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Elsevier

Libros en Química

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1 Edición
    • Volumen 46
    • Inglés

  • The Alkaloids: Chemistry and Pharmacology

    • 1 Edición
    • Volumen 34
    • Inglés

  • Analytical Artifacts

    GC, MS, HPLC, TLC and PC
    • 1 Edición
    • Volumen 44
    • B.S. Middleditch
    • Inglés
    This encyclopaedic catalogue of the pitfalls and problems that all analysts encounter in their work is destined to spend more time on the analyst's workbench than on a library shelf. The author has dedicated the book to ``the innumerable scientists who made mistakes, used impure chemicals and solvents, suffered the consequences of unanticipated side-reactions, and were otherwise exposed to mayhem yet were not too embarrassed to publish their findings''. Traditionally, the mass spectroscopist or gas chromatographer learnt his trade by participating in a 4-6 year apprenticeship as graduate student and post-doctoral researcher. Generally, no formal training was provided on the things that go wrong, but this information was accumulated by sharing in the experiences of colleagues. Nowadays, many novice scientists simply purchase a computerized instrument, plug it in, and use it. Much time can be wasted in studying and resolving problems due to artifacts and there is also a strong possibility that artifacts will not be recognized as such. For example, most analysts realize that they should use glass rather than plastic containers; but few of them would anticipate the possibility of plasticizer residues on glassware washed using detergent from a plastic bottle.This book is an easy-to-use compendium of problems encountered when using various commonly used analytical techniques. Emphasis is on impurities, by-products, contaminants and other artifacts. A separate entry is provided for each artifact. For specific chemicals, this entry provides the common name, mass spectrum, gas chromatographic data, CAS name and registry number, synonyms and a narrative discussion. More than 1100 entries are included. Mass spectral data are indexed in a 6-peak index (molecular ion, base peak, second peak, third peak) and there are also formula, author and subject indexes. An extensive bibliography contains complete literature citations.The book is designed to be used. It will not only allow experienced analysts to profit from the mistakes of others, but it will also be invaluable to other scientists who use analytical instruments in their work.

  • Strategies and Tactics in Organic Synthesis

    • 1 Edición
    • Volumen 2
    • Thomas Lindberg
    • Inglés
    This is a unique account of the synthesis of organic molecules. All of the contributors are acknowledged experts in organic synthesis.

  • Natural Products Isolation

    Separation Methods for Antimicrobials, Antivirals and Enzyme Inhibitors
    • 1 Edición
    • Volumen 43
    • G.H. Wagman + 1 más
    • Inglés
    This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products. It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Although there is a bias toward antibiotics, it was done because this is still the largest natural products area of research.The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPLC-photodiode array technology. Chapter 3 provides a review of affinity chromatography applied to the separation of antibiotics for the first time. Next are chapters on antimicrobials with an update on all the most recent &bgr;-lactam (after 1976) discoveries. A comprehensive review of a very important class of antiparasitic agents - the avermectins - follows. An update of isolation and purification of a variety of marine-derived compounds is next. The succeeding chapter is a comprehensive review of the most recent developments in isolation and purification of interferons. This is followed by a discussion of enzyme inhibitors and their isolation and purification and ties in with a chapter on plant-derived natural products, some of which are also in this same category. The final chapter is a futuristic essay indicating the isolation of minute amounts of natural products and the fascinating biological properties which they possess.The book has extensive isolation schemes, tables, figures and chemical structures. In many instances a short summary of the producing organism, brief chemical description and structure and biological activity of the compounds is presented. Detailed information of extraction, separation and purification techniques follow. Each chapter has an extensive bibliography and, where applicable, an appendix showing sources of materials and equipment. A detailed index to the subject matter is included at the end of the book.The book thus offers the reader: up-to-date reviews (including 1988) of specific topics in the natural products field not to be found elsewhere; information on new chromatographic methods and techniques described in sufficient detail to be utilized by investigators in this area of research; and extensive references to enable the serious researcher to pursue particular information. It will appeal to pharmaceutical and natural products researchers and is a valuable acquisition for university chemistry and biochemistry departments.

  • Vitamins and Hormones

    • 1 Edición
    • Volumen 44
    • Inglés

  • Separation of Individual Compound Classes

    • 1 Edición
    • Volumen B
    • Inglés

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1 Edición
    • Volumen 17
    • Inglés

  • Nuclear Magnetic Resonance Spectroscopy

    • 2 Edición
    • Frank A. Bovey + 2 más
    • Inglés
    Nuclear Magnetic Resonance Spectroscopy, Second Edition focuses on two-dimensional nuclear magnetic resonance (NMR) spectroscopy, high resolution NMR of solids, water suppression, multiple quantum spectroscopy, and NMR imaging. The selection first takes a look at the fundamental principles and experimental methods. Discussions focus on the NMR phenomenon, dipolar broadening and spin-spin relaxation, nuclear electric quadrupole relaxation, saturation, magnetic shielding and chemical shift, magnetic field, transitions between the nuclear energy levels, and resolution and sensitivity considerations. The manuscript then ponders on chemical shift, coupling of nuclear spins, and nuclear relaxation and chemical rate processes. Topics include spin lattice relaxation, spin-spin relaxation, spin decoupling and associated techniques, and description and analysis of spin systems. The text examines two-dimensional NMR spectroscopy, macromolecules, and NMR of solids, including magic angle spinning, cross polarization, proton dipolar broadening, biopolymers, and chain motion in macromolecules. The selection is a valuable source of data for readers interested in nuclear magnetic resonance spectroscopy.

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 43
    • Inglés

  • The Alkaloids: Chemistry and Pharmacology

    • 1 Edición
    • Volumen 32
    • Inglés

  • The Alkaloids: Chemistry and Pharmacology

    • 1 Edición
    • Volumen 33
    • Inglés

  • Advances in Quantum Chemistry

    • 1 Edición
    • Volumen 19
    • Inglés

  • Automatic Methods of Analysis

    • 1 Edición
    • Volumen 9
    • M. Valcárcel + 1 más
    • Inglés
    This new monograph provides a comprehensive overview of the state of the art of the automation of laboratory processes in analytical chemistry. The topics have been chosen according to such criteria as the degree of consolidation, scope of application and most promising trends.The first part of the book begins with the basic principles behind the automation of laboratory processes, then describes automatic systems for sampling and sample treatment. In the second part the principal types of analysers are discussed: continuous, batch and robotic. The third part is devoted to the automation of analytical instrumentation: spectroscopic, electroanalytical and chromatographic techniques and titrators. The last part presents some examples of the application of automation to clinical chemistry, environmental pollution monitoring and industrial process control.The text is supplemented by 290 figures and 800 literature references. It is written primarily for scientists directly involved in laboratory work and those responsible for industrial planning and control, research centres, etc. It will also be of interest to analytical chemists wishing to update their knowledge in this area, and will be of especial interest to scientists directly related to environmental sciences or clinical chemistry.

  • Advances in Inorganic Chemistry

    • 1 Edición
    • Volumen 32
    • Inglés

  • Quantitative Gas Chromatography for Laboratory Analyses and On-Line Process Control

    • 1 Edición
    • Volumen 42
    • G. Guiochon + 1 más
    • Inglés
    Here is an invaluable new book on quantitative gas chromatography which explains how the method can - or should - be used for accurate and precise analysis. Gas chromatography is firmly established as one of the few major methods for the quantitative analysis of complex mixtures. It is fast, accurate and inexpensive, with a broad range of applications. It has however become very complex and involved: over 200 stationary phases, more than 10 detector principles and several very different column types are available from among the catalogs of over 100 manufacturers and major retailers. The progressive changes in the nature of gas chromatography have created new needs for information which are not satisfied by the literature presently available.This book provides a complete discussion of all the problems involved in the achievement of quantitative analysis by gas chromatography, whether in the research laboratory, in the routine analysis laboratory or in process control. For this reason the presentation of theoretical concepts has been limited to the essential, while extensive explanations have been devoted to the various steps involved in the derivation of precise and accurate data. This starts with the selection of the instrumentation and column, continues with the choice of optimum experimental conditions, then calibration and ends with the use of correct procedures for data acquisition and calculations. Finally, there is almost always a way to reduce errors and an entire chapter deals with this single issue. Numerous relevant examples are presented.The first part of the book presents the theoretical background, simple enough to be understood by all analytical chemists, but still complete and up-to-date. It discusses the problems of flow dynamics, retention and band broadening. The changes in band profile associated with column overloading are explained without much recourse to mathematics. The second part describes the gas chromatograph and discusses the properties of each of its parts: gas flow and pressure controller sampling system, oven, column switching valves, detectors. The different implementations, their advantages and drawbacks are discussed and compared. In addition, three chapters present packed column technology, open tubular column technology and some sophisticated new phase systems, respectively. The new phase systems described use adsorbents, modified by coating or grafting organic phase, and carrier gases containing vapors which are sorbed by the stationary phase and modify it, such as steam. The third part discusses the applications in qualitative and quantitative analysis. Calibration, peak integration, sources of errors arising from the various parts of the instrument as well as from the measurement process itself are carefully described in four detailed chapters. Methods to carry out accurate and precise analysis are presented. A last chapter is devoted to process control analysis and gives a number of detailed examples of applications. A lexicon explaining the most important chromatographic terms and a detailed index complete the book.This is a book which no chemical analyst should be without. It should be on the library shelf of all universities, instrument companies and any laboratory and plant where gas chromatography is used.

  • The Biochemistry of Plants

    Carbohydrates
    • 1 Edición
    • Volumen 14
    • Walter Stumpf + 1 más
    • Inglés
    The Biochemistry of Plants, Volume 14: Carbohydrates provides information pertinent to the fundamental aspects of plant biochemistry. This book deals with the function and structure of the plant cell wall by describing the physical and chemical properties of cell wall components. Organized into 11 chapters, this volume begins with an overview of hexose phosphate metabolism in nonphotosynthetic tissues. This text then examines the findings in fructan structures, conformations, and linkages, the enzymes involved in fructan synthesis and degradation, and their cellular regulation, location, and metabolic role in plants. Other chapters consider the methods employing enzymes to determine starch structure. This book discusses as well the different biosynthetic modes of plant cell walls. The final chapter deals with the various environmental factors that influence expression of the ?-amylase gene, suggesting how molecular biology may help in understanding carbohydrate biochemistry and the enzymes involved in carbohydrate synthesis and metabolism. This book is a valuable resource for plant biochemists.

  • Aqueous Size-Exclusion Chromatography

    • 1 Edición
    • Volumen 40
    • P.L. Dubin
    • Inglés
    The rapid development of new packings for aqueous size-exclusion chromatography has revolutionized this field. High resolution non-adsorptive columns now make possible the efficient separation of proteins and the rapid and precise determination of the molecular weight distribution of synthetic polymers. This technology is also being applied to the separation of small ions, the characterization of associating systems, and the measurement of branching. At the same time, fundamental studies are elucidating the mechanisms of the various chromatographicproce... developments in principles and applications are assembled for the first time in this book. Fundamental issues are dealt with: the roles of pore structure and macromolecular dimensions, hydrophobic and electrostatic effects, and the determination and control of column efficiency. High-performance packings based on derivatized silica are reviewed in detail. Special techniques are thoroughly described, including SEC/LALLS, inverse exclusion chromatography, and frontal zone chromatography. Attention is focussed on special applications of size-exclusion methods, such as the characterization of micelles, separations of inorganic ions, and Hummel-Dreyer and related methods for equilibrium systems. Protein chromatography is dealt with in both dedicated sections and throughout the book as a whole.This is a particularly comprehensive and authoritative work - all the contributions review broad topics of general significance and the authors are of high repute. The material will be of special value for the characterization of synthetic water-soluble polymers, especially polyelectrolytes. Biochemists will find fundamental and practical guidance on protein separations. Researchers confronted with solutes that exhibit complex chromatographic behavior, such as humic acids, aggregating proteins, and micelles should find the contents of this volume illuminating.

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 20
    • Inglés

  • Principles, Materials and Techniques

    • 1 Edición
    • Volumen A
    • Inglés

  • Chemometrics

    A Textbook
    • 1 Edición
    • Volumen 2
    • S.N. Deming + 4 más
    • Inglés
    Most chemists, whether they are biochemists, organic, analytical, pharmaceutical or clinical chemists and many pharmacists and biologists need to perform chemical analysis. Consequently, they are not only confronted with carrying out the actual analysis, but also with problems such as method selection, experimental design, optimization, calibration, data acquisition and handling, and statistics in order to obtain maximum relevant chemical information. In other words: they are confronted with chemometrics. This book on chemometrics, written by some of the leaders in the field, aims to provide a thorough, up-to-date introduction to this subject. The reader is given the opportunity to acquaint himself with the tools used in this discipline and the way in which they are applied. Some practical examples are given and the reader is shown how to select the appropriate tools in a given situation.As such the book provides the means to approach and solve analytical problems strategically and systematically, without the need for the reader to become a fully-fledged chemometrician. The authors' aim was to write a tutorial book which would be useful to readers at every level in this field.

  • The Alkaloids: Chemistry and Pharmacology

    • 1 Edición
    • Volumen 30
    • Inglés
    “The Bisbenzylisoquinolin... Alkaloids,” reviewed in Vols. 7, 9, 13, and 16 of this treatise, represent the largest group among the isoquinoline alkaloids. Bisbenzylisoquinolin... alkaloids tubocurarine, thalicarpine, tetrandrine, and cepharanthine also have interesting pharmacological properties, and for these reasons this group of alkaloids is again updated, covering in the Appendix the pertinent literature until 1985. Indole alkaloids of the rare genus Pauridiantha are presented here for the first time under the title “The Alkaloids from Pauridiantha"; these alkaloids are found almost exclusively in Madagascar, where plant extracts are used by the natives for medicinal purposes. “The Amaryllidaceae Alkaloids," reviewed in Vols. 6, 11, and 15 of this treatise, have been updated, and several new alkaloids of this class are listed. Occurrence, spectral properties, structure, synthesis, and biosynthesis of these alkaloids are covered in these chapters, and pharmacological properties whenever known are reported.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1 Edición
    • Volumen 45
    • Inglés

  • Advances in Organometallic Chemistry

    • 1 Edición
    • Volumen 27
    • Inglés

  • Advances in Organometallic Chemistry

    • 1 Edición
    • Volumen 28
    • Inglés

  • Basic Gas Chromatography-Mass Spectrometry

    Principles and Techniques
    • 1 Edición
    • F.W. Karasek + 1 más
    • Inglés
    The book begins by covering the basic principles of both gas chromatography (GC) and mass spectrometry (MS) to the extent necessary to understand and deal with the data generated in a GC-MS analysis. The focus then turns to the particular requirements created by a direct combination of these two techniques into a single instrumentation system. The data generated and their use are covered in detail. The role of the computer and its specific software receives special attention, especially in the matter of compound identification via mass spectral search techniques. GC-MS-computer instrumentation has reached such a plateau of excellence today that the present commercial systems will not be obsolete for a long time to come. Therefore, a detailed description of these systems is not only informative but is also pertinent to the subject matter of this book. Finally, representative applications and results obtained with GC-MS-computer techniques are presented and chosen in such a way as to permit extrapolation of specific applications to similar problems encountered by the reader. To aid the reader in mastering the subject matter and increase understanding, interpretation problems and suggested readings are included. The format is instructional, informative and application-oriented with material presented in such a way as to be useful to a broad spectrum of people.The book serves as a text in its own right.The software package Gas Chromatography-Mass Spectrometry: A Knowledge Base, by F.A. Settle, Jr. and M.A. Pleva provides rapid access to a wealth of current information in the GC-MS field. Its three diskettes (51/4 inch) allow the user three ways to access: the index mode, the tree mode and a keyword search mode. The package may be purchased separately and is available for the IBM-PC and compatibles.The software provides a valuable supplement to the book.

  • The Alkaloids: Chemistry and Pharmacology

    • 1 Edición
    • Volumen 31
    • Inglés

  • Electrode Kinetics: Reactions

    • 1 Edición
    • Volumen 27
    • R.G. Compton
    • Inglés
    Volumes 26 and 27 are both concerned with reactions occurring at electrodes arising through the passage of current. They provide an introduction to the study of electrode kinetics. The basic ideas and experimental methodology are presented in Volume 26, whilst Volume 27 deals with reactions at particular types of electrodes.Chapter 1 of the present volume deals with redox reactions at metal electrodes, Chapter 2 with semiconducting electrodes and Chapter 3 with reactions at metal oxide electrodes. Both theoretical aspects and experimental results are covered.

  • Selective Sample Handling and Detection in High-Performance Liquid Chromatography

    • 1 Edición
    • Volumen A
    • Inglés
    This book is the first of a two-volume project which attempts to treat the sample handling and detection processes in a liquid chromatographic system in an integrated fashion. The need for more selective and sensitive chromatographic methods to help solve the numerous trace analysis problems in complex samples is undisputed. However, few workers realize the strong interdependence of the various steps - sample handling, separation and detection - which must be considered if one wants to arrive at an optimal solution. By introducing a strong element of selectivity and trace enrichment in the sample preparation step, fewer demands are placed on the quality of the chromatography and often a simple UV detector can be used. By using a selective detection mode, i.e. a reaction detector, the sample handling step can frequently be simplified and more easily automated. The impact of such a ``total system'' approach on handling series of highly complex samples such as environmental specimens or biological fluids can be easily imagined.Each chapter includes sufficient references to the literature to serve as a valuable starting point for more detailed investigation. Special emphasis is placed on the sample handling, and high priority has been given to the treatment of chemical principles applied to the topics presented, rather than to instrumentation. Written by experienced practitioners, this volume will be of interest to investigators in many areas of application, including environmental scientists and those active in the clinical, pharmaceutical and bioanalytical fields.

  • Heterocyclic Compounds

    A Modern Comprehensive Treatise
    • 1 Edición
    • Volumen G
    • Martin F. Ansell
    • Inglés

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 19
    • Inglés

  • Hetero Diels-Alder Methodology in Organic Synthesis

    • 1 Edición
    • Volumen 47
    • Inglés
    Organic Chemistry: A Series of Monographs, Volume 47: Hetero Diels-Alder Methodology in Organic Synthesis focuses on the use of hetero Diels-Alder reactions as pivotal steps in natural product total syntheses. The publication first offers information on N-sulfinyl compounds and sulfur diimides and imino dienophiles. Discussions focus on sulfur dioxide and related compounds, selenium dioxide, sulfur diimide cycloadditions, regiochemical, stereochemical, and mechanistic aspects, iminium salts and neutral imines, oximino compounds, and intramolecular cycloadditions. The text then takes a look at nitroso and thionitroso dienophiles and carbonyl dienophiles. The manuscript elaborates on thiocarbonyl and selenocarbonyl dienophiles and miscellaneous dienophiles. Topics include nitriles, azo compounds, selenoaldehydes, thioketones, thioesters, dithioesters, and related compounds, and thiophosgene and related compounds. The text also ponders on oxabutadienes, thiabutadienes, and azabutadienes. The publication is a valuable reference for chemists and readers interested in the Hetero Diels-Alder methodology.

  • The Alkaloids: Chemistry and Pharmacology

    • 1 Edición
    • Volumen 27
    • Inglés

  • Advances in Chemical Engineering

    • 1 Edición
    • Volumen 13
    • Inglés

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 42
    • Inglés

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1 Edición
    • Volumen 16
    • Inglés

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 26
    • Inglés

  • Advances in Physical Organic Chemistry

    • 1 Edición
    • Volumen 23
    • Inglés
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

  • Preparative Liquid Chromatography

    • 1 Edición
    • Volumen 38
    • B.A. Bidlingmeyer
    • Inglés
    This volume provides a straightforward approach to isolation and purification problems with a thorough presentation of preparative LC strategy including the interrelationship between the input and output of the instrumentation, while keeping to an application focus.The book stresses the practical aspects of preparative scale separations from TLC isolations through various laboratory scale column separations to very large scale production. It also gives a thorough description of the performance parameters (e.g. throughput, separation quality, etc.) as a function of operational parameters (e.g. particle size, column size, solvent usage, etc.). Experts in the field have contributed a well balanced presentation of separation development strategies from preparative TLC to commercial preparative process with practical examples in a wide variety of application areas such as drugs, proteins, nucleotides, industrial extracts, organic chemicals, enantiomers, polymers, etc.

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 41
    • Inglés

  • Advances in Inorganic Chemistry

    • 1 Edición
    • Volumen 31
    • Inglés

  • Synthesis of High-Silica Aluminosilicate Zeolites

    • 1 Edición
    • Volumen 33
    • J.A. Martens + 1 más
    • Inglés
    This book provides an overview of all new high-silica zeolites which have been discovered between 1975 and 1985. The first part presents some 25 proven recipes for the preparation of high-silica zeolites and describes the characteristics of the materials obtained. This will allow bench-scale production of these materials for scientific research. In the second part, high-silica zeolites with solved structure type are discussed. This part classifies many proprietary materials according to known structure types, and describes the rules and parameters which govern the formation of these materials. In the third part, the formation and characteristics of high-silica zeolites with unknown structure type are discussed. The book contains a wealth of information for all those scientists who incorporate the use of high-silica zeolites in their work.

  • Annual Reports on NMR Spectroscopy

    • 1 Edición
    • Volumen 18
    • Inglés

  • Polymer Characterization by Liquid Chromatography

    • 1 Edición
    • Volumen 34
    • G. Glöckner
    • Inglés
    The main subject of this book is the characterization of plastics. To a high degree the properties of these polymers depend on the distribution of the molar mass and of other structural features, and small deviations frequently have a great effect. Therefore the characterization of polymers cannot be restricted to the determination of mean values but must yield information on these distributions. Using classical methods, the analytical fractionation of polymer homologues and structurally isomeric polymers is extremely time-consuming. Therefore, efficient chromatographic techniques are being increasingly employed in modern polymer characterization.In the first place, high-performance liquid chromatography is applied, in the form of size exclusion chromatography. It is also possible, however, to use other separation modes. More space is devoted to these other possibilities in this volume than is merited by their current range of applications, as the author believes that many separation problems will be solved by separation techniques of the non-exclusion type. Nevertheless, much emphasis is placed on size exclusion chromatography. Not only because of its current wide range of applications, but also because its relative importance, as a complement to other chromatographic techniques may even increase in the forthcoming years.This book is the first to cover all phenomena related to the above considerations. Starting with an introduction to basic liquid chromatography and to polymer science, it deals with the adsorption behaviour of polymers, with gradient techniques, with the kinetic band broadening in liquid chromatography, with instrumental features and packing materials. The book consists of four balanced sections and related information from about 1800 references is compiled in the tables. Some 250 figures and 30 tables will help give the reader a clear insight of the topics discussed. The book is aimed at helping the analyst or polymer chemist who is looking for information about chromatographic methods for the characterization of polymers.

  • Advances in Physical Organic Chemistry APL

    • 1 Edición
    • Volumen 22
    • Inglés

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1 Edición
    • Volumen 44
    • Inglés

  • Experimental Design

    A Chemometric Approach
    • 1 Edición
    • Volumen 3
    • S.N. Deming + 1 más
    • Inglés
    Now available in a paperback edition is a book which has been described as ``...an exceptionally lucid, easy-to-read presentation... would be an excellent addition to the collection of every analytical chemist. I recommend it with great enthusiasm.'' (Analytical Chemistry). Unlike most current textbooks, it approaches experimental design from the point of view of the experimenter, rather than that of the statistician. As the reviewer in `Analytical Chemistry' went on to say: ``Deming and Morgan should be given high praise for bringing the principles of experimental design to the level of the practicing analytical chemist.''.The book first introduces the reader to the fundamentals of experimental design. Systems theory, response surface concepts, and basic statistics serve as a basis for the further development of matrix least squares and hypothesis testing. The effects of different experimental designs and different models on the variance-covariance matrix and on the analysis of variance (ANOVA) are extensively discussed. Applications and advanced topics (such as confidence bands, rotatability, and confounding) complete the text. Numerous worked examples are presented.The clear and practical approach adopted by the authors makes the book applicable to a wide audience. It will appeal particularly to those with a practical need (scientists, engineers, managers, research workers) who have completed their formal education but who still need to know efficient ways of carrying out experiments. It will also be an ideal text for advanced undergraduate and graduate students following courses in chemometrics, data acquisition and treatment, and design of experiments.

  • Chromatography of Lipids in Biomedical Research and Clinical Diagnosis

    • 1 Edición
    • Volumen 37
    • A. Kuksis
    • Inglés
    This multi-author volume provides an unprecedented in-depth coverage of the separation, identification and quantitation of simple and complex food and tissue fats and other lipids by chromatographic and mass spectrometric methods with emphasis on applications to biomedical research and clinical diagnosis. It contains a total of 13 chapters written by scientists who are internationally recognized in their specific fields. The volume covers analyses of molecular species of eicosanoids, sterols, and glycero and glycolipids in healthy and diseased human tissues and in appropriate animal models. The text complements the simpler group determinations of lipid classes commonly employed in clinical laboratories. The volume anticipates the discovery of the specific metabolism of molecular species of complex glycerolipids and provides the medical researcher and clinical investigator with the means for dealing with it.

  • Advances in Inorganic Chemistry

    • 1 Edición
    • Volumen 30
    • Inglés

  • Advances in Heterocyclic Chemistry

    • 1 Edición
    • Volumen 40
    • Inglés

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