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Elsevier

Libros en Química

  • Annual Reports in Computational Chemistry

    • 1 Edición
    • Volumen 4
    • Ralph A. Wheeler + 1 más
    • Inglés
    Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a "must" for researchers and students wishing to stay up-to-date on current developments in computational chemistry.

  • The Alkaloids

    Chemistry and Biology
    • 1 Edición
    • Volumen 66
    • Inglés
    This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

  • Carbohydrates: The Essential Molecules of Life

    • 2 Edición
    • Robert V. Stick + 1 más
    • Inglés
    This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes.A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place.Therefore the book will provide a taste for the subject of glycobiology.Coverin... the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology.

  • Molecular Characterization and Analysis of Polymers

    • 1 Edición
    • Volumen 53
    • John M. Chalmers + 1 más
    • Inglés
    Written by expert contributors from the academic and industrial sectors, this book presents traditional and modern approaches to polymer characterization and analysis. The emphasis is on pragmatics, problem solving and property determination; real-world applications provide a context for key concepts. The characterizations focus on organic polymer and polymer product microstructure and composition.

  • Annual Reports in Medicinal Chemistry

    • 1 Edición
    • Volumen 43
    • Inglés
    Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

  • Aspects of Explosives Detection

    • 1 Edición
    • Maurice Marshall + 1 más
    • Inglés
    Detection and quantification of trace chemicals is a major thrust of analytical chemistry. In recent years much effort has been spent developing detection systems for priority pollutants. Less mature are the detections of substances of interest to law enforcement and security personnel:in particular explosives. This volume will discuss the detection of these, not only setting out the theoretical fundamentals, but also emphasizing the remarkable developments in the last decade. Terrorist events—airplanes blown out of the sky (PanAm 103 over Lockerbie) and attacks on U.S. and European cities (Trade Center in New York and the Murrah Federal Building in Oklahoma City, railways in London and Madrid)--emphasize the danger of concealed explosives. However, since most explosives release little vapor, it was not possible to detect them by technology used on most organic substances. After PanAm 103 was downed over Scotland, the U.S. Congress requested automatic explosive detection equipment be placed in airports. This volume outlines the history of explosive detection research, the developments along the way, present day technologies, and what we think the future holds.

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 64
    • Graham A. Webb
    • Inglés
    The great importance of NMR in many areas of scientific research is once again highlighted in this volume of Annual Reports on NMR Spectroscopy.

  • Advances in Inorganic Chemistry

    • 1 Edición
    • Volumen 60
    • Rudi van Eldik
    • Inglés
    The Advances in Inorganic Chemistry series present timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1 Edición
    • Volumen 8
    • A. Leitmannova Liu
    • Inglés
    Advances in Planar Lipid Bilayers and Liposomes, Volume 8, is the latest in our series on both planar lipid bilayers and spherical liposomes. This field of research, based on a historic perspective of the lipid bilayer concept and its experimental realization as well as on spherical liposomes, is growing and developing stronger ties with many new exciting interdisciplinary areas. This volume includes invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. Many of the contributing authors collaborated in the past with the late Prof. H. Ti Tien, the founding editor of this book series. The book also includes chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers, and spherical liposomes, which is the further development of this interdisciplinary field worldwide. This book is an ideal resource for chemical Engineers, physical chemists, biologists and biochemists, biochemical engineers.

  • Progress in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 20
    • Gordon Gribble + 1 más
    • Inglés
    This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way.

  • Advances in Chemical Engineering

    Mathematics and Chemical Engineering and Kinetics
    • 1 Edición
    • Volumen 34
    • Inglés
    The cross-fertilization of physico-chemical and mathematical ideas has a long historical tradition. This volume of Advances in Chemical Engineering is almost completely dedicated to a conference on “Mathematics in Chemical Kinetics and Engineering” (MaCKiE-2007), which was held in Houston in February 2007, bringing together about 40 mathematicians, chemists, and chemical engineers from 10 countries to discuss the application and development of mathematical tools in their respective fields.

  • Liquid Sample Introduction in ICP Spectrometry

    A Practical Guide
    • 1 Edición
    • José-Luis Todoli + 1 más
    • Inglés
    Inductively coupled plasma atomic or mass spectrometry is one of the most common techniques for elemental analysis. Samples to be analyzed are usually in the form of solutions and need to be introduced into the plasma by means of a sample introduction system, so as to obtain a mist of very fine droplets. Because the sample introduction system can be a limiting factor in the analytical performance, it is crucial to optimize its design and its use. It is the purpose of this book to provide fundamental knowledge along with practical instructions to obtain the best out of the technique.

  • Frontiers of Molecular Spectroscopy

    • 1 Edición
    • Jaan Laane
    • Inglés
    Much of what we know about atoms, molecules, and the nature of matter has been obtained using spectroscopy over the last one hundred years or so. In this book we have collected together twenty chapters by eminent scientists from around the world to describe their work at the cutting edge of molecular spectroscopy. These chapters describe new methodology and applications, instrumental developments, and theory which is taking spectroscopy into new frontiers. The range of topics is broad. Lasers are utilized in much of the research, but their applications range from sub-femtosecond spectroscopy to the study of viruses and also to the investigation of art and archeological artifacts. Three chapters discuss work on biological systems and three others represent laser physics. The recent advances in cavity ringdown spectroscopy (CRDS), surface enhanced Raman spectroscopy (SERS), two-dimensional correlation spectroscopy (2D-COS), and microwave techniques are all covered. Chapters on electronic excited states, molecular dynamics, symmetry applications, and neutron scattering are also included and demonstrate the wide utility of spectroscopic techniques.

  • Protein Mass Spectrometry

    • 1 Edición
    • Volumen 52
    • Julian Whitelegge
    • Inglés
    This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to the study of protein structure and function as well as proteomics. It is a definite must-have work for:- libraries at academic institutions with Master and Graduate programs in biochemistry, molecular biology, structural biology and proteomics- individual laboratories with interests covering these areas - libraries and individual laboratories in the pharmaceutical and biotechnology industries.

  • Advances in Organometallic Chemistry

    • 1 Edición
    • Volumen 57
    • Anthony F. Hill + 1 más
    • Inglés
    Almost all branches of chemistry and material science now interface with organometallic chemistry--the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field that has expanded enormously since the publication of Volume 1 in 1964.

  • NMR Spectroscopy in Pharmaceutical Analysis

    • 1 Edición
    • Iwona Wawer + 2 más
    • Inglés
    For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.

  • Capillary Electrophoresis Methods for Pharmaceutical Analysis

    • 1 Edición
    • Volumen 9
    • Satinder Ahuja + 1 más
    • Inglés
    Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.

  • Inorganic Chemistry

    • 1 Edición
    • James E. House
    • Inglés
    Inorganic Chemistry provides essential information in the major areas of inorganic chemistry. The author emphasizes fundamental principles—including molecular structure, acid-base chemistry, coordination chemistry, ligand field theory, and solid state chemistry — and presents topics in a clear, concise manner. Concise coverage maximizes student understanding and minimizes the inclusion of details students are unlikely to use. The discussion of elements begins with survey chapters focused on the main groups, while later chapters cover the elements in greater detail. Each chapter opens with narrative introductions and includes figures, tables, and end-of-chapter problem sets. This text is ideal for advanced undergraduate and graduate-level students enrolled in the inorganic chemistry course. The text may also be suitable for biochemistry, medicinal chemistry, and other professionals who wish to learn more about this subject are.

  • The Practice of Medicinal Chemistry

    • 3 Edición
    • Camille Georges Wermuth
    • Inglés
    The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 96
    • Alan R. Katritzky
    • Inglés
    The definitive serial in the field -- since 1960.

  • Organic Structure Determination Using 2-D NMR Spectroscopy

    A Problem-Based Approach
    • 1 Edición
    • Jeffrey H. Simpson
    • Inglés
    Organic Structure Determination Using 2-D NMR Spectroscopy is a primary text for a course in NMR techniques, with the goal to learn to identify organic molecular structure. It presents strategies for assigning resonances to known structures and for deducing structures of unknown organic molecules based on their NMR spectra.It contains 20 known and 20 unknown structure determination problems and features a supporting website from which instructors can download the structures of the unknowns in selected chapters, digital versions of all figures, and raw data sets for processing. Many other books describe the methods used, but none offer a large number of problems. Instructors at universities and colleges are forced to cobble together problems from a wide range of sources. The fragmentary approach to assembling course materials has a negative impact on course continuity and thus adversely impacts student retention.This book will stand as a single source to which instructors and students can go to obtain a comprehensive compendium of NMR problems of varying difficulty.

  • Evolutionary Essays

    A Thermodynamic Interpretation of the Evolution
    • 1 Edición
    • Sven Erik Jørgensen
    • Inglés
    Evolution is nature’s most fascinating process, the possibility given sufficient time to combine simple inorganic compounds to more and more complex biochemical compounds, which make up more and more complex organisms. It is therefore crucial in our effort to understand the evolution to see it from as many different angles as possible. This books draw an image of evolution from the thermodynamic viewpoint, which gives new and surprising insights into the processes and mechanisms that have driven evolution. This new thermodynamic interpretation has made it possible to quantify the various steps of evolution and to show that evolution has followed an exponential growth curve.

  • Thermophysical Properties of Chemicals and Hydrocarbons

    • 1 Edición
    • Carl L. Yaws
    • Inglés
    Carl Yaws here presents over 7,800 organic and inorganic chemicals, and hydrocarbons. Spanning gases, liquids and solids, and covering all critical properties (including acentric factor, density, enthalpy of vaporization, and surface tension), this volume represents more properties on more chemicals than any single work of its kind, from C1 to C100 organics and Ac to Zr inorganics. Designed and formatted for field, lab or classroom usage, it gives the reader unparalleled access to invaluable data.

  • Computational Modeling of Membrane Bilayers

    • 1 Edición
    • Volumen 60
    • V. Sundararajan
    • Inglés
    Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.

  • Studies in Natural Products Chemistry

    • 1 Edición
    • Volumen 34
    • Atta-ur Rahman
    • Inglés
    This volume presents frontier reviews on recent developments on bioactive natural products in cutting-edge areas by eminent experts in their respective fields. Fourteen reviews treat diverse and different topics in natural products chemistry - basic ones, medicinally oriented ones, agro-oriented ones and ecologically oriented ones.It is an important addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic.

  • Carbohydrate Chemistry, Biology and Medical Applications

    • 1 Edición
    • Hari G. Garg + 2 más
    • Inglés
    The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research.

  • Characterization of Semiconductor Heterostructures and Nanostructures

    • 1 Edición
    • Giovanni Agostini + 1 más
    • Inglés
    In the last couple of decades, high-performance electronic and optoelectronic devices based on semiconductor heterostructures have been required to obtain increasingly strict and well-defined performances, needing a detailed control, at the atomic level, of the structural composition of the buried interfaces. This goal has been achieved by an improvement of the epitaxial growth techniques and by the parallel use of increasingly sophisticated characterization techniques and of refined theoretical models based on ab initio approaches. This book deals with description of both characterization techniques and theoretical models needed to understand and predict the structural and electronic properties of semiconductor heterostructures and nanostructures.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1 Edición
    • Volumen 7
    • A. Leitmannova Liu
    • Inglés
    Advances in Planar Lipid Bilayers and Liposomes, Volume 7, continues to include invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results in this exciting multidisciplinary field of their own research group.Many of the contributors working in both fields over many decades were in close collaboration with the late Prof. H. Ti Tien, the founding editor of this book series. There are also chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide.

  • Adsorption by Carbons

    • 1 Edición
    • Eduardo J. Bottani + 1 más
    • Inglés
    Adsorption by Carbons covers the most significant aspects of adsorption by carbons, attempting to fill the existing gap between the fields of adsorption and carbonaceous materials. Both basic and applied aspects are presented. The first section of the book introduces physical adsorption and carbonaceous materials, and is followed by a section concerning the fundamentals of adsorption by carbons. This leads to development of a series of theoretical concepts that serve as an introduction to the following section in which adsorption is mainly envisaged as a tool to characterize the porous texture and surface chemistry of carbons. Particular attention is paid to some novel nanocarbons, and the electrochemistry of adsorption by carbons is also addressed. Finally, several important technological applications of gas and liquid adsorption by carbons in areas such as environmental protection and energy storage constitute the last section of the book.

  • Physical Chemistry

    • 3 Edición
    • Robert G. Mortimer
    • Inglés
    In this third edition, core applications have been added along with more recent developments in the theories of chemical reaction kinetics and molecular quantum mechanics, as well as in the experimental study of extremely rapid chemical reactions.

  • Advances in Quantum Chemistry

    Applications of Theoretical Methods to Atmospheric Science
    • 1 Edición
    • Volumen 55
    • Michael M.E. Goodsite + 3 más
    • Inglés
    Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.Theoretical methods have dramatically extended the reach and grasp of atmospheric scientists. This edition of Advances in Quantum Chemistry collects a broad range of articles that provide reports from the leading edge of this interaction. The chemical systems span the range from atoms to clusters to droplets. Electronic structure calculations are used to uncover the details of the breakdown and removal of emissions from the atmosphere and the simultaneous development of air pollution including ozone and particles. The anomalous enrichment of heavy isotopes in atmospheric ozone is discussed using RRKM theory, and a number of techniques are presented for calculating the effect of isotopic substitution on the absorption spectra of atmospheric molecules.

  • Fluorine and Health

    Molecular Imaging, Biomedical Materials and Pharmaceuticals
    • 1 Edición
    • Alain Tressaud + 1 más
    • Inglés
    Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinall... relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized.

  • The Alkaloids

    Chemistry and Biology
    • 1 Edición
    • Volumen 65
    • Inglés
    This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

  • Interfacial and Confined Water

    • 1 Edición
    • Ivan Brovchenko + 1 más
    • Inglés
    Water in the proximity of a surface (interfacial water) is abundant on the earth. It is involved in various physical and chemical processes and crucial for biological function. Despite numerous studies of interfacial water, systematic analysis of its properties is missing in scientific literature. This book is a first comprehensive review of experimental and simulation studies of water in various confining environments, such as hydrophilic and hydrophobic surfaces, surfaces of biomolecules, porous media, etc. Systematic analysis of interfacial and confined water is based on the firm physical ground, which accounts for variety of the thermodynamic states of water near the surface, surface phase transitions, surface critical behaviour, effect of confinement on the bulk and surface phase transitions of water, clustering and formation of a spanning hydrogen-bonded water network via percolation transition. This allows distinguishing between universal features, common for all fluids, and some specific water properties, related to intermolecular hydrogen bonds. Special attention is paid to the properties of hydration water, which covers biomolecules and enables their biological activity. This book provides readers with basic information on interfacial and confined water, which will be useful for scientists and engineers working in the fields of bioscienses, nanociences and nanotechnologies.

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 46
    • Inglés
    Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxystero... dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)

  • Optical Biosensors

    Today and Tomorrow
    • 2 Edición
    • Frances S. Ligler + 1 más
    • Inglés
    Optical Biosensors, Second Edition describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field.

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 63
    • Graham A. Webb
    • Inglés
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science when precise structural determination is required and when the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Advances in Organometallic Chemistry

    The Organotransition Metal Chemistry of Poly(pyrazolyl)borates. Part 1
    • 1 Edición
    • Volumen 56
    • Robert C. West + 2 más
    • Inglés
    Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.Volume 56 comprises Part 1 of a themed collection of papers on "The Organotransition Metal Chemistry of Poly(pyrazolyl)borat...

  • Drug-like Properties: Concepts, Structure Design and Methods

    from ADME to Toxicity Optimization
    • 1 Edición
    • Li Di + 1 más
    • Inglés
    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 95
    • Alan R. Katritzky
    • Inglés
    Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Volume 94 of Advances in Heterocyclic Chemistry commences with a review of cascade reactions on heterocyclic synthesis. The chapter presents a fascinating array of complex sequences which provide efficient routes to a wide variety of heterocyclic systems. The second chapter is the twelfth in the series on the organic chemistry of heterocyclic ligands in metallic complexes. The present contribution deals with the chemistry of polypyridine ligands in organomanganese and organorhenium complexes. Its current importance can be measured by the fact that, of the nearly 700 references, approximately half date from the last 10 years. Preparation of aminoisoxazoles and their utility in the synthesis of condensed systems are also covered. In the final chapter, isothiazolium salts and their use in synthesis are reviewed. Many condensed S,N-heterocyclic systems are described in this, the first review dedicated to this topic.

  • Electrochemistry for Materials Science

    • 1 Edición
    • Walfried Plieth
    • Inglés
    This book introduces the principles of electrochemistry with a special emphasis on materials science. This book is clearly organized around the main topic areas comprising electrolytes, electrodes, development of the potential differences in combining electrolytes with electrodes, the electrochemical double layer, mass transport, and charge transfer, making the subject matter more accessible.In the second part, several important areas for materials science are described in more detail. These chapters bridge the gap between the introductory textbooks and the more specialized literature. They feature the electrodeposition of metals and alloys, electrochemistry of oxides and semiconductors, intrinsically conducting polymers, and aspects of nanotechnology with an emphasis on the codeposition of nanoparticles.This book provides a good introduction into electrochemistry for the graduate student. For the research student as well as for the advanced reader there is sufficient information on the basic problems in special chapters. The book is suitable for students and researchers in chemistry, physics, engineering, as well as materials science.

  • The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins

    • 1 Edición
    • Abhik Ghosh
    • Inglés
    This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists.

  • Strategies and Tactics in Organic Synthesis

    • 1 Edición
    • Volumen 7
    • Michael Harmata
    • Inglés
    A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

  • Biological Inorganic Chemistry

    An Introduction
    • 1 Edición
    • Robert R. Crichton
    • Inglés
    The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.

  • Advances in Physical Organic Chemistry

    • 1 Edición
    • Volumen 42
    • John P. Richard
    • Inglés
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

  • Advances in Physical Organic Chemistry

    • 1 Edición
    • Volumen 42
    • John P. Richard
    • Inglés
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

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    Chemistry and Biology
    • 1 Edición
    • Volumen 64
    • Inglés
    This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

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    • 1 Edición
    • Volumen 42
    • Inglés
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    Current Trends in Atomic Physics
    • 1 Edición
    • Volumen 53
    • Sten Salomonson + 1 más
    • Inglés
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    • 1 Edición
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    • Inglés
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