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Elsevier

Libros en Ciencias de la Vida

  • Managing the Drug Discovery Process

    How to Make It More Efficient and Cost-Effective
    • 1 Edición
    • Susan Miller + 3 más
    • Inglés
    Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry.

  • Sensory and Instrumental Evaluation of Alcoholic Beverages

    • 1 Edición
    • Hildegarde Heymann + 1 más
    • Inglés
    Sensory and Instrumental Evaluation of Alcoholic Beverages introduces the value of sensory analysis to the alcoholic beverage industry through the detailed lens of sensory analysis techniques. From traditional methods, to the most modern rapid methods, this book presents comprehensive insights and applications. Analytical methods for identifying and assessing the flavor compounds present in the beverages are included that address both volatile and non-volatile techniques, along with rapid methods of assessment. Case studies highlight the testing of different types of alcoholic beverages running the entire gamut of methods and the appropriate subset of methods. Also included is information of data analyses with the appropriate R-codes to allow practitioners to use the book as a handbook to analyze their own data.

  • Individualized Drug Therapy for Patients

    Basic Foundations, Relevant Software and Clinical Applications
    • 1 Edición
    • Roger W Jelliffe + 1 más
    • Inglés
    Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.

  • Developing Solid Oral Dosage Forms

    Pharmaceutical Theory and Practice
    • 2 Edición
    • Yihong Qiu + 4 más
    • Inglés
    Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more.

  • Biomarkers of Kidney Disease

    • 2 Edición
    • Charles L. Edelstein
    • Inglés
    Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine.

  • Cushing's Disease

    An Often Misdiagnosed and Not So Rare Disorder
    • 1 Edición
    • Edward R. Laws Jr + 1 más
    • Inglés
    Cushing’s Disease: An Often Misdiagnosed and Not So Rare Disorder reviews the epidemiology of Cushing’s, including statistics on the incidence and prevalence of this disease. There are discussions of the signs and symptoms and the most common co-morbidities, such as diabetes mellitus, hypertension, osteoporosis, amenorrhea, and infertility. Surgical, medical, and radiotherapeutic treatments, including indications, results, risks, and complications, are reviewed. Also featured is a chapter on the patient’s perspective, coping with Cushing’s, quality of life, and psychosomatic issues. This book is essential reading for the wide range of physicians who treat patients with Cushing’s disease symptoms, as well as biomedical researchers who investigate the etiology and mechanisms of rare genetic diseases, in particular rare endocrine disorders.

  • Krause's Food & the Nutrition Care Process, Iranian Edition

    • 1 Edición
    • L. Kathleen Mahan + 1 más
    • Inglés

  • Mycorrhizal Mediation of Soil

    Fertility, Structure, and Carbon Storage
    • 1 Edición
    • Nancy Collins Johnson + 2 más
    • Inglés
    Mycorrhizal Mediation of Soil: Fertility, Structure, and Carbon Storage offers a better understanding of mycorrhizal mediation that will help inform earth system models and subsequently improve the accuracy of global carbon model predictions. Mycorrhizas transport tremendous quantities of plant-derived carbon below ground and are increasingly recognized for their importance in the creation, structure, and function of soils. Different global carbon models vary widely in their predictions of the dynamics of the terrestrial carbon pool, ranging from a large sink to a large source. This edited book presents a unique synthesis of the influence of environmental change on mycorrhizas across a wide range of ecosystems, as well as a clear examination of new discoveries and challenges for the future, to inform land management practices that preserve or increase below ground carbon storage.

  • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

    • 2 Edición
    • Ali S. Faqi
    • Inglés
    A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

  • Immunopotentiators in Modern Vaccines

    • 2 Edición
    • Virgil E.J.C. Schijns + 1 más
    • Inglés
    Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful.

  • Ambient Assisted Living and Enhanced Living Environments

    Principles, Technologies and Control
    • 1 Edición
    • Ciprian Dobre + 4 más
    • Inglés
    Ambient Assisted Living and Enhanced Living Environments: Principles, Technologies and Control separates the theoretical concepts concerning the design of such systems from their real-world implementations. For each important topic, the book bridges theory and practice, introducing the instruments needed by professionals in their activities. To this aim, topics are presented in a logical sequence, with the introduction of each topic motivated by the need to respond to claims and requirements from a wide range of AAL/ELE applications. The advantages and limitations of each model or technology are presented through concrete case studies for AAL/ELE systems. The book also presents up-to-date technological solutions to the main aspects regarding AAL/ELE systems and applications, a highly dynamic scientific domain that has gained much interest in the world of IT in the last decade. In addition, readers will find discussions on recent AAL/ELE technologies that were designed to solve some of the thorniest business problems that affect applications in areas such as health and medical supply, smart city and smart housing, Big Data and Internet of Things, and many more.

  • Nutrition Economics

    Principles and Policy Applications
    • 1 Edición
    • Suresh Babu + 2 más
    • Inglés
    Nutrition Economics: Principles and Policy Applications establishes the core criteria for consideration as new policies and regulations are developed, including application-based principles that ensure practical, effective implementation of policy. From the economic contribution of nutrition on quality of life, to the costs of malnutrition on society from both an individual and governmental level, this book guides the reader through the factors that can determine the success or failure of a nutrition policy. Written by an expert in policy development, and incorporating an encompassing view of the factors that impact nutrition from an economic standpoint (and their resulting effects), this book is unique in its focus on guiding other professionals and those in advanced stages of study to important considerations for correct policy modeling and evaluation. As creating policy without a comprehensive understanding of the relevant contributing factors that lead to failure is not an option, this book provides a timely reference.

  • The Microwave Processing of Foods

    • 2 Edición
    • Marc Regier + 2 más
    • Inglés
    The Microwave Processing of Foods, Second Edition, has been updated and extended to include the many developments that have taken place over the past 10 years. Including new chapters on microwave assisted frying, microwave assisted microbial inactivation, microwave assisted disinfestation, this book continues to provide the basic principles for microwave technology, while also presenting current and emerging research trends for future use development. Led by an international team of experts, this book will serve as a practical guide for those interested in applying microwave technology.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1 Edición
    • Volumen 73
    • Inglés
    Advances in Carbohydrate Chemistry and Biochemistry has provided, since its inception in 1945, critical and informative articles written by research specialists that integrate the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology to the study of carbohydrates. Its articles present a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Biology of Stress in Fish

    • 1 Edición
    • Volumen 35
    • Carl B. Schreck + 3 más
    • Inglés
    Biology of Stress in Fish: Fish Physiology provides a general understanding on the topic of stress biology, including most of the recent advances in the field. The book starts with a general discussion of stress, providing answers to issues such as its definition, the nature of the physiological stress response, and the factors that affect the stress response. It also considers the biotic and abiotic factors that cause variation in the stress response, how the stress response is generated and controlled, its effect on physiological and organismic function and performance, and applied assessment of stress, animal welfare, and stress as related to model species.

  • The Liver

    Porta Malorum (the Gateway to Disease)
    • 1 Edición
    • Kasper Blond + 1 más
    • Inglés
    The Liver: Porta Malorum (The Gateway to Disease) presents the fundamental aspects and significance of liver as a detoxicating organ. This book explains the diversity of the signs produced by liver damage. Organized into 17 chapters, this book begins with an overview of the process of assimilation through the activities of the liver cells. This text then discusses the emptying mechanisms of the gall-bladder. Other chapters consider the various diseases, including jaundice, pancreatitis, Bright's disease, bronchial asthma, toxic goiter, hemorrhoids, spontaneous thrombosis in the rectal veins, and varicose veins of the leg. This book discusses as well the generally accepted theory concerning the etiology of appendicitis, with emphasis on bacterial inflammation. The final chapter deals with rectal varicose disorders. This book is a valuable resource for hepatologists, pathologists, morphologists, and physicians. Medical students and research workers interested in the fundamental aspects of the liver will also find this book extremely useful.

  • Recent Advances in Animal Nutrition

    • 1 Edición
    • W. Haresign + 1 más
    • Inglés
    Recent Advances in Animal Nutrition — 1986 focuses on developments in the compositions of animal feeds. The book first discusses studies on the fat content of human diet. The text also looks at future trends in the marketing of animal products with particular reference to fats. The book then discusses the manipulation of fat characteristics in animal products; antinutritional factors related with dietary fats and oils; and method of analysis of feedingstuffs for the identification of crude oils. The text highlights the implications for research and the feed compounder of oils and fats determination and the implications of biotechnology for animal nutrition. The book discusses the manipulation of milk yield with growth hormone (GH). Endogenous GH and lactation potential; mechanisms underlying the galactopoietic effects of bovine growth hormone (bGH); and galactopoietic action of exogenous bGH are discussed. The text also explains near infrared reflectance analysis of forages, residues in animal products, and nutrient modulation of the immune system. The book also highlights probiotics in pig diets and use of synthetic amino acids in poultry and pig diets. The book is a good source of information for readers wanting to study the compositions of animal feeds.

  • Lipid Mediators

    • 1 Edición
    • Fiona M. Cunningham
    • Inglés
    The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologist... immunologists, and pharmacologists will find the book invaluable.

  • Perspectives in Basic and Applied Toxicology

    • 1 Edición
    • Bryan Ballantyne
    • Inglés
    Perspectives in Basic and Applied Toxicology features a collection of essays on various aspects of toxicology. It aims to relate fundamental knowledge of toxicology to its application in assessing relevance of that information to the causation of adverse health effects, predicting hazardous situations, defining protective and precautionary measures, and the recognition and management of intoxication in humans. Another objective of this volume is to encourage those with responsibility for the training of toxicologists to instill a greater concern about ethical and moral issues as fundamental to the practice of toxicology as a profession with wide-ranging social implications. This book is organized into 14 chapters. The coverage of these chapters include assessment of chemical hazards in the workplace, the relation between animal studies and epidemiology in the context of industrial toxicology, carcinogenicity testing in animals, and biochemical evaluation of neurotoxicity. This book will be of interest to undergraduate and graduate toxicologists, pharmacologists, physicians, industrial hygienists, and other health professionals.

  • The Human Thymus

    • 1 Edición
    • Gideon Goldstein + 1 más
    • Inglés
    The Human Thymus presents the immunological aspect of the thymus. It discusses the lymphopoietic and immunological functions of the human thymus. It addresses the physiological function of thymus that regulates neuromuscular transmission by the secretion of thymin. Some of the topics covered in the book are the origin of thymic lymphocytes; development of Hassall’s corpuscles; humoral immune responses; neonatal thymectomy and wasting disease; mode of action of thymin at the neuromyal synapse; experimental autoimmune thymitis; and neuromuscular block associated with experimental autoimmune thymitis. The diseases induced with Freund’s complete adjuvant are covered. The spontaneously occurring autoimmune diseases are discussed. The text describes the size of the human thymus. A study of the experimental effect of hormones on thymic size is presented. A chapter is devoted to the thymic hypoplasia and immunological deficiencies. Another section focuses on the histopathology of thymus in myasthenia gravis. The book can provide useful information to scientists, doctors, students, and researchers.

  • Chemotherapy

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1 Edición
    • M. Adolphe
    • Inglés
    Advances in Pharmacology and Therapeutics, Volume 10: Chemotherapy covers the proceedings of the 7th International Congress of Pharmacology. The title presents papers that detail the advancement of pharmacological research in chemotherapy. The text first covers the chemotherapy of schistosomiasis. Next, the selection presents the trends in malaria and cancer chemotherapy, along with their pharmacological research. The text also details the use of cell cultures as tools in pharmacological investigations. The book will be of great interest to pharmacologists and oncologists.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 97
    • Inglés
    Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

  • Motivation

    Theory, Neurobiology and Applications
    • 1 Edición
    • Volumen 229
    • Inglés
    Motivation: Theory, Neurobiology and Applications is inspired by a question central to health care professionals, teachers, parents, and coaches alike, "How can an individual be motivated to perform a given activity or training?" It presents novel measurements of motivation developed in psychology and economics, recent insights into the neurobiology of motivation, and current research on applications designed to boost motivation in neurorehabilitation, education, and sports. In addition, tactics on how to connect these different research and knowledge fields within a common (theoretical) framework of motivation is discussed. Thus, in short, the book provides an integrative, interdisciplinary, up-to-date accounting on the neurobiology of motivation and how it might be boosted.

  • Molecular Diagnostics

    • 3 Edición
    • George P. Patrinos + 2 más
    • Inglés
    Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management.

  • Single-Molecule Enzymology: Fluorescence-Based and High-Throughput Methods

    • 1 Edición
    • Volumen 581
    • Inglés
    Single-Molecule Enzymology, Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in single-molecule enzymology, and includes sections on such topics as force-based and hybrid approaches, fluorescence, high-throughput sm enzymology, nanopores, and tethered particle motion.

  • Dominance and Aggression in Humans and Other Animals

    The Great Game of Life
    • 1 Edición
    • Henry R. Hermann
    • Inglés
    Dominance and Aggression in Humans and Other Animals: The Great Game of Life examines human nature and the influence of evolution, genetics, chemistry, nurture, and the sociopolitical environment as a way of understanding how and why humans behave in aggressive and dominant ways. The book walks us through aggression in other social species, compares and contrasts human behavior to other animals, and then explores specific human behaviors like bullying, abuse, territoriality murder, and war. The book examines both individual and group aggression in different environments including work, school, and the home. It explores common stressors triggering aggressive behaviors, and how individual personalities can be vulnerable to, or resistant to, these stressors. The book closes with an exploration of the cumulative impact of human aggression and dominance on the natural world.

  • Advances in Genetics

    • 1 Edición
    • Volumen 96
    • Inglés
    Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Understanding PCR

    A Practical Bench-Top Guide
    • 1 Edición
    • Sarah Maddocks + 1 más
    • Inglés
    Understanding PCR: A Practical Bench-Top Guide gives you all of the information you need to plan your first PCR, from reagents to conditions to analysis and beyond. It is a user friendly book that has step-by-step basic protocols, which can be adapted to your needs. Includes helpful information such as where to order your reagents and basic troubleshooting hints and tips.

  • Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine

    • 1 Edición
    • Justin Brown + 2 más
    • Inglés
    Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics.

  • Food Protection and Security

    Preventing and Mitigating Contamination during Food Processing and Production
    • 1 Edición
    • Shaun Kennedy
    • Inglés
    Food Protection and Security: Preventing and Mitigating Intentional and Unintentional Contamination of Food and Beverage presents the latest information on our need to protect our food supply from accidental contamination, economically motivated adulteration, and contamination with intent to harm (bioterrorism or agro-terrorism). This book covers all three branches of food protection, providing a comprehensive overview of the methods and strategy involved. Part one covers the need for food protection, looking at potential hazards in the production, processing, and supply chain. Part two looks at detection methods for contaminants in food, with the final section addressing food contamination incidents and prevention and response strategies.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
    • 1 Edición
    • Volumen 38
    • Inglés
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions was first published in 1977, and has been continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each annual provides clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing their expertise each year.

  • Big Mechanisms in Systems Biology

    Big Data Mining, Network Modeling, and Genome-Wide Data Identification
    • 1 Edición
    • Bor-Sen Chen + 1 más
    • Inglés
    Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsistent findings in existing resources. These inconsistencies may reflect the underlying biology time-varying systems and signal transduction events that are often context-dependent, which raises a significant problem for mechanistic modeling since it is not clear which genes/proteins to include in models or experimental measurements. The book is a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in an in-depth understanding on how to process and apply great amounts of biological data to improve research.

  • Glucosinolates

    • 1 Edición
    • Volumen 80
    • Inglés
    Glucosinolates, the latest volume in the Advances in Botanical Research series, presents in-depth and up-to-date reviews on a wide range of topics in the plant sciences, with this edition focusing on glucosinolates. The individual chapters cover all aspects of glucosinolate research from biosynthesis, degradation, regulation, and ecology, to the mechanisms of their health benefits. The chapters are written by the world leaders of glucosinolate research.

  • Management of Periprosthetic Joint Infections (PJIs)

    • 1 Edición
    • J.J. Chris Arts + 1 más
    • Inglés
    Management of Periprosthetic Joint Infections (PJIs): Management of PJIs discusses periprosthetic joint infection (PJI), a fairly rare occurrence that is nonetheless one of the most serious complications in joint replacement surgery. Intricate interactions between the pathogen, the host, and the implant can result in PJIs which are not only physically devastating for the patient, but also financially crippling for health authorities and insurance companies. Actions taken to minimize the risk of PJIs can be extremely challenging for the orthopaedic community. Consequently, new research, which is detailed in this comprehensive book, is being undertaken to minimize and manage these challenging infections.

  • Gut Microbiome and Behavior

    • 1 Edición
    • Volumen 131
    • Inglés
    Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications.

  • Chromatin Regulation and Dynamics

    • 1 Edición
    • Anita Göndör
    • Inglés
    Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.

  • Spinal Muscular Atrophy

    Disease Mechanisms and Therapy
    • 1 Edición
    • Charlotte J Sumner + 2 más
    • Inglés
    Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases.

  • Mesenchymal Stromal Cells as Tumor Stromal Modulators

    • 1 Edición
    • Marcela Bolontrade + 1 más
    • Inglés
    Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.

  • Reactive Species Detection in Biology

    From Fluorescence to Electron Paramagnetic Resonance Spectroscopy
    • 1 Edición
    • Frederick A. Villamena
    • Inglés
    Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis, computations, or experimental applications.

  • Cardioskeletal Myopathies in Children and Young Adults

    • 1 Edición
    • John Lynn Jefferies + 3 más
    • Inglés
    Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40’s-50’s and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health.

  • Developmental Signaling in Plants

    • 1 Edición
    • Volumen 40
    • Inglés
    Developmental Signaling in Plants, the latest volume in The Enzymes series, follows up on the themes discussed in volume 35, notably cell-to-cell and organ-to-organ communication. In addition, it looks at the environmental and hormonal effects on development and the epigenetics on development.

  • Pharmacology in Drug Discovery and Development

    Understanding Drug Response
    • 2 Edición
    • Terry P. Kenakin
    • Inglés
    Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induc... bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.

  • Induced Fish Breeding

    A Practical Guide for Hatcheries
    • 1 Edición
    • Nihar Ranjan Chattopadhyay
    • Inglés
    Induced Fish Breeding: A Practical Guide for Hatcheries takes a successive approach to explaining the use of breeding technology with proven scientific methods. It provides real-life examples for the purpose of maximizing fish and seed production to support overall sustainability in aquaculture. It is a concise reference to understanding the latest developments in the field, useful for anyone who is involved in fisheries or hatchery management as well as researchers and students who need to understand the technology. A practice originally developed to produce quality seed in captivity, induced breeding has made great strides in fish populations for India. The book offers a practical and succinct overview—from existing methods and operations to recent trends and their impacts on aquaculture for the future.

  • Endocrinology of the Heart in Health and Disease

    Integrated, Cellular, and Molecular Endocrinology of the Heart
    • 1 Edición
    • Jonathan C. Schisler + 2 más
    • Inglés
    Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology... the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.

  • A Historical Introduction to Mathematical Modeling of Infectious Diseases

    Seminal Papers in Epidemiology
    • 1 Edición
    • Ivo M. Foppa
    • Inglés
    A Historical Introduction to Mathematical Modeling of Infectious Diseases: Seminal Papers in Epidemiology offers step-by-step help on how to navigate the important historical papers on the subject, beginning in the 18th century. The book carefully, and critically, guides the reader through seminal writings that helped revolutionize the field. With pointed questions, prompts, and analysis, this book helps the non-mathematician develop their own perspective, relying purely on a basic knowledge of algebra, calculus, and statistics. By learning from the important moments in the field, from its conception to the 21st century, it enables readers to mature into competent practitioners of epidemiologic modeling.

  • Mediterranean Marine Mammal Ecology and Conservation

    • 1 Edición
    • Volumen 75
    • Inglés
    Mediterranean Marine Mammal Ecology and Conservation, the latest edition of the Advances in Marine Biology series providing in-depth and up-to-date reviews on all aspects of marine biology since 1963, presents the latest information on Mediterranean marine mammal ecology and conservation. The series is well known for its excellent reviews and editing, and is now edited by Barbara E. Curry (University of Central Florida, USA), along with an internationally renowned Editorial Board. This serial will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography. Volumes cover all areas of marine science, both applied and basic, a wide range of topical areas from all areas of marine ecology, oceanography, fisheries management, molecular biology, and the full range of geographic areas from polar seas to tropical coral reefs.

  • Advances in Food Security and Sustainability

    • 1 Edición
    • Volumen 1
    • Inglés
    Advances in Food Security and Sustainability takes a scientific look at the challenges, constraints, and solutions necessary to maintain a healthy and accessible food supply in different communities around the world. The series addresses a wide range of issues related to the principles and practices of food sustainability and security, exploring challenges related to protecting environmental resources while meeting human nutritional requirements.

  • Marine Enzymes Biotechnology: Production and Industrial Applications, Part II - Marine Organisms Producing Enzymes

    • 1 Edición
    • Volumen 79
    • Inglés
    Marine Enzymes Biotechnology: Production and Industrial Applications, Part II - Marine Organisms Producing Enzymes provides a huge treasure trove of information on marine organisms. Nowadays, marine organisms are good candidates for enzymes production and have been recognized as a rich source of biological molecules that are of potential interest to various industries. Marine enzymes such as amylases, carboxymethylcellula... proteases, chitinases, keratinases, xylanases, agarases, lipases, peroxidase and tyrosinases are widely used in the industry for the manufacture of pharmaceuticals, foods, beverages, and confectioneries, as well as in textile and leather processing, and in waste water treatment. The majority of the enzymes used in the industry are of microbial origin because microbial enzymes are relatively more stable than the corresponding enzymes derived from plants and animals.

  • Alcohol, Drugs, Genes and the Clinical Laboratory

    An Overview for Healthcare and Safety Professionals
    • 1 Edición
    • Amitava Dasgupta
    • Inglés
    Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials.

  • Advances in Immunology

    • 1 Edición
    • Volumen 132
    • Inglés
    Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews on immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

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