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Elsevier

Libros en Ciencias de la Vida

  • Antimicrobial Food Packaging

    • 1 Edición
    • Jorge Barros-Velazquez
    • Inglés
    Antimicrobial Food Packaging takes an interdisciplinary approach to provide a complete and robust understanding of packaging from some of the most well-known international experts. This practical reference provides basic information and practical applications for the potential uses of various films in food packaging, describes the different types of microbial targets (fungal, bacteria, etc.), and focuses on the applicability of techniques to industry. Tactics on the monitoring of microbial activity that use antimicrobial packaging detection of food borne pathogens, the use of biosensors, and testing antimicrobial susceptibility are also included, along with food safety and good manufacturing practices. The book aims to curtail the development of microbiological contamination of food through anti-microbial packaging to improve the safety in the food supply chain.

  • Relationship Inference with Familias and R

    Statistical Methods in Forensic Genetics
    • 1 Edición
    • Thore Egeland + 2 más
    • Inglés
    Relationship Inference in Familias and R discusses the use of Familias and R software to understand genetic kinship of two or more DNA samples. This software is commonly used for forensic cases to establish paternity, identify victims or analyze genetic evidence at crime scenes when kinship is involved. The book explores utilizing Familias software and R packages for difficult situations including inbred families, mutations and missing data from degraded DNA. The book additionally addresses identification following mass disasters, familial searching, non-autosomal marker analysis and relationship inference using linked markers. The second part of the book focuses on more statistical issues such as estimation and uncertainty of model parameters. Although written for use with human DNA, the principles can be applied to non-human genetics for animal pedigrees and/or analysis of plants for agriculture purposes. The book contains necessary tools to evaluate any type of forensic case where kinship is an issue.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 1 Edición
    • George C. Tsokos
    • Inglés
    Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

  • Clinical Engineering

    From Devices to Systems
    • 1 Edición
    • Roberto Miniati + 2 más
    • Inglés
    Clinical Systems Engineering: New Challenges for Future Healthcare covers the critical issues relating to the risk management and design of new technologies in the healthcare sector. It is a comprehensive summary of the advances in clinical engineering over the past 40 years, presenting guidance on compliance and safety for hospitals and engineering teams. This contributed book contains chapters from international experts, who provide their solutions, experiences, and the successful methodologies they have applied to solve common problems in the area of healthcare technology. Topics include compliance with the European Directive on Medical Devices 93/42/EEC, European Norms EN 60601-1-6, EN 62366, and the American Standards ANSI/AAMI HE75: 2009. Content coverage includes decision support systems, clinical complex systems, and human factor engineering. Examples are fully supported with case studies, and global perspective is maintained throughout. This book is ideal for clinical engineers, biomedical engineers, hospital administrators and medical technology manufacturers.

  • Rapid Detection of Food Adulterants and Contaminants

    Theory and Practice
    • 1 Edición
    • Shyam Narayan Jha
    • Inglés
    Rapid Detection of Food Adulterants and Contaminants: Theory and Practice contains solid information on common adulterants and contaminants in various foods, guidelines for different standards, permissible limits prescribed by food regulatory authorities, and related detection techniques. This is an essential reference for anyone interested in progressive research on detection methods for food safety, especially researchers engaged in developing fast, reliable, and often nondestructive methods for the evaluation of food safety.

  • Laterality

    Exploring the Enigma of Left-Handedness
    • 1 Edición
    • Clare Porac
    • Inglés
    Left-handedness has been connected to many different conditions, traits, and abilities. This is especially true for pathological syndromes, such as schizophrenia, along with learning disabilities and autism. The published research on handedness is vast and frequently contradictory, often raising more questions than providing answers. Questions such as: Is handedness genetic? Can handedness be changed? Are there consequences to training someone to switch handedness? Are there positive traits associated with left-handedness like creativity? Are there negative traits associated with left-handedness like trouble reading maps? Is it abnormal to do some things right-handed and other things left-handed? Are the brains of left-handers different from the brains of right-handers? Laterality: Exploring the Enigma of Left-Handedness examines the research conducted over the past 50 years with special emphasis on twenty-first century research on handedness and translates this literature into an accessible and readable form. Each chapter is based on a question or questions covering diverse topics such as genetic and biological origins of handedness, familial and hormonal influences on handedness, and the effects of a majority right-handed world on the behaviors of left-handers.

  • Encyclopedia of Food Grains

    • 2 Edición
    • Colin W Wrigley + 3 más
    • Inglés
    The Encyclopedia of Food Grains, Four Volume Set is an in-depth and authoritative reference covering all areas of grain science. Coverage includes everything from the genetics of grains to the commercial, economic and social aspects of this important food source. Also covered are the biology and chemistry of grains, the applied aspects of grain production and the processing of grains into various food and beverage products. With the paramount role of cereals as a global food source, this Encyclopedia is sure to become the standard reference work in the field of science. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedire...

  • Drug-Like Properties

    Concepts, Structure Design and Methods from ADME to Toxicity Optimization
    • 2 Edición
    • Li Di + 1 más
    • Inglés
    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 8- Human Diseases
    • 1 Edición
    • M. A. Hayat
    • Inglés
    Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington’s disease, Parkin’s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

  • Hydrogenation of Fats and Oils

    Theory and Practice
    • 2 Edición
    • Gary R. List + 1 más
    • Inglés
    As in the first edition, discussion is not confined to vegetable oils, and the hydrogenation technique is considered in detail. The "why" as well as the "how" of hydrogenation are addressed. Written for both production staff who need advice on specific problems and development personnel who seek directions, if not solutions, the book offers direct practical advice along with explanations of why changes occur as they do. The glossary of technical terms contains a more detailed explanation of some features mentioned throughout the text.

  • CAPA in the Pharmaceutical and Biotech Industries

    How to Implement an Effective Nine Step Program
    • 1 Edición
    • J Rodriguez
    • Inglés
    CAPA in the Pharmaceutical and Biotech Industries: How to Implement an Effective Nine Step Program contains the most current information on how to implement, develop, and maintain an effective Corrective Action and Preventive Action (CAPA) and investigation program using a nine step closed-loop process approach for medical devices and pharmaceutical and biologic manufacturers, as well as any anyone who has to maintain a quality system.This book addresses how companies often make the mistake of fixing problems in their processes by revising procedures or, more commonly, by retraining employees that may or may not have caused the problem. This event-focused fix leads to the false assumption that the errors have been eradicated and will be prevented in the future. The reality is that the causes of the failure were never actually determined, therefore the same problem will recur over and over. CAPA is a complete system that collects information regarding existing and potential quality problems. It analyzes and investigates the issues to identify the root cause of nonconformities. It is not just a quick-fix, simple approach, it is a process and has to be understood throughout organizations.

  • The Fungi

    • 3 Edición
    • Sarah C. Watkinson + 2 más
    • Inglés
    The Fungi, Third Edition, offers a comprehensive and thoroughly integrated treatment of the biology of the fungi. This modern synthesis highlights the scientific foundations that continue to inform mycologists today, as well as recent breakthroughs and the formidable challenges in current research. The Fungi combines a wide scope with the depth of inquiry and clarity offered by three leading fungal biologists. The book describes the astonishing diversity of the fungi, their complex life cycles, and intriguing mechanisms of spore release. The distinctive cell biology of the fungi is linked to their development as well as their metabolism and physiology. One of the great advances in mycology in recent decades is the recognition of the vital importance of fungi in the natural environment. Plants are supported by mycorrhizal symbioses with fungi, are attacked by other fungi that cause plant diseases, and are the major decomposers of their dead tissues. Fungi also engage in supportive and harmful interactions with animals, including humans. They are major players in global nutrient cycles. This book is written for undergraduates and graduate students, and will also be useful for professional biologists interested in familiarizing themselves with specific topics in fungal biology.

  • FORWARD to Professorship in STEM

    Inclusive Faculty Development Strategies That Work
    • 1 Edición
    • Rachelle S. Heller + 2 más
    • Inglés
    FORWARD to Professorship in STEM: Inclusive Faculty Development Strategies That Work provides best practices on how to design and implement inclusive workshops aimed at supporting faculty and staff in their career development. The book addresses fundamental skills and strategies to excel in academia, with a focus on assisting women and other underrepresented groups to succeed in obtaining tenure-track faculty positions, and in acquiring tenure. Contributors from wide geographical, disciplinary, and career backgrounds offer their insights on challenges in academia, lessons learned, successes, and outcomes, with chapters devoted to tenure and beyond, collaborations and funding, impact on, and of, the deaf culture, and engaging differences.

  • Amphioxus Immunity

    Tracing the Origins of Human Immunity
    • 1 Edición
    • An-Long Xu
    • Inglés
    Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity.

  • Molecular Nutrition and Diabetes

    A Volume in the Molecular Nutrition Series
    • 1 Edición
    • Didac Mauricio
    • Inglés
    Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.

  • Introduction to Protein Mass Spectrometry

    • 1 Edición
    • Pradip K. Ghosh
    • Inglés
    Introduction to Protein Mass Spectrometry provides a comprehensive overview of this increasingly important, yet complex, analytical technique. Unlike many other methods which automatically yield an absolutely unique protein name as output, protein mass spectrometry generally requires a deduction of protein identity from determination of peptide fragmentation products. This book enables readers to both understand, and appreciate, how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. Citing the most recent and relevant work in the field of biological mass spectrometry, the book is written for researchers and scientists new to the field, but is also an ideal resource for those hoping to hone their analytical abilities.

  • Cells and Tissues in Culture

    Methods, Biology and Physiology
    • 1 Edición
    • E. N. Willmer
    • Inglés
    Cells and Tissues in Culture: Methods, Biology and Physiology, Volume 1 covers the general fields of tissue culture, including an evaluation of its technique, effects, and contributions to biology. This book focuses on the three methods of culture—tissue culture, cell culture, and organ culture.Other topics include the design of complete synthetic media, possible evolution of the cell types, and energy relationships in growing and stationary cells. The RNA synthesis in cell cultures, culture of amphibian embryonic anlage, action of corticosteroids and adrenaline, and effects of parathyroid hormone on bone are also elaborated. This volume is recommended for biologists and specialists interested in the culture of cells and tissues.

  • Water, Radiation, Salt, and Other Stresses

    • 2 Edición
    • J. Levitt
    • Inglés
    Responses of Plants to Environmental Stresses, Second Edition, Volume II: Water, Radiation, Salt, and Other Stresses focuses on the effects of stresses on plants. This book discusses how stresses produce their damaging effects and how living organisms defend themselves against stresses. Organized into six parts encompassing 12 chapters, this edition starts with an overview of the various responses of plants to the severities of all the other environmental stresses, with emphasis on the physical and biological stresses and strains. This text then describes water stress in plants, which arise either from an excessive or from an insufficient water activity in the plant's environment. Other chapters consider the resistance to drought stress of plants. This book discusses as well the effects of flooding, which replaces gaseous air by liquid water. The final chapter deals with the comparative stress responses of plants. This book is a valuable resource for plant biologists.

  • The Photosystems

    Structure, Function and Molecular Biology
    • 1 Edición
    • Volumen 11
    • J. Barber
    • Inglés
    There is very little in this eleventh volume of Topics in Photosynthesis which could have been written when the first volume was published fifteen years ago. Advances over the last decade have been spectacular, most particularly in our understanding of the photosystems that is the subject of this volume. After a comparative introducution of bacterial and plant photosystems, the book begins with a consideration of what is theoretically possible in energy conversion. This is followed by light harvesting in photosystems II, followed by its molecular biology, protein engineering, thermoluminescence, photoinhibition, the effect of herbicides and heat shock, and, most important function of all and one about which so little is yet understood at the molecular level, the process by which it evolves oxygen. The last three chapters deal with the equivalent processes of photosystem I. The whole volume tells the story of a natural system of incredible ingenuity and complexity, but which as the chapters unfold, is seen to be within our grasp and eventual ability to comprehend.

  • Why and How

    Some Problems and Methods in Historical Biology
    • 1 Edición
    • George Gaylord Simpson
    • Mario Bunge
    • Inglés
    Why and How: Some Problems and Methods in Historical Biology discusses an overall approach to the study of fossils combined with paleontology. This book is divided into six chapters. Chapter 1 consists of a few examples of studies of the fossil record, focusing on its adequacy, and ways of looking at and representing some of its aspects. The most basic aspects of study of the fossil record such as the examination, description, and illustration of the morphology of fossils are described in Chapter 2. Chapter 3 focuses on paleoecology and faunal analysis, while Chapter 4 emphasizes some of the aspects of phylogenetic principles and eclectic taxonomic theory. The essential apparatus for zoological studies that include biometrical statistics both in concepts and in measures are deliberated in Chapter 5. The last chapter deliberates the geographic distribution of organisms. This publication is a good source for paleontologists and biologists interested in historical biology.

  • Handbook of Lipids in Human Function

    Fatty Acids
    • 1 Edición
    • Ronald Ross Watson + 1 más
    • Inglés
    Handbook of Lipids in Human Function: Fatty Acids presents current research relating to health issues whose impact may be modified by adopting personalized diets and lifestyle interventions of the consumption of fatty acids. Addressing cardiovascular and neurological diseases as well as cancer, obesity, inflammatory conditions, and lung disease, the authors correlate lipid sources with specific conditions, providing important insights into preventative as well as response-based actions designed to positively impact health outcomes. The material is presented in 29 chapters and brings together the research and work of an international team of experts. designed to bridge the gap between traditional approaches to dietary interventions and leading edge integrated health strategies, Handbook of Lipids in Human Function: Fatty Acids is a valuable resource for researchers and clinicians.

  • Epigenetic Biomarkers and Diagnostics

    • 1 Edición
    • Jose Luis Garcia-Gimenez
    • Inglés
    Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.

  • Exploration, Identification and Utilization of Barley Germplasm

    • 1 Edición
    • Guoping Zhang + 1 más
    • Inglés
    Exploration, Identification and Utilization of Barley Germplasm explores the timely global challenges related to barley production posed by the narrowing of biodiversity and problem soils, identifying elite genotypes which will enhance barley breeding and be essential to genetic and evolution studies. The book covers the utilization of barley germplasm for improving the quality of both food and feed barley as well as exploring and utilizing varieties of germplasm that are tolerant to drought, waterlogged, salt, and acid soil. Chapters are devoted to prime strategies for future research, including identifying barley germplasm by applying Omics, exploring barley germplasm by means of the Focused Identification of Germplasm Strategy (FIGS), and creating barley germplasm through mutation. Users will find this book to be a key research reference for both professionals and academics, providing a comprehensive update for established barley researchers that equips them with an understanding of the new methodologies needed for innovation and discovery, while also providing a helpful entry to the subject for young researchers and students.

  • Advances in Smart Medical Textiles

    Treatments and Health Monitoring
    • 1 Edición
    • Lieva van Langenhove
    • Inglés
    Advances in Smart Medical Textiles: Treatments and Health Monitoring provides comprehensive coverage on smart textiles, the emerging and important materials that are finding applications in the fields of medicine and healthcare. The book explores the range of smart textiles available for use in medicine and the transfer of these innovative technologies into medical applications. Early chapters survey various smart fibers, fabrics, and finishes, while subsequent sections focus on the role of smart textiles in treating patients, from wound care to rehabilitation, and the use of textile-based sensors and wearable electronics for monitoring patient health.

  • Anaerobiosis and Stemness

    An Evolutionary Paradigm for Therapeutic Applications
    • 1 Edición
    • Zoran Ivanovic + 1 más
    • Inglés
    Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration.

  • Cuban Blindness

    Diary of a Mysterious Epidemic Neuropathy
    • 1 Edición
    • Gustavo C. Román
    • Inglés
    On May 4, 1993, Cuba asked the international health community and the World Health Organization (WHO) to find the cause of a mysterious epidemic of blindness that was spreading uncontrollably. Contradictory hypotheses confronted the team of scientists on this mission. Is the epidemic the result of a plot to topple Castro, as the Cubans believe? Or exposure to radioactivity or an unidentified nerve toxin accidentally released by the Russian Army withdrawing from Cuba?Cuban Blindness: Diary of a Mysterious Epidemic Neuropathy is a firsthand account of the epidemic of blindness and the hardships of life in Cuba at the time of the "special period" that followed the collapse of the Soviet Union and the tightening of the US embargo. Dr. Román—who was at the time Chief of Neuroepidemiology at the US National Institutes of Health—was a participant in this scientific mission and describes the neurological symptoms experienced by the victims of this epidemic disease, and narrates the epidemiologists’ detective work struggling to solve the mystery. This book combines neuroscience and scientific discovery with political intrigue, finally bringing the reader to the unexpected solution provided by a WWII survivor of Changi POW Camp in Singapore. Cuban Blindness: Diary of a Mysterious Epidemic Neuropathy is a description of the neuroepidemiological study undertaken to identify the cause of the epidemic neurological disease that affected Cuba in 1993-1994.

  • Endocannabinoids

    • 1 Edición
    • Volumen 125
    • Inglés
    Endocannabinoids, the latest volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into the neurobiology of migraines. It reviews the current knowledge and understanding in the field, and provides a starting point for researchers and practitioners entering the field.

  • A Historical Perspective on Evidence-Based Immunology

    • 1 Edición
    • Edward J. Moticka
    • Inglés
    A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.

  • Plant Microbe Interactions

    • 1 Edición
    • Volumen 75
    • Inglés
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 75th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology.

  • Platelet-Activating Factor Acetylhydrolases (PAF-AH)

    • 1 Edición
    • Volumen 38
    • Inglés
    This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field.

  • Translational Medicine: Tools And Techniques

    • 1 Edición
    • Aamir Shahzad
    • Inglés
    Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine.

  • Engineered Nanoparticles

    Structure, Properties and Mechanisms of Toxicity
    • 1 Edición
    • Ashok K. Singh
    • Inglés
    Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects.

  • Mitochondrial Case Studies

    Underlying Mechanisms and Diagnosis
    • 1 Edición
    • Russell Saneto + 2 más
    • Inglés
    Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments.

  • Plant Cyclotides

    • 1 Edición
    • Volumen 76
    • Inglés
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 76th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology.

  • Regulatory T Cells in Health and Disease

    • 1 Edición
    • Volumen 136
    • Inglés
    Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

  • Basement Membranes

    • 1 Edición
    • Volumen 76
    • Inglés
    Basement Membranes focuses on specialized extracellular matrices that provide the scaffolds used and required by cells to organize themselves into tissues and organs. As basement membranes have been shown to be defective in numerous genetic and acquired diseases and to contribute to the microenvironment of both tumor cells and stem cells, this book presents a view of specific basement membrane components and their roles in development and disease, all written and commented on in chapters written by leaders in the basement membrane field.

  • Advances in Genetics

    • 1 Edición
    • Volumen 92
    • Inglés
    Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Regulating Safety of Traditional and Ethnic Foods

    • 1 Edición
    • V. Prakash + 6 más
    • Inglés
    Regulating Safety of Traditional and Ethnic Foods, a compilation from a team of experts in food safety, nutrition, and regulatory affairs, examines a variety of traditional foods from around the world, their risks and benefits, and how regulatory steps may assist in establishing safe parameters for these foods without reducing their cultural or nutritive value. Many traditional foods provide excellent nutrition from sustainable resources, with some containing nutraceutical properties that make them not only a source of cultural and traditional value, but also valuable options for addressing the growing need for food resources. This book discusses these ideas and concepts in a comprehensive and scientific manner.

  • International Review of Cell and Molecular Biology

    • 1 Edición
    • Volumen 320
    • Kwang W. Jeon
    • Inglés
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology, and includes articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists.

  • Applications of NMR Spectroscopy: Volume 1

    • 1 Edición
    • Atta-ur Rahman + 1 más
    • Inglés
    Applications of NMR Spectroscopy, Volume 1, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of edible oils and lipid content in foods, the role of NMR spectroscopy in the human metabolomics and the diagnosis of autism-related disorders, protein-protein interactions, and NMR spectroscopy of chiral molecules. The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field.

  • Applications of NMR Spectroscopy: Volume 3

    • 1 Edición
    • Atta-ur Rahman + 1 más
    • Inglés
    Applications of NMR Spectroscopy, Volume 3 presents the latest developments in the field of NMR spectroscopy, including the analysis of the structure-property relationship of polyphenols, breast cancer diagnosis, drug discovery and formulation, protein confirmation analysis using Fluorine NMR, and enaminone studies. The well-illustrated chapters contain comprehensive references to the recent literature. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. The book is organized into sections based on disciplines such as food science and medical diagnostics, with each chapter written by eminent experts in the field. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference.

  • Biosynthetic Polymers for Medical Applications

    • 1 Edición
    • Laura Poole-Warren + 2 más
    • Inglés
    Biosynthetic Polymers for Medical Applications provides the latest information on biopolymers, the polymers that have been produced from living organisms and are biodegradable in nature. These advanced materials are becoming increasingly important for medical applications due to their favorable properties, such as degradability and biocompatibility. This important book provides readers with a thorough review of the fundamentals of biosynthetic polymers and their applications. Part One covers the fundamentals of biosynthetic polymers for medical applications, while Part Two explores biosynthetic polymer coatings and surface modification. Subsequent sections discuss biosynthetic polymers for tissue engineering applications and how to conduct polymers for medical applications.

  • Fossil Parasites

    • 1 Edición
    • Volumen 90
    • Tim Littlewood + 1 más
    • Inglés
    Fossil Parasites, the latest edition in the Advances in Parasitology series established in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology, including medical studies of parasites of major influence, such as plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. Parasitism is a dominant life history strategy and we know it has existed for millions of years. Detecting parasitism in the fossil record is problematic because we rarely see direct evidence and usually must rely on indirect evidence to infer its existence. This unique volume takes a broad and systematic view of direct and indirect evidence for parasitism in the fossil record.

  • Advances in Tuna Aquaculture

    From Hatchery to Market
    • 1 Edición
    • Daniel Benetti + 2 más
    • Inglés
    Advances in Tuna Aquaculture: From Hatchery to Market provides detailed overviews on the current status of tuna fisheries, fattening, and farming practices, as well as advances in closed-cycle tuna aquaculture. Contributors are renowned scientists, internationally recognized as authorities in their fields. This book addresses all basic and applied aspects of tuna aquaculture, presenting and discussing the global status of tuna fisheries, reproduction, broodstock management, spawning, larval rearing and early developmental stages including nursery and grow out methods. It presents incorporates the most comprehensive and updated data, statistics, and trends in tuna fisheries and aquaculture, covering and addresses a variety of topics ranging fromfrom endocrinology, nutrition, diseases, and genetics to economics and markets. It covers describes recent up-to-date progress on tuna aquaculture and hatchery development. It also provides a synopsisn overview of the challenges presently confronted by tuna aquaculturists,facin... tuna aquaculture and and offers innovative views on the challengesbottle-nec... issues faced by the industry with the current shift from fisheries to fattening to closed-cycle aquaculture. This is the first book to encompass all aspects related to the tuna aquaculture industry, and merges them into a state-of-the-art compendium that will serve as seminal reference for students, researchers, and professionals working with tuna biology, fisheries, and aquaculture worldwide.

  • Axons and Brain Architecture

    • 1 Edición
    • Kathleen Rockland
    • Inglés
    Several excellent monographs exist which deal with axons. These, however, focus either on the cellular and molecular biology of axons proper or on network organization of connections, the latter with only an incidental or abstract reference to axons per se. Still relatively neglected, however, is the middle ground of terminations and trajectories of single axons in the mammalian central nervous system. This middle level of connectivity, between networks on the one hand and local, in vitro investigations on the other, is to some extent represented by retrograde tracer studies and labeled neurons, but there have so far been many fewer of the complementary anterograde studies, with total visualization of the axonal arborization. The present volume brings together in one source an interrelated treatment of single axons from the perspective of microcircuitry and as substrates of larger scale organization (tractography). Especially for the former area - axons in microcircuitry - an abundance of published data exists, but these are typically in specialty journals that are not often accessed by the broader community. By highlighting and unifying the span from microcircuitry to tractography, the proposed volume serves as a convenient reference source and in addition inspires further interactions between what currently tend to be separate communities. The volume also redresses the imbalance between in vitro/local connectivity and long-distance connections. Focusing on mammalian systems, Part 1 of this book is devoted to anatomical investigations of connections at the single axon level, drawing on modern techniques and classical methods from the 1990s. A particular emphasis is on broad coverage of cortical and subcortical connections from different species, so that common patterns of divergence, convergence, and collateralization can be easily appreciated. Part 2 addresses mechanisms of axon guidance, as these seem particularly relevant to pathways and branching patterns. Part 3 covers axon dynamics and functional aspects; and Part 4 focuses on tractography, notably including comparisons between histological substrates and imaging.

  • Atlas of the Human Brain

    • 4 Edición
    • Juergen K Mai + 2 más
    • Inglés
    The fourth edition of Atlas of the Human Brain presents the anatomy of the brain at macroscopic and microscopic levels, featuring different aspects of brain morphology and topography. This greatly enlarged new edition provides the most detailed and accurate delineations of brain structure available. It includes features which assist in the new fields of neuroscience – functional imaging, resting state imaging and tractography. Atlas of the Human Brain is an essential guide to those working with human brain imaging or attempting to relate their observations on experimental animals to humans. Totally new in this edition is the inclusion of Nissl plates with delineation of cortical areas (Brodmann’s areas), the first time that these areas have been presented in serial histological sections.

  • Drug Discovery in Cancer Epigenetics

    • 1 Edición
    • Gerda Egger + 1 más
    • Inglés
    Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic.

  • Medical Textile Materials

    • 1 Edición
    • Yimin Qin
    • Inglés
    Medical Textile Materials provides the latest information on technical textiles and how they have found a wide range of medical applications, from wound dressings and sutures, to implants and tissue scaffolds. This book offers a systematic review of the manufacture, properties, and applications of these technical textiles. After a brief introduction to the human body, the book gives an overview of medical textile products and the processes used to manufacture them. Subsequent chapters cover superabsorbent textiles, functional wound dressings, bandages, sutures, implants, and other important medical textile technologies. Biocompatibility testing and regulatory control are then addressed, and the book finishes with a review of research and development strategy for medical textile products.

  • Recent Advances in Microbial Oxygen-Binding Proteins

    • 1 Edición
    • Volumen 67
    • Inglés
    This latest volume in Advances in Microbial Physiology continues the long tradition of topical and important reviews in microbiology.

  • Atlas of Early Zebrafish Brain Development

    A Tool for Molecular Neurogenetics
    • 2 Edición
    • Dr. Thomas Mueller + 1 más
    • Inglés
    Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain.

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