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Elsevier

Libros en Química

  • Organic Structure Determination Using 2-D NMR Spectroscopy

    A Problem-Based Approach
    • 1 Edición
    • Jeffrey H. Simpson
    • Inglés
    Organic Structure Determination Using 2-D NMR Spectroscopy is a primary text for a course in NMR techniques, with the goal to learn to identify organic molecular structure. It presents strategies for assigning resonances to known structures and for deducing structures of unknown organic molecules based on their NMR spectra.It contains 20 known and 20 unknown structure determination problems and features a supporting website from which instructors can download the structures of the unknowns in selected chapters, digital versions of all figures, and raw data sets for processing. Many other books describe the methods used, but none offer a large number of problems. Instructors at universities and colleges are forced to cobble together problems from a wide range of sources. The fragmentary approach to assembling course materials has a negative impact on course continuity and thus adversely impacts student retention.This book will stand as a single source to which instructors and students can go to obtain a comprehensive compendium of NMR problems of varying difficulty.

  • Thermophysical Properties of Chemicals and Hydrocarbons

    • 1 Edición
    • Carl L. Yaws
    • Inglés
    Carl Yaws here presents over 7,800 organic and inorganic chemicals, and hydrocarbons. Spanning gases, liquids and solids, and covering all critical properties (including acentric factor, density, enthalpy of vaporization, and surface tension), this volume represents more properties on more chemicals than any single work of its kind, from C1 to C100 organics and Ac to Zr inorganics. Designed and formatted for field, lab or classroom usage, it gives the reader unparalleled access to invaluable data.

  • Evolutionary Essays

    A Thermodynamic Interpretation of the Evolution
    • 1 Edición
    • Sven Erik Jørgensen
    • Inglés
    Evolution is nature’s most fascinating process, the possibility given sufficient time to combine simple inorganic compounds to more and more complex biochemical compounds, which make up more and more complex organisms. It is therefore crucial in our effort to understand the evolution to see it from as many different angles as possible. This books draw an image of evolution from the thermodynamic viewpoint, which gives new and surprising insights into the processes and mechanisms that have driven evolution. This new thermodynamic interpretation has made it possible to quantify the various steps of evolution and to show that evolution has followed an exponential growth curve.

  • Bioinorganic Chemistry

    A Survey
    • 1 Edición
    • Ei-Ichiro Ochiai
    • Inglés
    Written by a preeminent teacher and scientist in the field, Bioinorganic Chemistry provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject.

  • Computational Modeling of Membrane Bilayers

    • 1 Edición
    • Volumen 60
    • V. Sundararajan
    • Inglés
    Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.

  • Studies in Natural Products Chemistry

    • 1 Edición
    • Volumen 34
    • Atta-ur Rahman
    • Inglés
    This volume presents frontier reviews on recent developments on bioactive natural products in cutting-edge areas by eminent experts in their respective fields. Fourteen reviews treat diverse and different topics in natural products chemistry - basic ones, medicinally oriented ones, agro-oriented ones and ecologically oriented ones.It is an important addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic.

  • Carbohydrate Chemistry, Biology and Medical Applications

    • 1 Edición
    • Hari G. Garg + 2 más
    • Inglés
    The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research.

  • Characterization of Semiconductor Heterostructures and Nanostructures

    • 1 Edición
    • Giovanni Agostini + 1 más
    • Inglés
    In the last couple of decades, high-performance electronic and optoelectronic devices based on semiconductor heterostructures have been required to obtain increasingly strict and well-defined performances, needing a detailed control, at the atomic level, of the structural composition of the buried interfaces. This goal has been achieved by an improvement of the epitaxial growth techniques and by the parallel use of increasingly sophisticated characterization techniques and of refined theoretical models based on ab initio approaches. This book deals with description of both characterization techniques and theoretical models needed to understand and predict the structural and electronic properties of semiconductor heterostructures and nanostructures.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1 Edición
    • Volumen 7
    • A. Leitmannova Liu
    • Inglés
    Advances in Planar Lipid Bilayers and Liposomes, Volume 7, continues to include invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results in this exciting multidisciplinary field of their own research group.Many of the contributors working in both fields over many decades were in close collaboration with the late Prof. H. Ti Tien, the founding editor of this book series. There are also chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide.

  • Adsorption by Carbons

    • 1 Edición
    • Eduardo J. Bottani + 1 más
    • Inglés
    Adsorption by Carbons covers the most significant aspects of adsorption by carbons, attempting to fill the existing gap between the fields of adsorption and carbonaceous materials. Both basic and applied aspects are presented. The first section of the book introduces physical adsorption and carbonaceous materials, and is followed by a section concerning the fundamentals of adsorption by carbons. This leads to development of a series of theoretical concepts that serve as an introduction to the following section in which adsorption is mainly envisaged as a tool to characterize the porous texture and surface chemistry of carbons. Particular attention is paid to some novel nanocarbons, and the electrochemistry of adsorption by carbons is also addressed. Finally, several important technological applications of gas and liquid adsorption by carbons in areas such as environmental protection and energy storage constitute the last section of the book.

  • Physical Chemistry

    • 3 Edición
    • Robert G. Mortimer
    • Inglés
    In this third edition, core applications have been added along with more recent developments in the theories of chemical reaction kinetics and molecular quantum mechanics, as well as in the experimental study of extremely rapid chemical reactions.

  • Advances in Quantum Chemistry

    Applications of Theoretical Methods to Atmospheric Science
    • 1 Edición
    • Volumen 55
    • Michael M.E. Goodsite + 3 más
    • Inglés
    Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.Theoretical methods have dramatically extended the reach and grasp of atmospheric scientists. This edition of Advances in Quantum Chemistry collects a broad range of articles that provide reports from the leading edge of this interaction. The chemical systems span the range from atoms to clusters to droplets. Electronic structure calculations are used to uncover the details of the breakdown and removal of emissions from the atmosphere and the simultaneous development of air pollution including ozone and particles. The anomalous enrichment of heavy isotopes in atmospheric ozone is discussed using RRKM theory, and a number of techniques are presented for calculating the effect of isotopic substitution on the absorption spectra of atmospheric molecules.

  • Fluorine and Health

    Molecular Imaging, Biomedical Materials and Pharmaceuticals
    • 1 Edición
    • Alain Tressaud + 1 más
    • Inglés
    Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinall... relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized.

  • The Alkaloids

    Chemistry and Biology
    • 1 Edición
    • Volumen 65
    • Inglés
    This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

  • Interfacial and Confined Water

    • 1 Edición
    • Ivan Brovchenko + 1 más
    • Inglés
    Water in the proximity of a surface (interfacial water) is abundant on the earth. It is involved in various physical and chemical processes and crucial for biological function. Despite numerous studies of interfacial water, systematic analysis of its properties is missing in scientific literature. This book is a first comprehensive review of experimental and simulation studies of water in various confining environments, such as hydrophilic and hydrophobic surfaces, surfaces of biomolecules, porous media, etc. Systematic analysis of interfacial and confined water is based on the firm physical ground, which accounts for variety of the thermodynamic states of water near the surface, surface phase transitions, surface critical behaviour, effect of confinement on the bulk and surface phase transitions of water, clustering and formation of a spanning hydrogen-bonded water network via percolation transition. This allows distinguishing between universal features, common for all fluids, and some specific water properties, related to intermolecular hydrogen bonds. Special attention is paid to the properties of hydration water, which covers biomolecules and enables their biological activity. This book provides readers with basic information on interfacial and confined water, which will be useful for scientists and engineers working in the fields of bioscienses, nanociences and nanotechnologies.

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 46
    • Inglés
    Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxystero... dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)

  • Optical Biosensors

    Today and Tomorrow
    • 2 Edición
    • Frances S. Ligler + 1 más
    • Inglés
    Optical Biosensors, Second Edition describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field.

  • Advances in Quantum Chemistry

    DV-Xá for Industrial-Academic Cooperation
    • 1 Edición
    • Volumen 54
    • Jun Kawai + 2 más
    • Inglés
    Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area. This volume concerns the proceedings of the 4th International Conference on the DV-Xá Method. The focus is on key issues of materials science, surfaces, boundaries, defects, metals, ceramics and organic materials and spectroscopy. The DV-Xá method is a Density Functional-like development, which has reached an unparalleled theoretical and practical sophistication in Japan and Korea.

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 63
    • Graham A. Webb
    • Inglés
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science when precise structural determination is required and when the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Advances in Organometallic Chemistry

    The Organotransition Metal Chemistry of Poly(pyrazolyl)borates. Part 1
    • 1 Edición
    • Volumen 56
    • Robert C. West + 2 más
    • Inglés
    Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.Volume 56 comprises Part 1 of a themed collection of papers on "The Organotransition Metal Chemistry of Poly(pyrazolyl)borat...

  • State Estimation in Chemometrics

    The Kalman Filter and Beyond
    • 1 Edición
    • Pierre C. Thijssen
    • Inglés
    This unique text blends together state estimation and chemometrics for the application of advanced data-processing techniques. It further applies system theory in order to develop a modular framework to be implemented on computer for the development of simple intelligent analyzers. Short reviews on the history of state estimation and chemometrics are given, together with examples of the applications described, including classical estimation, state estimation, non-linear estimation, the multi-component, calibration and titration systems and the Kalman filter. The contents are very systematic and build the ideas up logically to appeal to specialist post-graduates working in this area, together with professionals in other areas of chemistry and engineering.

  • Drug-like Properties: Concepts, Structure Design and Methods

    from ADME to Toxicity Optimization
    • 1 Edición
    • Li Di + 1 más
    • Inglés
    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 95
    • Alan R. Katritzky
    • Inglés
    Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Volume 94 of Advances in Heterocyclic Chemistry commences with a review of cascade reactions on heterocyclic synthesis. The chapter presents a fascinating array of complex sequences which provide efficient routes to a wide variety of heterocyclic systems. The second chapter is the twelfth in the series on the organic chemistry of heterocyclic ligands in metallic complexes. The present contribution deals with the chemistry of polypyridine ligands in organomanganese and organorhenium complexes. Its current importance can be measured by the fact that, of the nearly 700 references, approximately half date from the last 10 years. Preparation of aminoisoxazoles and their utility in the synthesis of condensed systems are also covered. In the final chapter, isothiazolium salts and their use in synthesis are reviewed. Many condensed S,N-heterocyclic systems are described in this, the first review dedicated to this topic.

  • Electrochemistry for Materials Science

    • 1 Edición
    • Walfried Plieth
    • Inglés
    This book introduces the principles of electrochemistry with a special emphasis on materials science. This book is clearly organized around the main topic areas comprising electrolytes, electrodes, development of the potential differences in combining electrolytes with electrodes, the electrochemical double layer, mass transport, and charge transfer, making the subject matter more accessible.In the second part, several important areas for materials science are described in more detail. These chapters bridge the gap between the introductory textbooks and the more specialized literature. They feature the electrodeposition of metals and alloys, electrochemistry of oxides and semiconductors, intrinsically conducting polymers, and aspects of nanotechnology with an emphasis on the codeposition of nanoparticles.This book provides a good introduction into electrochemistry for the graduate student. For the research student as well as for the advanced reader there is sufficient information on the basic problems in special chapters. The book is suitable for students and researchers in chemistry, physics, engineering, as well as materials science.

  • The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins

    • 1 Edición
    • Abhik Ghosh
    • Inglés
    This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists.

  • Strategies and Tactics in Organic Synthesis

    • 1 Edición
    • Volumen 7
    • Michael Harmata
    • Inglés
    A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

  • Biological Inorganic Chemistry

    An Introduction
    • 1 Edición
    • Robert R. Crichton
    • Inglés
    The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.

  • Advances in Physical Organic Chemistry

    • 1 Edición
    • Volumen 42
    • John P. Richard
    • Inglés
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

  • Advances in Physical Organic Chemistry

    • 1 Edición
    • Volumen 42
    • John P. Richard
    • Inglés
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

  • The Alkaloids

    Chemistry and Biology
    • 1 Edición
    • Volumen 64
    • Inglés
    This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

  • Advances in Quantum Chemistry

    Current Trends in Atomic Physics
    • 1 Edición
    • Volumen 53
    • Sten Salomonson + 1 más
    • Inglés
    Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1 Edición
    • Volumen 6
    • A. Leitmannova Liu
    • Inglés
    Advances in Planar Lipid Bilayers and Liposomes, Volume 6, continues to include invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results in this exciting multidisciplinary field of their own research group. Many of the contributors working in both fields over many decades were in close collaboration with the late Prof. H. Ti Tien, the founding editor of this book series. There are also chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide.

  • Profiles of Drug Substances, Excipients and Related Methodology

    Critical Compilation of pKa Values for Pharmaceutical Substances
    • 1 Edición
    • Volumen 33
    • Harry G. Brittain
    • Inglés
    Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

  • Cancer Drug Design and Discovery

    • 1 Edición
    • Stephen Neidle
    • Inglés
    The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options.

  • Lipidomics and Bioactive Lipids: Specialized Analytical Methods and Lipids in Disease

    • 1 Edición
    • Volumen 433
    • Inglés
    This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis; Measurement of eicosanoids in cancer tissues; Noninvasive Assessment of the Role of Cyclooxygenases in Cardiovascular HealthA Detailed HPLC/MS/MS Method; Lipidomics in Diabetes and the Metabolic Syndrome; LC-MS-MS Analysis of Neutral Eicosanoids; Quantification Of F2-Isoprostanes In Biological Fluids And Tissues As A Measure Of Oxidant Stress; Measurement of Products of Docosahexaenoic Acid Peroxidation, Neuroprostanes, and Neurofurans; Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography; Targeted Chiral Lipidomics Analysis by Liquid Chromatography Electron Capture Atmospheric Pressure Chemical Ionization Mass Spectrometry (LC-ECAPCI/MS); Shotgun Lipidomics by Tandem Mass Spectrometry under Data-Dependent Acquisition Control; Identification of Intact Lipid Peroxides by Ag+ Coordination Ionspray Mass Spectrometry (CIS-MS); Quantification of Cardiolipin by Liquid Chromatography Electrospray Ionization Mass Spectrometry.

  • Handbook of Thermal Analysis and Calorimetry

    Recent Advances, Techniques and Applications
    • 1 Edición
    • Volumen 5
    • Inglés
    This is Volume 5 of a Handbook that has been well-received by the thermal analysis and calorimetry community. All chapters in all five volumes are written by international experts in the subject. The fifth volume covers recent advances in techniques and applications that complement the earlier volumes. The chapters refer wherever possible to earlier volumes, but each is complete in itself. The latest recommendations on Nomenclature are also included. Amongst the important new techniques that are covered are micro-thermal analysis, pulsed thermal analysis, fast-scanning calorimetery and the use of quartz-crystal microbalances. There are detailed reviews of heating - stage spectroscopy, the range of electrical techniques available, applications in rheology, catalysis and the study of nanoparticles. The development and application of isoconversional methods of kinetic analysis are described and there are comprehensive chapters on the many facets of thermochemistry and of measuring thermophysical properties. Applications to inorganic and coordination chemistry are reviewed, as are the latest applications in medical and dental sciences, including the importance of polymorphism. The volume concludes with a review of the use and importance of thermal analysis and calorimetry in quality control.

  • Forensic Science

    • 2 Edición
    • Volumen 6
    • Inglés
    Forensic Science, Second Edition presents the applications of separation methods, manly chromatography, in forensic practice. The first part, devoted to forensic toxicology, contains reviews on forensic relevant groups of compounds, like: Opiate agonists, cocaine, amphetamines, hallucinogens, cannabinoids, sedatives and hypnotics, antidepressive and antipsychotic drugs, analgesics, antidiabetics, muscle relaxants, and mushroom toxins.In these parts, the preliminary immunochemical tests were also included, together with separation methods. Screening procedures used in forensic toxicology were presented in separate chapters on forensic screening with GC, GC-MS, HPLC, LC-MS, CE, and LC-ICP-MS. In the part on actual and emerging problems of forensic toxicology, following chapters were included: Analytical markers of alcohol abuse, toxicological aspects of herbal remedies, drugs and driving, analysis in alternative matrices, doping analysis, pharmacogenomics in forensic toxicology, and quality assurance. The second part presents application of separation methods in forensic chemistry, and comprises chapters on: Explosives, chemical warfare agents, arson analysis, and writing media. Third part on forensic identification contains chapter on forensic genetics.All chapters are written up-to-date and present specific information up to 2006. The authors of each chapter are known not only from their scientific activity, but are also reputed experts, proven in everyday forensic casework.

  • Spectroscopy and Modeling of Biomolecular Building Blocks

    • 1 Edición
    • Jean-Pierre Schermann
    • Inglés
    Spectroscopy and Modeling of Biomolecular Building Blocks presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy, quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties of biomolecular systems and those induced by the presence of their environment. The first chapters provide background in modelling (I), frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD techniques (III). Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations. The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes; chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular systems. The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules.

  • Medical Applications of Mass Spectrometry

    • 1 Edición
    • Karoly Vekey + 2 más
    • Inglés
    Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.

  • Advances in Organometallic Chemistry

    • 1 Edición
    • Volumen 55
    • Robert C. West + 2 más
    • Inglés
    Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 62
    • Graham A. Webb
    • Inglés
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science when precise structural determination is required and when the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and nonspecialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Solid-Liquid Two Phase Flow

    • 1 Edición
    • Sümer M. Peker + 1 más
    • Inglés
    This book is an undertaking of a pioneering work of uniting three vast fields of interfacial phenomena, rheology and fluid mechanics within the framework of solid-liquid two phase flow. No wonder, much finer books will be written in the future as the visionary aims of many nations in combining molecular chemistry, biology, transport and interfacial phenomena for the fundamental understanding of processes and capabilities of new materials will be achieved. Solid-liquid systems where solid particles with a wide range of physical properties, sizes ranging from nano- to macro- scale and concentrations varying from very dilute to highly concentrated, are suspended in liquids of different rheological behavior flowing in various regimes are taken up in this book. Interactions among solid particles in molecular scale are extended to aggregations in the macro scale and related to settling, flow and rheological behavior of the suspensions in a coherent, sequential manner. The classical concept of solid particles is extended to include nanoparticles, colloids, microorganisms and cellular materials. The flow of these systems is investigated under pressure, electrical, magnetic and chemical driving forces in channels ranging from macro-scale pipes to micro channels. Complementary separation and mixing processes are also taken under consideration with micro- and macro-scale counterparts.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1 Edición
    • Volumen 61
    • Inglés
    Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Solution Thermodynamics and its Application to Aqueous Solutions

    A Differential Approach
    • 1 Edición
    • Yoshikata Koga
    • Inglés
    As the title suggests, we introduce a novel differential approach to solution thermodynamics and use it for the study of aqueous solutions. We evaluate the quantities of higher order derivative than the normal thermodynamic functions. We allow these higher derivative data speak for themselves without resorting to any model system. We thus elucidate the molecular processes in solution, (referred to in this book “mixing scheme”), to the depth equal to, if not deeper, than that gained by spectroscopic and other methods. We show that there are three composition regions in aqueous solutions of non-electrolytes, each of which has a qualitatively distinct mixing scheme. The boundary between the adjacent regions is associated with an anomaly in the third derivatives of G. The loci of the anomalies in the temperature-composit... field form the line sometimes referred as “Koga line”. We then take advantage of the anomaly of a third derivative quantity of 1-propanol in the ternary aqueous solution, 1-propanol – sample species – H2O. We use its induced change as a probe of the effect of a sample species on H2O. In this way, we clarified what a hydrophobe, or a hydrophile, and in turn, an amphiphile, does to H2O. We also apply the same methodology to ions that have been ranked by the Hofmeister series. We show that the kosmotropes (salting out, or stabilizing agents) are either hydrophobes or hydration centres, and that chaotropes (salting in, or destablizing agents) are hydrophiles.

  • Laser-Induced Breakdown Spectroscopy

    • 1 Edición
    • Jagdish P. Singh + 1 más
    • Inglés
    Laser induced breakdown spectroscopy (LIBS) is basically an emission spectroscopy technique where atoms and ions are primarily formed in their excited states as a result of interaction between a tightly focused laser beam and the material sample. The interaction between matter and high-density photons generates a plasma plume, which evolves with time and may eventually acquire thermodynamic equilibrium. One of the important features of this technique is that it does not require any sample preparation, unlike conventional spectroscopic analytical techniques. Samples in the form of solids, liquids, gels, gases, plasmas and biological materials (like teeth, leaf or blood) can be studied with almost equal ease. LIBS has rapidly developed into a major analytical technology with the capability of detecting all chemical elements in a sample, of real- time response, and of close-contact or stand-off analysis of targets. The present book has been written by active specialists in this field, it includes the basic principles, the latest developments in instrumentation and the applications of LIBS . It will be useful to analytical chemists and spectroscopists as an important source of information and also to graduate students and researchers engaged in the fields of combustion, environmental science, and planetary and space exploration.

  • Annual Reports in Computational Chemistry

    • 1 Edición
    • Volumen 3
    • David Spellmeyer + 1 más
    • Inglés
    Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a 'must' for researchers and students wishing to stay up-to-date on current developments in computational chemistry.In Volume 3, topics covered include Simulation Methodologies (Carlos Simmerling), Biological and Biophysical Applications (Heather Carlson), Chemical Education (Theresa Zielinski), Materials and Polymers (Jeffry Madura), Quantum Chemistry (T. Daniel Crawford), and Emerging Technologies (Wendy Cornell). With this volume we extend the practice of cumulative indexing of both the current and past editions in order to provide easy identification of past reports.

  • Magnetic Cell Separation

    • 1 Edición
    • Volumen 32
    • Inglés
    Cell separation is at the core of current methods in experimental biology and medicine. Its importance is illustrated by the large number of physical and biochemical principles that have been evaluated for application to cell separation. The development of cell separation methods is driven by the needs of biological and medical research, and the ever-increasing demands for sensitivity, selectivity, yield, timeliness and economy of the process. The interdisciplinary nature of research in this area and the volume of information available in research publications and conferences necessitates a basic description of the fundamental processes involved in magnetic cell separation that may help the user in navigating this wealth of information available online and in scientific publications. This book will appeal to researchers in many areas utilizing this technique, including those working in cell biology, clinical research, inorganic chemistry, biochemistry, chemical engineering, materials science, physics and electrical engineering.

  • Progress in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 19
    • Gordon Gribble + 1 más
    • Inglés
    This is the 19th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2006. As with previous volumes in the series, Volume 19 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way.

  • Introduction to Non-equilibrium Physical Chemistry

    • 1 Edición
    • R. P. Rastogi
    • Inglés
    Introduction to Non-equilibrium Physical Chemistry presents a critical and comprehensive account of Non-equilibrium Physical Chemistry from theoretical and experimental angle. It covers a wide spectrum of non-equilibrium phenomena from steady state close to equilibrium to non-linear region involving transition to bistability, temporal oscillations, spatio-temporal oscillations and finally to far from equilibrium phenomena such as complex pattern formation, dynamic instability at interfaces, Chaos and complex growth phenomena (fractals) in Physico-chemical systems. Part I of the book deals with theory and experimental studies concerning transport phenomena in membranes (Thermo-osmosis,Elec... ) and in continuous systems (Thermal diffusion,Soret effect) close to equilibrium Experimental tests provide insight into the domain of validity of Non-equilibrium Thermodynamics ,which is the major theoretical tool for this region. Later developments in Extended Irreversible Thermodynamics and Non-equilibrium Molecular dynamics have been discussed in the Appendix. Part II deals with non-linear steady states and bifurcation to multistability, temporal and spatio- temporal oscillations (Chemical waves). Similarly Part II deals with more complex phenomena such as Chaos and fractal growth occurring in very far from equilibrium region. Newer mathematical techniques for investigating such phenomena along with available experimental studies. Part IV deals with analogous non-equilibrium phenomena occurring in the real systems (Socio-political, Finance and Living systems etc.) for which physico-chemical systems discussed in earlier chapters provide a useful model for development of theories based on non-linear science and science of complexity.

  • Chemical Bonding at Surfaces and Interfaces

    • 1 Edición
    • Anders Nilsson + 2 más
    • Inglés
    Molecular surface science has made enormous progress in the past 30 years. The development can be characterized by a revolution in fundamental knowledge obtained from simple model systems and by an explosion in the number of experimental techniques. The last 10 years has seen an equally rapid development of quantum mechanical modeling of surface processes using Density Functional Theory (DFT). Chemical Bonding at Surfaces and Interfaces focuses on phenomena and concepts rather than on experimental or theoretical techniques. The aim is to provide the common basis for describing the interaction of atoms and molecules with surfaces and this to be used very broadly in science and technology. The book begins with an overview of structural information on surface adsorbates and discusses the structure of a number of important chemisorption systems. Chapter 2 describes in detail the chemical bond between atoms or molecules and a metal surface in the observed surface structures. A detailed description of experimental information on the dynamics of bond-formation and bond-breaking at surfaces make up Chapter 3. Followed by an in-depth analysis of aspects of heterogeneous catalysis based on the d-band model. In Chapter 5 adsorption and chemistry on the enormously important Si and Ge semiconductor surfaces are covered. In the remaining two Chapters the book moves on from solid-gas interfaces and looks at solid-liquid interface processes. In the final chapter an overview is given of the environmentally important chemical processes occurring on mineral and oxide surfaces in contact with water and electrolytes.

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