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Elsevier

Libros en Ciencias de la Vida

  • Approaches to Understanding Breast Cancer

    • 1 Edición
    • Volumen 151
    • Inglés
    Approaches to Understanding Breast Cancer, Volume 151, the latest volume in the Progress in Molecular Biology and Translational Science series focuses on breast cancer, with new chapters that include information on Breast Cancer Epidemiology, Prevention, and Screening, DCIS: Current Principles of Management, Pregnancy and Hormonal Prevention of Breast Cancer, Chemokines: Key Players in Pathobiology of Breast Cancer, Mircrobiota and Breast Cancer, Experimental Therapeutic Use of Estrogen Receptor Beta Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations from Pre-Clinical Models, Targeting Breast Cancer Stem Cells: Key for Anti-Metastatic Therapy, and Experimental Therapy of Advanced Breast Cancer: Target NFAT1-MDM2-p53 Pathway.

  • Selenium and Selenoproteins in Cancer

    • 1 Edición
    • Volumen 136
    • Francesco Galli
    • Inglés
    Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium.

  • Peptidomics of Cancer-Derived Enzyme Products

    • 1 Edición
    • Volumen 42
    • Inglés
    Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellula... RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 101
    • Inglés
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  • Secondary Endosymbioses

    • 1 Edición
    • Volumen 84
    • Yoshihisa Hirakawa
    • Inglés
    Secondary Endosymbioses, Volume 84, the latest release in the Advances in Botanical Research series, summarizes eight major groups possessing complex plastids, including heterokonts, dinoflagellates, apicomplexans, chromerids, haptophytes, cryptophytes, euglenophytes and chlorarachniophytes. Updates to this new volume include sections on the Evolution of secondary plastid-bearing organisms, Primary plastids of Archeaplastida, Secondary plastids of heterokonts (diatoms), Secondary and tertiary plastids of dinoflagellates, Apicoplasts, Secondary plastids of chromerids, Secondary Plastids of haptophytes, Secondary Plastids of cryptophytes, Secondary Plastids of euglenids, and Secondary Plastids of chlorarachinophytes. Through an examination on how plastids evolved by multiple endosymbiotic events, this book discusses how diverse and abundant organisms harbor complex plastids.

  • Soil Management and Climate Change

    Effects on Organic Carbon, Nitrogen Dynamics, and Greenhouse Gas Emissions
    • 1 Edición
    • Maria Angeles Munoz + 1 más
    • Inglés
    Soil Management and Climate Change: Effects on Organic Carbon, Nitrogen Dynamics, and Greenhouse Gas Emissions provides a state of the art overview of recent findings and future research challenges regarding physical, chemical and biological processes controlling soil carbon, nitrogen dynamic and greenhouse gas emissions from soils. This book is for students and academics in soil science and environmental science, land managers, public administrators and legislators, and will increase understanding of organic matter preservation in soil and mitigation of greenhouse gas emissions. Given the central role soil plays on the global carbon (C) and nitrogen (N) cycles and its impact on greenhouse gas emissions, there is an urgent need to increase our common understanding about sources, mechanisms and processes that regulate organic matter mineralization and stabilization, and to identify those management practices and processes which mitigate greenhouse gas emissions, helping increase organic matter stabilization with suitable supplies of available N.

  • Overflow Metabolism

    From Yeast to Marathon Runners
    • 1 Edición
    • Alexei Vazquez
    • Inglés
    Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage.

  • Food and Feed Safety Systems and Analysis

    • 1 Edición
    • Steven Ricke + 3 más
    • Inglés
    Food and Feed Safety Systems and Analysis discusses the integration of food safety with recent research developments in food borne pathogens. The book covers food systems, food borne ecology, how to conduct research on food safety and food borne pathogens, and developing educational materials to train incoming professionals in the field. Topics include data analysis and cyber security for food safety systems, control of food borne pathogens and supply chain logistics. The book uniquely covers current food safety perspectives on integrating food systems concepts into pet food manufacturing, as well as data analyses aspects of food systems.

  • Nanomaterials for Biosensors

    Fundamentals and Applications
    • 1 Edición
    • Bansi D. Malhotra + 1 más
    • Inglés
    Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included.

  • In Loeffler’s Footsteps – Viral Genomics in the Era of High-Throughput Sequencing

    • 1 Edición
    • Volumen 99
    • Inglés
    In Loeffler’s Footsteps – Viral Genomics in the Era of High-Throughput Sequencing, Volume 99, the latest in the Advances in Virus Research series, contains new information on the topic, with chapters covering Loeffler 4.0 – diagnostic metagenomics, Detection of a novel orthobunyavirus by metagenomic analysis – the situation after five years, New Squirrel and Rodent Viruses Detected by NGS, Astroviridae – A Growing Family, New Leaves in the Growing Pestivirus Tree, New BTV Serotypes and no End?, and The recently discovered Bokeloh Bat Lyssavirus - Evidence for its continued transmission in Europe. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. The series is a valuable resource for information on all topics of virus research, from bacteriophages to human viruses, with this volume focusing on genomics.

  • Sweet Biochemistry

    Remembering Structures, Cycles, and Pathways by Mnemonics
    • 1 Edición
    • Asha Kumari
    • Inglés
    Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics makes biochemistry lively, interesting and memorable. by connecting objects, images and stories. Dr. Kumari has converted cycles and difficult pathways into very simple formula, very short stories and images which will help readers see familiar things in complicated cycles and better visualize biochemistry.

  • Sport and the Brain: The Science of Preparing, Enduring and Winning, Part B

    • 1 Edición
    • Volumen 234
    • Inglés
    Sport and the Brain: The Science of Preparing, Enduring and Winning, Part B, Volume 233 reflects recent advancements in the understanding of how elite athletes prepare for, and perform at, peak levels under the demands of competition. Topics discussed in this new release include a section on Exploring the Applicability of the Contextual Interference Effect in Sports Practice, The Resonant System: Linking Brain-body-environme... in Sport Performance, the Effects of Acute High-intensity Exercise on Cognitive Performance in Trained Individuals: A Systematic Review, Moving Concussion Care to the Next Level: The Emergence and Role of Concussion Clinics in the UK, and Neurocognitive Mechanisms of the Flow State. This longstanding series takes a multidisciplinary approach, focusing on aspects of psychology, neuroscience, skill learning, talent development and physiology.

  • Research in the Biomedical Sciences

    Transparent and Reproducible
    • 1 Edición
    • Michael Williams + 2 más
    • Inglés
    Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproduc... initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.

  • Food Packaging and Preservation

    • 1 Edición
    • Volumen 9
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Food Packaging and Preservation, Volume 9 in the Handbook of Food Bioengineering series, explores recent approaches to preserving and prolonging safe use of food products while also maintaining the properties of fresh foods. This volume contains valuable information and novel ideas regarding recently investigated packaging techniques and their implications on food bioengineering. In addition, classical and modern packaging materials and the impact of materials science on the development of smart packaging approaches are discussed. This book is a one-stop-shop for anyone in the food industry seeking to understand how bioengineering can foster research and innovation.

  • Role of Nutraceuticals in Cancer Chemosensitization

    • 1 Edición
    • Volumen 2
    • Inglés
    Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy.

  • Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes

    • 1 Edición
    • Miguel Cerrolaza + 2 más
    • Inglés
    Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes covers new and exciting modeling methods to help bioengineers tackle problems for which the Finite Element Method is not appropriate. The book covers a wide range of important subjects in the field of numerical methods applied to biomechanics, including bone biomechanics, tissue and cell mechanics, 3D printing, computer assisted surgery and fluid dynamics. Modeling strategies, technology and approaches are continuously evolving as the knowledge of biological processes increases. Both theory and applications are covered, making this an ideal book for researchers, students and R&D professionals.

  • Functional Connectivity, An Issue of Neuroimaging Clinics of North America

    • 1 Edición
    • Volumen 27-4
    • Jay J. Pillai
    • Inglés
    This issue of Neuroimaging Clinics of North America focuses on Functional Connectivity, and is edited by Dr. Jay Pillai. Articles will include: Applications of rs-fMRI to presurgical mapping: sensorimotor mapping; Dynamic functional connectivity methods; Machine learning applications to rs-fMRI analysis; Frequency domain analysis of rs-fMRI; Applications of rs-fMRI to epilepsy; Data-driven analysis methods for rs-fMRI; Applications of rs-fMRI to presurgical mapping: language mapping; Limitations of rs-fMRI in the setting of focal brain lesions; Applications of rs-fMRI to neuropsychiatric disease; Applications of rs-fMRI to Traumatic Brain Injury; Applications of rs-fMRI to neurodegenerative disease; Graph theoretic analysis of rs-fMRI; and more!

  • Coronary Artery Disease

    From Biology to Clinical Practice
    • 1 Edición
    • Dimitris Tousoulis
    • Inglés
    Coronary Artery Disease: From Biology to Clinical Practice links the most important basic concepts of atherosclerosis pathophysiology to treatment management of coronary artery disease. Comprehensive coverage starts with the basic pathophysiologic mechanisms of the disease, including molecular and genetic mechanisms, cells interaction and inflammation. In addition, sections on novel anti-atherosclerotic therapies and a thorough understanding of the recent trends in clinical management round out this comprehensive tome that is ideal for practitioners and researchers. By summarizing this novel knowledge and changes in diagnostic algorithm and treatment options, this is the perfect reference for cardiology researchers who want a volume with the most up-to-date experimental trends in the field of atherosclerosis, for cardiologists and physicians who manage patients with atherosclerotic risk factors and established coronary artery disease, and medical students who want to learn the basic concepts of atherosclerosis.

  • Food Microstructure and Its Relationship with Quality and Stability

    • 1 Edición
    • Sakamon Devahastin
    • Inglés
    Food Microstructure and Its Relationship with Quality and Stability is a comprehensive overview of the effects that the properties of the underlying structures of food have on its perceived quality to the consumer. The book's first section consists of chapters outlining the fundamentals of food microstructure, food composition, molecular mobility of various food constituents, and their relationships with food quality and stability. The role of various processing technologies in the production of specific microstructures for enhanced quality and stability is outlined. The second part of the book consists of various chapters devoted to microstructures, constituents and their relationship with quality, functionality, and stability of selected foods, for example, food hydrocolloids, frozen seafood, dried foods, extruded products, and dietary fibers. This information is of paramount importance for both academic researchers in the areas of food quality, preservation, and stability, as well as for food developers and processors.

  • Neurocritical Care, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 35-4
    • Alejandro A. Rabinstein
    • Inglés
    This issue of Neurologic Clinics, edited by Dr. Alejandro A. Rabinstein, will cover Neurocritical Care. Topics include, but are not limited to: Anoxic Brain Injury; Treatment of Intracranial Hypertension; Management of Traumatic Brain Injury; Cortical Spreading Depression and Ischemia in Neurocritical Patients; Temperature Control in Acute Brain Injury; HSV Encephalitis; Primary Acute Neuromuscular Respiratory Failure; ICU-Acquired Weakness; Emergency and Critical Care Management of Intracerebral Hemorrhage; New developments in Refractory Status Epilepticus; Acute Cardiac Complications in Critical Brain Disease; Nosocomial Infections in Neurocritical Patients; Neurological Complications after Solid Organ Transplantation; and Shared Decision Making in the NICU.

  • Cancer and Noncoding RNAs

    • 1 Edición
    • Volumen 1
    • Jayprokas Chakrabarti + 1 más
    • Inglés
    Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.

  • Hazard Analysis and Risk-Based Preventive Controls

    Improving Food Safety in Human Food Manufacturing for Food Businesses
    • 1 Edición
    • Hal King + 1 más
    • Inglés
    Hazard Analysis and Risk-Based Preventive Controls: Improving Food Safety in Human Food Manufacturing for Food Businesses is a comprehensive, first of its kind resource for the retail food industry on the Hazard Analysis and Risk-based Preventive Controls (PCHF) regulations of the Food Safety Modernization Act (FSMA). This book covers all aspects of PCHF, including the legislation's intent, applications to ensure safe food production, and resources to keep up-to-date on new food safety hazards and regulatory guidance. Written for food safety professionals and food business leaders, its emphasis on what the retail food industry needs to know about PCHF make it an indispensable resource for organizations buying food from companies required to demonstrate compliance with PCHF. PCHF implementation is (or soon will be) required for human food companies along the supply chain in the United States, as well as all food companies that import ingredients and products for human consumption into the U.S.

  • G Protein-Coupled Receptors Part A

    • 2 Edición
    • Volumen 142
    • Inglés
    G Protein Coupled Receptors, Second Edition, Volume 143, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. It contains a wide array of topics about the G protein coupled receptors, as well as updates of chapters from the first edition.

  • Cellular Aspects of Membrane Permeability

    International Series of Monographs in Pure and Applied Biology: Modern Trends in Physiological Sciences
    • 1 Edición
    • E. Schoffeniels
    • P. Alexander + 1 más
    • Inglés
    Cellular Aspects of Membrane Permeability describes the state of knowledge on permeability problems and interprets experimental results within the framework of working hypotheses. The book discusses membrane permeability with some biochemical perspective presented to explain the origin and adaptations of animal life. The text explains the process and the driving forces affecting the permeability characteristics of the experimental object. It then discusses the distribution of ions and molecules between two phases separated by a living membrane. Then the text analyzes the chemical nature of the molecular architecture that causes such permeability characteristics. The book addresses the electrical potential profiles of epithelial tissues, and then discusses the conducting membranes. It also explains the relationships between inorganic ions, sugar, amino acids, fatty acids, and bioelectric potentials. The book also explains the physical nature of such chemical nature and structure of living membranes. The text then describes the structure of the cellular surface and the structural organization of the cell. The selection can prove useful for biologists, microbiologists, zoologists, and students and professors of biology and its related disciplines.

  • The Handbook of Histopathological Practices in Aquatic Environments

    Guide to Histology for Environmental Toxicology
    • 1 Edición
    • Pedro M. Costa
    • Inglés
    The Handbook of Histopathological Practices in Aquatic Environments: Guide to Histology for Environmental Toxicology offers readers in aquatic biology and other water-based environmental sciences a comprehensive resource on histopathology, which is a key tool in the growing field of ecotoxicology. This work brings together the necessary knowledge, from sample preparation, to trait identification, and scoring and data treatment. Furthermore, with examples from several groups of organisms (from worms to fish), these practices can be applied across a wide array of aquatic ecosystems. This book provides a step-by-step approach to solving the questions researchers encounter in aquatic biology and related fields.

  • Medicinal Plants for Holistic Health and Well-Being

    • 1 Edición
    • Namrita Lall
    • Inglés
    Medicinal Plants for Holistic Health and Well-Being discusses, in depth, the use of South African plants to treat a variety of ailments, including tuberculosis, cancer, periodontal diseases, acne, postmacular hypomelanosis, and more. Plants were selected on the basis of their traditional use, and the book details the scientific evidence that supports their pharmacological and therapeutic potential to safely and effectively treat each disease. Thus, this book is a valuable resource for all researchers, students and professors involved in advancing global medicinal plant research. Many plants found in South Africa are also found in other parts of the world. Each chapter highlights plants from other worldwide locations so that scientists can study which plants belong to the same family, and how similar qualities can be used to treat a specific disease.

  • Arachnoid Cysts

    Clinical and Surgical Management
    • 1 Edición
    • Knut Wester
    • Inglés
    Arachnoid Cysts: Clinical and Surgical Management gives a broad and updated presentation of the condition, including symptomatology, diagnostics, management and treatment. The book covers the effects of surgical treatment on clinical symptoms and the effects cysts have on cognition, as well as cognitive improvement after surgical cyst decompression. This book is written for researchers, residents and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology and pediatrics.

  • Arachnoid Cysts

    Epidemiology, Biology, and Neuroimaging
    • 1 Edición
    • Knut Wester
    • Inglés
    Intracranial arachnoid cysts are congenital malformations with a predilection for the middle cranial fossa and an estimated prevalence in the general population as high as 1.7%. The common assumption is that these cysts are incidental findings and the symptoms associated with them are not caused by the cyst and consequently, that surgical intervention will not benefit the patient. However, there is now a growing understanding reflected in the international literature among neurologists and neurosurgeons that arachnoid cysts do harm and that the patients’ complaints can be relieved by surgical treatment. Arachnoid Cysts: Epidemiology, Biology, and Neuroimaging gives a broad and updated presentation of the condition, including epidemiology, etiology, biology (including genetics and molecular biology), and neuroimaging of same. This book is written for researchers, residents, and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology, and pediatrics.

  • Finding the Nerve

    The Story of Impedance Neurography
    • 1 Edición
    • Philip C Cory
    • Inglés
    Finding the Nerve: The Story of Impedance Neurography discusses research that elucidates the nature of nerve simulation via externally applied electrical fields, and how it has led to an entirely new understanding of neuronal cell membrane biophysics and defined a novel nerve imaging technology. It details how these discoveries came about and the nature of research that derives from unexplained clinical observations. The primary technology, impedance neurography, is a wholly new way of nerve-specific visualization in 2-D or 3-D, with the ability to define both normal and abnormal functioning of nerves, heretofore unavailable from techniques such as MRI neurography. This is of particular importance with respect to the obesity epidemic where physicians performing nerve-related procedures cannot use ultrasound visualization due to the depth limitations of that technology.

  • Environmental Causes and Prevention Measures for Alzheimer’s Disease

    • 1 Edición
    • George J. Brewer
    • Inglés
    Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers.

  • Mutagenicity: Assays and Applications

    • 1 Edición
    • Ashutosh Kumar + 3 más
    • Inglés
    Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

  • Endocrine Biomarkers

    Clinicians and Clinical Chemists in Partnership
    • 1 Edición
    • Hossein Sadrzadeh + 1 más
    • Inglés
    Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.

  • G Protein-Coupled Receptors in Immune Response and Regulation

    • 1 Edición
    • Volumen 136
    • Inglés
    G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors in immune response and pathogenic infections, and sections on GPCR signaling in C. elegans and its implications in immune response, GPCR Kinases in Inflammatory response and signaling, and GRK2 in Inflammation: Regulation of T cell receptors and IgE signaling. Chapters in this book discuss not only the well-known aspects of GPCR signaling in immunology, but also presents many emerging paradigms that have not yet been reported in classical textbooks. Each chapter presents a forward-looking discussion, providing a glimpse of the tremendous potential associated with the specific receptor systems discussed.

  • Therapeutic Foods

    • 1 Edición
    • Volumen 8
    • Alexandru Mihai Grumezescu + 1 más
    • Inglés
    Therapeutic Foods, Volume 8 in the Handbook of Food Bioengineering series, is an essential resource for anyone investigating foods that may be utilized as therapeutic agents. Plants and animal products have been utilized since ancient times as medicine to treat diseases, and the properties within foods and ingredients are still investigated for food therapy and prophylaxis. The book is a comprehensive resource for researchers and scientists already in the field or those just entering. It covers many spices, plant extracts, essential oils and vegetal mixtures that have immune-stimulatory effects and can be efficiently utilized in the treatment of infections and cancer.

  • SPEC – Handbook of Clinical Neurology, Volume 144, Huntington Disease, 12-Month Access, eBook

    • 1 Edición
    • Volumen 144
    • Inglés
    Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.

  • Functionalised Cardiovascular Stents

    • 1 Edición
    • Gerard Wall + 2 más
    • Inglés
    Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 146
    • Inglés
    Advances in Agronomy, Volume 146 is the latest in a series that continues to be recognized as a leading reference for the latest research in agronomy. Updated chapters in this new release include the Significance and Role of Si in Crop Production, National Comparison of the Total and Sequestered Organic Matter Contents of Conventional and Organic Farm Soils, Purine – N Metabolism in Drought or Salinity Challenged Food Security Crops, Plant Rooting and Cropping Systems Management to Improve N Use Efficiency, and The Important Role of Layered Double Hydroxides in Soil Chemical Processes and Remediation: What We Have Learned Over the Past 20 Years. Each volume in the evolving series contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

  • Advances in Genetics

    • 1 Edición
    • Volumen 98
    • Inglés
    Advances in Genetics, Volume 98 provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions. Topics of interest in this updated volume include the Genetics of Mitochondrial Disease, a Genetic analysis of depression, happiness and other normal personality traits, The Evolving Centromere and Kinetochore, and The Genetics of Parkinson’s Disease.

  • Federal Data Science

    Transforming Government and Agricultural Policy Using Artificial Intelligence
    • 1 Edición
    • Feras A. Batarseh + 1 más
    • Inglés
    Federal Data Science serves as a guide for federal software engineers, government analysts, economists, researchers, data scientists, and engineering managers in deploying data analytics methods to governmental processes. Driven by open government (2009) and big data (2012) initiatives, federal agencies have a serious need to implement intelligent data management methods, share their data, and deploy advanced analytics to their processes. Using federal data for reactive decision making is not sufficient anymore, intelligent data systems allow for proactive activities that lead to benefits such as: improved citizen services, higher accountability, reduced delivery inefficiencies, lower costs, enhanced national insights, and better policy making. No other government-dedicated work has been found in literature that addresses this broad topic. This book provides multiple use-cases, describes federal data science benefits, and fills the gap in this critical and timely area. Written and reviewed by academics, industry experts, and federal analysts, the problems and challenges of developing data systems for government agencies is presented by actual developers, designers, and users of those systems, providing a unique and valuable real-world perspective.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 98
    • Inglés
    Advances in Parasitology, Volume 98, first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The latest release in this series contains chapters on The battle against flystrike – past research and new prospects through genomics, Life history, systematics and evolution of the Diplostomoidea Poirier, 1886: progress, promises and challenges emerging from molecular studies, Hook, line and infection: a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback, and Trypanosoma congolense: a molecular toolkit and resources for studying a major livestock pathogen and model trypanosome. The series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications.

  • Neuroepidemiology in Tropical Health

    • 1 Edición
    • Pierre-Marie Preux + 1 más
    • Inglés
    Neuroepidemiology in Tropical Health covers major neurological diseases of relevance in tropical settings and examines the specificities of epidemiology of neurological diseases in the context of tropical countries that face many challenges when compared to the developed world. Part One focuses on methods and their eventual specificities, and how such methods, like sampling, can be adapted for specific scenarios. Parts Two and Three discuss environmental factors and their consequences for neurology in the tropical world, as well as large geographical areas and their specificities. Finally, Part Four presents relevant neurological diseases in in-depth chapters. This invaluable information will help readers recognize the various neurological conditions presented, with the inclusion of their aetiologies and treatment in tropical areas. The book therefore fills a gap in the neuroepidemiology literature, with chapters written by an international collection of experienced authors in the field.

  • Innovative Technologies for Food Preservation

    Inactivation of Spoilage and Pathogenic Microorganisms
    • 1 Edición
    • Francisco J. Barba + 3 más
    • Inglés
    Innovative Technologies for Food Preservation: Inactivation of Spoilage and Pathogenic Microorganisms covers the latest advances in non-thermal processing, including mechanical processes (such as high pressure processing, high pressure homogenization, high hydrodynamic pressure processing, pressurized fluids); electromagnetic technologies (like pulsed electric fields, high voltage electrical discharges, Ohmic heating, chemical electrolysis, microwaves, radiofrequency, cold plasma, UV-light); acoustic technologies (ultrasound, shockwaves); innovative chemical processing technologies (ozone, chlorine dioxide, electrolysis, oxidized water) and others like membrane filtration and dense phase CO2. The title also focuses on understanding the effects of such processing technologies on inactivation of the most relevant pathogenic and spoilage microorganisms to ensure food safety and stability. Over the course of the 20th century, the interest and demand for the development and application of new food preservation methods has increased significantly. The research in the last 50 years has produced various innovative food processing technologies and the use of new technologies for inactivation of spoilage and/or pathogenic microorganisms will depend on several factors. At this stage of development there is a need to better understand the mechanisms that govern microbial inactivation as induced by new and innovative processing technologies, as well as suitable and effective conditions for inactivating the microorganism.

  • Basic Finite Element Method as Applied to Injury Biomechanics

    • 1 Edición
    • King-Hay Yang
    • Inglés
    Basic Finite Element Method as Applied to Injury Biomechanics provides a unique introduction to finite element methods. Unlike other books on the topic, this comprehensive reference teaches readers to develop a finite element model from the beginning, including all the appropriate theories that are needed throughout the model development process. In addition, the book focuses on how to apply material properties and loading conditions to the model, how to arrange the information in the order of head, neck, upper torso and upper extremity, lower torso and pelvis and lower extremity. The book covers scaling from one body size to the other, parametric modeling and joint positioning, and is an ideal text for teaching, further reading and for its unique application to injury biomechanics. With over 25 years of experience of developing finite element models, the author's experience with tissue level injury threshold instead of external loading conditions provides a guide to the "do’s and dont's" of using finite element method to study injury biomechanics.

  • History of Risk Assessment in Toxicology

    • 1 Edición
    • Sol Bobst
    • Inglés
    History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect. The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries. Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested.

  • The Bifidobacteria and Related Organisms

    Biology, Taxonomy, Applications
    • 1 Edición
    • Paola Mattarelli + 3 más
    • Inglés
    The Bifidobacteria and Related Organisms: Biology, Taxonomy, Applications brings together authoritative reviews on all aspects of Bifidobacteria and related genera. Their place within the Phylum Actinobacteria is discussed first, and this is followed by descriptions of the genera Bifidobacterium, Alloscardovia, Aeriscardovia, Bombiscardovia, Gardnerella, Metascardovia, Parascardovia and Scardovia and the currently accredited species within those genera. The increased availability of genome sequences and molecular tools for studying bifidobacteria provides important information about their taxonomy, physiology and interactions with their host. Also considerations about common bifidobacterial core maintenance during the mutual coevolution of a host and its intestinal microbes could be relevant for health claims for the ability of symbiotic gut bacteria to provide health benefits to their host, and for evaluating such claims in scientifically valid experiments. Chemotaxonomy is important to our understanding of these genera and so is considered along with physiological and biochemical aspects before proceeding to examine clinical and other practical aspects. The ability to maintain pure cultures and to grow cells in industrial quantities when required for applications requires that the cells’ environmental and nutritional needs are well understood. Some species are important clinically and as animal digestive tract synbionts—and even play a part in honey production—so these matters are considered along with milk oligosaccharides’ roles in gut flora development in neonates.

  • Environmental Factors in Neurodegenerative Diseases

    • 1 Edición
    • Volumen 1
    • Inglés
    Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

  • Mechanical Circulatory and Respiratory Support

    • 1 Edición
    • Shaun D. Gregory + 2 más
    • Inglés
    Mechanical Circulatory and Respiratory Support is a comprehensive overview of the past, present and future development of mechanical circulatory and respiratory support devices. Content from over 60 internationally-reno... experts focusses on the entire life-cycle of mechanical circulatory and respiratory support – from the descent into heart and lung failure, alternative medical management, device options, device design, implantation techniques, complications and medical management of the supported patient, patient-device interactions, cost effectiveness, route to market and a view to the future. This book is written as a useful resource for biomedical engineers and clinicians who are designing new mechanical circulatory or respiratory support devices, while also providing a comprehensive guide of the entire field for those who are already familiar with some areas and want to learn more. Reviews of the most cutting-edge research are provided throughout each chapter, along with guides on how to design new devices and which areas require specific focus for future research and development.

  • Kent’s Technology of Cereals

    An Introduction for Students of Food Science and Agriculture
    • 5 Edición
    • Kurt A. Rosentrater + 1 más
    • Inglés
    Kent’s Technology of Cereals: An Introduction for Students of Food Science and Agriculture, Fifth Edition, is a classic and well-established book that continues to provide students, researchers and practitioners with an authoritative and comprehensive study of cereal technology. This new edition has been thoroughly updated with new sections, including extrusion cooking and the use of cereals for animal feed. In addition, it offers information on statistics, new products, the impact of climate changes and genetics, new economic trends, nutrition regulations and new technologies. The book is useful for students, researchers, and industrial practitioners alike, covering the full spectrum of cereal grain production, processing, and use for foods, feeds, fuels, industrial materials, and other uses.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 82
    • Inglés
    Advances in Clinical Chemistry, Volume 82, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. This updated volume includes chapters on Calcium and Bone Metabolism Indices, Cytokines and MicroRNA in Coronary Artery Disease, Biological and molecular characterization of circulating tumor cells: A creative strategy for precision medicine?, Towards a blood-borne biomarker of chronic hypoxemia: Red cell distribution width and respiratory disease, miRNAs: nanomachines that microManage the pathophysiology of Diabetes mellitus, and Fortilin, A Potential Target for the Prevention and Treatment of Human Diseases. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Computational Psychiatry

    Mathematical Modeling of Mental Illness
    • 1 Edición
    • Alan Anticevic + 1 más
    • Inglés
    Computational Psychiatry: Mathematical Modeling of Mental Illness is the first systematic effort to bring together leading scholars in the fields of psychiatry and computational neuroscience who have conducted the most impactful research and scholarship in this area. It includes an introduction outlining the challenges and opportunities facing the field of psychiatry that is followed by a detailed treatment of computational methods used in the service of understanding neuropsychiatric symptoms, improving diagnosis and guiding treatments. This book provides a vital resource for the clinical neuroscience community with an in-depth treatment of various computational neuroscience approaches geared towards understanding psychiatric phenomena. Its most valuable feature is a comprehensive survey of work from leaders in this field.

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