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Elsevier

Libros en Toxicología

  • Pesticide Biotransformation and Disposition

    • 1 Edición
    • Ernest Hodgson
    • Inglés
    Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans.

  • Histopathology of Preclinical Toxicity Studies

    Interpretation and Relevance in Drug Safety Evaluation
    • 4 Edición
    • Peter Greaves
    • Inglés
    The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

  • Human Toxicology of Chemical Mixtures

    • 2 Edición
    • Harold Zeliger
    • Inglés
    In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author’s focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body’s methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers.

  • “Venomous” Bites from Non-Venomous Snakes

    A Critical Analysis of Risk and Management of “Colubrid” Snake Bites
    • 1 Edición
    • Scott A Weinstein + 2 más
    • Inglés
    This book is the first significant contribution to thoroughly examine the potential hazards associated with snakes of the former family, Colubridae. This family contained >65% of living snake species (approximately 3,000 taxa) and has recently been split into multiple families. Many of these snakes produce oral secretions that contain toxins and other biologically-active substances. A large variety of these snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-nineteenth century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of snakes belonging to this diverse, artificial family. There is a need for "one-stop shopping" offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. This book is the first synthesis of this information and includes evidence-based risk assessment, hazard rankings and specific recommendations regarding important species, many common in captivity.

  • Reproductive and Developmental Toxicology

    • 1 Edición
    • Ramesh C. Gupta
    • Ramesh C. Gupta
    • Inglés
    Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.

  • Comprehensive Toxicology

    • 2 Edición
    • Charlene McQueen
    • Inglés
    An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today.

  • Fire Toxicity

    • 1 Edición
    • A A Stec + 1 más
    • Inglés
    Toxic fire effluents are responsible for the majority of fire deaths, and an increasing large majority of fire injuries, driven by the widespread and increasing use of synthetic polymers. Fire safety has focused on preventing ignition and reducing flame spread through reducing the rate of heat release, while neglecting the important issue of fire toxicity. This is the first reference work on fire toxicity and the only scientific publication on the subject in the last 15 years.Assessment of toxic effects of fires is increasingly being recognised as a key factor in the assessment of fire hazards. This book raises important issues including the types of toxic effluents that different fires produce, their physiological effects, methods for generation and assessment of fire toxicity, current and proposed regulations and approaches to modelling the toxic impact of fires.The contributors to Fire toxicity represent an international team of the leading experts in each aspect of this challenging and important field. This book provides an important reference work for professionals in the fire community, including fire fighters, fire investigators, regulators, fire safety engineers, and formulators of fire-safe materials. It will also prove invaluable to researchers in academia and industry.

  • Fundamentals of Toxicologic Pathology

    • 2 Edición
    • Matthew A. Wallig + 2 más
    • Inglés
    Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists.

  • Information Resources in Toxicology

    • 4 Edición
    • Philip Wexler + 3 más
    • Inglés
    This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the “hot topics” covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated.

  • Advances in Molecular Toxicology

    • 1 Edición
    • Volumen 3
    • Inglés
    <I>Advances in Molecular Toxicology</I> features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. <I>Advances in Molecular Toxicology</I> will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.

  • Foodborne Pathogens

    Hazards, Risk Analysis and Control
    • 2 Edición
    • Clive de W Blackburn + 1 más
    • Inglés
    Effective control of pathogens continues to be of great importance to the food industry. The first edition of Foodborne pathogens quickly established itself as an essential guide for all those involved in the management of microbiological hazards at any stage in the food production chain. This major edition strengthens that reputation, with extensively revised and expanded coverage, including more than ten new chapters.Part one focuses on risk assessment and management in the food chain. Opening chapters review the important topics of pathogen detection, microbial modelling and the risk assessment procedure. Four new chapters on pathogen control in primary production follow, reflecting the increased interest in safety management early in the food chain. The fundamental issues of hygienic design and sanitation are also covered in more depth in two extra chapters. Contributions on safe process design and operation, HACCP and good food handling practice complete the section.Parts two and three then review the management of key bacterial and non-bacterial foodborne pathogens. A new article on preservation principles and technologies provides the context for following chapters, which discuss pathogen characteristics, detection methods and control procedures, maintaining a practical focus. There is expanded coverage of non-bacterial agents, with dedicated chapters on gastroenteritis viruses, hepatitis viruses and emerging viruses and foodborne helminth infections among others.The second edition of Foodborne pathogens: hazards, risk analysis and control is an essential and authoritative guide to successful pathogen control in the food industry.

  • Handbook of Toxicology of Chemical Warfare Agents

    • 1 Edición
    • Ramesh C. Gupta
    • Inglés
    This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.

  • Asthma and COPD

    Basic Mechanisms and Clinical Management
    • 2 Edición
    • Peter J. Barnes + 3 más
    • Inglés
    Asthma and COPD: Basic Mechanisms and Clinical Management, Second Edition continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

  • Human Toxicology of Chemical Mixtures

    Toxic Consequences Beyond the Impact of One-Component Product and Environmental Exposures
    • 1 Edición
    • Harold Zeliger
    • Inglés
    This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals.

  • Advances in Molecular Toxicology

    • 1 Edición
    • Volumen 2
    • Inglés
    Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed

  • Radioactive Aerosols

    • 1 Edición
    • Volumen 12
    • Constantin Papastefanou
    • Inglés
    Whenever radioactivity is released to the atmosphere, for example by the detonation of nuclear weapons or the testing of nuclear weapons or from nuclear reactor accidents that fraction of it which remains airborne for more than a few hours is liable to be attached to aerosol particles. The resulting radioactive aerosols are carried by atmospheric mixing processes until they settle out or are scavenged by precipitation. The radiation exposure pathway of maximum concern to humans is by inhalation of aerosols and their deposition in the respiratory tract. In this context, it is important to note that radioactive aerosols are commonly of natural origin alos. In particular, the associated radionuclides can be of natural terrestrial origin, such as the decay products of radon gas, or they can e cosmogenic, such as beryllium-7. The exposure of miners of uranium and other ores and minerals to radon and its aerosol-borne decay products is of major significance. The book describes the formation of aerosols, their aerodynamic size distribution, their atmospheric residence time, their sampling and measurement, the range of radioactive aerosols found and studied thus far, including man-made nuclides and radon decay products and their interaction with man, including deposition in the lung and subsequent health effects.

  • Drugs During Pregnancy and Lactation

    Treatment Options and Risk Assessment
    • 2 Edición
    • Christof Schaefer + 2 más
    • Inglés
    The latest edition is the resource for any practicing OB/GYN, family physician, midwife, or pharmacist who prescribes medicinal products to or evaluates environmental or occupational exposures in women who are or may become pregnant. Based on the highly successful seven German editions of this reference, the up-to-date drug listings have been revised into a handy pocket guide color tabbed for quick access to important information. Easy to reference each drug is listed discussing the side effects, general impact on organ systems, potential toxicity, and risks before offering dosage recommendations. It is the only book of its kind to provide conclusive information on treatments for diseases during pregnancy and lactation and actions to be taken after (inadvertant) exposure to drugs suspected to be developmentaly toxic. Unlike other dosage guides, this edition is an affordable, compact compendium of knowledge on the very latest drugs and their effects on pregnant/lactating women.

  • Veterinary Toxicology

    Basic and Clinical Principles
    • 1 Edición
    • Ramesh C. Gupta
    • Inglés
    Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pharmaceuticals and much more. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology.

  • Histopathology of Preclinical Toxicity Studies

    Interpretation and Relevance in Drug Safety Evaluation
    • 3 Edición
    • Peter Greaves
    • Inglés
    This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology.

  • Lead

    Chemistry, Analytical Aspects, Environmental Impact and Health Effects
    • 1 Edición
    • José S. Casas + 1 más
    • Inglés
    Lead covers the salient aspects of the chemistry of lead, its environmental impact, and its effects on health. The technical, economic and social importance of Lead, at the present time, is beyond all doubt. However, over the last few decades little attention has been given to its behaviour (the properties and applications of its compounds, the environmental distribution of these derivatives, and their impacts on living creatures), this book addresses that gap. It includes coverage of historical aspects, lead mining and production, metal properties, common lead compounds, uses of lead and its derivatives, coordination chemistry, organometallic chemistry, environmental chemistry, toxicity mechanisms, and treatment strategies for lead poisoning. Finally, describing analytical procedures for the determination of lead in chemical, biological and environmental samples.

  • Hazardous Substances and Human Health

    Exposure, Impact and External Cost Assessment at the European Scale
    • 1 Edición
    • Volumen 8
    • Till M Bachmann
    • Inglés
    There is widespread public concern about hazardous chemicals that are contained in air, soil, water and food. Policy has therefore adopted a series of laws and regulations concerning emissions into and concentration levels in different media including food. As policy makers do not only have to consider the protection of the environment but also need to ensure a well-functioning economy at the same time, these limit or target values need to be set in a balanced way. The main problem, however, is to compare the costs for achieving these targets with the benefits to society by having a smaller exposure to hazardous substances (cost-benefit analysis). This book sets out to improve the reliability of cost-benefit analyses particularly of hazardous substances present in air, water, soil and food. It suggests that the human health risk assessment of chemicals is performed in a bottom-up analysis, i.e., following a spatially resolved multimedia modelling approach. In order to support cost-benefit analyses, the approach is accompanied by monetary valuation of human health impacts, yielding so-called external costs. Results for selected priority metals show that these external costs are small compared to those by the classical air pollutants and involve rather long time horizons touching on the aspect of intergenerational equity within sustainable development. When including further hazardous substances, the total external costs attributable to contaminants are expected to be more substantial.

  • Encyclopedia of Toxicology

    • 2 Edición
    • Philip Wexler + 9 más
    • Inglés
    The second edition of the Encyclopedia of Toxicology continues its comprehensive survey of toxicology. This new edition continues to present entries devoted to key concepts and specific chemicals. There has been an increase in entries devoted to international organizations and well-known toxic-related incidents such as Love Canal and Chernobyl. Along with the traditional scientifically based entries, new articles focus on the societal implications of toxicological knowledge including environmental crimes, chemical and biological warfare in ancient times, and a history of the U.S. environmental movement. With more than 1150 entries, this second edition has been expanded in length, breadth and depth, and provides an extensive overview of the many facets of toxicology.Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedire...

  • Handbook of Forensic Drug Analysis

    • 1 Edición
    • Fred Smith
    • Inglés
    The Handbook of Forensic Drug Analysis is a comprehensive chemical and analytic reference for the forensic analysis of illicit drugs. With chapters written by leading researchers in the field, the book provides in-depth, up-to-date methods and results of forensic drug analyses. This Handbook discusses various forms of the drug as well as the origin and nature of samples. It explains how to perform various tests, the use of best practices, and the analysis of results. Numerous forensic and chemical analytic techniques are covered including immunoassay, gas chromatography, and mass spectrometry. Topics range from the use of immunoassay technologies for drugs-of-abuse testing, to methods of forensic analysis for cannabis, hallucinogens, cocaine, opioids, and amphetamine. The book also looks at synthetic methods and law enforcement concerns regarding the manufacture of illicit drugs, with an emphasis on clandestine methamphetamine production. This Handbook should serve as a widely used reference for forensic scientists, toxicologists, pharmacologists, drug companies, and professionals working in toxicology testing labs, libraries, and poison control centers. It may also be used by chemists, physicians and those in legal and regulatory professions, and students of graduate courses in forensic science.

  • Pesticide, Veterinary and Other Residues in Food

    • 1 Edición
    • David Watson
    • Inglés
    This wide-ranging text reviews the wealth of recent research on assessing and managing the risks from pesticide, veterinary and other chemical residues in food. After an introductory chapter on the key issues in food toxicology,Part one covers the assessment and management of risks, with individual chapters on genetic susceptibility to dietary carcinogens, good agricultural practice and HACCP systems, targeted and rapid methods for analysing residues in food and ways of assessing the mutagenicity of chemicals in food. Part two looks at veterinary residues, covering their safety, toxicology and detection. Part three examines pesticides, with chapters on surveillance and detection methods for fungicides and herbicides. In the final part, there are chapters summarising a wide range of other chemical residues in food, from xenostrogens/endocri... disruptors and dietary estrogens to polycyclic aromatic hydrocarbons, dioxins and polychlorinated biphenyls.Pesticide, veterinary and other residues in food is a standard reference for all those concerned with ensuring the safety of food.

  • Mycotoxins in Food

    Detection and Control
    • 1 Edición
    • N Magan + 1 más
    • Inglés
    Mycotoxins, toxic compounds produced by fungi, pose a significant contamination risk in both animal feed and foods for human consumption. With its distinguished editors and international team of contributors, Mycotoxins in food summarises the wealth of recent research on how to assess the risks from mycotoxins, detect particular mycotoxins and control them at differing stages in the supply chain.Part one addresses risk assessment techniques, sampling methods, modelling and detection techniques used to measure the risk of mycotoxin contamination and the current regulations governing mycotoxin limits in food. Part two looks at how the risk of contamination may be controlled, with chapters on the use of HACCP systems and mycotoxin control at different stages in the supply chain. Two case studies demonstrate how these controls work for particular products. The final section details particular mycotoxins, from ochratoxin A and patulin to zearalenone and fumonisins.Mycotoxin... in food is a standard reference for all those concerned with ensuring the safety of food.

  • Teratology in the Twentieth Century

    Congenital Malformations in Humans and How their Environmental Causes were Established
    • 1 Edición
    • H. Kalter
    • Inglés
    This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.

  • Hallucinogens

    A Forensic Drug Handbook
    • 1 Edición
    • Richard Laing
    • Inglés
    Hallucinogens: A Forensic Drug Handbook is a comprehensive reference for everyone involved in the identification, investigation, and forensic analysis of hallucinogenic drugs. The text begins with a review of the history of these drugs and their abuse, and then takes an in-depth look at the many different types of hallucinogens, their chemical make-up, how they affect users, how they are manufactured and distributed, and how they can be detected and analyzed.Hallucinoge... covers the most commonly abused drugs such as LSD, MDMA ("Ecstasy"), and PCP ("Angel Dust"), as well as many lesser-known chemical substances that cause similar effects. Chapters have been contributed by leading analysts and investigators around the world, and are highlighted with numerous illustrations. This unique handbook will serve is a cross-disciplinary source of information for forensic toxicologists, law enforcement officers, and others involved in the fight against drugs.

  • Cellular and Molecular Toxicology

    Volume 14
    • 1 Edición
    • J.P. Vanden Heuvel + 3 más
    • Inglés
    Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately.Toxicolog... is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response.Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation.A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

  • Biomarkers in Marine Organisms

    A Practical Approach
    • 1 Edición
    • Ph. Garrigues + 3 más
    • Inglés
    Many previous studies and books have been dedicated to fundamental and developmental aspects of biomarkers. The purpose of this book is to provide, through various case studies, an overview of the practical use of biological markers in marine animals to evaluate the health effects of environmental contamination in marine ecosystems.More precisely, the book presents the results obtained during the development and application of biological markers as indicators of exposure/effect to toxic chemicals in marine environments, using diverse sentinel species such as fish, bivalves and crustaceans. An important aspect is also the publication of technical annexes that describe in detail the experimental procedures developed for both chemical and biochemical measurement.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology

    • 2 Edición
    • Brad Bolon + 5 más
    • Inglés
    A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology.This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.

  • Drug-Facilitated Sexual Assault

    A Forensic Handbook
    • 1 Edición
    • Marc A. LeBeau + 1 más
    • Inglés
    Drug-Facilitated Sexual Assault educates readers on the ways in which drugs are used as weapons in committing sexual assaults and how to successfully investigate these crimes. It looks at the history of these crimes over the years, and includes an in-depth discussion of the drugs and drug classes in use today. It describes the effects of these drugs on the victims, the process for reporting these crimes, details on the type of person who uses drugs to sexually assault an individual, and obstacles to investigating the suspect. The authors show the proper techniques in collecting and analyzing evidence; ways to overcome some of the unique difficulties encountered in these types of investigations; and how to work with other professionals to prosecute these cases successfully. The concluding appendixes are valuable samples of the necessary forms needed to complete these investigations. This book is ideal for anyone involved in investigating these crimes, including forensic scientists, law enforcement officers, lawyers, toxicologists, and medical professionals.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 55
    • Inglés
    Virology is the branch of microbiology that deals with viruses and viral infections. The overall goal of virus research is understand the action of various viruses and develop vaccines or techniques that are effective at preventing or treating the diseases caused by them. Viruses that affect humans range in severity from the rhinoviruses that cause the "common cold" to the human immune deficiency (HIV) virus that causes AIDS.By their very nature, viruses are highly contagious and therefore affect millions of people, plants, and animals. This field continues to have new discoveries that are important to researchers and clinicians in the field.

  • Handbook of Oxidants and Antioxidants in Exercise

    • 1 Edición
    • C. Sen + 2 más
    • Inglés
    Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress.The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes.This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.

  • Information Resources in Toxicology

    • 3 Edición
    • Philip Wexler + 3 más
    • Inglés
    Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists.

  • Toxicology

    • 1 Edición
    • Hans Marquardt + 3 más
    • Inglés
    Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.

  • Emergency Response Planning

    For Corporate and Municipal Managers
    • 1 Edición
    • Paul A. Erickson
    • Inglés
    Emergencies wreak havoc on businesses and governments on a daily basis. Whether it is a hurricane pounding a coastal community, a terrorist attack on a company's headquarters, or a hazardous chemical spill at a local school, the results can be loss of life, health, and property. How can you prevent or reduce the effects of such occurrences? By planning ahead.Emergency Response Planning is designed to help corporate and municipal managers quickly understand their roles in proactive and reactive emergency management. Author Paul Erickson shows how to develop partnerships with federal, state, and local government agencies, as well as community groups in order to prevent, prepare for, and respond to natural disasters and manmade emergencies.Emergenc... Response Planning provides essential information to help you comply with government regulations, design an emergency response plan, train personnel, use the proper safety equipment, safeguard information systems, and resume normal operations after an emergency as quickly as possible. It will also help consultants design emergency response plans for their clients, and provide practical information for students studying business continuity and emergency issues.

  • Piperonyl Butoxide

    • 1 Edición
    • Denys Glynne Jones
    • Inglés
    Piperonyl Butoxide contains 20 chapters contributed by world experts in the field on the properties, uses, plant metabolism, and mammalian and environmental toxicology of piperonyl butoxide. The mode of action of piperonyl butoxide is discussed as well as many other specialist topics, including the measurement of synergism in the laboratory, and the potential use of this chemical alone for the control of whiteflies, as well as with insect growth regulators. This book will prove to be a valuable reference for all concerned with the designing of safe and cost-effective insecticide formulations, particularly those used in the home, industry, or on or near animals and food.

  • Acute Toxicology Testing

    • 2 Edición
    • Shayne C. Gad + 1 más
    • Inglés
    Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.

  • Diuretic Agents

    Clinical Physiology and Pharmacology
    • 1 Edición
    • Donald W. Seldin + 1 más
    • Inglés
    The only comprehensive work to cover all aspects of diuretic agents, the book discusses the pharmacology and toxicology of diuretic agents as well as the physiological effects. Experts in the field present the principles and experimental approaches for the study of interactions between pharmacologic compounds in relation to specific target organs. Diuretic Agents contains information on the mechanisms of action and application of diuretics, and details FDA regulations and pharmaceutical industry guidelines.

  • In Vitro Methods in Pharmaceutical Research

    • 1 Edición
    • Jose V. Castell + 1 más
    • Inglés
    In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies.

  • Human Toxicology

    • 1 Edición
    • J. Descotes
    • Inglés
    This excellent volume was designed and edited with two major ideas in mind: firstly, the field of clinical toxicology is changing and an acknowledgement of these changes is warranted; secondly, no comprehensive compilation of recently published case reports of, and clinical studies on, human poisonings is available, which is in sharp contrast to the closely related field of drug-induced side-effects.The book focusses on issues of recent concern, or issues poorly documented in the past. It is important that clinical toxicologists gain a better knowledge of all the available techniques of toxicological analysis. A better understanding of the way a sound interpretation of results should be conducted for the benefit of the patient's management, and a comprehensive set of data on the kinetics of the most common pharmaceutical drugs and many chemicals is required.Human Toxicology is a timely reference work which will be welcomed by a broad audience of toxicology professionals.

  • Loomis's Essentials of Toxicology

    • 4 Edición
    • A. Wallace Hayes + 1 más
    • Inglés
    Loomis's Essentials of Toxicology is an introductory text on the science of harmful biologic effects associated with exposures to chemicals of all types. The scope of this book includes a discussion of the major types of chemicals involved; the general properties of chemicals and biologic systems as they influence the occurrence of detrimental biologic effects; the methods used to demonstrate these effects; and the basis for clinical diagnosis and therapy of harmful effects of chemicals on humans. Individual examples are used to demonstrate each of the principles under discussion. This text is an invaluable resource for toxicologists as well as a comprehensive introduction to the topic for graduate and advanced undergraduate students in toxicology and public health.

  • Biochemistry, Molecular Biology, and Therapeutic Implications

    Nitric Oxide: Biochemistry, Molecular Biology, And Therapeutic Implications
    • 1 Edición
    • Volumen 34
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types.

  • Advances in Pharmacology

    • 1 Edición
    • Volumen 30
    • Inglés
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Biological Effects of Electric and Magnetic Fields

    Sources and Mechanisms
    • 1 Edición
    • David O. Carpenter + 1 más
    • Inglés
    Recent concerns over the possible hazards of electrical and magnetic fields in the home and workplace are comprehensively addressed within this book. The chapters contain detailed research on the biological effects of electric and magnetic fields, and evidence for and against any interaction of electromagnetic fields (EMFs) and biological systems.

  • Biological Effects of Electric and Magnetic Fields

    Beneficial and Harmful Effects
    • 1 Edición
    • David O. Carpenter + 1 más
    • Inglés
    Recent concerns over the possible hazards of electrical and magnetic fields in the home and workplace are comprehensively addressed within this book. The chapters contain detailed research on the biological effects of electric and magnetic fields, and evidence for and against any interaction of electromagnetic fields (EMFs) and the biological systems.

  • In Vitro Toxicity Indicators

    • 1 Edición
    • Volumen 1B
    • Charles A. Tyson
    • Inglés
    About the Series:In the tradition of Methods in Enzymology and Methods in Neurosciences, Academic Press is pleased to announce a new serial: Methods in Toxicology. There is a pressing need among researchers involved in toxicologic investigation for a series of publications that organizes and presents information on the latest experimental methodologies. To address the needs of researchers in toxicology, toxicologic pathology, pharmacology, and clinical biochemistry, this new serial provides comprehensive descriptions of state-of-the-art methods for evaluating drug and chemical toxicity. Thematic volumes focus on mechanistic approaches to the study of toxicity both in vitro and in vivo, taking advantage of the recent advances in the biological and chemical sciences that allow closer scrutiny of the mechanisms by which agents cause damage. Each volume begins with an introductory chapter that offers a broad guide to the application of methods addressed in that volume. Subsequent chapters contain detailed descriptions of research protocols, accessible both to experts and those new to toxicologic investigation. Included in each chapter are clearly defined procedures, discussions of limitations of the method, comparative considerations (species, sex, strain), interpretations of results, and explanations of how the methods may serve as alternatives to in vivo testing. Each volume of Methods in Toxicology is available in case binding for the library and Wire-O-binding for the laboratory. About the Book:Concurrent with the development of biological systems for in vitro toxicologic investigations (Volume 1A-In Vitro Biological Systems), techniques have evolved to detect and evaluate the diverse effects produced when toxicants interact with these systems. This volume describes methods for detecting and quantifying pertubations in various cellular parameters related to cell dysfunction and death (including apoptosis) associated with adverse toxicant action. Each endpoint measurement probes one aspect of the response of the biological system to a toxicant. When several techniques are used in combination, it is possible to derive a more complete understanding of the mechanism of toxicity at the cellular, tissue, or organ level. The methods collected here are organized by major categories of toxic effects, such as membrane damage, disruption of energy metabolism, and lipid peroxidation, commonly monitored by toxicologists during a comprehensive toxicity study. Specialized techniques of interest and value in mechanistic investigations are included. As with the first volume, the goal is not to obtain an exhaustive collection of methods, but rather to assemble in a single central reference a set of valuable techniques that are used for toxicologic investigations, along with cautionary remarks on their use and limitations.

  • Organophosphates Chemistry, Fate, and Effects

    Chemistry, Fate, and Effects
    • 1 Edición
    • Janice E. Chambers + 1 más
    • Inglés
    This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity.

  • Teratogens

    Chemicals Which Cause Birth Defects
    • 1 Edición
    • Volumen 31
    • V. Kolb Meyers
    • Inglés
    This multi-author work deals with the practical aspects of teratogens - chemicals which cause birth defects. It is designed for use as a unique guide to these chemicals in which one can find all relevant information. The issues covered include: how to obtain information about the teratogenic potential of chemicals; teratogenic chemicals in undergraduate chemistry laboratories; safe handling of teratogenic chemicals; teratogenicity of pesticides and other pollutants in the environment; occupational exposure and pregnancy outcome; identification and prevention of reproductive hazards in industry; and the long-term effects of chemicals on the developing brain. A list of approximately 5,000 chemicals known to cause reproductive effects is given. A comprehensive bibliography is included with each chapter providing up-to-date references for more in-depth coverage. The monograph will be of interest to academic and industrial chemists, health professionals, as well as both undergraduate and graduate students in health and related sciences.

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