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Elsevier

Libros en Ciencias de la Vida

  • Gangliosides in Health and Disease

    • 1 Edición
    • Volumen 156
    • Inglés
    Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field.

  • Immunology in the Twentieth Century

    From Basic Science to Clinical Application
    • 1 Edición
    • Domenico Ribatti
    • Inglés
    Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry... immunogenetics and immunopathology.

  • Multivariate Analysis in the Pharmaceutical Industry

    • 1 Edición
    • Ana Patricia Ferreira + 2 más
    • Inglés
    Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators.

  • Developmental Biology and Musculoskeletal Tissue Engineering

    Principles and Applications
    • 1 Edición
    • Martin J. Stoddart + 3 más
    • Inglés
    Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biolog... based approaches are also likely to be extremely amenable for use with more primitive stem cells.

  • Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research

    • 1 Edición
    • Robert T. Gerlai
    • Inglés
    Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

  • Biomechanics of the Spine

    Basic Concepts, Spinal Disorders and Treatments
    • 1 Edición
    • Fabio Galbusera + 1 más
    • Inglés
    Biomechanics of the Spine encompasses the basics of spine biomechanics, spinal tissues, spinal disorders and treatment methods. Organized into four parts, the first chapters explore the functional anatomy of the spine, with special emphasis on aspects which are biomechanically relevant and quite often neglected in clinical literature. The second part describes the mechanics of the individual spinal tissues, along with commonly used testing set-ups and the constitutive models used to represent them in mathematical studies. The third part covers in detail the current methods which are used in spine research: experimental testing, numerical simulation and in vivo studies (imaging and motion analysis). The last part covers the biomechanical aspects of spinal pathologies and their surgical treatment. This valuable reference is ideal for bioengineers who are involved in spine biomechanics, and spinal surgeons who are looking to broaden their biomechanical knowledge base. The contributors to this book are from the leading institutions in the world that are researching spine biomechanics.

  • Keys to Running Successful Research Projects

    All the Things They Never Teach You
    • 1 Edición
    • Katherine Christian
    • Inglés
    Keys to Running Successful Research Projects: All the Things They Never Teach You provides a step-by-step guide for the management of a successful research project or program. Through the use of illustrative case studies, the book covers all aspects of management that should be included during researcher training, helping researchers overcome the many challenges they face in their day-to-day management of people, time and resources. Links throughout provide more detailed information from gold standard sources on every topic. It is a must-have reference for postdocs, research managers and administrators in colleges, universities, hospitals and research institutes. In addition, it is an ideal resource for those working in grant and contract funding groups in the life sciences and medical fields.

  • Ranunculales Medicinal Plants

    Biodiversity, Chemodiversity and Pharmacotherapy
    • 1 Edición
    • Da-Cheng Hao
    • Inglés
    Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource.

  • G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A

    • 1 Edición
    • Volumen 338
    • Inglés
    G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation, Part A, Volume 337 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This new release includes comprehensive sections on the classical paradigms of GCPR signaling and regulation, the family of small GTPases: Beyond heterotrimeric G proteins, GPCR endocytosis: Arrestins, arrestin-like proteins, signaling from internalized G Protein-Coupled Receptors, GPCR kinases, and more.

  • Introductory Review on Sirtuins in Biology, Aging, and Disease

    • 1 Edición
    • Leonard Guarente + 2 más
    • Inglés
    Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.

  • The Auditory System in Sleep

    • 2 Edición
    • Ricardo Velluti
    • Inglés
    The Auditory System in Sleep, Second Edition presents a view of a sensory system working in a different state, that of the sleeping brain. This updated edition contains new chapters on topics such as implanted deaf patients and sleep and tinnitus treatments. It is written for basic auditory system and sleep researchers, as well as practitioners and clinicians in the Auditory/Sensory Neurosciences and Sleep Medicine. As the auditory system is always “open”, thus receiving information from the environment and the body itself (conscious and unconscious data), the incoming sensory information may alter sleep and waking physiology, and conversely, the sleeping brain. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, and more.

  • Neurobiology of the Placebo Effect, Part I

    • 1 Edición
    • Volumen 138
    • Inglés
    Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biologi... process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

  • Signal Processing for Neuroscientists

    • 2 Edición
    • Wim van Drongelen
    • Inglés
    Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus. With a robust modeling component, this book describes modeling from the fundamental level of differential equations all the way up to practical applications in neuronal modeling. It features nine new chapters and an exercise section developed by the author. Since the modeling of systems and signal analysis are closely related, integrated presentation of these topics using identical or similar mathematics presents a didactic advantage and a significant resource for neuroscientists with quantitative interest. Although each of the topics introduced could fill several volumes, this book provides a fundamental and uncluttered background for the non-specialist scientist or engineer to not only get applications started, but also evaluate more advanced literature on signal processing and modeling.

  • Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors

    • 1 Edición
    • Prashant Kesharwani + 1 más
    • Inglés
    Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 102
    • Inglés
    Advances in Applied Microbiology, Volume 102, the latest release in one of the most widely read and authoritative review sources in microbiology, contains comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Twenty-five Years of Investigating the Universal Stress Protein: Structure, function and applications, Fungal Genomes and Genotyping, Fungi in deep subsurface environments, Spore germination in pathogenic fungi, Host sensing by pathogenic fungi, Advances in the Microbial Ecology of Biohydrometallurgy, and The mycosphere and turnover of contaminants, amongst others.

  • Therapeutic Proteins and Peptides

    • 1 Edición
    • Volumen 112
    • Inglés
    Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 149
    • Inglés
    Advances in Agronomy, Volume 149, the latest release in the series, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

  • Neuromuscular Junction Disorders, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 36-2
    • Mazen M. Dimachkie + 1 más
    • Inglés
    This issue of Neurologic Clinics, edited by Dr. Mazen M. Dimachkie and Dr. Richard J. Barohn, focuses on Neuromuscular Junction Disorders. Topics include--but are not limited to--History of myasthenia gravis and neuromuscular junction disorders; Practical immunology of the neuromuscular junction; Practical anatomy of the neuromuscular junction in health and disease; Generalized myasthenia gravis; Ocular myasthenia gravis; Diagnosis of myasthenia gravis; MuSK and myasthenia gravis due to other autoantibodies; Treatment of myasthenia gravis; Evidenced-based approach of thymectomy for myasthenia gravis; Myasthenia gravis and pregnancy; Congenital myasthenic syndromes; Botulism; Lambert-Eaton myasthenic syndrome; and Measuring clinical treatment response in myasthenia gravis.

  • Therapeutic, Probiotic, and Unconventional Foods

    • 1 Edición
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Therapeutic, Probiotic and Unconventional Foods compiles the most recent, interesting and innovative research on unconventional and therapeutic foods, highlighting their role in improving health and life quality, their implications on safety, and their industrial and economic impact. The book focuses on probiotic foods, addressing the benefits and challenges associated with probiotic and prebiotic use. It then explores the most recently investigated and well-recognized nutraceutical and medicinal foods and the food products and ingredients that have both an impact on human health and a potential therapeutic effect. The third and final section explores unconventional foods and discusses intriguing and debated foods and food sources. While research has been conducted on the beneficial biological effects of probiotics and therapeutic food, the use of these foods remains controversial. To overcome the suspicion of the use of alternative, homeopathic and traditional products as therapy, this book reveals and discusses the most recent and scientifically sound and confirmed aspects of the research.

  • Pharmacy Education in the Twenty First Century and Beyond

    Global Achievements and Challenges
    • 1 Edición
    • Ahmed Fathelrahman + 3 más
    • Inglés
    Pharmacy Education in the Twenty First Century and Beyond: Global Achievements and Challenges offers a complete reference on global pharmacy education, along with a detailed discussion of future issues and solutions. This book begins with a brief overview of the history of pharmacy education, covering all levels of education and styles of learning, from undergraduate, continuing professional education, and methods for self-learning and development. Teaching strategies such as team-based learning, problem-based learning and interdisciplinary education are also described and compared to conclude why certain pharmacy programs attract students, and why educators prefer particular teaching strategies, assessment tools and learning styles. As a result, this book provides pharmacy educators, administrators, students and practitioners with a comprehensive guide to pharmacy education that will enable readers to choose the best approaches to improve, reform or select a program based on worldwide experience and the latest available evidence and research.

  • Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B

    • 1 Edición
    • Volumen 603
    • Inglés
    Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more.

  • Food Safety and Preservation

    Modern Biological Approaches to Improving Consumer Health
    • 1 Edición
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Food Safety and Preservation: Modern Biological Approaches to Improving Consumer Health explores the most recent and investigated hot topics in food safety, microbial contamination, food-borne diseases and advanced preservation methods. It brings together the significant, evidence-based scientific progress of various approaches to improve the safety and quality of foods, also offering solutions to help address food industry challenges. Recent studies and technological advancements in biological control are presented to control foodborne pathogens. In addition, analytical methods for reducing potential biological hazards make this book essential to researchers, scientists, technologists and grad students.

  • EEG-Based Diagnosis of Alzheimer Disease

    A Review and Novel Approaches for Feature Extraction and Classification Techniques
    • 1 Edición
    • Nilesh Kulkarni + 1 más
    • Inglés
    EEG-Based Diagnosis of Alzheimer Disease: A Review and Novel Approaches for Feature Extraction and Classification Techniques provides a practical and easy-to-use guide for researchers in EEG signal processing techniques, Alzheimer’s disease, and dementia diagnostics. The book examines different features of EEG signals used to properly diagnose Alzheimer’s Disease early, presenting new and innovative results in the extraction and classification of Alzheimer’s Disease using EEG signals. This book brings together the use of different EEG features, such as linear and nonlinear features, which play a significant role in diagnosing Alzheimer’s Disease.

  • Waste Biorefinery

    Potential and Perspectives
    • 1 Edición
    • Thallada Bhaskar + 4 más
    • Inglés
    Waste Biorefinery: Potential and Perspectives offers data-based information on the most cutting-edge processes for the utilisation of biogenic waste to produce biofuels, energy products, and biochemicals – a critical aspect of biorefinery. The book explores recent developments in biochemical and thermo-chemical methods of conversion and the potential generated by different kinds of biomass in more decentralized biorefineries. Additionally, the book discusses the move from 200 years of raw fossil materials to renewable resources and how this shift is accompanied by fundamental changes in industrial manufacturing technologies (from chemistry to biochemistry) and in logistics and manufacturing concepts (from petrochemical refineries to biorefineries). Waste Biorefinery: Potential and Perspectives designs concepts that enable modern biorefineries to utilize all types of biogenic wastes, and to integrate processes that convert byproduct streams to high-value products, achieving higher cost benefits. This book is an essential resource for researchers and students studying biomass, biorefineries, and biofuels/products/pr... as well as chemists, biochemical/chemical engineers, microbiologists, and biotechnologists working in industries and government agencies.

  • Autophagy and Cardiometabolic Diseases

    From Molecular Mechanisms to Translational Medicine
    • 1 Edición
    • Jun Ren + 2 más
    • Inglés
    Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 85
    • Inglés
    Advances in Clinical Chemistry, Volume 85, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Imaging of Salivary Glands, An Issue of Neuroimaging Clinics of North America

    • 1 Edición
    • Volumen 28-2
    • Ahmed Abdel Khalek Abdel Razek
    • Inglés
    This issue of Neuroimaging Clinics of North America focuses on Imaging of Salivary Glands, and is edited by Dr. Ahmed Abdel Khalek Abdel Razek. Articles will include: Cross sectional imaging techniques and normal anatomy of the salivary glands; Imaging of benign salivary gland tumors; Imaging of cancer salivary glands; Imaging of Sjögren's syndrome and immunoglobulin g4-related disorder of salivary glands; Imaging of post treatment of salivary glands; Imaging of pediatric salivary glands; Imaging of submandibular and sublingual salivary glands; Scintigraphy and PET of salivary glands; Imaging of inflammatory disorders of salivary glands; Routine and advanced ultrasound of salivary glands; and more!

  • Progress in Medicinal Chemistry

    • 1 Edición
    • Volumen 57
    • Inglés
    Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

  • Conn's Handbook of Models for Human Aging

    • 2 Edición
    • Jeffrey L. Ram + 1 más
    • Inglés
    Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advant... of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.

  • Biodiversity and Climate Change Adaptation in Tropical Islands

    • 1 Edición
    • Chandrakasan Sivaperuman + 3 más
    • Inglés
    Biodiversity and Climate Change Adaptation in Tropical Islands provides comprehensive information on climate change, biodiversity, possible impacts, adaptation measures and policy challenges to help users rehabilitate and preserve the natural resources of tropical islands. While biodiversity and climate change of tropical islands has previously received less attention, it is ironically one of the most vulnerable regions in this regard. The core content of the work derives largely from the ideas and research output from various reputed scientists and experts who have recorded climate change impacts on aquatic and coastal life in tropical regions. Contributors have direct working experience with the tribes in some of the tropical islands. All of their expertise and information is compiled and presented in the work, including coverage related to climate change. This work highlights the ever-growing need to develop and apply strategies that optimize the use of natural resources, both on land and in water and judicious use of biodiversity. It functions as a critical resource on tropical island biodiversity for researchers, academicians, practitioners and policy makers in a variety of related disciplines.

  • Intestinal Stem Cell Niche

    • 1 Edición
    • Volumen 2
    • Inglés
    Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice.

  • Illustrated Toxicology

    With Study Questions
    • 1 Edición
    • PK Gupta
    • Inglés
    Illustrated Toxicology: With Study Questions is an essential, practical resource for self-study and guidance catering to a broad spectrum of students. This book covers a range of core toxicological areas, including pesticides, radioactive materials and poisonous plants, also presenting a section on veterinary toxicology. Across 16 chapters, the book presents key concepts with the aid of over 250 detailed, full-color illustrations. Each section is supplemented with practical exercises to support active learning. This combination of clear illustrations and sample testing will help readers gain a deeper understanding of toxicology. This book is useful for toxicology, pharmacy, medical and veterinary students, and also serves as a refresher for academics and professionals in the field, including clinical pharmacists, forensic toxicologists, environmentalists and veterinarians.

  • Biopolymers for Food Design

    • 1 Edición
    • Volumen 20
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Biopolymers for Food Design, Volume 20 in the Handbook of Bioengineering series, describes how biopolymers have made a major impact in the food industry, from food design, to food control and safety. Biopolymers can be used in the development of novel nutritional alternatives, to replace difficult to obtain food products, or for foods inaccessible or inappropriate for a particular population (i.e. allergic to specific components). In addition, some polymers can be used as functional ingredients, and can also represent efficient scaffolds for food ingredients with therapeutic values. This valuable reference is ideal for those looking for new solutions for the food industry.

  • The Neurology of HIV Infection

    • 1 Edición
    • Volumen 152
    • Inglés
    The Neurology of HIV Infection covers all aspects of nervous system involvement and pathology in HIV-infected individuals. Specialists in this field cover epidemiology, global aspects, pathology and pathogenesis of nervous system disease in HIV-infection. All complications, including the pathology caused by HIV itself and all opportunistic infections of the nervous system are reviewed in detail. Both central nervous and peripheral nervous system complications, including neuropathies and myopathies, are discussed. Key chapters on global developments, HIV-associated neurocognitive disorders, IRIS, stroke and neuro-aids in children complete this volume.

  • The Molecular and Cellular Basis of Neurodegenerative Diseases

    Underlying Mechanisms
    • 1 Edición
    • Michael S. Wolfe
    • Inglés
    The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

  • Role of Materials Science in Food Bioengineering

    • 1 Edición
    • Volumen 19
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    The Role of Materials Science in Food Bioengineering, Volume 19 in the Handbook of Food Bioengineering, presents an up-to-date review of the most recent advances in materials science, further demonstrating its broad applications in the food industry and bioengineering. Many types of materials are described, with their impact in food design discussed. The book provides insights into a range of new possibilities for the use of materials and new technologies in the field of food bioengineering. This is an essential reference on bioengineering that is not only ideal for researchers, scientists and food manufacturers, but also for students and educators.

  • Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

    • 1 Edición
    • Volumen 3
    • Inglés
    Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

  • Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

    • 2 Edición
    • Herbert B. Newton
    • Inglés
    Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed.

  • Brugada Phenocopy

    The Art of Recognizing the Brugada ECG Pattern
    • 1 Edición
    • Adrian Baranchuk
    • Inglés
    Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists... internists, emergency care doctors and students, residents and fellows.

  • Surgery in Rheumatic and Musculoskeletal Disease

    • 1 Edición
    • Volumen 15
    • Fabiola Atzeni + 4 más
    • Inglés
    Surgery in Systemic Autoimmune Disease, Volume 15, describes the state-of-the-art of the use of surgery in treating the most common systemic autoimmune diseases (SADS). The volume consists of an introductory chapter concerning the impact of surgery on SADs, follow by eight chapters describing the use of surgery in the treatment of specific diseases in various areas (cardiology, gastroenterology, orthopedics, neurology. etc.) and the possible difficulties and complications. The final five chapters deal with the possible complications arising during the course of biological and non-biological treatment, also providing recommendation concerning their management. International in scope, the list of more than 20 contributors from Europa and America reads like a who’s who of clinical researchers in the field.

  • Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A

    • 1 Edición
    • Volumen 602
    • Inglés
    Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.

  • Plant Micronutrient Use Efficiency

    Molecular and Genomic Perspectives in Crop Plants
    • 1 Edición
    • Mohammad Anwar Hossain + 4 más
    • Inglés
    Plant Micronutrient Use Efficiency: Molecular and Genomic Perspectives in Crop Plants presents information on the complex mechanisms regulating micronutrient use efficiency in plants. Understanding this science is essential for the development of new varieties of crop plants that are more resilient to micronutrient stress, as well as plants with increased bioavailable concentrations of essential micronutrients. This book explores the discovery of novel genes and key metabolic pathways associated with micronutrient use efficiency in plants, gives an analyses of the gene expression patterns in plants in response to low and/or high nutrient levels, and investigates the potential functions of these genes and their products. Strategies to enhance micronutrient use efficiency and stress tolerance, to develop bio-fortified crop, and to improve the sustainable utilization of natural resources are critically evaluated. The book contains both fundamental and advanced information as well as critical commentaries that are useful for those involved in the various fields that make up the plant sciences.

  • Biodiversity and Evolution

    • 1 Edición
    • Philippe Grandcolas + 1 más
    • Inglés
    Biodiversity and Evolution includes chapters devoted to the evolution and biodiversity of organisms at the molecular level, based on the study of natural collections from the Museum of Natural History. The book starts with an epistemological and historical introduction and ends with a critical overview of the Anthropocene epoch.

  • Ischemic and Traumatic Brain and Spinal Cord Injuries

    Mechanisms and Potential Therapies
    • 1 Edición
    • Akhlaq A. Farooqui
    • Inglés
    Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases.

  • Food Processing for Increased Quality and Consumption

    • 1 Edición
    • Volumen 18
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Food Processing for Increased Quality and Consumption, Volume 18 in the Handbook of Food Bioengineering series, offers an updated perspective on the novel technologies utilized in food processing. This resource highlights their impact on health, industry and food bioengineering, also emphasizing the newest aspects of investigated technologies and specific food products through recently developed processing methods. As processed foods are more frequently consumed, there is increased demand to produce foods that attract people based on individual preferences, such as taste, texture or nutritional value. This book provides advantageous tools that improve food quality, preservation and aesthetics.

  • Stem Cells

    Therapeutic Innovations under Control
    • 1 Edición
    • Nicole Arrighi
    • Inglés
    Stem Cells: Therapeutic Innovations under Control traces the discovery of stem cells and induced pluripotent cells. It establishes the link between knowledge about cell development and tissue engineering, and presents perspectives in regenerative medicine. Cell proliferation and tissue architecture open up unexpected applications in tissue engineering, with the development of tissues or organs. In this context emerges the need to address the issue of bioethics and regulatory considerations. Because stem cells can multiply and differentiate into cells specific to a particular tissue or organ, they represent vast potential in the health field.

  • Lipid Modification by Enzymes and Engineered Microbes

    • 1 Edición
    • Uwe T. Bornscheuer
    • Inglés
    Lipid Modification by Enzymes and Engineered Microbes covers the state-of-the art use of enzymes as natural biocatalysts to modify oils, also presenting how microorganisms, such as yeast, can be designed. In the past ten years, the field has made enormous progress, not only with respect to the tools developed for the development of designer enzymes, but also in the metabolic engineering of microbes, the discovery of novel enzyme activities, and in reaction engineering/process development. For the first time, these advances are covered in a single-volume that is edited by leading enzymatic scientist Uwe Borchscheuer and authored by an international team of experts.

  • Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

    • 1 Edición
    • Salvatore V. Pizzo
    • Inglés
    Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.

  • Plant Metabolites and Regulation under Environmental Stress

    • 1 Edición
    • Parvaiz Ahmad + 5 más
    • Inglés
    Plant Metabolites and Regulation Under Environmental Stress presents the latest research on both primary and secondary metabolites. The book sheds light on the metabolic pathways of primary and secondary metabolites, the role of these metabolites in plants, and the environmental impact on the regulation of these metabolites. Users will find a comprehensive, practical reference that aids researchers in their understanding of the role of plant metabolites in stress tolerance.

  • Gum Arabic

    Structure, Properties, Application and Economics
    • 1 Edición
    • Abdalbasit Adam Mariod
    • Inglés
    Gum Arabic: Structure, Properties, Application and Economics explores the management practices of gum Arabic producing trees and their environmental role, the characteristics and properties of the gum, and presents current and developing uses in food, feed, and medicinal applications. The book provides insight into regulatory aspects of production and quality control as well as underscoring some of the geographically based differences in gum Arabic trees, production, and regulation of products. Written by experts in the field, the book provides current research and developments in gum Arabic. It is an important resource for researchers in industry and academia interested in the advances in this area.

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