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Elsevier

Libros en Inmunopatogénesis

  • Diagnosis and Treatment of Infectious Diseases

    • 1 Edición
    • Saeed Soleiman Meigooni
    • Inglés
    Diagnosis and Treatment of Infectious Diseases summarizes practical content in infectious diseases using keys topics for better coding and grasping of material. The book's author uses his experience from over 15 years of teaching and working in infectious diseases in more than ten hospitals with thousands of patients as a backdrop. All of its contents use a clinical perspective for a wide range of audiences, such as medical students, general practitioners, nurses, and others. As infectious diseases are among the most common diseases, and a cause of death in many societies, they can create health challenges in developed and developing countries.Medical students have a limited time for infectious diseases rotation in their curriculum and may not learn many infectious diseases syndromes during their entire medical course. Also, due to the high volume of infectious disease subjects in textbooks which overlap symptoms and signs of many microorganisms, they may forget some of the materials. Therefore, access to a comprehensive compact book such as this one seems necessary for any medical staff.

  • Inflammation in Tumorigenesis and Cancer Treatment, Volume 9

    From Molecular Mechanisms to Personalized Therapeutic Strategies
    • 1 Edición
    • Chunxiang Zhang + 1 más
    • Inglés
    Inflammation in Tumorigenesis and Cancer Treatment: From Molecular Mechanisms to Personalized Therapeutic Strategies explores the pivotal role of inflammation in cancer. It uncovers the molecular dialogue between inflammatory factors and tumor cells, illuminating pathways that drive oncogenesis and metastasis. Highlighting the rapid pace of discovery, the book bridges the gap by translating complex data into actionable clinical strategies, catering to students and professionals and addressing personalized medicine. Early chapters focus on the fundamental concepts of inflammation in cancer and recent advances in research, while also covering the impact of inflammatory mediators on signaling pathways and oncogenesis.Other sections explore therapeutic strategies targeting inflammatory pathways and the role of immunometabolism and discuss biomarker discovery and personalized treatment plans. The final section examines the tumor microenvironment, the microbiome's role, and the intersection of immunotherapy and inflammation. The book offers numerous benefits to its audience. For scientists and researchers, it provides cutting-edge knowledge to inspire new research directions and foster interdisciplinary collaboration while serving as a valuable educational tool for the next generation of researchers.

  • The Dual Role of Inflammation in Cancer

    • 1 Edición
    • Surajit Pathak + 1 más
    • Inglés
    The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how chronic inflammation creates a microenvironment that supports tumor growth by promoting cellular proliferation, survival, and migration while suppressing immune responses. It traces historical observations, linking inflammation to cancer while also examining how inflammatory cells and mediators contribute to various stages of tumorigenesis. In addition, it discusses the implications of inflammation on cancer treatment, highlighting the potential of anti-inflammatory agents and immunotherapy in targeting the inflammatory tumor microenvironment.By elucidating on the intricate relationship between inflammation and cancer, the book aims to pave the way for more effective and personalized cancer treatment strategies. As such, it is a valuable resource for researchers in immunology and oncology.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 3 Edición
    • George C. Tsokos
    • Inglés
    Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects has been an essential resource for scientists and clinicians in this field since its original publication in 2015. The third edition of this work has been completely updated and expanded with the latest scientific and clinical developments in Systemic Lupus Erythematosus (SLE) to date. Contributors at the forefront of each topic come together to enhance content on epidemiology and diagnosis, pathogenesis, mechanisms of tissue damage, clinical aspects of the disease, antiphospholipid syndrome, and treatments. Also added is the latest information on new treatments, criteria, monogenic forms of lupus, insights on the role of microbiome, and advances in understanding disease pathogenesis. This must-have reference is an indispensable resource for specialists in the diagnosis and management of patients with SLE as well as early career or experienced investigators studying basic aspects of the disease. It is a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a key reference work for hospital libraries.

  • Lateral Flow Assays for Rapid Point-of-care Testing

    Recent Advances, Emerging Trends, and Future Direction
    • 1 Edición
    • Seema Nara + 2 más
    • Inglés
    The emergence and re-emergence of new infectious diseases places emphasis on the need for greater investment in rapid healthcare diagnostic solutions. As a result, lateral flow immunoassay technology is quickly evolving with new inventions. Lateral Flow Assay for Rapid Point-of-Care Testing covers today’s most significant advancements, emerging trends, and future directions linked with this technology. The book begins with a review of the format, flow, and design of old-generation lateral flow assays and the challenges impeding performance before moving into innovation in materials for rapid test strips, advances in manipulating sample flow, and the latest developments in molecular imprinting and bioconjugation techniques. Subsequent sections cover various biorecognition elements and review signal amplification as well as quantification trends. Final chapters delve into recent applications for infectious diseases detection, monitoring antibiotic resistance, multiplex detection of analytes, as well as future directions leading to the next generation of healthcare. Academicians, researchers, industrialists, and device manufacturers linked to the development of rapid and affordable point-of-care immunodiagnostics will find value in this resource.

  • Endotoxin in Critical Illness

    • 1 Edición
    • John Kellum + 1 más
    • Inglés
    Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.

  • Myasthenia Gravis

    Disease, Diagnosis and Management
    • 1 Edición
    • Bhupendra G. Prajapati + 2 más
    • Inglés
    Myasthenia Gravis: Disease, Diagnosis and Management is a comprehensive resource that explores recent advancements in diagnosing and treating Myasthenia Gravis, a rare autoimmune disease affecting the neuromuscular junction. With contributions from global experts, this book addresses the increasing prevalence of Myasthenia Gravis, reflecting the latest in diagnostic techniques and novel therapies such as complement inhibitors and FcRn antagonists. It aims to support healthcare professionals in delivering optimal care through evidence-based insights and patient-centered approaches. The book is divided into several chapters, beginning with an overview of the pathogenesis and immunoregulatory defects in Myasthenia Gravis. Subsequent chapters cover diagnostic methods, non-immunosuppressiv... treatments, and biological therapies targeting the immune system. Key topics include the role of intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) in severe exacerbations, thymectomy, molecular mechanisms, and the potential of hematopoietic stem cell transplants. The book also delves into precision medicine, AI applications, clinical trial considerations, and novel therapeutics like anti-FcRn antibodies. Management strategies for ocular Myasthenia Gravis, and a holistic view of living with the disease are also discussed. Myasthenia Gravis: Disease, Diagnosis and Management is invaluable for healthcare providers, physicians, immunologists, ophthalmologists, rheumatologists, physical therapists, pharmacists, and translators. It offers a modern guide to understanding and managing Myasthenia Gravis, integrating clinical expertise with the latest research to improve patient outcomes.

  • Handbook of Food Allergen Detection and Control

    • 2 Edición
    • Simon Flanagan
    • Inglés
    Handbook of Food Allergen Detection and Control, Second Edition continues to be an essential resource of scientific and technical information in the food and analytical communities. This book provides information on current and emerging technologies for detecting and reducing allergens to improve allergen control overall. Written by experts in the field, it offers a wide scientific perspective on allergens and includes hot topics such as food allergen labeling and consumer perspectives on food allergen labels. Chapters are fully revised to include the latest information in the industry, including practical applications of new methods and control strategies. The book is useful for anyone in the food supply chain.The book reviews current and emerging technologies for detecting and reducing allergens, as well as issues such as traceability, regulation, and consumer attitudes. Following an introductory chapter by a distinguished expert, Part One covers allergen management throughout the food chain. Part Two details current and emerging methods of allergen detection in food, with Part Three covering methods for reducing and eliminating allergens in food. Finally, Part Four focuses on the control and detection of individual food allergens and the risks each one presents in food manufacturing.

  • Infection and Autoimmunity

    • 3 Edición
    • Naim Mahroum + 2 más
    • Inglés
    In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus.

  • Translational Neuroimmunology, Volume 7

    Neuroinflammation
    • 1 Edición
    • Nima Rezaei + 1 más
    • Inglés
    Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.

  • Translational Neuroimmunology, Volume 8

    Multiple Sclerosis
    • 1 Edición
    • Nima Rezaei + 1 más
    • Inglés
    Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.

  • Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination

    • 1 Edición
    • Volumen 1
    • Yehuda Shoenfeld + 1 más
    • Inglés
    Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.

  • Allergic and Immunologic Diseases

    A Practical Guide to the Evaluation, Diagnosis and Management of Allergic and Immunologic Diseases
    • 1 Edición
    • Christopher Chang
    • Inglés
    **Selected for Doody’s Core Titles® 2024 in Allergy/Clinical Immunology**Allergic and Immunologic Diseases: A Practical Guide to the Evaluation, Diagnosis and Management of Allergic and Immunologic Diseases is a valuable resource for researchers and others involved in the day-to-day practice of allergy and immunology, with specific information, protocols and algorithms to guide their thinking. The book provides practical information and an explanation of why and how we do things, while also addressing the limitations of testing and treatment. Other sections focus on scientific based practices and the known pathophysiology of allergic and immunologic diseases, along with mechanisms of action in various treatment modalities.This book is unique in that it explains the rationale behind everything we do in allergy and immunology, hence it offers readers specific information on procedures and how to order tests and treat allergic and immunologic diseases.

  • The Paradox of the Immune System

    Protection, Chronic Inflammation, Autoimmune Disease, Cancer, and Pandemics
    • 1 Edición
    • Louis J. Catania
    • Inglés
    The Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our greatest protector, it is also the cause of chronic inflammation that leads to autoimmune disease, cancer and infectious diseases like COVID-19. Sections cover the basic science of immunology and its intimate genetic associations, biomedical hypotheses asserting immunology as the basis of all human diseases, and elaborate on immunology as "the enemy within us." This engaging, original approach to a science so personal provides new and invaluable understanding on the bioscience that controls our lives.

  • Eosinophil Ultrastructure

    Atlas of Eosinophil Cell Biology and Pathology
    • 1 Edición
    • Rossana C.N. Melo + 2 más
    • Inglés
    Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions. Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils. The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases.

  • Translational Autoimmunity, Volume 4

    Autoimmune Diseases in Different Organs
    • 1 Edición
    • Nima Rezaei
    • Inglés
    As the autoimmune diseases could affect different organs, Translational Autoimmunity: Autoimmune Diseases in Different Organs addresses the spectrum of autoimmune diseases. The fourth volume of Translational Immunology Series focuses on clinical and laboratory details of autoimmune diseases which are broadly categorized into two types of organ-specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Autoimmune rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis, autoimmune rheumatic diseases such as diabetes mellitus and thyroid diseases, autoimmune neurologic diseases such as multiple sclerosis, as well as autoimmune hepatobiliary diseases, autoimmune renal diseases and autoimmune cutaneous diseases as the subject of discussion in Translational Autoimmunity: Autoimmune Diseases in Different Organs.

  • Translational Autoimmunity, Volume 3

    Autoimmune Disease Associated with Different Clinical Features
    • 1 Edición
    • Nima Rezaei
    • Inglés
    Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases. The book addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that it's able to maintain self-tolerance, how does it work in infections, and how it elicits an auto-reactive state and develops self-antigens seen in autoimmune conditions. This is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases).

  • Recent Advancements in Microbial Diversity

    Macrophages and their Role in Inflammation
    • 1 Edición
    • Jae Youl Cho
    • Inglés
    In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study.

  • Cardiovascular Pathology

    • 5 Edición
    • L. Maximilian Buja + 1 más
    • Inglés
    Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

  • Translational Autoimmunity, Volume 2

    Treatment of Autoimmune Diseases
    • 1 Edición
    • Nima Rezaei
    • Inglés
    Translational Autoimmunity: Treatment of Autoimmune Diseases, Volume Two in the Translational Immunology series, focuses on advances in therapeutic modalities in autoimmune diseases. Efficacy and safety of not only the current biologic therapies, but also novel drug targets are discussed. Therapeutic targeting of B regulatory cells, T regulatory cells, as well as the immunomodulation effects of nanoparticles and organisms are also covered, along with our understanding and future challenges of prognostic significance of treatments in autoimmune diseases.

  • A New History of Vaccines for Infectious Diseases

    Immunization - Chance and Necessity
    • 1 Edición
    • Anthony R. Rees
    • Inglés
    A New History of Vaccines for Infectious Diseases: Immunization - Chance and Necessity covers the developments of vaccines and how they have obliterated many fatal diseases and infections over time. The book treads a neutral path but does not avoid discussion. As uncertainty in the outcome of vaccination can only be determined by experiment, the path to vaccine development has been scientifically complex because the immune system and the manner in which humans respond to infection is variable and complex. Finally, the book describes the risks and benefits of vaccines in a visibly objective manner.

  • Immunology of Endometriosis

    Pathogenesis and Management
    • 1 Edición
    • Kaori Koga
    • Inglés
    Immunology of Endometriosis: Etiology and Management, a volume in the Reproductive Immunology series, provides updates on one of most common gynecological diseases, including basic science concepts and their clinical applications related to endometriosis immunology. Various immunological factors are believed to play roles in the pathogenesis of endometriosis, providing potential targets for the disease. Endometriosis is now considered to be a disease of both endocrine and immune dysregulation. However, recognition of the direct involvement of two major physiological mechanisms brings about a change of focus which might represent an interesting advance in the understanding of this disease and new focus for further research.

  • Translational Autoimmunity, Volume 1

    Etiology of Autoimmune Diseases
    • 1 Edición
    • Nima Rezaei
    • Inglés
    Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.

  • Lahita's Systemic Lupus Erythematosus

    • 6 Edición
    • Robert G. Lahita
    • Inglés
    Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

  • Trichinella and Trichinellosis

    • 1 Edición
    • Fabrizio Bruschi
    • Inglés
    　 Trichinella and Trichinellosis provides an up-to-date account of the nematode Trichinella spp., including infections and diseases caused by this parasite in both animals and humans. This book will fill the long gap in time during which an exhaustive monograph on this subject has been missing in the international literature. The chapters have been written by the most prolific researchers in the world on the different aspects of Trichinella and trichinellosis. This book serves as an original resource for research on Trichinella and trichinellosis, exploring cutting-edge advances on such parasites and the infections they cause. This book will be a valuable resource for students, biologists, epidemiologists, veterinarians, physicians, and scientists involved in the study of the parasites of the Trichinella genus and their related diseases. It will be particularly helpful for those who are beginning their research in this fascinating field.

  • Applications of Nanobiotechnology for Neglected Tropical Diseases

    • 1 Edición
    • Fabio Rocha Formiga + 2 más
    • Inglés
    Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs. Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.

  • Mucosal Vaccines

    Innovation for Preventing Infectious Diseases
    • 1 Edición
    • David W. Pascual
    • Inglés
    Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format.

  • Mosaic of Autoimmunity

    The Novel Factors of Autoimmune Diseases
    • 1 Edición
    • Carlo Perricone + 1 más
    • Inglés
    The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammat... syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

  • Translational Inflammation

    • 1 Edición
    • Inglés
    Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology.

  • The Value of BCG and TNF in Autoimmunity

    • 2 Edición
    • Denise Faustman
    • Inglés
    The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs.

  • The Epigenetics of Autoimmunity

    • 1 Edición
    • Volumen 5
    • Rongxin Zhang
    • Inglés
    The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment.

  • Immunology

    Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases.

  • Japanese Kampo Medicines for the Treatment of Common Diseases

    Focus on Inflammation
    • 1 Edición
    • Somasundaram Arumugam + 1 más
    • Inglés
    Japanese Kampo Medicines for the Treatment of Common Diseases - Focus on Inflammation provides researchers and clinicians with a current look at how Kampo medicines can be used to effectively treat inflammatory disorders. Japanese Kampo medicines are a mixture of natural and herbal medicines that are available in Japan for the treatment of various diseases. Given their therapeutic potential, they are often prescribed instead of, or alongside, allopathic medicines.Kampo medicines are becoming more widespread and have proven effective for the treatment of a variety of inflammatory diseases, such as colitis, dermatitis, myocarditis, hepatitis, cardiomyopathy, and nephritis. This book offers background on Japanese Kampo medicines, along with a compilation of the published scientific data for several different types of Kampo medicines. It is an evidence-based guide for all those involved in, or interested in, the research and practice of Kampo medicine.

  • The Heart in Systemic Autoimmune Diseases

    • 2 Edición
    • Volumen 14
    • Fabiola Atzeni + 3 más
    • Inglés
    The Heart in Systemic Autoimmune Diseases, Second Edition, provides an overview on our current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population. This excess mortality is largely due to cardiovascular diseases (CVDs)-particularly those of atherosclerotic origin, such as ischemic heart disease-and is gaining recognition in all branches of medicine, from cardiology, to internal medicine, and from rheumatologists to orthopedics.

  • The Heart in Rheumatic, Autoimmune and Inflammatory Diseases

    Pathophysiology, Clinical Aspects and Therapeutic Approaches
    • 1 Edición
    • Udi Nussinovitch
    • Inglés
    The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.

  • The Digestive Involvement in Systemic Autoimmune Diseases

    • 2 Edición
    • Volumen 13
    • Manuel Ramos-Casals + 4 más
    • Inglés
    The Digestive System in Systemic Autoimmune Diseases, Second Edition, represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    • 1 Edición
    • M. A. Hayat
    • Inglés
    Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enrich... vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections.

  • Systemic Inflammatory Disease and the Eye

    • 1 Edición
    • W. J. Dinning
    • Inglés
    Systemic Inflammatory Disease and the Eye present an overview of the systemic conditions associated with ocular inflammation. It discusses the factors for ocular connection in some conditions. It addresses the nature of ocular lesions and eye infections. Some of the topics covered in the book are the symptoms of inflammation of the eye; the aetiology of sarcoidosis; posterior segment inflammation; pathology and immunology of systemic vasculitis syndromes; aetiology of polyarteritis nodosa; diagnosis of systemic lupus erythematosus; and the different types of Sjogren’s syndrome. The pathology and immunopathology of Keratoconjunctivitis Sicca are fully covered. The diagnosis of rheumatoid arthritis is discussed in detail. The text describes in depth the rheumatoid factors and histopathology of joint lesions. The diagnosis of juvenile chronic polyarthritis is presented completely. A chapter is devoted to the epidemiology and clinical features of ankylosing spondylitis. The book can provide useful information to ophthalmologists, doctors, chemists, students, and researchers.

  • Antiphospholipid Syndrome in Systemic Autoimmune Diseases

    • 2 Edición
    • Volumen 12
    • R. Cervera + 3 más
    • Inglés
    Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics.

  • Pediatrics in Systemic Autoimmune Diseases

    • 2 Edición
    • Volumen 11
    • Rolando Cimaz + 1 más
    • Inglés
    Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathie... may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases.

  • Sjogren's Syndrome

    Novel Insights in Pathogenic, Clinical and Therapeutic Aspects
    • 1 Edición
    • Alessia Alunno + 2 más
    • Inglés
    Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 9: Human Diseases and Autophagosome
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 9: Human Diseases and Autophagosome offers a valuable guide to both cellular processes while helping researchers explore their potentially important connections. Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal and antibacterial immunity, and transplantation. This volume also explains, in detail, the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of omegasomes to autophagosomes. This information is important because one of the major functions of autophagy is to degrade and eliminate excessive, old, and harmful materials from the cell. Autophagosomes receive these materials (cellular cargo) and transport them to lysosomes for degradation. Lysosomes contain the digestive enzymes (hydrolases) that breakdown proteins, lipids, carbohydrates, etc. (self-digestion). To further explain this phenomenon, the role of the endoplasmic reticulum (ER) in the formation of autophagosomes is discussed. ULK1 and Beclin 1 proteins are also important in the initial formation of autophagosomes, and are also discussed. Because much of the early research in this area was carried out using yeast cells, the role of Golgi complex in the autophagosome formation in these cells is explained. This volume also includes an explanation of the role of the autophagy-related gene ATG5 in cancer (e.g., gastrointestinal cancer). Paradoxically, autophagy is a “double-edged sword” because it eliminates some pathogens, whereas it can be used by some intracellular pathogens to multiply and cause infection. This book is an asset to newcomers, providing a concise overview of the role of autophagy in necrosis and inflammation, while also serving as an excellent reference for more experienced scientists and clinicians.

  • Core Concepts in Clinical Infectious Diseases (CCCID)

    • 1 Edición
    • Carlos Franco-Paredes
    • Inglés
    Core Concepts in Clinical Infectious Diseases (CCCID) provides medical students and researchers, infectious disease fellows, and practicing clinicians with key clinical concepts in the differential diagnosis and workup of infectious diseases. With the use of tables, charts, and problem-oriented medical diagnosis, it will provide a way of organizing and thinking about commonly seen clinical presentations of infectious diseases. Instead of discussing each disease process or any particular infectious process, this book will assist clinicians in seeing the forest and not focusing on the leaf. Graphs and tables have been constructed over 14 years of taking notes, teaching clinical infectious diseases, and discussing real clinical cases. This book is not about acquiring the structure of infectious diseases that is presented in classic textbooks of infectious disease; instead, it is about refining the process of putting the pieces together in clinical thinking to achieve an accurate clinical diagnosis and thus improved patient care.

  • Viral Pathogenesis

    From Basics to Systems Biology
    • 3 Edición
    • Michael G. Katze + 3 más
    • Inglés
    Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interactio... networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 1 Edición
    • George C. Tsokos
    • Inglés
    Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

  • Amphioxus Immunity

    Tracing the Origins of Human Immunity
    • 1 Edición
    • An-Long Xu
    • Inglés
    Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity.

  • Regulatory T Cells in Health and Disease

    • 1 Edición
    • Volumen 136
    • Inglés
    Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

  • Translational Immunology

    Mechanisms and Pharmacologic Approaches
    • 1 Edición
    • Seng-Lai Tan
    • Inglés
    Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field.

  • Allergy, Immunity and Tolerance in Early Childhood

    The First Steps of the Atopic March
    • 1 Edición
    • Hans Ulrich Wahn + 1 más
    • Inglés
    Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world. As the natural history of these chronic diseases has been extensively studied, including their major genetic, environmental, and lifestyle determinants and potential protective factors, the book presents tactics on how pediatric allergists can provide early intervention. In addition, the book unites key, global experts in the field who summarize their collective, and current, knowledge of the early stage of the "Atopic March", along with novel ideas for potential options of prevention.

  • The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

    • 1 Edición
    • Rainer Straub
    • Inglés
    Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituita... axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging.