ramesh C. Gupta
    • Inglés
    Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields.

  • Toxicogenomics-Based Cellular Models

    Alternatives to Animal Testing for Safety Assessment
    • 1 Edición
    • Jos Kleinjans
    • Inglés
    Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

  • Handbook of Nanosafety

    Measurement, Exposure and Toxicology
    • 1 Edición
    • Ulla Vogel + 5 más
    • Inglés
    Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment.

  • Electrocardiography of Laboratory Animals

    • 1 Edición
    • Jeffrey W. Richig + 1 más
    • Inglés
    Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.

  • Toxicology

    Mechanisms and Analytical Methods
    • 1 Edición
    • C. P. Stewart + 1 más
    • Inglés
    Toxicology: Mechanisms and Analytical Methods, Volume II provides an account of the general methods of chemical analysis available to the toxicologist, discussion of the principles on which they are based, and a survey of the material to which they are applied. The volume supplements the methods presented in the first volume. It provides specific examples of general procedures; considers the important groups of poisons; arranges the order of extraction from biological material; and discusses the methods for identifying and determining the members of each poison group. The book will be invaluable to toxicologists, clinical chemists, and biochemists.

  • Insecticides

    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Vol. 2
    • 1 Edición
    • Gunter Zweig
    • Inglés
    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Volume II: Insecticides contains detailed analytical procedures for analysis of 47 widely used insecticides. This volume is composed of 47 chapters that cover the history, biological and chemical properties, and physical constants of these insecticides. Each chapter presents first the general information, followed by intensive discussion of the methods of occurrence and residue analysis of the insecticide. Methods of analysis covered in each chapter include chemical methods, gas-liquid chromatography, colorimetry, and enzymatic techniques. Each chapter also provides analysis of phosphorus and acetylcholinesterase inhibition of the insecticide, which is classified into two groups, namely, organochlorine and organophosphorus. Agriculturists, analytical chemists, and toxicologists will find this book rewarding.

  • Micro Aerosol

    Physiology, Pharmacology, Therapeutics
    • 1 Edición
    • Lucien Dautrebande
    • Inglés
    Microaerosols: Physiology, Pharmacology, Therapeutics presents a summary of the experimental and technical data on aerosols. This book focuses on the production, measurement, sampling, and biological importance of submicroscopic and submicronic air-borne particles and to their pharmacological, therapeutic, and physiological effects after their deposition in the respiratory tract. Organized into 22 chapters, this book begins with an overview of the process of obligatory liquid filtration. This text then examines the factors that affect the sizing and numbering of aerosols, including the duration of the aerosol dispersion into a closed space, the duration of aerosol sampling, and the location of the particles. Other chapters consider the authenticity of the penetration of aerosols into the pulmonary depths. This book discusses as well the recommendations for preparations of airway dilating solutions. The final chapter deals with the effects on the lungs of airway constricting substances dispersed in aerosols. This book is a valuable resource for physicians.

  • Heredity and Environment in the Functional Psychoses

    An Epidemiological–Clinical Twin Study
    • 1 Edición
    • Einar Kringlen
    • Inglés
    Heredity and Environment in the Functional Psychoses involves an epidemiological clinical study of twins carried out at the University Psychiatric Institute in Oslo. The author reviews the history and nosological aspects of psychiatry. In his study of twin genetics, the author seeks to answer the questions "What is inherited?" and "How is it inherited?" In his review of 342 pairs of twins in the Central Register of Psychosis, his study had the following aims: to obtain true concordance figures for all types of functional psychoses; to study problems pertaining to nosology; and to study a larger sample of discordant pairs in order to clarify crucial environmental factors. His findings show that concordance figures for schizophrenia are 25-38 per cent in monozygotic twins and 4-10 per cent ion dizygotic twins. He points out that the difference in such concordance rates between the two types of twins is statistically significant. The data supports the (weak) assumption of a genetic factor in the etiology of schizophrenia. Behavioral scientists, psychiatrists, child psychologists, and researchers involved in genetics will find this book helpful and informative.

  • Keep off the Grass

    A Scientific Enquiry Into the Biological Effects of Marijuana
    • 1 Edición
    • Gabriel G. Nahas
    • Inglés
    Keep Off the Grass is a scientific inquiry into the scientific effects of marijuana. Marijuana, like most drugs ingested by man, gives the user the impression that his senses are enhanced, when in fact they have been distorted and impaired. This book is composed of 27 chapters, and starts with a brief introduction to the history of marijuana, the properties of its chemical components, called cannabinoids, and its widespread use and abuse. The succeeding chapters deal with the first scientific meetings on marijuana, social impact of marijuana, and its widespread use in some countries, such as in Morocco and Egypt. These topics are followed by discussions on the immunological and DNA effects of marijuana. The remaining chapters highlight the legal issues and government policies concerning the utility of this plant.

  • Principles of Epidemiology

    A Self-Teaching Guide
    • 1 Edición
    • Lewis H. Roht + 2 más
    • Inglés
    Principles of Epidemiology: A Self-Teaching Guide consists of a series of problem-solving exercises designed to introduce and guide readers toward an understanding of the principles and methods of epidemiology, rather than the epidemiology of specific diseases or subject areas such as ""infectious disease"" or ""chronic disease"" epidemiology. The guide has been formulated to be used by itself or as a supplement to standard textbooks. It illustrates and illuminates the principles and concepts of epidemiology and provides the reader an opportunity to practice the application of these principles in a logical sequence. The guide is divided into 14 exercises. Each exercise will help readers to understand principles or methods used by epidemiologist. Topics covered include the patterns of disease, populations at risk and risk assessment, screening for disease, investigation of an epidemic, etiology of disease, principles of causation, study design in epidemiologic investigation, data interpretation, and the uses and applications of epidemiology.

  • Screening Methods in Pharmacology

    Volume II
    • 1 Edición
    • Robert Turner + 1 más
    • Inglés
    Screening Methods in Pharmacology, Volume II is a collection of papers that presents practical techniques and information on the selection of a screening program for a particular pharmacological activity. The book contains the most reliable, simplest, and the most preferred screening methods in pharmacology. The text presents screening methods for alpha and beta Adrenergic blocking agents; compounds for antianginal activity; topical products for excessive eccrine sweating; antidepressant agents; and agents with analgesic and analgesic antagonist activity. Pharmacologists, pharmacists, researchers, and physicians will find this book a good source of information.

  • Advances in Drug Research

    • 1 Edición
    • Volumen 20
    • Bernard Testa
    • Inglés
    Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

  • Advances in Drug Research

    • 1 Edición
    • Volumen 21
    • Bernard Testa
    • Inglés
    Advances in Drug Research, Volume 21 comprises three chapters that deal with the general subject, specific therapeutic class, and chemical family of diverse drugs. The first chapter of this book discusses the absorption and distribution of drugs in the lymphatic system. A presentation of the anti-infective quinolones is provided in Chapter 2, while the design and therapeutic potential of peptides are elaborated in Chapter 3. Other topics covered include lymphotropic carriers and the lymph uptake mechanism; basis of circulation in lymphatic transport of molecules through various routes of administration; and general aspects and characteristics of quinolone antibacterial agents. The mode of action and mechanisms of resistance of quinolones; potent agonists and antagonists of peptides; and inhibitors of atrial natriuretic factor-degrading enzymes are also deliberated in this text. This publication is valuable to drug researchers and students interested in advances in drugs.

  • Neonatal Clinical Pharmacology and Therapeutics

    • 1 Edición
    • George Rylance + 2 más
    • Inglés
    Neonatal Clinical Pharmacology and Therapeutics covers the significant advances in clinical pharmacology and the principles of neonatal therapeutics. This book is composed of 20 chapters that tackle various neonatal diseases and their corresponding therapeutic options. The opening chapters review the pharmacological principles and kinetics, placental drug transfer, and drug therapy in pregnancy. The next chapters consider the other aspects of clinical pharmacology, including tocolytics, oxytocin, maternal drug use, neonatal withdrawal, prophylaxis, and the effect of material analgesia and anesthetics on newborn. Considerable chapters are devoted to the treatment options of neonatal diseases, including apnea, pulmonary and systemic disorders, cardiac diseases, jaundice, hypoglycemia, and nutrient deficiencies. The remaining chapters discuss other therapeutic options, such as blood cell component therapy, the use of analgesia and muscle relaxants, and parenteral nutrition. This book is intended primarily for all doctors who care for newborn babies and clinical pharmacologists.

  • Presystemic Drug Elimination

    Butterworths International Medical Reviews: Clinical Pharmacology and Therapeutics
    • 1 Edición
    • Charles F. George + 1 más
    • Inglés
    Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Section 2 considers the contribution of the liver to presystemic drug elimination, with a particular emphasis on the physiological factors, which determine the rate of breakdown of drugs in vivo. This section also deals with the effects of hepatic cirrhosis on presystemic drug elimination. Section 3 presents first a brief outline of the knowledge of pulmonary structure and relevant physiology, followed by a discussion on “first-pass” metabolism of endogenous substrates and drugs across the pulmonary circulation and of environmental chemicals after inhalation. This section also provides the methods for distinguishing between the contribution of the various sites to presystemic drug elimination and the problems associated with attempts to analyze available pharmacokinetic data. This work is an ideal source for clinical pharmacologists and researchers.

  • Forensic Toxicology

    Proceedings of a Symposium Held at the Chemical Defence Establishment, Porton Down, 29-30 June 1972
    • 1 Edición
    • Bryan Ballantyne
    • Inglés
    Forensic Toxicology presents the legal and medical aspects of the detrimental effects of chemicals on humans. This book discusses the immediate and long-term consequences of accident or deliberate poisoning, the detection of such poisoning, and the interpretation of the possible importance of demonstrating exogenous substances in biological fluids and tissues. Organized into 14 chapters, this compilation of papers begins with an overview of the fundamental procedure and interpretation in forensic toxicology. This text then examines the ways in which enzymes may be used in the analysis of drugs. Other chapters consider the equipment and reagents required in the rapid tests for drugs in urine. This book presents as well barbiturate poisoning from the viewpoint of the forensic pathologist performing the post mortem over the cause of death. The final chapter deals with further advances in forensic toxicology. This book is a valuable resource for general practitioners, forensic toxicologists, forensic pathologists, and police officers.

  • Radiation Research

    Biomedical, Chemical, and Physical Perspectives
    • 1 Edición
    • Oddvar F. Nygaard + 2 más
    • Inglés
    Radiation Research: Biomedical, Chemical and Physical Perspectives documents the proceedings of the Fifth International Congress of Radiation Research held in Seattle, Washington, 14-20 July 1974. While the focus of the Congress was on fundamental research, there were several well-attended sessions on the practical aspects of radiation research as it relates to radiotherapy, central station power generation by both nuclear fission and fusion, and the environment. This volume contains 126 papers organized into 31 parts. Beginning with a keynote address and a lecture on the time scale in radiobiology, the subsequent contributions cover a wide range of topics presented over several sessions. Topics discussed during these sessions include energy needs, nuclear power, and the environment; prospects for fusion power; technological applications of radiation; human radiobiology; hazards of radiation exposure relative to other environmental agents; the basic physics of the interactions of radiation with matter; particle penetration phenomena; and radiation effects in frozen media.

  • Drug Therapy During Pregnancy

    • 1 Edición
    • Tom K. A. B. Eskes + 1 más
    • Inglés
    Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.

  • Male Reproductive Toxicology

    • 1 Edición
    • Robert E. Chapin + 1 más
    • Inglés
    Methods in Toxicology, Volume 3: Male Reproductive Toxicology, Part A, deals with the male reproductive system and discusses methods that will help identify toxicant-induced changes at all levels in living organisms. It is important to realize that a toxic effect does not occur in a vacuum. All work in toxicology must be predicated on a demonstrated adverse effect in vivo. If good toxicology cannot exist in a vacuum, then there must be a structure. Thus, the book begins by presenting a few models as examples of the ways experiments could be grouped to define the toxicity of a chemical. This is followed by separate chapters on methods such as male mouse sexual behavior test; in vitro techniques for assessing pituitary secretory function; histological methods for preservation of the rat testis; procedures for assessing testicular sperm head counts in mice, rats, and dogs; and guidelines for conducting rodent dominant lethal tests. Subsequent chapters cover topics such as methods for the isolation and purification of Leydig cells from rat and mouse testes, and techniques used in semen analysis and fertility assessment in the rabbit.

  • Toxicology and Occupational Medicine

    Proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine, Key Biscayne (Miami), Florida, October 22-25, 1978
    • 1 Edición
    • William B. Deichmann
    • Inglés
    Toxicology and Occupational Medicine documents the proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine held in Key Biscayne (Miami), Florida, on 22-25 October 1978. The purpose of the conference was the presentation by delegates of research reports on subjects in the broad field of Toxicology and Occupational Medicine, followed by free discussions by all participants. This volume contains 47 papers and begins by tracing the history of the Inter-American Conferences. Subsequent chapters present papers on topics such as legal and scientific concerns over food safety; factors to consider to ensure the validity of the design of the experiment, the procedure for carrying it out, and the method of interpreting the results; and comparison of mutagenic, carcinogenic, and epidemiological data on known human carcinogens. Other papers cover the hidden carcinogen in the manufacture of isopropyl alcohol; developments in protecting workers from chemical hazards on the job; and safety evaluation of cosmetic ingredients.

  • Venoms of the Hymenoptera

    Biochemical, Pharmacological and Behavioural Aspects
    • 1 Edición
    • Tom Piek
    • Inglés
    Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.

  • The Pathophysiology and Pharmacotherapy of Myocardial Infarction

    • 1 Edición
    • Nabil El-Sherif + 1 más
    • Inglés
    The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related complications. This book covers two major consequences—cardiac muscle dysfunction and cardiac electrical dysfunction. This text begins by reviewing the controversy surrounding the pathogenetic mechanisms of atheroma formation and its potential reversibility, including the status of coronary risk factors and benefits of primary prevention. The pathophysiologic mechanisms of pump failure and the current approach to its management are then deliberated, followed by a discussion on the rational use of vasodilators in post-infarction heart failure and pharmacotherapy of cardiogenic shock. The rationale for the interest in the role of coronary vasospasm and thrombolytic therapy for acute myocardial infarction is also covered. This publication concludes by reviewing the approaches for the management of post-infarction ventricular tachyarrhythmias and concept of secondary prevention of sudden cardiac death. This compilation is valuable to medical students, primary care physicians, and cardiovascular specialists.

  • Pharmacology of Antihypertensive Drugs

    • 1 Edición
    • P.A. Van Zwieten
    • Inglés
    Handbook of Hypertension, Volume 3: Pharmacology of Antihypertensive Drugs presents the biological and clinical knowledge in the field of hypertension. This book discusses the fundamental pharmacology of antihypertensive drugs. Organized into 12 chapters, this volume begins with an overview of the classification of antihypertensive mechanisms of drugs. This text then examines the effects of antihypertensive drugs in animal models and discusses the importance of these models and responses to human hypertension. Other chapters consider the pharmacological basis for the treatment of hypertension. This book discusses as well the various classes of antihypertensive drugs, which depends on two factors. The final chapter deals with the inhibitors of angiotensin-converti... enzyme, which are essential in the drug treatment of hypertensive disease. This book is a valuable resource for clinicians, pharmacists, physiologists, epidemiologists, biological scientists, and general practitioners. Clinical investigators and medical students will also find this book extremely useful.

  • Advances in Endogenous and Exogenous Opioids

    Proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) Held in Kyoto, Japan on July 26–30, 1981
    • 1 Edición
    • Hiroshi Takagi + 1 más
    • Inglés
    Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.

  • Pharmaceutical and Cosmetic Products for Topical Administration

    Pharmaceutical Monographs
    • 1 Edición
    • N. J. Van Abbé + 2 más
    • J. B. Stenlake
    • Inglés
    Pharmaceutical and Cosmetic Products for Topical Administration , Volume 9 provides the product characteristics, formulation, and rationale of topical therapeutic preparations. The book attempts to take the reader logically from the physiological and pathological aspects through to the reasoning behind topical medication. The text discusses such topics as the physiology and structure of the skin; the differential diagnosis of various skin diseases; the theoretical basis of emulsion technology; and the mechanism of percutaneous absorption. Undergraduate students and teachers of pharmacy and allied subjects will find the monograph very useful.

  • Man and Biologically Active Substances

    The Effect of Drugs, Diet and Pollution on Health
    • 1 Edición
    • I. I. Brekhman
    • Inglés
    Man and Biologically Active Substances: The Effect of Drugs, Diet and Pollution on Health discusses the theory and the aims of pharmacosanation; the pharmacosanation medicaments; and the future of pharmacosanation.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 3
    • 1 Edición
    • E. J. Ariëns
    • Inglés
    Drug Design, Volume III covers the mode of action of biologically active compounds. The book discusses microbial transformations that have been used in the preparation of drugs or closely related substances; the use of linear free energy parameters and other experimental constants in structure-activity studies; and the mode of action of anticoagulants structurally and functionally related to vitamin K. The text also describes the design of beta-blocking drugs, biologically active acridines, local anesthetics, and insect chemosterilants. The molecular approach for designing inhibitors to enzymes involved in blood clotting is also considered. Chemists, pharmacologists, and people involved in drug design.

  • Essays in Toxicology

    Volume 2
    • 1 Edición
    • Frank R. Blood
    • Inglés
    Essays in Toxicology, Volume 2 covers essays on toxicology and related topics. The book presents essays on fungal toxins, such as mycotoxin, aflatoxin, moldy corn toxicoses, alimentary toxic aleukia, ochratoxin, sporidesmin, zearalenone and other estrogenic compounds, pink rot dermatitis, and slaframine. The text also includes essays on hyperbilirubinemia and cholestasis induced by alpha-naphthylisothi... taurolithocholic acid, and 2-ethyl-2-phenyl butyramide, as different forms of liver injury produced in animals. The evolution of pesticide analyses is also encompassed. Biochemists, physiologists, pathologists, and microbiologists will find the book invaluable.

  • Advances in Drug Research

    • 1 Edición
    • Volumen 22
    • Bernard Testa
    • Inglés
    Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

  • Essays in Toxicology

    Volume 1
    • 1 Edición
    • Frank R. Blood
    • Inglés
    Essays in Toxicology, Volume 1 covers essays in toxicology and related topics. The book presents essays on the use of poisons as tools in studying the nervous system as well as teratology. The text also includes essays on the significance of methemoglobinemia in toxicology and lead poisoning. Biochemists, plant and animal physiologists, pharmacologists, pathologists, microbiologists, entomologists, food technologist, and people involved in forensic medicine and industrial medicine.

  • Physiology and Toxicology of Male Reproduction

    • 1 Edición
    • James C. Lamb + 1 más
    • Inglés
    Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.

  • Cardiac Pharmacology

    • 1 Edición
    • R. Douglas Wilkerson
    • Inglés
    Cardiac Pharmacology aims to interface basic and clinical knowledge of those interventions used or being studied for use in the treatment of heart disease. The book is divided into four major sections which address intrinsic and neural control of cardiac function, pharmacologic modification of cardiac contractility and cardiac output, the genesis and control of cardiac arrhythmias, and pharmacologic manipulation of myocardial oxygen supply and demand. The last three sections contain a chapter describing the techniques employed in the study of that particular aspect of cardiac function and its alterations by pharmacologic interventions. Cardiologists, pharmacologists, physiologists, and those interested in the area of cardiovascular medicine will find the book insightful.

  • Blood

    • 1 Edición
    • Walter S. Root + 1 más
    • Inglés
    Physiological Pharmacology, Volume V: Blood describes the interrelationships between pharmacology and blood. This volume is organized into five parts encompassing 16 chapters that consider the effect of therapeutic agents on the physiology of blood, whether it be coagulation, the white cells, red cells, or platelets. The opening part deals first with the physiology of blood coagulation and the mode of action of anticoagulants. This part also covers the mechanism of thrombogenesis and thrombolysis, as well as the in vivo actions of thrombolytic agents. The subsequent parts initially examine the biochemistry and physiology of platelets, hematopoietic stem cells, and white cells. These topics are followed by discussions of the mechanism of thrombocytosis and clinical manifestations of thrombocythemia, as well as the mechanisms of immunologic drug effect on blood cells. These parts also explore the effects of drugs on myelopoiesis and the physiological and immunological activities of lymphocytes. The closing part reviews the iron, vitamin B12, folic acid, erythropoietin, and transferrin components of red blood cells. This part also examines the mechanism of erythropoietic cellular proliferation and the initiation of hyperoxia. This book is intended primarily to physiological pharmacologists, hematologists, and researchers.

  • The Toxicology of Radioactive Substances

    Volume 3.59
    • 1 Edición
    • A. A. Letavet + 1 más
    • Inglés
    The Toxicology of Radioactive Substances, Volume 3: Iron-59 deals with the experimental results of tests conducted at the Radiotoxicology Laboratory of the Institute of Occupational Hygiene and Disease, Academy of Medical Sciences, U.S.S.R. The book focuses on studies made on iron-59, which is widely used in science and technology, such as in the metal industry and in the research of hemoglobin metabolism in the bone marrow and red cells. Other studies show, however, that there is a long-term detrimental effect of intake of iron-59. The text then gives a brief outline of the physical, chemical, and biological properties of iron. Research also shows that the body's reaction to radioactive substances depends on how these are transmitted to the body and on their physicochemical properties. The effect of prolonged administration of radioactive iron on the electrical activity of the cerebral cortex of animals is analyzed, of which, possibly, the nervous system is most affected. The book notes also the changes in the red blood cells during chronic administration of iron-59 in small doses, wherein the hemoglobin levels increased temporarily. Studies of prolonged exposure to radioactive isotopes during pregnancy of the test animals show that there are significant changes in erythropoiesis, associated with iron deficiency. In another study, the prolonged internal administration of radioactive substances showed phasic changes in the height of electrocardiographic waves of the test animals. The text is suitable for physicists, nuclear scientists, doctors of toxicology, and researchers in nuclear medicine.

  • Additional Principles and Methods of Analysis

    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Vol. 5
    • 1 Edición
    • Gunter Zweig
    • Inglés
    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Volume V: Additional Principles and Methods of Analysis covers the major advances in the analytical techniques used for the qualitative and quantitative determinations of minute amounts of pesticide and plant growth regulator residues in foods and crops. The book discusses developments in analytical methods (i.e. the polarographic technique, thin-layer chromatography) and their general applications; the analytical aspects of pesticide residue analyses in the environment; and specific analytical methods for formulation and residue analyses of insecticides, fungicides, herbicides and plant growth regulators. Agriculturists, agricultural engineers, toxicologists, and people involved in the study of pesticides and biochemicals will find the book invaluable.

  • A Guide to Alcohol and Drug Dependence

    • 2 Edición
    • J. S. Madden
    • Inglés
    A Guide to Alcohol and Drug Dependence, Second Edition provides information on the recognition of alcohol misuse, on alcohol dependence among the elderly, and on outpatient withdrawal from opioids. This book emphasizes the detection and early treatment of alcohol misuse, the detoxification of drug users followed by drug-free counseling, and preventive measures. Organized into nine chapters, this edition begins with an overview of the various types of dependence-producing drugs, including morphine, cocaine, cannabis, alcohol-barbiturate, amphetamine, hallucinogen, and inhalants and volatile solvents. This text then explains the depressant actions of alcohol on the central nervous system that affects first the higher cerebral functions responsible for concern about personal behavior and for self-restraint. Other chapters consider the physical disabilities that heavy drinkers are prone to develop. The final chapter deals with the preventive measures directed against the problems presented by drugs and alcohol. This book is a valuable resource for social workers, nurses, occupational therapists, and clinical psychologists.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 10
    • 1 Edición
    • E. J. Ariëns
    • Inglés
    Drug Design, Volume X covers promising and current developments in drug design. The book discusses procedures as applied in the practice of drug design; the structural aspects of the structure-activity relationships of neuroleptics; and promising perspectives in the highly actual field of bioactive peptides. The text also describes the application of the dynamic systems analysis to the antihypertensive drug action; polymeric drug delivery systems; and the design of biocompatible polymers. The structure-activity relationships of insect repellents as a basis for the design of such agents, as well as the approaches to the multivariate data analysis in structure-activity relationships, which is an essential aspect of drug design, are also encompassed. Chemists, pharmacologists, bioengineers, and people involved in drug design and manufacture will find the book invaluable.

  • Biological and Environmental Effects of Arsenic

    • 1 Edición
    • Volumen 6
    • B.A. Fowler
    • Inglés
    Topics in Environmental Health, Volume 6: Biological and Environmental Effects of Arsenic focuses on the properties, characteristics, and reactions of arsenic and its effects on the environment. The selection first tackles the mobilization of arsenic by natural and industrial processes and emissions, cycling, and effects of arsenic in soil ecosystems. Discussions focus on the effects of arsenic on plants and soil microorganisms, exposure through consumption, sources of arsenic, and mobilization of arsenic by natural processes and industrial activities. The publication then ponders on environmental reaction and analysis methods and arsenical metabolism and toxicity to freshwater and marine species. The text examines the metabolism of arsenic and epidemiology of human arsenic exposure, including acute and chronic effects by arsenic in man, absorption, tissue distribution and retention, and elimination and biological half-time. The publication then takes a look at the toxicity of arsenic and its compounds, as well as biological transformation of arsenic compounds in soil ecosystems and effects on plants; biotransformation of arsenic compounds and toxicity to freshwater and marine biota; and environmental transformation of arsenic in freshwater/marine ecosystems. The selection is a dependable reference for readers interested in the biological and environmental effects of arsenic.

  • Ions-Cyclic Nucleotides-Cholinergy

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1 Edición
    • J.C. Stoclet
    • Inglés
    Advances in Pharmacology and Therapeutics, Volume 3: Ions – Cyclic Nucleotides – Cholinergy covers the proceedings of the Seventh International Congress of Pharmacology, held in Paris in 1978. This book mainly focuses on studying ions, cyclic nucleotides, and cholinergy. Specifically, this text discusses the pharmacology of calcium homeostasis and presents lectures given in the symposium. The role of cyclic nucleotides in the regulation of muscular tissue functions and the evaluation of cyclic AMP and cyclic GMP are also looked into. This text presents in its latter part papers on chemical structure and cholinergic activity. This volume will be valuable to students and experts in the field of pharmacology, therapeutics, and related fields.

  • Acute Drug Abuse Emergencies

    A Treatment Manual
    • 1 Edición
    • Peter G. Bourne
    • Inglés
    Acute Drug Abuse Emergencies: A Treatment Manual presents the most commonly encountered drug abuse emergencies. This book discusses how various drug-related conditions should be managed by practicing physicians and all those who are dealing with drug abusers. Organized into nine parts encompassing 28 chapters, this book begins with an overview of the various emergency drug reactions, including behavioral disturbances, organ malfunction, central nervous system depression, exacerbation of pre-existing illness, or combinations. This text then examines the profile of a typical heroin overdose victim. Other chapters consider severe poisoning due to nonbarbiturate sedative overdosage. This book discusses as well the types of adverse reactions to marihuana and the dangers of marihuana use. The final chapter deals with the ease of synthesis and the potency of arylcyclohexylamines as a mind-altering drug. This book is a valuable resource for toxicologists, emergency room physicians, and nurses. Readers who are dealing with drug abusers will also find this book extremely useful.

Temas relacionados