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Elsevier

Libros en Ciencias de la Vida

  • Metabolic Pathways

    Second Edition of Chemical Pathways of Metabolism
    • 2 Edición
    • David M. Greenberg
    • Inglés
    Metabolic Pathways, Volume II focuses on the metabolism, biosynthesis, and catabolism of amino acids. The selection first offers information on nitrogen and carbon metabolism of amino acids. Discussions focus on amino acids linked with citric acid cycle, sulfur amino acids, proline and hydroxyproline, histidine, hydroxyamino acids, urea biosynthesis and related systems, and deamidation. The text then ponders on the biosynthesis of amino acids and related compounds and metabolism of sulfur-containing compounds. Topics include metabolism of methionine, biotin, biological importance of sulfur in animals, interconversions of glutamic acid, ornithine, and prolines, and biosynthesis of the branched-chain amino acids. The publication takes a look at the synthesis of proteins, purines and pyrimidines, and nucleotides and nucleosides, including the components of nucleotides, purine degradation, and incorporation of preformed purine compounds into nucleic acids. The selection is a valuable reference for researchers interested in the metabolism, catabolism, and biosynthesis of amino acids.

  • An Introduction to Medical Laboratory Technology

    • 1 Edición
    • F. J. Baker + 2 más
    • Inglés
    An Introduction to Medical Laboratory Technology, Second Edition provides information pertinent to medical laboratory technology. This book discusses the importance of laboratory technology in hospital practice. Organized into seven sections encompassing 33 chapters, this edition begins with an overview of the role of the medical technologist in the diagnosis of disease by the use of certain accepted laboratory methods. This text then explains the general types of glassware that is widely used in medical laboratories. Other chapters consider the main methods of estimating the sugar content of body fluids, methods in feces and gastric analysis, and microscopical and chemical examination of urine. This book discusses as well the microscopic examination of bacteria, which necessitates making smears and hanging-drop preparations on microscope slides. The final chapter deals with some aspects of elementary physiology. This book is a valuable resource for students and junior technicians, as well as for qualified technologists and medical students.

  • Proceedings of the First International Congress of Parasitology

    Roma, 21-26 September 1964
    • 1 Edición
    • Augusto Corradetti
    • Inglés
    Proceedings of the First International Congress of Parasitology, Volume One focuses on the advancements of processes, methodologies, approaches, and reactions involved in parasitology. The selection first offers information on the role of molluscan hosts in trematode speciation; ecological analysis of the fluke fauna of birds in the USSR; digenetic trematodes of fishes as indicators of the ecology, phylogeny, and zoogeography of their hosts; and aspects of the biology of a monogenean skin parasite. The text then examines bacterial flora as one of the etiological factors influencing the establishment of parasites in the bowel of their host, responses of helminths to temperature gradients, and reservoir parasitism in helminths. The publication takes a look at the physical and biochemical characteristics of helminth glycogens; effect of insulin on glucose uptake and glycogen synthesis in the liver fluke Fasciola hepatica L.; regulation of glycogen synthesis in the liver fluke Fasciola hepatica L.; and changes in catalase activity during embryonation of Ascaris eggs and its relationship to respiration and cytochrome oxidase activity. The selection is a vital reference for researchers interested in parasitology.

  • The Status of Enzymes and Hormones in Therapy

    • 1 Edición
    • G. F. Walker
    • Inglés
    The Status of Enzymes and Hormones in Therapy reviews the status of therapy with enzymes and hormones, with emphasis on endocrine preparations of thyroid and parathyroid, ovarian hormones, pituitary hormones, thymus, and suprarenal glands as well as testis, spleen, brain and muscle tissue, and other organs such as the bile and placenta. The landmarks used are the British Pharmacopoeia, the British Pharmaceutical Codex published in September 1934, and clinical records selected from the literature. Comprised of two chapters, this book begins with an introduction to endocrine therapy, focusing on the need for clinicians to properly assess the clinical potency of the remedies they use based on considerations such as whether they clearly recognize in their patient a hormonic lack, or whether the preparation is smoothly active when administered by the route they propose. The second chapter deals with various endocrine preparations, including commercial preparations of thyroid; ovarian and pituitary hormones; stomach; pancreas; bone marrow; hemoglobin; and pineal, mammary, lymphatic, and prostate glands. This monograph is intended for clinicians interested in the therapeutic uses of enzymes and hormones.

  • Immunological Influence on Human Fertility

    Proceedings of the Workshop on Fertility in Human Reproduction, University of Newcastle, Australia, July 11-13, 1977
    • 1 Edición
    • Barry Boettcher
    • Inglés
    Immunological Influence on Human Fertility covers the proceedings of the Workshop on Fertility in Human Reproduction, held at the Department of Biological Science, University of Newcastle, Australia on July 11 -13, 1977. The book focuses on topics on the immunological control of human and animal fertility. The selection first discusses the zona pellucida as a possible target in immunocontraception, immunological aspects of vasectomy, and the clinical significance of antibodies to spermatozoa. Topics include performance and significance of the SCMC-test, antibodies and fertility after vasovasostomy, vasectomy and the blood-testis barrier, cellular immune response, active and passive immunization, and tissue and species specificity. The book then tackles the nature of the barrier to autoimmunity in the excurrent ducts of the mammalian testis, immune activities of the male and female reproductive tracts, and isolation of spermatozoal antigens. The manuscript examines the immunological capacity of the male genital tract, clinical significance of antibodies to antigens of the reproductive tract, immunological aspects of vasectomy, and antigens of human trophoblasts. The text also takes a look at the immunological and anti-tumor effects of orchidectomy, immune infertility and approaches to treatment, natural insemination as an immune phenomenon, and modified seminal plasma antigens and subfertility. The selection is a valuable source of information for researchers wanting to study the immunological control of human and animal fertility.

  • Illustrated Guide for Theatre Nurses

    • 1 Edición
    • A. Marjorie Matthias + 2 más
    • Inglés
    Illustrated Guide for Theatre Nurses provides practical instruction on how to perform correctly the many duties of a nurse. It presents the various procedures that are described in a series of photographs. This text begins with a series of photographs showing how the nurse should carry out her duties in the operating room. It then demonstrates the fundamental principles that underlie all modern operating techniques. This book is a valuable resource for nurses, technicians, student nurses, medical students, and clinical instructors.

  • Biochemistry and Physiology of Protozoa

    • 1 Edición
    • André Lwoff
    • Inglés
    Biochemistry and Physiology of Protozoa, Volume I focuses on the chemical and physiological features of Protozoa, including nutrition, metabolism, and growth of phytoflagellates, Trypanosomidae and Bodonidae, biochemistry of ciliates and Plasmodium, and the influence of antimalarials. The selection first offers information on the biochemistry of Protozoa and phytoflagellates, including sexuality in Chlamydomonas, growth factors and chemical asepsis, descriptive chemistry and phylogenetic relationships, evolutionary aspects of photosynthesis, nutrition and biochemistry of Protozoa, and the biochemical evolution of Protozoa. The text then ponders on the nutrition of parasitic flagellates and metabolism of Trypanosomidae and Bodonidae. The publication takes a look at the nutrition of parasitic amebae, biochemistry of Plasmodium and the influence of antimalarials, and the biochemistry of ciliates in pure culture. Topics include carbon metabolism and respiration, nitrogen metabolism, antimalarial compounds and their influence on the metabolism of malarial parasites, metabolism of malarial parasites, and nutrition of the dysentery ameba, Entamoeba histolytica. The selection is a valuable reference for cytologists, geneticists, and pathologists interested in the biochemistry and physiology of protozoa.

  • Introduction to Enzymology

    • 1 Edición
    • Alan H. Mehler
    • Inglés
    Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.

  • Studies of the Development and Decay of the Human Frame

    • 1 Edición
    • Joseph Trueta
    • Inglés
    Studies of the Development and Decay of the Human Frame provides information pertinent to the development of human skeleton. This book presents the study of the nature and reactions of the living tissues that constitute the skeleton. Organized into four parts encompassing 40 chapters, this book begins with an overview of the origin and characteristics of the chondroblast. This text then presents the investigations on the vascular characteristics of the blood supply in bone under variable experimental conditions. Other chapters consider the early descriptions of calcification, its role in osteogenesis, and the belief that calcification is a prerequisite to the laying down of bone. This book discusses as well the vascular anatomy of bone and the development of the nutrient arteries. The final chapter deals with the close origin and independence from the earliest stage of development of vessels and muscles on the one hand and bones and joint on the other. This book is a valuable resource for orthopedic surgeons.

  • Physical and Chemical Methods

    Methods in Immunology and Immunochemistry, Vol. 2
    • 1 Edición
    • Curtis A. Williams + 1 más
    • Inglés
    Methods in Immunology: Volume II, Physical and Chemical Methods is a collection of papers dealing with electrophoresis, analytical ultracentrifugation, dialysis, ultrafiltration, cellulose ion exchangers, and chromatographic separation of macromolecules on porous gels. Some papers explain the applications of radioisotopes, optical analysis, and chemical analysis of proteins, carbohydrates, lipids, and nucleic acid. One paper describes the theory of electro-migration. Factors such as electrical charge or frictional coefficients govern the rate of migration of charged particles in an electric field. The differences found in their velocities can be used to separate substances or analyze them. Mobility is a characteristic property of molecules and can also be influenced by the composition of the medium or solution. Dialysis separates solvents too large to diffuse through a barrier from smaller solutes; ultrafiltration (reverse osmosis) forces solvent and solutes up to a certain critical size through the barrier by a high pressure on one side. The book notes that the membrane never becomes plugged in dialysis because of some opposite movement of the solvent. Another paper points out that the significance of radioactive tracers in immunochemistry employed to identify and label macromolecules functioning as antigens and antibodies. The collection can prove valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in immunological research.

  • An Introduction to General Virology

    • 1 Edición
    • Thomas M. Bell
    • Inglés
    An Introduction to General Virology provides information pertinent to all aspects of virology. This book discusses the viruses affecting plants and insects. Organized into 25 chapters, this book begins with an overview of prevention of disease that can be effected by the immunization of susceptible hosts to produce circulating antibodies that neutralize viral infectivity. This text then discusses the general properties of the viruses. Other chapters consider the methods of preparing tissue cultures and explain the methods used for titrations of serum antibodies and serological identification of viruses. This book discusses as well the spread of diseases, the various invasion routes of the body, and the multitude of viruses which cause respiratory symptoms and which cannot easily be conquered. The final chapter deals with the types of vaccine in use. This book is a valuable resource for undergraduates in Medicine and Science and for postgraduates in the class of Public Health.

  • Mechanisms in Bioenergetics

    • 1 Edición
    • Efraim Racker
    • Anthony San Pietro
    • Inglés
    Advanced Biochemistry: Mechanisms in Bioenergetics provides information pertinent to the fundamental aspects of the mechanisms in bioenergetics. This book covers a variety of topics, including the enzymatic mechanism of ATP formation and the regulatory mechanisms that control its metabolic utilization. Organized into three parts encompassing 18 lectures, this book begins with an overview of the process of converting nutrients into forms of useful energy, which is the essence of energy metabolism. This text then explores the properties that have a specific bearing on the problem of oxidative phosphorylation. Other lectures consider the phosphoroclastic reaction with pyruvate, which plays a curious and apparently specific role in nitrogen fixation. This book discusses as well the operation of control mechanisms of energy metabolism in intact cells. The final lecture analyzes the rate-limiting steps in carbohydrate metabolism of various cells and some of the metabolic factors that govern them. This book is a valuable resource for graduate students.

  • Bacterial Immunoglobulin–Binding Proteins

    Applications in Immunotechnology
    • 1 Edición
    • Michael D. P. Boyle
    • Inglés
    Bacterial Immunoglobulin-Bindi... Proteins: Applications in Immunotechnology, Volume 2 covers the state of knowledge of bacterial immunoglobulin-bindi... proteins. The book focuses on practical approaches to isolation, characterization, and use of bacterial immunoglobulin-bindi... proteins. The majority of these studies involve the type I Fc-binding protein (staphylococcal protein A) and the type III Fc-binding protein (streptococcal protein G). Physiological chemists, pediatricians, and microbiologists will find the book invaluable.

  • The Receptors

    Volume III
    • 1 Edición
    • P. Michael Conn
    • Inglés
    The Receptors, Volume III deals with receptors for interferons, hormones, and growth factors as well as for ?-aminobutyric acid, tuftsin, somatomedin, and insulin. Prolactin and nicotine receptors are also considered, along with the protein tyrosine kinase activity of hormone and growth factor receptors. Comprised of 12 chapters, this volume begins with a detailed account of secretory component (SC) as a receptor for polymeric immunoglobulins and the importance of SC-polymeric immunoglobulin A interactions in the mucosal immune system. The discussion then turns to interferon receptors and what is known about the fate of interferons and their receptors after binding; the use of muscimol in ligand-binding studies aimed at characterizing ?-aminobutyric acid receptors; and the role of protease nexins in the interaction of proteases with cells and in the regulation of proteolytic activity in the interstitial fluid immediately surrounding cells. Subsequent chapters focus on receptor regulation of phosphoinositides and calcium; effects of phospholipid turnover on receptor function; dynamics of tuftsin receptors; and the structure, function, and regulation of somatomedin receptors. The book also examines the internalization and intracellular processing of insulin receptors before concluding with an analysis of prolactin and nicotine receptors. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

  • Structural RNA, Synthetic, and Unannotated Sequences

    A Compilation from the GenBank® and EMBL data libraries
    • 1 Edición
    • Edwin J. Atencio + 2 más
    • Inglés
    Nucleotide Sequences 1986/1987, Volume VII: Structural RNA, Synthetic, and Unannotated Sequences presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into three sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Progress in Immunology

    First International Congress of Immunology
    • 1 Edición
    • Bernard Amos
    • Inglés
    Progress in Immunology: First International Congress of Immunology is a collection of papers and summaries of the workshops conducted at the First International Congress of Immunology. The proceedings review significant advances that have been made in the field of immunology and covers topics ranging from the structure and genetics of antibodies to lymphocyte membranes and the role of antibodies and complexes in immune tissue damage. Cell cooperation in the immune response is also examined. This volume is organized into 15 sections and begins with a discussion on the structure of immunoglobulins and results of experiments which support the domain hypothesis and the evolution of immunoglobulins by gene duplication, along with the presence of genetic markers in V regions. The reader is then introduced to expansion and contraction in the evolution of immunoglobulin gene pools; receptors for C3 on B lymphocytes and their possible role in the immune response; and subpopulations of thymus cells and thymus-derived lymphocytes. Tne remaining sections focus on effector mechahisms of cell-mediated immunity; genetic control of immune responsiveness; immune disorders in humans such as glomerulonephritis and rheumatoid arthritis; and viruses involved in immunopathology. This book is dedicated to immunologists.

  • Bacteria and Bacteriophage

    A Compilation from the GenBank® and EMBL data libraries
    • 1 Edición
    • Edwin J. Atencio + 2 más
    • Inglés
    Nucleotide Sequences 1986/1987, Volume V: Bacteria and Bacteriophage presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Proteins and Nucleic Acids

    The Biochemistry of Plants
    • 1 Edición
    • Abraham Marcus
    • Inglés
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 6: Proteins and Nucleic Acids provides information pertinent to the nucleic acids and the regulation of the expression of this information. This book presents the processes by which the nucleic acids are finally expressed as proteins. Organized into 14 chapters, this volume begins with an overview of the overall structure of eukaryotic genomes, with emphasis on higher-plant DNA. This text then examines the enzymes involved in the cleavage and degradation of DNA. Other chapters provide a critical assessment of eukaryotic nucleic acid polymerases. This book discusses as well some examples from plant mitochondrial systems. The final chapter deals with two special areas of plant biology where the expression of the nucleic acids is seen in striking relief, the formation of plant tumors, and the growth and expression of plant viruses. This book is a valuable resource for plant biochemists, molecular biologists, senior graduate students, and research workers.

  • Analytical Microbiology

    Volume II
    • 1 Edición
    • Frederick Kavanagh
    • Inglés
    Analytical Microbiology, Volume II is a six-chapter work that covers the significant changes and improvements made in the theory and practice of analytical microbiology. The first chapter is devoted to the theoretical aspects of assaying of specific compounds. These topics are followed by discussions of the theoretical and practical aspects of diffusions assays, as well as the theoretical developments of photometric methods of assay, including their improvement resulting from automation. A chapter explores the assay methods for various antibiotic groups. Another chapter discusses the advances in assay technology and analytically important interrelations among the folic acid complex. The last chapter describes a simple diffusion method designed for the assay of certain amino acids in a wide variety of samples. This book will prove useful to analytical microbiologists.

  • Biochemistry of Metabolism

    The Biochemistry of Plants
    • 1 Edición
    • David D. Davies
    • Inglés
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 11: Biochemistry of Metabolism provides information pertinent to the chemical and biochemical aspects of metabolism. This book discusses the control mechanisms of metabolism. Organized into nine chapters, this volume begins with an overview of the history of biochemistry and discusses the developments in the kinetics of regulatory enzymes. This text then examines a theory that explains how subunit interactions modulate the rate of conversion of a substrate into a product. Other chapters consider some relation between cell-wall elongation and cell-wall charge density and explore the subcellular localization of the enzymes of glycolysis. This book discusses as well the regulation of glycolysis and the pentose phosphate pathway. The final chapter deals with the pathways of C1 metabolism that are of prime importance, as the synthesis of several cellular constituents depends directly or indirectly on folate metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • The Antigens

    Volume I
    • 1 Edición
    • Michael Sela
    • Inglés
    The Antigens, Volume I is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology, structure and function, their initiation of the immune response, and the nature of the products of this response. The nature of the reaction of antigens with antibodies and with sensitized cells is also explored. Comprised of seven chapters, this volume begins with a discussion on the antigenic functions of nucleic acids as well as their immunogenicity, hapten functions, and serologic reactions. The reader is then introduced to the immunochemistry and antigenic determinants of enzymes, along with the structure and phylogeny of immunoglobulins and immunoglobulin allotypes. The evolution of proteins and their structure and function is also considered, paying particular attention to evolution by the random fixation of selectively neutral alleles, the rates of protein evolution, gene duplication, and divergence or convergence. The final chapter is devoted to the chemistry and biology of immunoglobulin E as well as the regulation of formation of their antibodies. This book will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • The Receptors

    Volume IV
    • 1 Edición
    • P. Michael Conn
    • Inglés
    The Receptors, Volume IV deals with receptors for intracellular hormones, estrogen, and sex steroids as well as for dopamine, cholecystokinin, and corticotropin. The role of surface recognition receptors in disease is also discussed, along with receptors for plant auxin action and auxin transport. Comprised of 11 chapters, this volume begins with a detailed account of the ?-adrenergic receptor-coupled adenylate cyclase and the reconstitution of the functional interactions of its various purified components. The discussion then turns to the mechanism of action of steroid and thyroid hormones and how abnormalities in their receptors lead to disease; nuclear location of estrogen receptors; and the biochemistry of the fungal sex steroid receptors as well as the use of Achlya as a model system for the study of the mechanism of action of steroid hormones in general. Subsequent chapters focus on dopamine receptors; cholecystokinin receptor; corticotropin receptors; and the search for receptors that mediate sweetness. The book concludes with an analysis of endocrine receptors on lymphocytes and the integration of endocrine and immune systems, with emphasis on large granular lymphocytes. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

  • The Cell: Supplementary Volume

    Biochemistry, Physiology, Morphology
    • 1 Edición
    • Jean Brachet + 1 más
    • Inglés
    The Cell: Biochemistry, Physiology, Morphology, Volume VI: Supplementary Volume focuses on the advancements of processes, technologies, and approaches employed in studies on the structure and functions of cells. The selection first offers information on the cytoplasm of Protozoa, fungi, and the aspects of the form and function of plant cells. Topics include special structures, basic genetics, physiology, life cycles and sexuality, special fungal genetics, basal bodies or kinetosomes, mitochondria, and symbiotes in Protozoa. The text then elaborates on sensory and connective tissue cells.Discussions focus on some catabolic processes of connective tissues, formation and cytology of connective tissues, nature of the extracellular constituents, and pseudosensory, neurosensory, and true sensory cells. The selection is a vital reference for researchers interested in the biochemistry, physiology, and morphology of cells.

  • Primates

    A Compilation from the GenBank® and EMBL data libraries
    • 1 Edición
    • Edwin J. Atencio + 2 más
    • Inglés
    Nucleotide Sequences 1986/1987, Volume I: Primates presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into one section, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Synthetic Peptides

    Volume 3
    • 1 Edición
    • George R. Pettit
    • Inglés
    Synthetic Peptides discusses racemization, protecting group techniques, peptide bond-forming methodology, amino acids, and dipeptide syntheses. The book explains solid phase synthesis methods, cyclopeptides, nucleopeptides, chromopeptides of the actinomycin D type, and cites examples of syntheses of peptides of different sizes. The text describes tripeptides, tetrapeptides, pentapeptides, hexapeptides, and also undecapeptides to nonadecapeptides. Riniker and colleagues explain the revised structures (for the human and porcine hormone, Asn for Asp at position 25 and Glu for Gin at position 30) for the 39-unit adrenocorticotropic hormone. A synthesis of the 32-unit human calcitonin M is associated with the fragment condensation approach to complex peptides. The book also reviews cyclodepsipeptide valinomycin based on the possible transport of a potassium ion through biological membranes by this substance and the synthesis of a D-Pro analog. The text describes the cyclic decapeptide antibiotic gramicidin S, belonging to a family of similar substances isolated from Bacillus brevi, that can treat certain eye-threatening infections. The book can prove beneficial for biochemists, micro-biologists, cellular investigators, and researchers involved in physiology, oncology or therapeutics.

  • Amino Acids and Derivatives

    The Biochemistry of Plants
    • 1 Edición
    • B. J. Miflin
    • Inglés
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 5: Amino Acids and Derivatives provides information pertinent to the fundamental aspects of plant biochemistry relating to the metabolism of amino acids with emphasis on amino acids present in proteins. This book discusses the metabolism of sulfur and nitrogen from the inorganic sources available to plants through their incorporation into organic compounds. Organized into 17 chapters, this volume begins with an overview of some aspects of the biochemistry of symbiotic nitrogen fixation. This text then examines the ultrastructure and metabolism of the developing nodule with particular emphasis on interactions between the host legumes and the bacterial symbiont. Other chapters consider the characteristics of the enzymes involved in nitrate and nitrite reduction. The final chapter deals with the essential roles of amino acids and other soluble nitrogenous compounds in plant metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • Database Directory and Master Indices

    Nucleotide Sequences 1986/1987, Vol. 8
    • 1 Edición
    • Edwin J. Atencio + 2 más
    • Inglés
    Nucleotide Sequences 1986/1987, Volume VIII: Database Directory and Master Indices presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into 13 sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main emphasis in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Protection of Functional Groups in Peptide Synthesis

    The Peptides Analysis, Synthesis, Biology, Vol. 3
    • 1 Edición
    • Erhard Gross + 1 más
    • Inglés
    The Peptides: Analysis, Synthesis, Biology, Volume 3: Protection of Functional Groups in Peptide Synthesis focuses on protection of functional groups in peptide synthesis. This book consists of seven chapters. Chapter 1 reviews the large variety of amine protecting groups. The protection of carboxyl groups is described in Chapter 2, while the chemistry of sulfhydryl group protection in peptide synthesis is discussed in Chapter 3. Chapter 4 covers the protection of the hydroxyl groups of serine, threonine, tyrosine, and other hydroxyl-containing amino acids. Differential protection and selective deprotection in peptide synthesis is deliberated in Chapter 5. In chapter 6, the opportunities and constraints of the tactics of minimal protection of side-chain functions during peptide synthesis are reviewed. The last chapter is devoted to the interesting aspects of dual function groups. This volume is recommended for specialists and researchers concerned with peptide and protein research.

  • Conformation in Biology and Drug Design

    The Peptides: Analysis, Synthesis, Biology, Vol. 7
    • 1 Edición
    • Sidney Udenfriend + 2 más
    • Inglés
    The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

  • Recent Progress in Hormone Research

    Proceedings of the 1991 Laurentian Hormone Conference
    • 1 Edición
    • C. Wayne Bardin
    • Inglés
    Recent Progress in Hormone Research, Volume 48 provides information pertinent to endocrine research dealing with all aspects of biological organization. This book covers a variety of topics, including differentiation of the embryo, development and growth at puberty, maintenance of adult well-being, and aging. Organized into 29 chapters, this volume begins with an overview of the role of oncogenes in fetal development. This text then compares the molecular descriptions of the genes for growth hormone and prolactin receptors to receptors for s variety of other hormones, peptide, and growth factors. Other chapters consider the three-dimensional structure of the growth hormone receptor. This book discusses as well the conventional and nonconventional uses of human growth hormone, with emphasis on the wide availability of protein that is possible only through molecular biology. The final chapter deals with the effect of hormones on primate behavior. This book is a valuable resource for geneticists and biologists.

  • The Antigens

    Volume VII
    • 1 Edición
    • Michael Sela
    • Inglés
    The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Agglutination, Complement, Neutralization, and Inhibition

    Methods in Immunology and Immunochemistry, Vol. 4
    • 1 Edición
    • Curtis A. Williams + 1 más
    • Inglés
    Methods in Immunology and Immunochemistry, Volume IV: Agglutination, Complement, Neutralization, and Inhibition provides information pertinent to direct and indirect agglutination reactions. This book covers a variety of topics, including complement-fixation procedures, isolation of complement components, hemolytic intermediates, complement-related proteins, and neutralization reactions. Organized into three chapters, this volume begins with an overview of test-tube agglutinations that are preferred for blood grouping with saline agglutinins that require more than a few minutes for agglutination. This text then describes blood group antibodies that agglutinate red blood cells suspended in saline. Other chapters consider the classical pathway of complement utilization. This book discusses as well the complexity of events leading to hemolysis of erythrocytes by complement. The final chapter deals with the ability of antitoxin to neutralize diphtheria toxin and explains the quantitative relationships between antigen and antibody. This book is a valuable resource for immunologists, scientists, and research workers.

  • Metabolic Conjugation and Metabolic Hydrolysis

    Volume I
    • 1 Edición
    • William H. Fishman
    • Inglés
    Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis. Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminid... and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described. This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

  • Metabolic Regulation

    Metabolic Pathways
    • 3 Edición
    • Henry J. Vogel
    • Inglés
    Metabolic Pathways, Third Edition, Volume V: Metabolic Regulation presents the regulation of metabolism in terms of the control of protein synthesis. This book discusses the significance of the control of metabolism in regard to the remarkable mechanisms involved and to the provision of an effective conceptual framework for appreciating the workings of the cell. Organized into 15 chapters, this edition begins with an overview of the numerous and diversified activities of a living cell. This text then examines the ability of living organisms to regulate the storage and mobilization of metabolizable energy. Other chapters consider the cytochrome system that represents the final common path of oxidation and coupled phosphorylation in the eukaryotic cell. This book discusses as well the profound changes that cell metabolism undergoes during differentiation. The final chapter deals with the chemical and genetic bases of the induction response in Gram-positive bacteria. This book is a valuable resource for biologists and physicians.

  • Alcohol and Aldehyde Metabolizing Systems

    Intermediary Metabolism and Neurochemistry
    • 1 Edición
    • Ronald G. Thurman + 2 más
    • Inglés
    Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoli... derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.

  • Reactions of Antibodies with Soluble Antigens

    Methods in Immunology and Immunochemistry, Vol. 3
    • 1 Edición
    • Curtis A. Williams + 1 más
    • Inglés
    Methods in Immunology and Immunochemistry, Volume III: Reactions of Antibodies with Soluble Antigens provides information pertinent to antigen–antibody and hapten–antibody reactions in vitro, in free solution and in gels. This book presents the development of research in immunology and immunochemistry. Organized into three chapters, this volume begins with an overview of protein–antiprotein reactions. This text then discusses the inhibitory activity of protein fragments, which suggested that antigenic combining sites of proteins were limited regions of the whole antigen molecule. Other chapters consider the measurement of inhibitory activity, which is still the principal assay to characterize antigenic sites of proteins. This book discusses as well the immunological techniques prior to the development of gel-diffusion methods. The final chapter deals with fluorescence labeling techniques that provide powerful approaches for exploring the thermodynamic and kinetic parameters of antigen–antibody interactions. This book is a valuable resource for mathematicians and immunologists.

  • Disorders of Mineral Metabolism

    Trace Minerals
    • 1 Edición
    • Felix Bronner + 1 más
    • Inglés
    Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

  • Cell Biology

    A Laboratory Handbook
    • 1 Edición
    • Julio E Celis
    • Inglés
    Cell Biology: A Laboratory Handbook, Volume 3 is a handbook on cell biology and covers topics ranging from transfer of macromolecules and small molecules to cloning of embryos, transgenics, and gene targeting. Cell-free extracts, permeabilized cell systems, and expression systems are also discussed, along with proteins. Comprised of 58 chapters, this volume begins with a detailed account of microinjection of RNA, DNA, and proteins into somatic cells, followed by an analysis of computer-automated capillary microinjection of macromolecules into living cells. The reader is then introduced to syringe loading as a method for inserting macromolecules into cells in suspension; electroporation of cells; and the use of liposomes in drug targeting. Subsequent chapters focus on the cloning of rabbit embryos by nuclear transplantation; gene targeting by homologous recombination in embryonic stem cells; production and isolation of recombinant viruses; and gel electrophoresis. This book will be of interest to geneticists and molecular biologists.

  • Disorders of Auditory Function

    Volume III
    • 1 Edición
    • Ian G. Taylor + 1 más
    • Inglés
    Disorders of Auditory Function, Volume III presents the proceedings of the Third Conference of the British Society of Audiology, held at the University of Manchester on July 18–20, 1979. This book provides information pertinent to five major areas of interest to the principles and practice of audiology, namely, pediatric audiology, communication, vestibular function, noise-induced hearing loss, and aural rehabilitation. Organized into four sections encompassing 29 chapters, this volume begins with an overview of the conditions that occur in the first years of life that may result in hearing impairment. This text then examines the methods for the early identification of hearing loss. Other chapters consider the implementation of an effective mass hearing screening program for neonates. This book discusses as well the rules and strategies that hearing-impaired children are using to interpret word order. The final chapter reviews the development in British audiology. This book is a valuable resource for otologists, audiologists, and physicians.

  • Molecular Aspects of Animal Development

    • 1 Edición
    • Rudolf Weber
    • Inglés
    The Biochemistry of Animal Development, Volume III: Molecular Aspects of Animal Development provides an account of the developments in the molecular approach to vertebrate development with particular emphasis on the functions of nucleic acids. The book discusses topics on oocyte maturation, transcriptional patterns in early development, the post-transcriptional control of gene expression, and the significance of gene amplification. Morphogenetic substances, growth-promoting proteins, and the functional differentiation of mitochondria in embryonic systems are covered as well. Biochemists, biologists, and zoologists will find the book invaluable.

  • Opioid Peptides: Biology, Chemistry, and Genetics

    The Peptides: Analysis, Synthesis, Biology, Vol. 6
    • 1 Edición
    • Sidney Udenfriend + 1 más
    • Inglés
    The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activit... relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.

  • The Antigens

    Volume IV
    • 1 Edición
    • Michael Sela
    • Inglés
    The Antigens, Volume IV is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from the immune reactions of lipids and lipid model membranes to the immunology of antibiotics and protective antigens of bacteria. Antigens of pathogenic fungi are also explored, along with adjuvants and antigenic competition. Comprised of seven chapters, this volume begins with a review of lipids as antigens, followed by a discussion on the immunological aspects of antibiotics. The next two chapters are concerned with more complex antigens, namely, bacteria and fungi, as well as the relationship between immunity and infection. The last three chapters deal with three important areas of immunology: antigenic competition, adjuvants, and lectins. In particular, the chemistry of lectins and their application to immunology are examined. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Meiosis and Mitosis

    Biochemistry, Physiology, Morphology
    • 1 Edición
    • Jean Brachet + 1 más
    • Inglés
    The Cell: Biochemistry, Physiology, Morphology, Volume III: Meiosis and Mitosis covers chapters on meiosis and mitosis. The book discusses meiosis with regard to the meiotic behavior of chromosomes; the anomalous meiotic behavior in organisms with localized centromeres and in forms with nonlocalized centromeres; and the nature of the synaptic force. The text also describes the mechanism of crossing over; the relationship of chiasmata to crossing over and metaphase pairing; and the reductional versus equational disjunction. The process of mitosis and the physiology of cell division are also considered. The book further tackles the significance of cell division and chromosomes; the essential mitotic plan and its variants; the preparations for mitosis; and the transition period. The text also demonstrates the time course of mitosis; the mobilization of the mitotic apparatus; metakinesis; the metaphase; the mitotic apparatus; anaphase; telophase; cytokinesis; and the physiology of the dividing cell. Physiological reproduction; mitotic rhythms and experimental synchronization; and the blockage and stimulation of division are also encompassed. Biologists, microbiologists, zoologists, and botanists will find the book invaluable.

  • Enzymology in the Practice of Laboratory Medicine

    Proceedings of a Continuation Course Held at the University of Minnesota, Minneapolis, Minnesota, 10-12 May 1972
    • 1 Edición
    • Philip Blume + 1 más
    • Inglés
    Enzymology in the Practice of Laboratory Medicine focuses on disease processes, enzymatic reactions and activities, and diagnosis and management of diseases. The selection first offers information on developments in the search for mechanisms of enzymic catalysis; application of the spin labeling technique to biological membranes; and the properties of membrane bound enzymes involved in energy transduction processes. Discussions focus on possible clinical interrelationships of membrane function, mitochondrial membrane transactions, mechanical details of chymotryptic catalysis, and physical nature of globular proteins. The text then elaborates on metalloenzymes, enzyme measurement, and enzymology, clinical chemistry, and development of fast analyzers. The publication examines the analytical uses of immobilized enzymes; origin of serum enzymes and the basis for their variation; and the screening methods for glycolytic enzyme deficiencies in red blood cells. Topics include factors contributing to normal variation of enzyme activity, catabolism of enzymes, mechanism of release from cells to plasma, and determination of urea in blood and urine. The selection is a dependable reference for researchers interested in the application of enzymology in laboratory medicine.

  • The Antigens

    Volume V
    • 1 Edición
    • Michael Sela
    • Inglés
    The Antigens, Volume V is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Four complex problems of direct relevance to human health are explored, namely, tumor antigens, antigens of helminths, cytotoxic lymphocytes, and complement. Comprised of four chapters, this volume begins with a review of classic studies of tumor-specific transplantation antigens, followed by a discussion on the detection and purification of tumor antigens; the immune response to tumor antigens; and the role of tumor antigens in the escape of tumors from immunological control. The reader is then introduced to some aspects of the different functions of antigens of helminths, along with the immune response in helminthiasis. The book also examines the generation, properties, and mode of action of antibody-independent cytolytic T lymphocytes before concluding with an analysis of the complement system and its reaction pathways as well as its role as an autoantigen. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Carbohydrates: Structure and Function

    The Biochemistry of Plants
    • 1 Edición
    • Jack Preiss
    • Inglés
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 3: Carbohydrates: Structure and Function is a compilation of contributions dealing with studies in the area of plant carbohydrates. The articles in this volume are grouped into three sections. The first section deals with topics concerning the monosaccharides and their derivatives found in plants. The integration and control of vital pathways concerned with hexose phosphate metabolism, glycolysis, gluconeogenesis; the metabolism of monosaccharide derivatives; and the formation of sugar nucleotides and their various transformations to the many novel sugar derivatives normally found in plant cell walls and complex carbohydrates are discussed in this section. The second part deals with the occurrence, biosynthesis, and transport of disaccharides and oligosaccharides. The final section of the volume is concerned with the occurrence, structure, and biosynthesis of simple and complex polysaccharides and glycoconjugates associated with cell walls and membranes. Biochemists and botanists will find the book a great reference material.

  • Monoclonal Antibodies Against Bacteria

    Volume II
    • 1 Edición
    • Alberto J. L. Macario + 1 más
    • Inglés
    Monoclonal Antibodies Against Bacteria, Volume II provides the basis for understanding new developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume starts with the analysis of streptococcal antigens implicated in the causation of rheumatic fever and heart disease to find ways of inducing protective immunity. The next chapters deal with the detection of staphylococcal enterotoxins in foods and treatment of staphylococcal food poisoning, the classification of meningococcal isolates associated with meningitis and related disorders, and the immunology of brucellosis with emphasis on the problem of distinguishing antibrucella antibodies elicited by vaccination of cattle from antibodies elicited by infection. These topics are followed by discussions of the diagnostic and epidemiologic studies of legionellosis; the identification of antigens in gram-negative bacteria; and the development of means to study and control infections by Pseudomonas in cystic fibrosis and other pathologic conditions. Other chapters explore the analysis of toxigenicity and neutralization of botulinum toxin, the pathogenetic role of Escherichia coli's pili, and study of its antigens to understand regulatory networks of the immune system involving antiidiotypic antibodies. The remaining chapters consider the elucidation of antigenic mosaics of archaebacteria and identification of their molecular signatures in their ecological niches and other life forms. These chapters also look into the combination of bacterial genetics with hybridoma technology for elucidating structure-function relationships in membrane molecules, as well as the strategies, methods, quality control, and other practical aspects connected with industrial production of monoclonal antibodies against bacteria. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

  • Antigen-Antibody Reactions In Vivo

    Methods in Immunology and Immunochemistry, Vol. 5
    • 1 Edición
    • Curtis A. Williams + 1 más
    • Inglés
    Methods in Immunology and Immunochemistry, Volume V: Antigen-Antibody Reactions In Vivo deals primarily with immune phenomena in tissues or in cell preparations. This book covers a variety of topics, including anaphylaxis, tolerance, immune suppression with chemical agents, radiation effects, antibody synthesis in vitro, immunological methods, and applied electron microscopy. Organized into 10 chapters, this volume begins with an overview of systemic anaphylaxis investigations in other more resistant species. This text then presents the analysis of mechanisms involved in the pathogenesis of the Arthus phenomenon, which shed light on the understanding of other lesions of hypersensitivity. Other chapters consider the effects of antigen–antibody interaction on connective tissue. This book discusses as well the degree and duration of acquired tolerance. The final chapter deals with the application of electron microscopy in the elucidation of the mechanisms of immune reactions. This book is a valuable resource for immunologists, students, and research workers.

  • Penicillins and Cephalosporins

    • 1 Edición
    • Robert B. Morin + 1 más
    • Inglés
    Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

  • Viruses

    A Compilation from the GenBank® and EMBL data libraries
    • 1 Edición
    • Edwin J. Atencio + 2 más
    • Inglés
    Nucleotide Sequences 1986/1987, Volume VI: Viruses presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into one section, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

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