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Elsevier

Libros en Ciencias de la Vida

  • The Biology of Cilia and Flagella

    International Series of Monographs on Pure and Applied Biology: Zoology, Vol. 12
    • 1 Edición
    • M. A. Sleigh
    • G. A. Kerkut
    • Inglés
    The Biology of Cilia and Flagella reviews advances in the study of cilia and flagella since 1928. This book focuses on four main topics—structure of cilia, factors that affect ciliary activity, movement of cilia and flagella, and coordination of beat of cilia. In these topics, this compilation specifically discusses the intracellular structures associated with ciliary bases; viscosity of the medium and ciliary activity, and energy relationships of cilia and flagella. The compounding of synchronously beating cilia, variations in shaft structure, and control of ciliary activity by the organism are also elaborated. This text likewise covers the determination of the rate of beat of cilia and root-fiber systems and coordination of ciliary beat. This publication is suitable for biologists and clinicians of other disciplines researching on the structure and physiology of cilia and flagella.

  • Actinomycosis

    • 2 Edición
    • Marcell Bronner + 1 más
    • Inglés
    Actinomycosis, Second Edition covers a comprehensive survey of actinomycosis in existence. The book starts by describing the etiology, microscopical appearance, production of odor, epidemiology and pathogenesis, direction of peripheral spreading, differential and clinical diagnosis, prognosis, and treatment of antinomycosis. The book then discusses cytology and morphology, distribution, pathogenesis, diagnosis, and treatment of aerobic actinomycetes. Saprophytism; parasitism; the classification and morphology of leptotrichia; chief bacteria and cocci in the mouth; and Actinomyces odontolyticus, a new species of antinomycete regularly isolated from deep carious dentine, are also looked into. The book further tackles the discovery of antibiotics and the role of antibiotics in the treatment of actinomycosis. The text also describes the nature and properties, group divisions, mode of action, investigations of sensitivities, methods of administration, and the side effects and toxic effects of penicillin. Antibiotic production in soil; problems of generic nomenclature; relation of actinomycetes to bacteria and fungi; and the classification systems of actinomycetes are also considered. Dental and medical professionals will find the book useful.

  • Marine Auxiliary Machinery

    • 6 Edición
    • David W. Smith + 2 más
    • Inglés
    Marine Auxiliary Machine: Sixth Edition explains the correct operation and maintenance of marine auxiliary machinery. The book discusses topics such as the arrangements of the engine and boiler room; pipes and fittings and pumps; compressors and separators; and heat exchangers - its types, control of temperature, and maintenance. The book also talks about other machineries such as diesel engines, steam turbines, propellers, and gears; refrigeration and air conditioning systems; deck machinery; and safety equipment. The text is recommended for engineers in ships who would like to know more about the auxiliary machines onboard ships, how they are operated, and the principles behind them.

  • Isotope Labeling of Biomolecules – Applications

    • 1 Edición
    • Volumen 566
    • Inglés
    Isotope Labeling of Biomolecules: Applications, the latest in the Methods in Enzymology series, focuses on stable isotope labeling methods and applications for biomolecules. This practical guide to biomolecular labeling looks at new techniques that are becoming widely used.

  • Advances in Immunology

    • 1 Edición
    • Volumen 129
    • Inglés
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Polymers and Nanomaterials for Gene Therapy

    • 1 Edición
    • Ravin Narain
    • Inglés
    Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy.

  • Ebola Virus Disease

    From Origin to Outbreak
    • 1 Edición
    • Adnan I. Qureshi
    • Inglés
    Ebola Virus Disease: From Origins to Outbreak covers Ebola virus disease in its entirety from its origins through major outbreaks in the past to the present day outbreak. It contains information on the West Saharan response to Ebola as well as highlights from the field in West Africa from Dr. Qureshi and Dr. Chughtai, helping to solve the primary question of what’s next and aiding in formulating a path forward. With a growing awareness of the devastating effects of this viral disease and an influx of topical research, this book provides the information the global community of researchers, clinicians and students need to better inform their research and study of Ebola virus disease.

  • Dynamic Plasma Membranes: Portals Between Cells and Physiology

    • 1 Edición
    • Volumen 77
    • Inglés
    This volume focuses on the recent advances in understanding plasma membrane organization and function beginning with simple systems and extending to specialized membrane domains of vertebrate cells.

  • Synthesis of Best-Seller Drugs

    • 1 Edición
    • Ruben Vardanyan + 1 más
    • Inglés
    Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

  • Humpback Dolphins (Sousa spp.): Current Status and Conservation, Part 2

    • 1 Edición
    • Volumen 73
    • Inglés
    Humpback Dolphins (Sousa spp.): Current Status and Conservation, Part 2 is part of Advances in Marine Biology, a series that has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963 — more than 50 years of outstanding coverage from a reference that is well known for its contents and editing. This latest addition to the series includes updates on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography. Specialty areas for the series include marine science, both applied and basic, a wide range of topical areas from all corners of marine ecology, oceanography, fisheries management, and molecular biology, and the full range of geographic areas from polar seas to tropical coral reefs.

  • Psychophysics

    A Practical Introduction
    • 2 Edición
    • Frederick A.A. Kingdom + 1 más
    • Inglés
    Psychophysics: A Practical Introduction, Second Edition, is the primary scientific tool for understanding how the physical world of colors, sounds, odors, movements, and shapes translates into the sensory world of sight, hearing, touch, taste, and smell; in other words, how matter translates into mind. This timely revision provides a unique introduction to the techniques for researching and understanding how the brain translates the external physical world to the internal world of sensation. The revision expands and refines coverage of the basic tools of psychophysics research and better integrates the theory with the supporting software. The new edition continues to be the only book to combine, in a single volume, the principles underlying the science of psychophysical measurement and the practical tools necessary to analyze data from psychophysical experiments. The book, written in a tutorial style, will appeal to new researchers as well as to seasoned veterans. This introduction to psychophysics research methods will be of interest to students, scholars and researchers within sensory neuroscience, vision research, behavioral neuroscience, and the cognitive sciences.

  • Abiotic and Biotic Stresses in Soybean Production

    Soybean Production Volume 1
    • 1 Edición
    • Mohammad Miransari
    • Inglés
    Abiotic and Biotic Stresses in Soybean Production: Soybean Production Volume One presents the important results of research in both field and greenhouse conditions that guide readers to effectively manage the chemical, physical, and biological factors that can put soybean production at risk. Including the latest in genetics, signaling, and biotechnology, the book identifies these types of stresses, their causes, and means of avoiding, then addresses existing stresses to provide a comprehensive overview of key production yield factors. By presenting important insights into the historical and emerging uses for soybean, the book educates readers on the factors for consideration as new uses are developed. It is an ideal complement to volume two, Environmental Stress Conditions in Soybean Production, that work together to provide valuable insights into crop protection.

  • Viral Pathogenesis

    From Basics to Systems Biology
    • 3 Edición
    • Michael G. Katze + 3 más
    • Inglés
    Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interactio... networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.

  • Peanuts

    Genetics, Processing, and Utilization
    • 1 Edición
    • Thomas Stalker + 1 más
    • Inglés
    Peanuts: Genetics, Processing, and Utilization (Oilseed Monograph) presents innovations in crop productivity and processing technologies that help ensure global food security and high quality peanut products. The authors cover three central themes, modern breeding methods for development of agronomic varieties in the U.S., China, West Central Africa, and India, enhanced crop protection and quality through information from the peanut genome sequence, and state-of-the-art processing and manufacturing of products in market environments driven by consumer perception, legislation, and governmental policy.

  • Neuroscience of Pain, Stress, and Emotion

    Psychological and Clinical Implications
    • 1 Edición
    • Magne Arve Flaten + 1 más
    • Inglés
    Neuroscience of Pain, Stress, and Emotion: Psychological and Clinical Implications presents updated research on stress, pain, and emotion, all key research areas within both basic and clinical neuroscience. Improved research understanding of their interaction is ultimately necessary if clinicians and those working in the field of psychosomatic medicine are to alleviate patient suffering. This volume offers broad coverage of that interaction, with chapters written by major researchers in the field. After reviewing the neuroscience of pain and stress, the contents go on to address the interaction between stress and chronic/acute pain, the role of different emotions in pain, neurobiological mechanisms mediating these various interactions, individual differences in both stress and pain, the role of patient expectations during treatment (placebo and nocebo responses), and how those relate to stress modulation. While there are books on the market which discuss pain, stress, and emotion separately, this volume is the first to tackle their nexus, thus appealing to both researchers and clinicians.

  • Antimicrobial Food Packaging

    • 1 Edición
    • Jorge Barros-Velazquez
    • Inglés
    Antimicrobial Food Packaging takes an interdisciplinary approach to provide a complete and robust understanding of packaging from some of the most well-known international experts. This practical reference provides basic information and practical applications for the potential uses of various films in food packaging, describes the different types of microbial targets (fungal, bacteria, etc.), and focuses on the applicability of techniques to industry. Tactics on the monitoring of microbial activity that use antimicrobial packaging detection of food borne pathogens, the use of biosensors, and testing antimicrobial susceptibility are also included, along with food safety and good manufacturing practices. The book aims to curtail the development of microbiological contamination of food through anti-microbial packaging to improve the safety in the food supply chain.

  • Relationship Inference with Familias and R

    Statistical Methods in Forensic Genetics
    • 1 Edición
    • Thore Egeland + 2 más
    • Inglés
    Relationship Inference in Familias and R discusses the use of Familias and R software to understand genetic kinship of two or more DNA samples. This software is commonly used for forensic cases to establish paternity, identify victims or analyze genetic evidence at crime scenes when kinship is involved. The book explores utilizing Familias software and R packages for difficult situations including inbred families, mutations and missing data from degraded DNA. The book additionally addresses identification following mass disasters, familial searching, non-autosomal marker analysis and relationship inference using linked markers. The second part of the book focuses on more statistical issues such as estimation and uncertainty of model parameters. Although written for use with human DNA, the principles can be applied to non-human genetics for animal pedigrees and/or analysis of plants for agriculture purposes. The book contains necessary tools to evaluate any type of forensic case where kinship is an issue.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 1 Edición
    • George C. Tsokos
    • Inglés
    Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

  • Clinical Engineering

    From Devices to Systems
    • 1 Edición
    • Roberto Miniati + 2 más
    • Inglés
    Clinical Systems Engineering: New Challenges for Future Healthcare covers the critical issues relating to the risk management and design of new technologies in the healthcare sector. It is a comprehensive summary of the advances in clinical engineering over the past 40 years, presenting guidance on compliance and safety for hospitals and engineering teams. This contributed book contains chapters from international experts, who provide their solutions, experiences, and the successful methodologies they have applied to solve common problems in the area of healthcare technology. Topics include compliance with the European Directive on Medical Devices 93/42/EEC, European Norms EN 60601-1-6, EN 62366, and the American Standards ANSI/AAMI HE75: 2009. Content coverage includes decision support systems, clinical complex systems, and human factor engineering. Examples are fully supported with case studies, and global perspective is maintained throughout. This book is ideal for clinical engineers, biomedical engineers, hospital administrators and medical technology manufacturers.

  • Rapid Detection of Food Adulterants and Contaminants

    Theory and Practice
    • 1 Edición
    • Shyam Narayan Jha
    • Inglés
    Rapid Detection of Food Adulterants and Contaminants: Theory and Practice contains solid information on common adulterants and contaminants in various foods, guidelines for different standards, permissible limits prescribed by food regulatory authorities, and related detection techniques. This is an essential reference for anyone interested in progressive research on detection methods for food safety, especially researchers engaged in developing fast, reliable, and often nondestructive methods for the evaluation of food safety.

  • Laterality

    Exploring the Enigma of Left-Handedness
    • 1 Edición
    • Clare Porac
    • Inglés
    Left-handedness has been connected to many different conditions, traits, and abilities. This is especially true for pathological syndromes, such as schizophrenia, along with learning disabilities and autism. The published research on handedness is vast and frequently contradictory, often raising more questions than providing answers. Questions such as: Is handedness genetic? Can handedness be changed? Are there consequences to training someone to switch handedness? Are there positive traits associated with left-handedness like creativity? Are there negative traits associated with left-handedness like trouble reading maps? Is it abnormal to do some things right-handed and other things left-handed? Are the brains of left-handers different from the brains of right-handers? Laterality: Exploring the Enigma of Left-Handedness examines the research conducted over the past 50 years with special emphasis on twenty-first century research on handedness and translates this literature into an accessible and readable form. Each chapter is based on a question or questions covering diverse topics such as genetic and biological origins of handedness, familial and hormonal influences on handedness, and the effects of a majority right-handed world on the behaviors of left-handers.

  • Encyclopedia of Food Grains

    • 2 Edición
    • Colin W Wrigley + 3 más
    • Inglés
    The Encyclopedia of Food Grains, Four Volume Set is an in-depth and authoritative reference covering all areas of grain science. Coverage includes everything from the genetics of grains to the commercial, economic and social aspects of this important food source. Also covered are the biology and chemistry of grains, the applied aspects of grain production and the processing of grains into various food and beverage products. With the paramount role of cereals as a global food source, this Encyclopedia is sure to become the standard reference work in the field of science. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedire...

  • Drug-Like Properties

    Concepts, Structure Design and Methods from ADME to Toxicity Optimization
    • 2 Edición
    • Li Di + 1 más
    • Inglés
    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 8- Human Diseases
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington’s disease, Parkin’s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

  • Hydrogenation of Fats and Oils

    Theory and Practice
    • 2 Edición
    • Gary R. List + 1 más
    • Inglés
    As in the first edition, discussion is not confined to vegetable oils, and the hydrogenation technique is considered in detail. The "why" as well as the "how" of hydrogenation are addressed. Written for both production staff who need advice on specific problems and development personnel who seek directions, if not solutions, the book offers direct practical advice along with explanations of why changes occur as they do. The glossary of technical terms contains a more detailed explanation of some features mentioned throughout the text.

  • CAPA in the Pharmaceutical and Biotech Industries

    How to Implement an Effective Nine Step Program
    • 1 Edición
    • J Rodriguez
    • Inglés
    CAPA in the Pharmaceutical and Biotech Industries: How to Implement an Effective Nine Step Program contains the most current information on how to implement, develop, and maintain an effective Corrective Action and Preventive Action (CAPA) and investigation program using a nine step closed-loop process approach for medical devices and pharmaceutical and biologic manufacturers, as well as any anyone who has to maintain a quality system.This book addresses how companies often make the mistake of fixing problems in their processes by revising procedures or, more commonly, by retraining employees that may or may not have caused the problem. This event-focused fix leads to the false assumption that the errors have been eradicated and will be prevented in the future. The reality is that the causes of the failure were never actually determined, therefore the same problem will recur over and over. CAPA is a complete system that collects information regarding existing and potential quality problems. It analyzes and investigates the issues to identify the root cause of nonconformities. It is not just a quick-fix, simple approach, it is a process and has to be understood throughout organizations.

  • The Fungi

    • 3 Edición
    • Sarah C. Watkinson + 2 más
    • Inglés
    The Fungi, Third Edition, offers a comprehensive and thoroughly integrated treatment of the biology of the fungi. This modern synthesis highlights the scientific foundations that continue to inform mycologists today, as well as recent breakthroughs and the formidable challenges in current research. The Fungi combines a wide scope with the depth of inquiry and clarity offered by three leading fungal biologists. The book describes the astonishing diversity of the fungi, their complex life cycles, and intriguing mechanisms of spore release. The distinctive cell biology of the fungi is linked to their development as well as their metabolism and physiology. One of the great advances in mycology in recent decades is the recognition of the vital importance of fungi in the natural environment. Plants are supported by mycorrhizal symbioses with fungi, are attacked by other fungi that cause plant diseases, and are the major decomposers of their dead tissues. Fungi also engage in supportive and harmful interactions with animals, including humans. They are major players in global nutrient cycles. This book is written for undergraduates and graduate students, and will also be useful for professional biologists interested in familiarizing themselves with specific topics in fungal biology.

  • FORWARD to Professorship in STEM

    Inclusive Faculty Development Strategies That Work
    • 1 Edición
    • Rachelle S. Heller + 2 más
    • Inglés
    FORWARD to Professorship in STEM: Inclusive Faculty Development Strategies That Work provides best practices on how to design and implement inclusive workshops aimed at supporting faculty and staff in their career development. The book addresses fundamental skills and strategies to excel in academia, with a focus on assisting women and other underrepresented groups to succeed in obtaining tenure-track faculty positions, and in acquiring tenure. Contributors from wide geographical, disciplinary, and career backgrounds offer their insights on challenges in academia, lessons learned, successes, and outcomes, with chapters devoted to tenure and beyond, collaborations and funding, impact on, and of, the deaf culture, and engaging differences.

  • Amphioxus Immunity

    Tracing the Origins of Human Immunity
    • 1 Edición
    • An-Long Xu
    • Inglés
    Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity.

  • Molecular Nutrition and Diabetes

    A Volume in the Molecular Nutrition Series
    • 1 Edición
    • Didac Mauricio
    • Inglés
    Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.

  • Introduction to Protein Mass Spectrometry

    • 1 Edición
    • Pradip K. Ghosh
    • Inglés
    Introduction to Protein Mass Spectrometry provides a comprehensive overview of this increasingly important, yet complex, analytical technique. Unlike many other methods which automatically yield an absolutely unique protein name as output, protein mass spectrometry generally requires a deduction of protein identity from determination of peptide fragmentation products. This book enables readers to both understand, and appreciate, how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. Citing the most recent and relevant work in the field of biological mass spectrometry, the book is written for researchers and scientists new to the field, but is also an ideal resource for those hoping to hone their analytical abilities.

  • Cells and Tissues in Culture

    Methods, Biology and Physiology
    • 1 Edición
    • E. N. Willmer
    • Inglés
    Cells and Tissues in Culture: Methods, Biology and Physiology, Volume 1 covers the general fields of tissue culture, including an evaluation of its technique, effects, and contributions to biology. This book focuses on the three methods of culture—tissue culture, cell culture, and organ culture.Other topics include the design of complete synthetic media, possible evolution of the cell types, and energy relationships in growing and stationary cells. The RNA synthesis in cell cultures, culture of amphibian embryonic anlage, action of corticosteroids and adrenaline, and effects of parathyroid hormone on bone are also elaborated. This volume is recommended for biologists and specialists interested in the culture of cells and tissues.

  • Water, Radiation, Salt, and Other Stresses

    • 2 Edición
    • J. Levitt
    • Inglés
    Responses of Plants to Environmental Stresses, Second Edition, Volume II: Water, Radiation, Salt, and Other Stresses focuses on the effects of stresses on plants. This book discusses how stresses produce their damaging effects and how living organisms defend themselves against stresses. Organized into six parts encompassing 12 chapters, this edition starts with an overview of the various responses of plants to the severities of all the other environmental stresses, with emphasis on the physical and biological stresses and strains. This text then describes water stress in plants, which arise either from an excessive or from an insufficient water activity in the plant's environment. Other chapters consider the resistance to drought stress of plants. This book discusses as well the effects of flooding, which replaces gaseous air by liquid water. The final chapter deals with the comparative stress responses of plants. This book is a valuable resource for plant biologists.

  • The Photosystems

    Structure, Function and Molecular Biology
    • 1 Edición
    • Volumen 11
    • J. Barber
    • Inglés
    There is very little in this eleventh volume of Topics in Photosynthesis which could have been written when the first volume was published fifteen years ago. Advances over the last decade have been spectacular, most particularly in our understanding of the photosystems that is the subject of this volume. After a comparative introducution of bacterial and plant photosystems, the book begins with a consideration of what is theoretically possible in energy conversion. This is followed by light harvesting in photosystems II, followed by its molecular biology, protein engineering, thermoluminescence, photoinhibition, the effect of herbicides and heat shock, and, most important function of all and one about which so little is yet understood at the molecular level, the process by which it evolves oxygen. The last three chapters deal with the equivalent processes of photosystem I. The whole volume tells the story of a natural system of incredible ingenuity and complexity, but which as the chapters unfold, is seen to be within our grasp and eventual ability to comprehend.

  • Why and How

    Some Problems and Methods in Historical Biology
    • 1 Edición
    • George Gaylord Simpson
    • Mario Bunge
    • Inglés
    Why and How: Some Problems and Methods in Historical Biology discusses an overall approach to the study of fossils combined with paleontology. This book is divided into six chapters. Chapter 1 consists of a few examples of studies of the fossil record, focusing on its adequacy, and ways of looking at and representing some of its aspects. The most basic aspects of study of the fossil record such as the examination, description, and illustration of the morphology of fossils are described in Chapter 2. Chapter 3 focuses on paleoecology and faunal analysis, while Chapter 4 emphasizes some of the aspects of phylogenetic principles and eclectic taxonomic theory. The essential apparatus for zoological studies that include biometrical statistics both in concepts and in measures are deliberated in Chapter 5. The last chapter deliberates the geographic distribution of organisms. This publication is a good source for paleontologists and biologists interested in historical biology.

  • Handbook of Lipids in Human Function

    Fatty Acids
    • 1 Edición
    • Ronald Ross Watson + 1 más
    • Inglés
    Handbook of Lipids in Human Function: Fatty Acids presents current research relating to health issues whose impact may be modified by adopting personalized diets and lifestyle interventions of the consumption of fatty acids. Addressing cardiovascular and neurological diseases as well as cancer, obesity, inflammatory conditions, and lung disease, the authors correlate lipid sources with specific conditions, providing important insights into preventative as well as response-based actions designed to positively impact health outcomes. The material is presented in 29 chapters and brings together the research and work of an international team of experts. designed to bridge the gap between traditional approaches to dietary interventions and leading edge integrated health strategies, Handbook of Lipids in Human Function: Fatty Acids is a valuable resource for researchers and clinicians.

  • Epigenetic Biomarkers and Diagnostics

    • 1 Edición
    • Jose Luis Garcia-Gimenez
    • Inglés
    Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.

  • Exploration, Identification and Utilization of Barley Germplasm

    • 1 Edición
    • Guoping Zhang + 1 más
    • Inglés
    Exploration, Identification and Utilization of Barley Germplasm explores the timely global challenges related to barley production posed by the narrowing of biodiversity and problem soils, identifying elite genotypes which will enhance barley breeding and be essential to genetic and evolution studies. The book covers the utilization of barley germplasm for improving the quality of both food and feed barley as well as exploring and utilizing varieties of germplasm that are tolerant to drought, waterlogged, salt, and acid soil. Chapters are devoted to prime strategies for future research, including identifying barley germplasm by applying Omics, exploring barley germplasm by means of the Focused Identification of Germplasm Strategy (FIGS), and creating barley germplasm through mutation. Users will find this book to be a key research reference for both professionals and academics, providing a comprehensive update for established barley researchers that equips them with an understanding of the new methodologies needed for innovation and discovery, while also providing a helpful entry to the subject for young researchers and students.

  • Advances in Smart Medical Textiles

    Treatments and Health Monitoring
    • 1 Edición
    • Lieva van Langenhove
    • Inglés
    Advances in Smart Medical Textiles: Treatments and Health Monitoring provides comprehensive coverage on smart textiles, the emerging and important materials that are finding applications in the fields of medicine and healthcare. The book explores the range of smart textiles available for use in medicine and the transfer of these innovative technologies into medical applications. Early chapters survey various smart fibers, fabrics, and finishes, while subsequent sections focus on the role of smart textiles in treating patients, from wound care to rehabilitation, and the use of textile-based sensors and wearable electronics for monitoring patient health.

  • Anaerobiosis and Stemness

    An Evolutionary Paradigm for Therapeutic Applications
    • 1 Edición
    • Zoran Ivanovic + 1 más
    • Inglés
    Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration.

  • Cuban Blindness

    Diary of a Mysterious Epidemic Neuropathy
    • 1 Edición
    • Gustavo C. Román
    • Inglés
    On May 4, 1993, Cuba asked the international health community and the World Health Organization (WHO) to find the cause of a mysterious epidemic of blindness that was spreading uncontrollably. Contradictory hypotheses confronted the team of scientists on this mission. Is the epidemic the result of a plot to topple Castro, as the Cubans believe? Or exposure to radioactivity or an unidentified nerve toxin accidentally released by the Russian Army withdrawing from Cuba?Cuban Blindness: Diary of a Mysterious Epidemic Neuropathy is a firsthand account of the epidemic of blindness and the hardships of life in Cuba at the time of the "special period" that followed the collapse of the Soviet Union and the tightening of the US embargo. Dr. Román—who was at the time Chief of Neuroepidemiology at the US National Institutes of Health—was a participant in this scientific mission and describes the neurological symptoms experienced by the victims of this epidemic disease, and narrates the epidemiologists’ detective work struggling to solve the mystery. This book combines neuroscience and scientific discovery with political intrigue, finally bringing the reader to the unexpected solution provided by a WWII survivor of Changi POW Camp in Singapore. Cuban Blindness: Diary of a Mysterious Epidemic Neuropathy is a description of the neuroepidemiological study undertaken to identify the cause of the epidemic neurological disease that affected Cuba in 1993-1994.

  • Endocannabinoids

    • 1 Edición
    • Volumen 125
    • Inglés
    Endocannabinoids, the latest volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into the neurobiology of migraines. It reviews the current knowledge and understanding in the field, and provides a starting point for researchers and practitioners entering the field.

  • A Historical Perspective on Evidence-Based Immunology

    • 1 Edición
    • Edward J. Moticka
    • Inglés
    A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.

  • Plant Microbe Interactions

    • 1 Edición
    • Volumen 75
    • Inglés
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 75th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology.

  • Platelet-Activating Factor Acetylhydrolases (PAF-AH)

    • 1 Edición
    • Volumen 38
    • Inglés
    This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field.

  • Translational Medicine: Tools And Techniques

    • 1 Edición
    • Aamir Shahzad
    • Inglés
    Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine.

  • Engineered Nanoparticles

    Structure, Properties and Mechanisms of Toxicity
    • 1 Edición
    • Ashok K. Singh
    • Inglés
    Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects.

  • Mitochondrial Case Studies

    Underlying Mechanisms and Diagnosis
    • 1 Edición
    • Russell Saneto + 2 más
    • Inglés
    Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments.

  • Plant Cyclotides

    • 1 Edición
    • Volumen 76
    • Inglés
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 76th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology.

  • Regulatory T Cells in Health and Disease

    • 1 Edición
    • Volumen 136
    • Inglés
    Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

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