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Elsevier

Libros en Ciencias de la Vida

  • Skin Tissue Models

    • 1 Edición
    • Alexandra P. Marques + 3 más
    • Inglés
    Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury – from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

  • zika virus disease

    From origin to outbreak
    • 1 Edición
    • Adnan I. Qureshi
    • Inglés
    Zika Virus provides an authoritative account of one of most fascinating viruses of the 21st century, covering all the main points. It includes coverage of clinical manifestations, such as fever and fatigue, but also delves into neurological manifestations like acute demyelinating neuropathy. In addition, the book discusses new evidence that suggests that Zika fever in pregnant women can cause abnormal brain development in fetuses by mother-to-child transmission. The Zika virus infection has become one of the first where women are actively discouraged from getting pregnant. Readers will find this book to be a comprehensive resource on the topic.

  • Designing Healthcare That Works

    A Sociotechnical Approach
    • 1 Edición
    • Mark Ackerman + 3 más
    • Inglés
    Designing Healthcare That Works: A Sociotechnical Approach takes up the pragmatic, messy problems of designing and implementing sociotechnical solutions which integrate organizational and technical systems for the benefit of human health. The book helps practitioners apply principles of sociotechnical design in healthcare and consider the adoption of new theories of change. As practitioners need new processes and tools to create a more systematic alignment between technical mechanisms and social structures in healthcare, the book helps readers recognize the requirements of this alignment. The systematic understanding developed within the book’s case studies includes new ways of designing and adopting sociotechnical systems in healthcare. For example, helping practitioners examine the role of exogenous factors, like CMS Systems in the U.S. Or, more globally, helping practitioners consider systems external to the boundaries drawn around a particular healthcare IT system is one key to understand the design challenge. Written by scholars in the realm of sociotechnical systems research, the book is a valuable source for medical informatics professionals, software designers and any healthcare providers who are interested in making changes in the design of the systems.

  • Medical and Scientific Publishing

    Author, Editor, and Reviewer Perspectives
    • 1 Edición
    • Jasna Markovac + 2 más
    • Inglés
    Very few doctors and scientists receive any sort of systematic training in publishing, editing, and reviewing scholarly articles, despite the central importance of that work for scientific research and for their careers. Medical and Scientific Publishing will help fill the gap and help readers to:Understand processes of scientific and medical publishingUnderstand the role of an academic in medical publishingBecome a better scientific communicatorDevelop skills to effectively serve as the editor of a medical journal Medical and Scientific Publishing is based on a successful course at the University of Michigan Medical School for third and fourth year medical students. The course teaches students not just how to write scientific and medical articles, but addresses key issues surrounding copyright, ethics, open access and much more. Students will build a strong foundation on how to do peer review and how to be authors and editors which are important skills in building a professional career.

  • Notes in the Category of C

    Reflections on Laboratory Animal Care and Use
    • 1 Edición
    • Steven M. Niemi
    • Inglés
    Notes in the Category C: Reflections on Laboratory Animal Care and Use addresses how to improve laboratory animal care and use, also characterizing the current state of the industry and speculating on its long-term future. It offers analysis from a professional who has spent a lot of time in the trenches, also highlighting new approaches to produce further advances in the field. As the proper care and use of lab animals is critically important to scientists and those who depend on data generated from those animals, this comprehensive book is an ideal resource on the topic. Physicians, patients and their families, consumers, federal and non-profit research funding entities, health advocacy organizations, the FDA, EPA, regulatory approval agencies, and companies that invest billions in R&D to create new diagnostics, drugs, vaccines and medical devices will find this an informative addition for their work.

  • Epigenetics of Aging and Longevity

    Translational Epigenetics vol 4
    • 1 Edición
    • Volumen 4
    • Alexey Moskalev + 1 más
    • Inglés
    Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

  • Proteins in Food Processing

    • 2 Edición
    • Rickey Y. Yada
    • Inglés
    Proteins in Food Processing, Second Edition, reviews how proteins may be used to enhance the nutritional, textural and other qualities of food products. After two introductory chapters, the book discusses sources of proteins, examining the caseins, whey, muscle and soy proteins, and proteins from oil-producing plants, cereals and seaweed. Part Two illustrates the analysis and modification of proteins, with chapters on testing protein functionality, modeling protein behavior, extracting and purifying proteins and reducing their allergenicity. A final group of chapters delves into the functional value of proteins and how they are used as additives in foods.

  • In Vitro Toxicology

    • 1 Edición
    • Alok Dhawan + 1 más
    • Inglés
    In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.

  • Harnessing the Power of Viruses

    • 1 Edición
    • Boriana Marintcheva
    • Inglés
    Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses.

  • Intracranial Epidural Bleeding

    History, Management, and Pathophysiology
    • 1 Edición
    • Jeremy Christopher Ganz
    • Inglés
    Intracranial Epidural Bleeding: History, Management, and Pathophysiology examines the history of the concepts underlying the understanding of the clinical features of epidural bleeding. The pathophysiology of epidural bleeding was examined in two PhD theses in the 1980s, with the results published in top international journals. However, these concepts have not been understood by the general neurosurgical community. This book provides a comprehensive overview of how epidural bleeding actually works. It can be used to help improve the interpretation of images during management, and to assess degrees of urgency. This book is written for neurosurgeons, neurologists, cerebrovascular physiologists, trauma surgeons, and medical historians.

  • Neuromonitoring Techniques

    Quick Guide for Clinicians and Residents
    • 1 Edición
    • Hemanshu Prabhakar
    • Inglés
    Neuromonitoring Techniques: Quick Guide for Clinicians and Residents provides a quick and easy guide to understanding various neuromonitoring equipment. Chapters include intracranial pressure monitoring, EEG-based monitors, evoked potentials and transcranial doppler. This book is written for trainees, clinicians and researchers in the fields of neurosurgery, neurocritical care, neuroradiology, neuroanesthesia and neurology. As specialized neuromonitoring is now routinely done in neurosurgical cases, it provides an important resource for neurologists, neurophysiologists, anesthesiologists and residents who are expected to have theoretical and practical knowledge on different systems. Each monitoring system is discussed separately, with examples, images, reference values and their interpretations.

  • Handbook of Neuroemergency Clinical Trials

    • 2 Edición
    • Brett E. Skolnick + 1 más
    • Inglés
    Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.

  • Fundamentals of Soil Ecology

    • 3 Edición
    • David C. Coleman + 2 más
    • Inglés
    Fundamentals of Soil Ecology, 3rd Edition,　offers a holistic approach to soil biology and ecosystem function, providing students and ecosystem researchers with a greater understanding of the central roles that soils play in ecosystem development and function. The text emphasizes the increasing importance of soils as the organizing center for all terrestrial ecosystems and provides an overview of theory and practice in soil ecology, both from an ecosystem and evolutionary biology point of view. This new edition is fully updated, including an expanded treatment of microbial ecology and new sections on advances in molecular techniques and climate change research. These updates make this edition an essential resource for researchers and students in soil ecology and microbiology.

  • Genomic and Precision Medicine

    Cardiovascular Disease
    • 3 Edición
    • Geoffrey S. Ginsburg + 1 más
    • Inglés
    Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.

  • Advances in Pig Welfare

    • 1 Edición
    • Irene Camerlink
    • Inglés
    Advances in Pig Welfare analyzes current topical issues in the key areas of pig welfare assessment and improvement. With coverage of both recent developments and reviews of historical welfare issues, the volume provides a comprehensive survey of the field. The book is divided into two sections. Part One opens with an overview of main welfare challenges in commercial pig production systems and then reviews pig welfare hot spots from birth to slaughter. Part Two highlights emerging topics in pig welfare, such as pain and health assessment, early socialization and environmental enrichment, pig-human interactions, breeding for welfare, positive pig welfare and pigs as laboratory animals. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs and poultry. With its expert editor and international team of contributors, Advances in Pig Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of pig.

  • Pharmaceutical Medicine and Translational Clinical Research

    • 1 Edición
    • Divya Vohora + 1 más
    • Inglés
    Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features.As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource.

  • CRISPR in Animals and Animal Models

    • 1 Edición
    • Volumen 152
    • Inglés
    CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges.

  • Human Biochemistry

    • 1 Edición
    • Gerald Litwack
    • Inglés
    Human Biochemistry includes clinical case studies and applications that are useful to medical, dentistry and pharmacy students. It enables users to practice for future careers as both clinicians and researchers. Offering immediate application of biochemical principles into clinical terms in an updated way, this book is the unparalleled textbook for medical biochemistry courses in medical, dental and pharmacy programs.

  • Reasoning

    The Neuroscience of How We Think
    • 1 Edición
    • Daniel Krawczyk
    • Inglés
    Reasoning: The Neuroscience of How We Think is a comprehensive guide to the core topics related to a thorough understanding of reasoning. It presents the current knowledge of the subject in a unified, complete manner, ranging from animal studies, to applied situations, and is the only book available that presents a sustained focus on the neurobiological processes behind reasoning throughout all chapters, while also synthesizing research from animal behavior, cognitive psychology, development, and philosophy for a truly multidisciplinary approach. The book considers historical perspectives, state-of-the-art research methods, and future directions in emerging technology and cognitive enhancement. Written by an expert in the field, this book provides a coherent and structured narrative appropriate for students in need of an introduction to the topic of reasoning as well as researchers seeking well-rounded foundational content. It is essential reading for neuroscientists, cognitive scientists, neuropsychologists and others interested in the neural mechanisms behind thinking, reasoning and higher cognition.

  • Epigenetic Mechanisms in Cancer

    • 1 Edición
    • Volumen 3
    • Sabita Saldanha
    • Inglés
    Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

  • Vitamin D, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 46-4
    • J. Chris Gallagher + 1 más
    • Inglés
    This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. J. Chris Gallagher and Daniel Bikle, is devoted to Vitamin D. Articles in this issue include: The Molecular and Cellular Mechanisms of Action of Vitamin D, Worldwide Review of Serum 25OHD Status; RDA Update (7 Years Post IOM); The Use of Vitamin D Metabolites and Analogs in the Treatment of Chronic Kidney Disease; Effect of Vitamin D on Falls and Physical Performance; Vitamin D Effect on BMD and Fractures; Bariatric Surgery and Vitamin D Metabolism, Role of Vitamin D in the Prevention and Treatment of Cancer; Role of Vitamin D in Cardiovascular Disease; Regulation of Immune Function by Vitamin D and its Use in Diseases of Immunity; Genetic Diseases of Vitamin D Metabolizing Enzymes; Measurement of Vitamin D Metabolites: Clinical Issues; The Free 25OHD Hypothesis, and Ethnic/Racial Differences in Vitamin D Levels: Physiologic or Pathologic.

  • Case Studies in the Traditional Food Sector

    A volume in the Consumer Science and Strategic Marketing series
    • 1 Edición
    • Alessio Cavicchi + 1 más
    • Inglés
    Consumer Science and Strategic Marketing: Case Studies in the Traditional Food Sector aims to close the gap between academic researchers and industry professionals through real world scenarios and field-based research. The book explores how consumer and sensory science has been implemented in the food industry for achieving the following strategic aims: rejuvenating product image, shaping new market places, achieving market differentiation and geographical diffusion, achieving customer loyalty, promoting traditional features of the product and defining product positioning in competitive environment. There is an emerging demand from food industry professionals and undergraduate and postgraduate students who attend business and agricultural studies courses who want to gain practical information through real cases and field-based research. This book aims to answer the following questions, amongst others: How research in the field of consumer science became relevant for marketing strategies?, Which tangible economic and financial outcomes have been obtained by the joint work of sensory scientists, researchers in marketing field and food business professionals?, and which communication methods and practices have been relevant to make the most of R&D in the food industry? Through case studies, successful examples and practices are provided, with newer inputs for further theoretical investigation given. Both current and future professionals in the food industry will gain insights that can be used in their business environment.

  • Cell Polarity in Development and Disease

    • 1 Edición
    • Douglas W Houston
    • Inglés
    Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research.

  • Molecular Pathology

    The Molecular Basis of Human Disease
    • 2 Edición
    • William B. Coleman + 1 más
    • Inglés
    As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

  • Disaster Epidemiology

    Methods and Applications
    • 1 Edición
    • Jennifer Horney
    • Inglés
    Disaster Epidemiology: Methods and Applications applies the core methods of epidemiological research and practice to the assessment of the short- and long-term health effects of disasters. The persistent movement of people and economic development to regions vulnerable to natural disasters, as well as new vulnerabilities related to environmental, technological, and terrorism incidents, means that in spite of large global efforts to reduce the impacts and costs of disasters, average annual expenditures to fund rebuilding from catastrophic losses is rising faster than either population or the gross world product. Improving the resilience of individuals and communities to these natural and technological disasters, climate change, and other natural and manmade stressors is one of the grand challenges of the 21st century. This book provides a guide to disaster epidemiology methods, supported with applications from practice. It helps researchers, public health practitioners, and governmental policy makers to better quantify the impacts of disaster on the health of individuals and communities to enhance resilience to future disasters. Disaster Epidemiology: Methods and Applications explains how public health surveillance, rapid assessments, and other epidemiologic studies can be conducted in the post-disaster setting to prevent injury, illness, or death; provide accurate and timely information for decisions makers; and improve prevention and mitigation strategies for future disasters. These methods can also be applied to the study of other types of public health emergencies, such as infectious outbreaks, emerging and re-emerging diseases, and refugee health. This book gives both the public health practitioner and researcher the tools they need to conduct epidemiological studies in a disaster setting and can be used as a reference or as part of a course.

  • Genetics of Bone Biology and Skeletal Disease

    • 2 Edición
    • Rajesh V. Thakker + 3 más
    • Inglés
    Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.

  • Hemocompatibility of Biomaterials for Clinical Applications

    Blood-Biomaterials Interactions
    • 1 Edición
    • Christopher Siedlecki
    • Inglés
    Hemocompatibility of Biomaterials for Clinical Applications: Blood-Biomaterials Interactions summarizes the state-of-the-art on this important subject. The first part of the book reviews the latest research on blood composition and response, mechanisms of coagulation, test standards and methods. Next, the book assesses techniques for modifying biomaterial surfaces and developing coatings to improve hemocompatibility. In the final sections, users will find discussions on ways to improve the hemocompatibility of particular classes of biomaterials and a review of methods for improving medical devices.

  • Advances in Food Security and Sustainability

    • 1 Edición
    • Volumen 2
    • Inglés
    Advances in Food Security and Sustainability, Volume Two takes a scientific look at the challenges, constraints and solutions necessary to maintain a healthy and accessible food supply in different communities around the world. Topics covered in this new volume include the Management of major fungal diseases for sustainable oilseed rape crop production in the UK, Public Policy and the Construction of New Markets to Family Farms: Analyzing the Case of School Meals in São Paulo, Brazil, The environmental, social and market sustainability of sugar, and Sustainability performance of food chains: linking biodiversity and nutritional value in the Italian wheat to bread chain. This ongoing series addresses a wide range of issues on the principles and practices of food sustainability and security, exploring challenges related to protecting environmental resources while also meeting human nutritional requirements.

  • Foods, Nutrients and Food Ingredients with Authorised EU Health Claims

    Volume 3
    • 1 Edición
    • Michele Sadler
    • Inglés
    Foods, Nutrients and Food Ingredients with Authorized EU Health Claims, Volume Three, provides an overview of how health claims are regulated in the European Union, along with detailed scientific and regulatory information about permitted health claims for foods and ingredients. The latest volume in this series focuses on regulatory coverage from EC 1924/2006, including the most recently authorized claims. Topics discussed include sections on the Authorized reduction of disease risk claims, including calcium, calcium with Vitamin D, Vitamin D, Folic Acid, Limicol® and MUFA and PUFA., health claims based on emerging science, recent regulatory announcements, and finally, general function claims. The book represents the go-to resource for R&D managers and technical managers in the food and beverage and dietary supplements industry, product development managers, health professionals and academic researchers in the field.

  • Metagenomics

    Perspectives, Methods, and Applications
    • 1 Edición
    • Muniyandi Nagarajan
    • Inglés
    Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the growing field of metagenomics. A diverse range of chapters from international experts offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments. The emphasis on application makes this text particularly useful for applied researchers, practitioners, clinicians and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case-study based application chapters examine topics ranging from viral metagenome profiling, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. Additionally, perspectives on future potential at the end of each chapter provoke new thought and motivations for continued study in this exciting and fruitful research area.

  • Immunology

    Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases.

  • GERD

    A New Understanding of Pathology, Pathophysiology, and Treatment
    • 1 Edición
    • Parakrama T. Chandrasoma
    • Inglés
    GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.

  • Sensory Panel Management

    A Practical Handbook for Recruitment, Training and Performance
    • 1 Edición
    • Lauren Rogers
    • Inglés
    Covering all aspects of sensory panel management, this volume describes the different types of sensory panels (for example panels for quality control, descriptive analysis and discrimination tests), discusses the issues involved with sensory testing, and gives detailed information about sensory panel recruitment, training and on-going management. Sensory Panel Management gives both theoretical and practical information from deciding what type of panel to recruit and how to conduct panel training, to creating the best sensory team and how to deal with any issues. Downloads of several of the documents included in the book are available from http://www.laurenlro... The book is divided into three main sections. The first section looks at the recruitment of sensory panels, covering the process from both a scientific and a human resources angle. The second section deals with the training of a sensory panel. Initial training, as well as method and product specific training is covered. Example session plans for running panel sessions for quality control, discrimination tests, descriptive profiling, temporal methods and consumer tests are included within the specific chapters. Refresher and advanced training such as training panelists to take part in gas chromatography-olfac... are also included. The third section examines the performance of sensory panels. Chapters within this section explore performance measures and ways of preventing (and dealing with) difficult situations relating to panellists. A final chapter looks at the future of sensory panels. Throughout the book there are short case study examples demonstrating the practical application of the methods being discussed. Sensory Panel Management is a key reference for academics, technical and sensory staff in food companies. Lauren Rogers is an independent sensory science consultant in the UK with more than twenty years of practical experience. She has worked on a wide variety of projects, including shelf life studies, product and flavor optimization, new flavor development and in-depth brand analyses. She is a member of the Society of Sensory Professionals, the Institute of Food Science and Technology’s Sensory Science Group, the Sensometric Society and is also a member of the ASTM Sensory Evaluation Committee (E18).

  • Laboratory Animals

    Regulations and Recommendations for the Care and Use of Animals in Research
    • 2 Edición
    • Javier Guillen
    • Inglés
    Laboratory Animals: Regulations and Recommendations for the Care and Use of Animals in Research, Second Edition, is the only publication to offer a global compilation of standards on the care, welfare and use of animals in research. The book provides updated information that will be of great interest to professionals across laboratory animal science and biomedical research. Users will find a broad picture of the regulations required in other areas of the world that will be essential to appropriately manage animal care and use programs.

  • The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption

    • 1 Edición
    • Volumen 136
    • Inglés
    The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption, Volume 136 in the International Review of Neurobiology series, provides an overview of the top candidate neuropeptides in the modulation of alcohol and drug abuse, also covering eating disorders and obesity. Topics covered in this latest release include Corticotropin Releasing Factor (CRF) and Addictive Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role of Ghrelin Signaling in Additive Behaviors, The Role of the Melanocortin System in Drug and Eating Disorders, Substance P and the Neurokinin-1 Receptor: The New CRH, and the Role of Neuropeptide Y (NPY) in Drug and Eating Disorders. The book uniquely highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders.

  • Northeast Pacific Shark Biology, Research and Conservation Part B

    • 1 Edición
    • Volumen 78
    • Inglés
    Northeast Pacific Shark Biology, Research and Conservation, Part B, Volume 78, the latest release in the Advances in Marine Biology series contains updated chapters that focus on a variety of topics, including, but not limited to, an Introduction to Northeast Pacific shark biology, ecology, and conservation, Shark Interactions with Directed and Incidental Fisheries in the Northeast Pacific Ocean: historic and current encounters and challenges for shark conservation, An Introduction to modeling abundance and demographic parameters in shark populations, and Sharks in Captivity: The Role of Husbandry, Breeding, Education and Citizen Science in Shark Conservation. Specialty areas in this longstanding series include marine science, both applied and basic, a wide range of topical areas from all areas of marine ecology, oceanography, fisheries management and molecular biology, and the full range of geographic areas from polar seas, to tropical coral reefs are included making this an ideal reference and resource for postgraduates and researchers in a variety of fields.

  • Neuropathology

    • 1 Edición
    • Volumen 145
    • Inglés
    Neuropathology, Volume 145, the latest release in the Handbook of Clinical Neurology series, includes all the major topics found in a typical neuropathology text, but differentiates itself by providing a thorough overview of the morphological background of neurological disorders for researchers and clinicians who do not specialize in pathology or its clinicopathological aspects. This volume offers strong coverage of brain imaging and advances in molecular pathology and genetics, and is particularly timely given the amount of neuropathological research currently taking place.

  • Fundamentals of Toxicologic Pathology

    • 3 Edición
    • Matthew A. Wallig + 3 más
    • Inglés
    Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.

  • The Postdoc Landscape

    The Invisible Scholars
    • 1 Edición
    • Audrey J. Jaeger + 1 más
    • Inglés
    The Postdoc Landscape offers historical, international, and domestic examples, solutions, and strategies for addressing the needs of postdoctoral scholars in terms of their presence in government, industry, and the academy. Growing issues and concerns are identified with a clear direction in terms of what practitioners, policymakers, and educators can do to improve the working conditions of postdoctoral scholars. The book includes chapters centered on three themes: the Postdoc Landscape, Postdoc Support and Postdoc Career Literacy, Agency and Choice. This comprehensive reference serves as a guide for scholars, individuals who supervise and mentor postdoctoral scholars and policymakers.

  • Social and Administrative Aspects of Pharmacy in Low- and Middle-Income Countries

    Present Challenges and Future Solutions
    • 1 Edición
    • Mohamed Izham Mohamed Ibrahim + 2 más
    • Inglés
    Social and Administrative Aspects of Pharmacy in Low- and Middle-Income Countries: Present Challenges and Future Solutions examines the particularities of low- and middle-income countries and offers solutions based on their needs, culture and available resources. Drawing from the firsthand experience of researchers and practitioners working in these countries, this book addresses the socio-behavioral aspects of pharmacy and health, pharmacoeconomics, pharmaceutical policy, supply management and marketing, pharmacoepidemiology and public health pharmacy specific to low- and middle-income countries. While some practices may be applied appropriately in disparate places, too often pharmacy practice in low- and middle-income countries is directly copied from successes in developed countries, despite the unique needs and challenges low- and middle-income countries face.

  • Microbial Contamination and Food Degradation

    • 1 Edición
    • Volumen 10
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Microbial Contamination and Food Degradation, Volume 10 in the Handbook of Food Bioengineering series, provides an understanding of the most common microbial agents involved in food contamination and spoilage, and highlights the main detection techniques to help pinpoint the cause of contamination. Microorganisms may cause health-threatening conditions directly by being ingested together with contaminated food, or indirectly by producing harmful toxins and factors that can cause food borne illness. This resource discusses the potential sources of contamination, the latest advances in contamination research and strategies to prevent contamination using key methods of analysis and evaluation.

  • Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

    • 1 Edición
    • Tahira Farooqui + 1 más
    • Inglés
    Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline.

  • The Neurobiology of Brain and Behavioral Development

    • 1 Edición
    • Robbin Gibb + 1 más
    • Inglés
    The Neurobiology of Brain and Behavioral Development provides an overview of the process of brain development, including recent discoveries on how the brain develops. This book collates and integrates these findings, weaving the latest information with core information on the neurobiology of brain development. It focuses on cortical development, but also features discussions on how the other parts of the brain wire into the developing cerebral cortex. A systems approach is used to describe the anatomical underpinnings of behavioral development, connecting anatomical and molecular features of brain development with behavioral development.The disruptors of typical brain development are discussed in appropriate sections, as is the science of epigenetics that presents a novel and instructive approach on how experiences, both individual and intergenerational, can alter features of brain development. What distinguishes this book from others in the field is its focus on both molecular mechanisms and behavioral outcomes. This body of knowledge contributes to our understanding of the fundamentals of brain plasticity and metaplasticity, both of which are also showcased in this book.

  • Ethnozoology

    Animals in Our Lives
    • 1 Edición
    • Romulo Romeu Nobrega Alves + 1 más
    • Inglés
    Ethnozoology: Animals In Our Lives represents the first book about this discipline, providing a discussion on key themes on human-animal interactions and their implications, along with recent major advances in research. Humans share the world with a bewildering variety of other animals, and have interacted with them in different ways. This variety of interactions (both past and present) is investigated through ethnozoology, which is a hybrid discipline structured with elements from both the natural and social sciences, as it seeks to understand how humans have perceived and interacted with faunal resources throughout history. In a broader context, ethnozoology, and its companion discipline, ethnobotany, form part of the larger body of the science of ethnobiology. In recent years, the importance of ethnozoological/ethn... studies has increasingly been recognized, unsurprisingly given the strong human influence on biodiversity. From the perspective of ethnozoology, the book addresses all aspects of human connection, animals and health, from its use in traditional medicine, to bioprospecting derivatives of fauna for pharmaceuticals, with expert contributions from leading researchers in the field.

  • Nuclear Architecture and Dynamics

    • 1 Edición
    • Volumen 2
    • Christophe Lavelle + 1 más
    • Inglés
    Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.

  • Natural Variation and Clocks

    • 1 Edición
    • Volumen 99
    • Inglés
    Natural Variances and Clocks, Volume 99 in the Advances in Genetics series provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs and advances. This updated release includes chapters on a variety of new research, including the Natural variation of the circadian clock in Neurospora, Natural variation and genetics of the photoperiodic timer in the pitcher-plant mosquito, Natural variation in human clocks, and Natural variation in the circadian clock genes in Drosophila and other insects. This series continually publishes important reviews that are ideal for geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Brain Research in Addiction

    • 1 Edición
    • Volumen 235
    • Inglés
    Brain Research in Addiction, Volume 235, the latest volume in this groundbreaking series on addiction, presents the neurobiological, pathological, cognitive and evolutionary aspects of addiction, with new chapters covering the Neurobiology of drug intake escalation, the Role of the orexinergic system in reward, Mental time travel and addictive behaviors, An evolutionary perspective on addiction- Addiction is the price we pay for innovation and adaptability, and how Cocaine exposure affects object-place recognition memory in non-human primates. Chapters in this serial are presented by leading researchers from North America, South America, Europe, Africa, Asia and Australia, who present addiction research from the bottom up, including how addiction evolved, basic research on animal models, and the psychiatric, psychological and cognitive characteristics of addictive behaviors in humans.

  • Bioactive Polysaccharides

    • 1 Edición
    • Shaoping Nie + 2 más
    • Inglés
    Bioactive Polysaccharides offers a comprehensive review of the structures and bioactivities of bioactive polysaccharides isolated from traditional herbs, fungi, and seaweeds. It describes and discusses specific topics based on the authors’ rich experience, including extraction technologies, practical techniques required for purification and fractionation, strategies and skills for elucidating the fine structures, in-vitro and in-vivo protocols, and methodologies for evaluating the specific bioactivities, including immune-modulating activities, anti-cancer activities, anti-oxidant activities, and others. This unique book also discusses partial structure-functional... (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and nutraceutical areas for commercial interests.

  • The Complement FactsBook

    • 2 Edición
    • Scott R. Barnum + 1 más
    • Inglés
    The Complement FactsBook, Second Edition, provides in-depth insights and an overview of the components of the complement system. This new edition highlights the use of newly recommended complement nomenclature, covering new pathways and proteins and adding information on mouse homologs. It is a completely revised and updated edition containing entries on all components of the complement system, and is an excellent source of one-stop shopping for complement information and references. It is the most convenient compilation of biochemical, biological and molecular biology for complementologists and those new in the field. This new edition is expanded to include relevant updates and topics that have evolved since the last edition was published, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
    • 1 Edición
    • Volumen 39
    • Inglés
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 39 presents the latest on a variety of topics, with new chapters in this volume covering Central nervous system stimulants and drugs that suppress appetite, Antidepressant drugs, Lithium, Drugs of abuse, Hypnotics and sedatives, Antipsychotic Drugs, Antiepileptic Drugs, Opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, General anesthetics and therapeutic gases, Local anesthetics, Neuromuscular blocking agents and skeletal muscle relaxants, and more. First published in 1977, and continually published as a yearly update, this series provides clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing their expertise each year.

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