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Elsevier

Libros en Ciencias de la Vida

  • Medicinal Chemistry of Anticancer Drugs

    • 2 Edición
    • Carmen Avendaño + 1 más
    • Inglés
    Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

  • Waking and the Reticular Activating System in Health and Disease

    • 1 Edición
    • Edgar Garcia-Rill
    • Inglés
    Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating” properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders.

  • Handbook of Fertility

    Nutrition, Diet, Lifestyle and Reproductive Health
    • 1 Edición
    • Ronald Ross Watson
    • Inglés
    Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health focuses on the ways in which food, dietary supplements, and toxic agents, including alcohol and nicotine affect the reproductive health of both women and men. Researchers in nutrition, diet, epidemiology, and endocrinology will find this comprehensive resource invaluable in their long-term goal of understanding and improving reproductive health. This book brings together a broad range of experts researching the different aspects of foods and dietary supplements that promote or detract from reproductive health. Section One contains several overview chapters on fertility, how it is assessed, and how it can be affected by different metabolic states, nutritional habits, dietary supplements, the action of antioxidants, and lifestyle choices. Sections Two and Three consider how male and female fertility are affected by obesity, metabolic syndrome, hormonal imbalance, and even bariatric surgery. Section Four explores the ways diet, nutrition, and lifestyle support or retard the success of in vitro fertilization, while Section Five explores how alcohol and other drugs of abuse lower fertility in both women and men.

  • Basic Principles of Drug Discovery and Development

    • 1 Edición
    • Benjamin E. Blass
    • Inglés
    Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

  • The Science and Ethics of Antipsychotic Use in Children

    • 1 Edición
    • Nina Di Pietro + 1 más
    • Inglés
    The Science and Ethics of Antipsychotic Use in Children reviews the latest findings for the safety and efficacy of the rapidly rising incidence of antipsychotic use in children and examines tensions that are created by off-label use, both in clinical psychiatric practice and research.In the past ten years, the number of antipsychotics prescribed to children with psychiatric disorders has skyrocketed. Despite this rapid growth, most medications have been inadequately studied in children for safety or efficacy and many have serious adverse health. Measures are needed to ensure that the health and safety of children are being protected, and debates have emerged over whether or not clinical trials in this population should be conducted.

  • Essentials of Medical Biochemistry

    With Clinical Cases
    • 2 Edición
    • Chung Eun Ha + 1 más
    • Inglés
    Essentials of Medical Biochemistry, Second Edition: With Clinical Cases is the most condensed, yet detailed biochemistry overview available on the topic. It presents contemporary coverage of the fundamentals of biochemistry, emphasizing relevant physiologic and pathophysiologic biochemical concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find basic and fundamental concepts that will aid students and professionals in biochemistry, medicine, and other healthcare disciplines. the text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 91
    • Inglés
    A compilation of up to date reviews of topics in biotechnology and the medical field.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 69
    • Inglés
    Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Studies in Natural Products Chemistry

    • 1 Edición
    • Volumen 46
    • Inglés
    Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 46 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry.

  • Monoclonal Antibodies

    Meeting the Challenges in Manufacturing, Formulation, Delivery and Stability of Final Drug Product
    • 1 Edición
    • Steven Shire
    • Inglés
    Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies.

  • Regenerative Engineering of Musculoskeletal Tissues and Interfaces

    • 1 Edición
    • Syam Nukavarapu + 2 más
    • Inglés
    Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces.

  • Modeling Food Processing Operations

    • 1 Edición
    • Serafim Bakalis + 2 más
    • Inglés
    Computational modeling is an important tool for understanding and improving food processing and manufacturing. It is used for many different purposes, including process design and process optimization. However, modeling goes beyond the process and can include applications to understand and optimize food storage and the food supply chain, and to perform a life cycle analysis. Modeling Food Processing Operations provides a comprehensive overview of the various applications of modeling in conventional food processing. The needs of industry, current practices, and state-of-the-art technologies are examined, and case studies are provided. Part One provides an introduction to the topic, with a particular focus on modeling and simulation strategies in food processing operations. Part Two reviews the modeling of various food processes involving heating and cooling. These processes include: thermal inactivation; sterilization and pasteurization; drying; baking; frying; and chilled and frozen food processing, storage and display. Part Three examines the modeling of multiphase unit operations such as membrane separation, extrusion processes and food digestion, and reviews models used to optimize food distribution.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 88
    • Inglés
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2013 impact factor is 4.36

  • Grapevine Breeding Programs for the Wine Industry

    • 1 Edición
    • Andrew G. Reynolds
    • Inglés
    Grapevine Breeding Programs for the Wine Industry: Traditional and Molecular Techniques summarizes recent trends in grapevine breeding, both in terms of research and practical programs. The first group of chapters covers the challenges faced by breeders and existing and emerging techniques used to combat them. Two further groups of chapters focus on grapevine breeding programs in different wine-producing countries around the world. With authoritative contributions from experts across the world’s winemaking regions, this book will be an essential reference for all those involved in viticulture and oeneology wanting to explore new methods, understand different approaches and refine existing practices.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 131
    • Inglés
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. Five volumes are published yearly which ensures that authors’ contributions are disseminated to the readership in a timely manner. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • The Protective Arm of the Renin Angiotensin System (RAS)

    Functional Aspects and Therapeutic Implications
    • 1 Edición
    • Thomas Unger + 2 más
    • Inglés
    The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications.

  • Sunflower

    Chemistry, Production, Processing, and Utilization
    • 1 Edición
    • Enrique Martínez-Force + 2 más
    • Inglés
    This comprehensive reference delivers key information on all aspects of sunflower. With over 20 chapters, this book provides an extensive review of the latest developments in sunflower genetics, breeding, processing, quality, and utilization; including food, energy and industrial bioproduct applications. World-renowned experts in this field review U.S. and international practices, production, and processing aspects of sunflower.

  • Antimicrobial Resistance and Food Safety

    Methods and Techniques
    • 1 Edición
    • Chin-Yi Chen + 2 más
    • Inglés
    Antimicrobial Resistance and Food Safety: Methods and Techniques introduces antimicrobial resistant food-borne pathogens, their surveillance and epidemiology, emerging resistance and resistant pathogens. This analysis is followed by a systematic presentation of currently applied methodology and technology, including advanced technologies for detection, intervention, and information technologies. This reference can be used as a practical guide for scientists, food engineers, and regulatory personnel as well as students in food safety, food microbiology, or food science.

  • Nerves and Nerve Injuries

    Vol 2: Pain, Treatment, Injury, Disease and Future Directions
    • 1 Edición
    • R. Shane Tubbs + 5 más
    • Inglés
    Nerves and Nerve Injuries is a must-have for clinicians and researchers dealing with the Peripheral Nervous System and neuropathy. An indispensable work for anyone studying the nerves or treating patients with nerve injuries, these books will become the ‘go to’ resource in the field. The nerves are treated in a systematic manner, discussing details such as their anatomy (both macro- and microscopic), physiology, examination (physical and imaging), pathology, and clinical and surgical interventions. The authors contributing their expertise are international experts on the subject. The books cover topics from detailed nerve anatomy and embryology to cutting-edge knowledge related to treatment, disease and mathematical modeling of the nerves. Nerves and Nerve Injuries Volume 2 focuses on pain, treatment, injury, disease and future directions in the field. This volume also addresses new information regarding neural interfaces, stem cells, medical and surgical treatments, and medical legal issues following nerve injury.

  • Nerves and Nerve Injuries

    Vol 1: History, Embryology, Anatomy, Imaging, and Diagnostics
    • 1 Edición
    • R. Shane Tubbs + 5 más
    • Inglés
    Nerves and Nerve Injuries is the first comprehensive work devoted to the nerves of the body. An indispensable work for anyone studying the nerves or treating patients with nerve injuries, these books will become the ‘go to’ resource in the field. The nerves are treated in a systematic manner, discussing details such as their anatomy (both macro- and microscopic), physiology, examination (physical and imaging), pathology, and clinical and surgical interventions. The authors contributing their expertise are international experts on the subject. The books cover topics from detailed nerve anatomy and embryology to cutting-edge knowledge related to treatment, disease and mathematical modeling of the nerves. Nerves and Nerve Injuries Volume 1 focuses on the history of nerves, embryology, anatomy, imaging, and diagnostics. This volume provides a greatly detailed overview of the anatomy of the peripheral and cranial nerves as well as comprehensive details of imaging modalities and diagnostic tests.

  • Olive and Olive Oil Bioactive Constituents

    • 1 Edición
    • Dimitrios Boskou
    • Inglés
    The market is flooded with products posing as elixirs, supplements, functional foods, and olive oil alternatives containing phenols obtained from multiple olive sources. This technically-oriented book will be of value to nutritionists and researchers in the biosciences. It unravels the body of science pertaining to olive minor constituents in relation to new chemical knowledge, technological innovations, and novel methods of recovery, parallel to toxicology, pharmacology, efficacy, doses, claims, and regulation. Topics include: the biological importance of bioactive compounds present in olive products; developments and innovations to preserve the level of bioactives in table olives and olive oil; and importance of variety, maturity, processing of olives, storage, debittering of olives and table olives as a valuable source of bioactive compounds.

  • Sensorimotor Rehabilitation

    At the Crossroads of Basic and Clinical Sciences
    • 1 Edición
    • Volumen 218
    • Inglés
    This volume of Progress in Brain Research focuses on Sensorimotor Rehabilitation.

  • Psychology and Geriatrics

    Integrated Care for an Aging Population
    • 1 Edición
    • Benjamin A. Bensadon
    • Inglés
    Psychology and Geriatrics demonstrates the value of integrating psychological knowledge and insight with medical training and geriatric care. Leading physician and geropsychologist contributors come together to share their collective wisdom about topics that are as emotionally uncomfortable as they are universally relevant. As the world struggles to respond to unprecedented gains in life expectancy and an explosion of new retirees living with chronic health conditions, this collaboration could not be more timely. This exceptional resource is, itself, evidence that physicians and psychologists can work together to optimize truly patient-centered geriatric care. Here at last is a scientifically rigorous, evidence-based response to the aging mind and body from those most expertly trained.

  • Dielectric Properties of Agricultural Materials and their Applications

    • 1 Edición
    • Stuart Nelson
    • Inglés
    Dielectric Properties of Agricultural Materials and Their Applications provides an understanding of the fundamental principles governing dielectric properties of materials, describes methods for measuring such properties, and discusses many applications explored for solving industry problems. The information in this reference stimulates new research for solving problems associated with production, handling, and processing of agricultural and food products. Anyone seeking a better understanding of dielectric properties of materials and application of radio-frequency and microwave electromagnetic energy for solution of problems in agriculture and related fields will find this an essential resource.

  • Stellate Cells in Health and Disease

    • 1 Edición
    • Chandrashekhar Gandhi + 1 más
    • Inglés
    Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.

  • Advances in the Study of Behavior

    • 1 Edición
    • Volumen 47
    • Marc Naguib
    • Inglés
    This is a special 50th year anniversary volume of Advances in the Study of Behavior with contributions from past and present editors and authors of the serial. Initiated 50 years ago, Advances in the Study of Behavior strives to serve the increasing number of scientists engaged in the study of animal behavior. That number is still expanding. This volume makes another important "contribution to the development of the field" by presenting theoretical ideas and research to those studying animal behavior and to their colleagues in neighboring fields.

  • The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

    • 1 Edición
    • Rainer Straub
    • Inglés
    Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituita... axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging.

  • Principles of Measurement and Transduction of Biomedical Variables

    • 1 Edición
    • Vera Button
    • Inglés
    Principles of Measurement and Transduction of Biomedical Variables is a comprehensive text on biomedical transducers covering the principles of functioning, application examples and new technology solutions. It presents technical and theoretical principles to measure biomedical variables, such as arterial blood pressure, blood flow, temperature and CO2 concentration in exhaled air and their transduction to an electrical variable, such as voltage, so they can be more easily quantified, processed and visualized as numerical values and graphics. The book includes the functioning principle, block diagram, modelling equations and basic application of different transducers, and is an ideal resource for teaching measurement and transduction of biomedical variables in undergraduate and postgraduate biomedical engineering programs.

  • Membrane Proteins – Production and Functional Characterization

    • 1 Edición
    • Volumen 556
    • Inglés
    Membrane Proteins – Production and Function Characterization a volume of Methods in Enzymology, encompasses chapters from the leading experts in the area of membrane protein biology. The chapters provide a brief overview of the topics covered and also outline step-by-step protocol. Illustrations and case example images are included wherever appropriate to help the readers understand the schematics and general experimental outlines.

  • Principles of Translational Science in Medicine

    From Bench to Bedside
    • 2 Edición
    • Martin Wehling
    • Inglés
    Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine.

  • Global Legislation for Food Contact Materials

    • 1 Edición
    • J.S. Baughan
    • Inglés
    Food contact materials such as packaging, storage containers and processing surfaces can pose a substantial hazard to both food manufacturer and consumer due to the migration of chemicals or other substances from the material to the food, which can cause tainting of flavours and other sensory characteristics, or even illness. This book reviews the main materials used for food contact in terms of the global legislation in place to ensure their safe and effective use. Part One provides an overview of food contact legislation issues such as chemical migration and compliance testing. Part Two looks in detail at the legislation for specific food contact materials and their advantages, hazards and use in industry.

  • Integrative Approaches for Health

    Biomedical Research, Ayurveda and Yoga
    • 1 Edición
    • Bhushan Patwardhan + 2 más
    • Inglés
    Despite spectacular advances, modern medicine faces formidable global challenges in several key areas—notably the persistence of major killer diseases such as malaria, tuberculosis, leprosy, and newer threats including HIV/AIDS, resistant infections, and Ebola. As such, modern medicine has not led to a significant decrease in chronic diseases like diabetes, obesity, and other degenerative and autoimmune diseases. The authors believe that modern medicine needs to experience a paradigm shift, an integration of traditions—in particular from the ancient systems like Ayurveda and Yoga. Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga brings together the basic principles of interdisciplinary systems approach for an evolving construct of future medicine. Such an approach is already emerging at the cutting edge of current research in omics, bioinformatics, computational and systems biology. Several leading institutions of medicine have adopted Yoga and complementary medicine to widen their reach, and deepen effectiveness in therapeutic practices. The amalgam of modern medicine, with its strengths in scientific rigor, blended with the basic principles of life drawn from Ayurveda and Yoga might evolve into a medicine of tomorrow. Integrative approaches are no longer alternative, perhaps taking these approaches is the only possible way to heal our sick planet. This book introduces important trends and tools for biomedical researchers and physicians alike, to innovate the practice of medicine for the better.

  • The Transformation of Academic Health Centers

    Meeting the Challenges of Healthcare’s Changing Landscape
    • 1 Edición
    • Steven Wartman
    • Inglés
    The Transformation of Academic Health Centers: The Institutional Challenge to Improve Health and Well-Being in Healthcare’s Changing Landscape presents the direct knowledge and vision of accomplished academic leaders whose unique positions as managers of some of the most complex academic and business enterprises make them expert contributors. Users will find invaluable insights and leadership perspectives on healthcare, health professions education, and bio-medical and clinical research that systematically explores the evolving role of global academic health centers with an eye focused on the transformation necessary to be successful in challenging environments. The book is divided into five sections moving from the broad perspective of the role of academic health centers to the role of education, training, and disruptive technologies. It then addresses the discovery processes, improving funding models, and research efficiency. Subsequent sections address the coming changes in healthcare delivery and future perspectives, providing a complete picture of the needs of the growing and influential healthcare sector.

  • Genomics, Physiology and Behaviour of Social Insects

    • 1 Edición
    • Volumen 48
    • Inglés
    Physiology, Behavior, Genomics of Social Insects provides comprehensive information on the social insect groups described, including new and unique reviews on emerging model social organisms. The book's interdisciplinary approach integrates behavior, genomics, and physiology, providing readers with great insights into the present state of a rapidly expanding area of research. It also discusses areas where new research tools will bring hope to longstanding problems.

  • Essential Pharmacokinetics

    A Primer for Pharmaceutical Scientists
    • 1 Edición
    • Thorsteinn Loftsson
    • Inglés
    Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.

  • Methods in Cilia and Flagella

    • 1 Edición
    • Volumen 127
    • Inglés
    The goal of this book is to collect methods and protocols for studying cilia in a wide range of different cell types, so that researchers from many fields of biology can start exploring the role of cilia in their own system.

  • Plant Nematode Interactions

    A View on Compatible Interrelationships
    • 1 Edición
    • Volumen 73
    • Inglés
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 73rd volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on molecular and developmental aspects of the compatible plant-nematode interaction. The contributors all actively work in the field of molecular genetics and genomics of plant parasitic nematodes and nematode feeding sites. Reviews focus on molecular and physiological aspects of nematode feeding site development and includes specific chapters on nematode effectors as well as plant responses.

  • Highlights of the Chinese Exposure Factors Handbook

    • 1 Edición
    • Xiaoli Duan
    • Inglés
    The Chinese Research Academy of Environmental Sciences (CRAES) has conducted the Environmental exposure related activity pattern research of Chinese population (Adults). Exposure Factors Handbook of Chinese Population (Adults) was compiled based on the results from this study. Highlights of the Chinese Exposure Factors Handbook is a brief introduction to the content of Exposure Factors Handbook of Chinese Population (Adults). In each chapter, definitions, possible influence factors, and survey methods have been introduced, followed by recommended values for urban/rural areas, different genders, age groups and regions with information of mean, median and P5, P25, P75, P95 values. With the abundant data and tables, readers are provided with an accessible and comprehensive overview of Chinese exposure factors.

  • Hormones and Transport Systems

    • 1 Edición
    • Volumen 98
    • Inglés
    First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on hormone and transport systems.

  • Protein and Peptide Nanoparticles for Drug Delivery

    • 1 Edición
    • Volumen 98
    • Inglés
    Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

  • Neural Surface Antigens

    From Basic Biology Towards Biomedical Applications
    • 1 Edición
    • Jan Pruszak
    • Inglés
    Neural Surface Antigens: From Basic Biology towards Biomedical Applications focuses on the functionalrole of surface molecules in neural development, stem cell research, and translational biomedical paradigms.With an emphasis on human and rodent model systems, this reference covers fundamentals of neural stemcell biology and flow cytometric methodology. Addressing cell biologists as well as clinicians working in theneurosciences, the book was conceived by an international panel of experts to cover a vast array of particularsurface antigen families and subtypes. It provides insight into the basic biology and functional mechanisms ofneural cell surface signaling molecules influencing mammalian development, regeneration, and treatments.

  • International Review of Cell and Molecular Biology

    • 1 Edición
    • Volumen 316
    • Kwang W. Jeon
    • Inglés
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2013: 4.522.

  • Endocrine Disruption and Human Health

    • 1 Edición
    • Philippa D. Darbre
    • Inglés
    Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students.

  • Handbook of Material Biodegradation, Biodeterioration, and Biostablization

    • 2 Edición
    • Michalina Falkiewicz-Dulik + 2 más
    • Inglés
    Handbook of Material Biodegradation, Biodeterioration, and Biostabilization, Second Edition gives extensive information on the microorganisms involved in the biodegradation of materials, along with the biocides which are permitted for use according to the most up-to-date worldwide legislation. Mechanisms of biodegradation and biodeterioration, results of biodeterioration, and methods of biostabilization are covered for a large number of products, making the title relevant for a range of industries and applications, including construction, coatings/paints, medical and pharmaceutical applications, and electronics. In addition, the health and safety aspects of biocide application are covered in detail, as well as the personal protection of practitioners who are required to use them. The contents and the most-up-to-date information make this book essential for almost all the fields of applied chemistry.

  • Marine Mammals

    Evolutionary Biology
    • 3 Edición
    • Annalisa Berta + 2 más
    • Inglés
    Marine Mammals: Evolutionary Biology, Third Edition is a succinct, yet comprehensive text devoted to the systematics, evolution, morphology, ecology, physiology, and behavior of marine mammals. Earlier editions of this valuable work are considered required reading for all marine biologists concerned with marine mammals, and this text continues that tradition of excellence with updated citations and an expansion of nearly every chapter that includes full color photographs and distribution maps.

  • Economic Evaluation in Genomic Medicine

    • 1 Edición
    • Vasilios Fragoulakis + 3 más
    • Inglés
    Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine.

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    • 1 Edición
    • Volumen 21
    • Inglés
    The Elsevier book-series "Advances in Planar Lipid Bilayers and Liposomes’ (APLBL) provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes and lipid self-assemblies from the micro- to the nanoscale. Planar lipid bilayers are widely studied due to their ubiquity in nature and find their application in the formulation of biomimetic model membranes and in the design of artificial dispersion of liposomes. Moreover, lipids self-assemble into a wide range of other structures including micelles and the liquid crystalline hexagonal and cubic phases. Consensus has been reached that curved membrane phases do play an important role in nature as well, especially in dynamic processes such as vesicles fusion and cell communication. Self-assembled lipid structures have enormous potential as dynamic materials ranging from artificial lipid membranes to cell membranes, from biosensing to controlled drug delivery, from pharmaceutical formulations to novel food products to mention a few. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.

  • TRP Channels as Therapeutic Targets

    From Basic Science to Clinical Use
    • 1 Edición
    • Arpad Szallasi
    • Inglés
    TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

  • Comparative Biology of the Normal Lung

    • 2 Edición
    • Richard A. Parent
    • Inglés
    Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung.

  • Headache and Migraine Biology and Management

    • 1 Edición
    • Seymour Diamond + 4 más
    • Inglés
    There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field.

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