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Elsevier

Libros en Ciencias de la Vida

  • Evolution

    Components and Mechanisms
    • 1 Edición
    • David Zeigler
    • Inglés
    Evolution: Components and Mechanisms introduces the many recent discoveries and insights that have added to the discipline of organic evolution, and combines them with the key topics needed to gain a fundamental understanding of the mechanisms of evolution. Each chapter covers an important topic or factor pertinent to a modern understanding of evolutionary theory, allowing easy access to particular topics for either study or review. Many chapters are cross-referenced. Modern evolutionary theory has expanded significantly within only the past two to three decades. In recent times the definition of a gene has evolved, the definition of organic evolution itself is in need of some modification, the number of known mechanisms of evolutionary change has increased dramatically, and the emphasis placed on opportunity and contingency has increased. This book synthesizes these changes and presents many of the novel topics in evolutionary theory in an accessible and thorough format. This book is an ideal, up-to-date resource for biologists, geneticists, evolutionary biologists, developmental biologists, and researchers in, as well as students and academics in these areas and professional scientists in many subfields of biology.

  • Molecular Diagnostics and Treatment of Pancreatic Cancer

    Systems and Network Biology Approaches
    • 1 Edición
    • Asfar Azmi
    • Inglés
    Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.

  • Malnutrition and the Eye

    • 1 Edición
    • Donald McLaren
    • Inglés
    Malnutrition and the Eye discusses the nutritional influences on vision structure and function. This book is organized into three parts encompassing 17 chapters that cover that nutritional aspects of vision, malnutrition, and eye diseases related to nutrient deficiency. The first part describes the anatomy, development, and growth of the eye. This part also examines the significant effect of intrauterine nutrition in the growth of the eye and its components. The second part focuses on the role of various nutrients in vision, such as vitamin A and B complex, proteins, amino acids, carbohydrates, cholesterol, and fats. This part also emphasizes the mechanism of congenital malformations related to malnutrition, together with the genetic factors induced by dietary deficiency. A discussion on the vision effects of ingested dietary and non-dietary toxins is included. The third part describes the eye problems and diseases related to nutrient deficiency. This book is of value to nutritionists, ophthalmologists, clinicians, and anatomists.

  • Mollusca

    • 1 Edición
    • Marcel Florkin
    • Inglés
    Chemical Zoology, Volume VII, Mollusca, provides zoologists and chemists with an overview of the state of knowledge in chemistry and zoology and an introduction to the existing literature. The treatise is arranged by phyla, an arrangement which seemed most suitable for presenting chemical information of zoological significance and for bringing to the attention of chemists those aspects of biochemical diversity of greatest potential interest. Each section, dealing with a major phylum, is introduced by a discussion of the biology and systematics of the group. This is followed by chapters dealing with various aspects of the biochemistry of the group. This volume contains 14 chapters and begins with a discussion of the molluscan framework. This is followed by separate chapters on shell structure and formation, respiratory proteins, and nitrogen metabolism in molluscs. Subsequent chapters deal with molluscan byssus fibers, chemical embryology, pigments, carbohydrate metabolism, lipid metabolism and distribution, endocrinology, anisosmotic and isosmotic cellular regulation, pharmacology, and biochemical ecology.

  • Emerging Technologies and Management of Crop Stress Tolerance

    Volume 1-Biological Techniques
    • 1 Edición
    • Parvaiz Ahmad + 1 más
    • Inglés
    Emerging Technologies and Management of Crop Stress Tolerance: Volume 1 - Biological Techniques presents the latest technologies used by scientists for improvement the crop production and explores the various roles of these technologies for the enhancement of crop productivity and inhibition of pathogenic bacteria that can cause disease. This resource provides a comprehensive review of how proteomics, genomics, transcriptomics, ionomics, and micromics are a pathway to improve plant stress tolerance to increase productivity and meet the agricultural needs of the growing human population. This valuable resource will help any scientist have a better understanding of environmental stresses to improve resource management within a world of limited resources.

  • Integrative Anatomy and Pathophysiology in TCM Cardiology

    • 1 Edición
    • Anika Niambi Al-Shura
    • Inglés
    Integrative Anatomy and Pathophysiology in Traditional Chinese Medicine Cardiology covers the structure, function, and pathology of the cardiovascular system from the TCM and western medical perspectives. It focuses specifically on western medicine anatomy and pathophysiology, along with TCM aspects of essence, qi, blood and body fluid concepts, production, and function to explain cardiovascular system dysfunction, its independent role and dependent interactions with the functions of other organ systems. This book is designed for US-based licensed TCM practitioners as well as cardiology researchers.

  • Essential Treatments in Cardiovascular Chinese Medicine 1: Hyperlipidemia

    • 1 Edición
    • Anika Niambi Al-Shura
    • Inglés
    Essential Treatments in Cardiovascular Chinese Medicine includes information on the basic medical sciences of blood lipids, clinical significance, diagnosis, and treatment methods. It also covers TCM differentiations, diagnosis, treatment principles, and methods. In recent years, TCM practitioners have not been specifically trained in treating patients with hyperlipidemia. The book gives a detailed explanation of cholesterol problems and offers Chinese medicine as a solution. This book is intended for US-based licensed TCM practitioners as well as cardiology researchers.

  • Diagnosing in Cardiovascular Chinese Medicine

    • 1 Edición
    • Anika Niambi Al-Shura
    • Inglés
    Diagnosing in Cardiovascular Chinese Medicine instructs readers on the finer details of cardiovascular patient examination techniques used in western medicine, together with TCM examination techniques. It explains the six basic signs and symptoms connected to cardiac diseases, along with their clinical significance, and shows the methods and techniques used in physical examination to detect the signs. This book is intended for US-based licensed TCM practitioners as well as cardiology researchers.

  • Postharvest Handling

    A Systems Approach
    • 3 Edición
    • Wojciech J. Florkowski + 3 más
    • Inglés
    Postharvest Handling, Third Edition takes a global perspective in offering a system of measuring, monitoring, and managing produce processing to improve food quality, minimize food waste, reduce risks and uncertainties, and maximize time and resources. This unique resource provides an overview of the postharvest system and its role in the food value chain, and offers essential tools to monitor and control the handling process. It shows how to predict and combat unexpected events (e.g., spoilage), and manage the food quality and safety within a facility. Proven research methods and applications from various viewpoints are available to help you maintain high-quality produce and achieve the highest yields possible. The book also explores current challenges—including oversupply, waste, food safety, lack of resources, sustainability—and best practices for production to thrive in spite of these challenges.

  • Predictive Modeling of Pharmaceutical Unit Operations

    • 1 Edición
    • Preetanshu Pandey + 1 más
    • Inglés
    The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Qualityby Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included.

  • Hematology in Traditional Chinese Medicine Cardiology

    • 1 Edición
    • Anika Niambi Al-Shura
    • Inglés
    Hematology in Traditional Chinese Medicine Cardiology instructs readers on the blood, complement and immune system from the western and Chinese medicine perspectives. The book focuses on the cardiovascular issues concerning blood and the immune system, provides laboratory values concerning blood and the cardiovascular system, and covers cardiovascular diseases from the Chinese medicine and western medicine perspectives. It compares the eight principles in traditional Chinese medicine with basic science perspectives in western medicine, analyzes laboratory blood testing for heart diseases, and discusses the use of blood results for diagnosing and monitoring.

  • Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System

    Biomaterials and Tissues
    • 1 Edición
    • Z Jin
    • Inglés
    Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System reviews how a wide range of materials are modelled and how this modelling is applied. Computational modelling is increasingly important in the design and manufacture of biomedical materials, as it makes it possible to predict certain implant-tissue reactions, degradation, and wear, and allows more accurate tailoring of materials' properties for the in vivo environment. Part I introduces generic modelling of biomechanics and biotribology with a chapter on the fundamentals of computational modelling of biomechanics in the musculoskeletal system, and a further chapter on finite element modelling in the musculoskeletal system. Chapters in Part II focus on computational modelling of musculoskeletal cells and tissues, including cell mechanics, soft tissues and ligaments, muscle biomechanics, articular cartilage, bone and bone remodelling, and fracture processes in bones. Part III highlights computational modelling of orthopedic biomaterials and interfaces, including fatigue of bone cement, fracture processes in orthopedic implants, and cementless cup fixation in total hip arthroplasty (THA). Finally, chapters in Part IV discuss applications of computational modelling for joint replacements and tissue scaffolds, specifically hip implants, knee implants, and spinal implants; and computer aided design and finite element modelling of bone tissue scaffolds. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and mechanical engineers, and those in academia.

  • Biotechnology Entrepreneurship

    Starting, Managing, and Leading Biotech Companies
    • 1 Edición
    • Craig Shimasaki
    • Inglés
    As an authoritative guide to biotechnology enterprise and entrepreneurship, Biotechnology Entrepreneurship and Management supports the international community in training the biotechnology leaders of tomorrow. Outlining fundamental concepts vital to graduate students and practitioners entering the biotech industry in management or in any entrepreneurial capacity, Biotechnology Entrepreneurship and Management provides tested strategies and hard-won lessons from a leading board of educators and practitioners. It provides a ‘how-to’ for individuals training at any level for the biotech industry, from macro to micro. Coverage ranges from the initial challenge of translating a technology idea into a working business case, through securing angel investment, and in managing all aspects of the result: business valuation, business development, partnering, biological manufacturing, FDA approvals and regulatory requirements. An engaging and user-friendly style is complemented by diverse diagrams, graphics and business flow charts with decision trees to support effective management and decision making.

  • Perspectives in Total Hip Arthroplasty

    Advances in Biomaterials and their Tribological Interactions
    • 1 Edición
    • Saverio Affatato
    • Inglés
    Total hip arthroplasty, the most commonly performed orthopedic procedure, is used to replace or reconstruct the hip with an artificial joint. Perspectives in Total Hip Arthroplasty outlines developments in technologies and biomaterials used for this procedure, with a focus on the tribological interactions of the materials used. Part one outlines the history of total hip arthroplasty and goes on to explore advances in techniques and biomaterials. Part two focuses on the tribology of materials used to perform this procedure, explaining the impact of wear on the load-bearing surface, a major cause of failure in hip prostheses. Chapters review a range of materials, including modern biomaterials, hybrid materials, metal, ceramic, and polyethylene. The book also discusses the tribological interactions of these materials when used in total hip arthroplasty. Perspectives in Total Hip Arthroplasty is a key resource for clinicians, researchers, and academics interested in the tribology of total hip arthroplasty, as well as materials researchers, engineers, and academics concerned with the tribology of biomaterials.

  • International Review of Cell and Molecular Biology

    • 1 Edición
    • Volumen 310
    • Kwang W. Jeon
    • Inglés
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973.

  • Processing and Impact on Antioxidants in Beverages

    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Processing and Impact on Antioxidants in Beverages presents information key to understanding how antioxidants change during production of beverages, how production options can be used to enhance antioxidant benefit, and how to determine the production process that will result in the optimum antioxidant benefit while retaining consumer acceptability. In the food industry, antioxidants are added to preserve the shelf life of foods and to prevent off-flavors from developing. These production-added components also contribute to the overall availability of essential nutrients for intake. Moreover, some production processes reduce the amount of naturally occurring antioxidants. Thus, in terms of food science, it is important to understand not only the physiological importance of antioxidants, but what they are, how much are in the different food ingredients, and how they are damaged or enhanced through the processing and packaging phases. This book specifically addresses the composition and characterization of antioxidants in coffee, green tea, soft drinks, beer, and wine. Processing techniques considered here include fermentation and aging, high-pressure homogenization, enzymatic debittering, and more. Lastly, the book considers several selective antioxidant assays, such as Oxygen Radical Absorbance Capacity (ORAC) and Trolox Equivalent Antioxidant Capacity (TEAC) assays.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 64
    • Inglés
    Volume 64 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Foods, Nutrients and Food Ingredients with Authorised EU Health Claims

    Volume 1
    • 1 Edición
    • Michele Jeanne Sadler
    • Inglés
    Foods, Nutrients and Food Ingredients with Authorised EU Health Claims provides an overview of how health claims are regulated in the European Union, as well as detailed scientific and regulatory information about permitted health claims for particular types of foods and ingredients. Part one provides a background to the regulation of health claims in Europe. Part two focuses on authorised disease risk reduction claims, claims relating to children’s development, and health and proprietary claims. Part three sets out ingredients with permitted “general function” claims, including choline, creatine, sweeteners, dietary lactase supplements, and polyphenols in olive oil. Part four outlines foods and nutrients with permitted health claims, with chapters on vitamins and minerals, proteins, meat, fish, water, and the replacement of saturated fats. Foods, Nutrients and Food Ingredients with Authorised EU Health Claims is the go-to resource for R&D managers and technical managers in the food, and beverage and dietary supplements industry, product development managers, health professionals and academic researchers in the field.

  • The Eye in Systemic Disease

    • 2 Edición
    • Jack J. Kanski + 1 más
    • Inglés
    The Eye in Systemic Disease, Second Edition presents an overview of the relationship of the eye and medicine. The book details the systemic aspects of diseases. The topics discussed include various eye conditions such as conjunctivitis, episcleritis, keratitis, keratoconjunctivitis sicca, and cataract. Endocrine, circulatory, rheumatological, neurological, pulmonary, and blood disorders are covered as well. Physicians and students of medicine and pathology will find the book very useful.

  • Origins and Phylogeny of Rices

    • 1 Edición
    • N.M. Nayar
    • Inglés
    Origin and Phylogeny of Rices provides an evolutionary understanding of the origin, spread, and extent of genetic diversity in rice. This single volume is the first to review and synthesize the significant work done in this area in the last 30 years.Rice is the most important food crop of humankind. It provides more energy and also forms the staple food for more humans than any other food plant. This book assesses multiple aspects of this crucial crop in chapters devoted to rice's history and spread, phylogeny of the genus Oryza, Oryza species and their interrelationships, and the origins of west African and Asian rice.

  • Brain Metastases from Primary Tumors Volume 1

    Epidemiology, Biology, and Therapy
    • 1 Edición
    • M. A. Hayat
    • Inglés
    With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors Volume 1 fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection.

  • Encyclopedia of Food Microbiology

    • 2 Edición
    • Richard K. Robinson + 1 más
    • Inglés
    Written by the world's leading scientists and spanning over 400 articles in three volumes, the Encyclopedia of Food Microbiology, Second Edition is a complete, highly structured guide to current knowledge in the field. Fully revised and updated, this encyclopedia reflects the key advances in the field since the first edition was published in 1999The articles in this key work, heavily illustrated and fully revised since the first edition in 1999, highlight advances in areas such as genomics and food safety to bring users up-to-date on microorganisms in foods. Topics such as DNA sequencing and E. coli are particularly well covered.With lists of further reading to help users explore topics in depth, this resource will enrich scientists at every level in academia and industry, providing fundamental information as well as explaining state-of-the-art scientific discoveries.

  • Handbook of Nutrition, Diet, and the Eye

    • 1 Edición
    • Victor R. Preedy
    • Inglés
    The Handbook of Nutrition, Diet and the Eye is the first book to thoroughly address common features and etiological factors in how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss can be devastating. One of the biggest contributors to complete vision loss in the western hemisphere is diabetes, precipitated by metabolic syndrome. In some developing countries, micronutrient deficiencies are major contributory factors to impaired vision. However, there are a range of ocular defects that have either their origin in nutritional deficiencies or excess or have been shown to respond favorably to nutritional components. The eye from the cornea to the retina may be affected by nutritional components. Effects may be physiological or molecular. This book represents essential reading for nutritionists, dietitians, optometrists, ophthalmologists, opticians, endocrinologists, and other clinicians and researchers interested in eye health and vision in general.

  • Physical Examination in Cardiovascular Chinese Medicine

    • 1 Edición
    • Anika Niambi Al-Shura
    • Inglés
    Physical Examination in Cardiovascular Chinese Medicine details the basics of how to take and record cardiac patient history and triage vitals, then apply the basic western and TCM methods for examining cardiovascular patients in the clinic. It outlines the basic procedure for creating intake questions and then examining the cardiovascular patient using both western and TCM techniques. This book is intended for US-based licensed TCM practitioners as well as cardiology researchers.

  • Health Communication in Traditional Chinese Medicine

    • 1 Edición
    • Anika Niambi Al-Shura
    • Inglés
    Health Communication in Traditional Chinese Medicine Cardiology presents an overview of health communications including history, cardiovascular prevalence and role of Chinese medicine, interpersonal communications between practitioners and patients, and explores methods in epidemiology to follow symptom, diagnostic, treatment and follow-up patterns in the clinic. The book integrates the role of Chinese medicine in public health efforts, classifying the identity of the practitioner and the needs of certain patient types who require this kind of matching for better health and research methods to help sharpen the focus for specializing practitioners.

  • Clinical Decision Support

    The Road to Broad Adoption
    • 2 Edición
    • Robert Greenes
    • Inglés
    With at least 40% new or updated content since the last edition, Clinical Decision Support, 2nd Edition explores the crucial new motivating factors poised to accelerate Clinical Decision Support (CDS) adoption. This book is mostly focused on the US perspective because of initiatives driving EHR adoption, the articulation of 'meaningful use', and new policy attention in process including the Office of the National Coordinator for Health Information Technology (ONC) and the Center for Medicare and Medicaid Services (CMS). A few chapters focus on the broader international perspective. Clinical Decision Support, 2nd Edition explores the technology, sources of knowledge, evolution of successful forms of CDS, and organizational and policy perspectives surrounding CDS.Exploring a roadmap for CDS, with all its efficacy benefits including reduced errors, improved quality, and cost savings, as well as the still substantial roadblocks needed to be overcome by policy-makers, clinicians, and clinical informatics experts, the field is poised anew on the brink of broad adoption. Clinical Decision Support, 2nd Edition provides an updated and pragmatic view of the methodological processes and implementation considerations. This book also considers advanced technologies and architectures, standards, and cooperative activities needed on a societal basis for truly large-scale adoption.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 4 Edición
    • Terry P. Kenakin
    • Inglés
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

  • Food Structures, Digestion and Health

    • 1 Edición
    • Mike Boland + 2 más
    • Inglés
    This selection of key presentations from the Food Structures, Digestion and Health conference is devoted to the unique and challenging interface between food science and nutrition, and brings together scientists across several disciplines to address cutting-edge research issues. Topics include modeling of the gastrointestinal tract, effect of structures on digestion, and design for healthy foods. New knowledge in this area is vital to enable the international food industry to design of a new generation of foods with enhanced health and sensory attributes. The multidisciplinary approach includes research findings by internationally renowned scientists, and presents new research findings important and pertinent to professionals in both the food science and nutrition fields.

  • Laboratory Methods in Enzymology: Protein Part C

    • 1 Edición
    • Volumen 541
    • Inglés
    In this volume we have brought together a number of core protocols concentrating on Protein, carefully written and edited by experts.

  • Preservation and Shelf Life Extension

    UV Applications for Fluid Foods
    • 1 Edición
    • Tatiana Koutchma
    • Inglés
    Preservation and Shelf Life Extension focuses on the basic principles of ultraviolet light technology as applied in low-UV transmittance treatments of food fluids and solid foods. It describes the features of UV light absorption in food fluids and available commercial systems, and provides case studies for UV treatment of fresh juices, dairy products, wines, and beer. The book also includes information on various continuous and pulsed UV sources and processing systems, as well as examples of specific treatments for fruits, vegetables, meat and poultry products.

  • Colour Atlas of Ophthalmology

    • 2 Edición
    • Arthur Lim Siew Ming + 1 más
    • Inglés
    Colour Atlas of Ophthalmology, Second Edition provides information pertinent to the fundamental aspects of ophthalmology. This book provides the correct diagnosis and treatment of many ocular disorders. Organized into 11 chapters, this edition begins with an overview of the process of assessment of a patient with eye disease, which includes taking a good history, examining the eyes with adequate illumination, and testing the visual function. This text then describes exophthalmos, which is the most common condition of the orbit and indicates the possibility of thyroid disease or a space-occupying lesion. Other chapters consider the common causes of ocular injuries, including injury from flying particles, sharp instruments, chemicals, and ocular injury associated with head injury. The final chapter deals with the common, therapeutic, and diagnostic ocular drugs. This book is a valuable resource for ophthalmologists, physicians, nurses, students, and all those paramedical personnel who have to deal with common eye disease.

  • Toxicological Aspects of Drug-Facilitated Crimes

    • 1 Edición
    • Pascal Kintz
    • Inglés
    Toxicological Aspects of Drug-Facilitated Crimes provides readers with an overview of the field of DFC: its history, toxicological effects, analysis, interpretation of results, the roles that age, gender and race may play, and clinical presentations of these drugs. The most commonly used drugs in DFC are addressed (alcohol, cannabis, MDMA, and cocaine), as well as an emerging range of pharmaceuticals (benzodiazepines, hypnotics, sedatives, neuroleptics, histamine H1-antagonists, or anesthetics), which are becoming more widely used, but are more difficult to detect. Edited by a world-renowned expert in the field of Forensic and Analytical Toxicology, Pascal Kintz, this book investigates toxicants of emerging concern and brings together a number of experts in the field to address the most recent discoveries on DFC toxicology.

  • Cancer Theranostics

    • 1 Edición
    • Xiaoyuan Chen + 1 más
    • Inglés
    Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives.

  • Silk Biomaterials for Tissue Engineering and Regenerative Medicine

    • 1 Edición
    • Subhas C. Kundu
    • Inglés
    Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering.

  • Microbiology for Surgical Infections

    Diagnosis, Prognosis and Treatment
    • 1 Edición
    • Kateryna Kon + 1 más
    • Inglés
    Microbiology for Surgical Infections: Diagnosis, Prognosis and Treatment explores current trends in etiology and antibiotic resistance of pathogens responsible for devastating and complex surgical infections. Clinicians and researchers report the most recent advances in diagnostic approaches to bacterial and non-bacterial surgical infections, including invasive fungal infections. Current guidelines for prophylaxis of community-acquired and nosocomial infections, complications in surgery, and improvement of diagnosis and treatment of these devastating surgical infections are also discussed. The work gives specific attention to intra-abdominal and wound infections, as well as infections in cardiac surgery and neurosurgery. Taken together, these explorations inform the work of specialists in different surgical arenas, as well as those working in microbiology. Microbiology for Surgical Infections provides a resource to those working to improve outcomes in this complicated arena by discussing prospects for future study and identifying targets for future research.

  • The Value of BCG and TNF in Autoimmunity

    • 1 Edición
    • Denise Faustman
    • Inglés
    The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such as type 1 diabetes and multiple sclerosis. Overall, the book focuses on the lessons that can be learned from the researchers' individual experiences and data, and provides a rationale for bringing the inexpensive, generic BCG vaccine to the forefront of clinical trials in different forms of autoimmunity.

  • Diabetes Mellitus: Associated Conditions, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 43-1
    • Leonid Poretsky
    • Inglés
    This issue of the Endocrinology and Metabolism Clinics, guest edited by Drs. Leonid Poretsky and Emilia Pauline Liao, will focus on Diabetes Mellitus: Associated Conditions. Articles in this issue include Metabolic syndrome; The role of glucocorticoids and insulin resistance in adipose tissue function and lipid metabolism; Cardiovascular disease; The Relationships between Cardiovascular Disease and Diabetes: Focus on Pathogenesis; Interventions for coronary artery disease; Peripheral Arterial Disease; Hypertension; Sleep apnea; Osteoporosis; Vitamin D deficiency; Diabetes and cancer; Dementia; Depression; and Polycystic Ovary Syndrome.

  • Therapeutic Risk Management of Medicines

    • 1 Edición
    • Stephen J. Mayall + 1 más
    • Inglés
    Therapeutic risk management of medicines is an authoritative and practical guide on developing, implementing and evaluating risk management plans for medicines globally. It explains how to assess risks and benefit-risk balance, design and roll out risk minimisation and pharmacovigilance activities, and interact effectively with key stakeholders.A more systematic approach for managing the risks of medicines arose following a number of high-profile drug safety incidents and a need for better access to effective but potentially risky treatments. Regulatory requirements have evolved rapidly over the past decade. Risk management plans (RMPs) are mandatory for new medicinal products in the EU and a Risk Evaluation and Mitigation Strategy (REMS) is needed for certain drugs in the US.This book is an easy-to-read resource that complements current regulatory guidance, by exploring key areas and practical implications in greater detail. It is structured into chapters encompassing a background to therapeutic risk management, strategies for developing RMPs, implementation of RMPs, and the continuing evolution of the risk management field.The topic is of critical importance not only to the pharmaceutical and biotechnology industries, but also regulators and healthcare policymakers.Some chapters feature contributions from selected industry experts.

  • Food Plant Safety

    UV Applications for Food and Non-Food Surfaces
    • 1 Edición
    • Tatiana Koutchma
    • Inglés
    Food Plant Safety: UV Applications for Food and Non-Food Surfaces discusses the fundamental principles of ultraviolet (UV) light technology, and gives practical recommendations on UV processes and systems design for specific processing operations, as well as how microbial efficacy of UV light can improve the quality of existing product lines. Innovative research of ultraviolet light for food applications has been growing worldwide. With increased consumer demand for fresher, minimally processed but safe foods, comes the need for novel technologies to meet that demand. Ultraviolet technology has been taking its niche in food production as a non-chemical treatment to control and enhance safety of processing plants and storage facilities. This concise resource covers the fundamentals of this promising technology and its applications; it will benefit a broad audience of professionals in food engineering, processing, and product development, as well as graduate level students.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 125
    • Inglés
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • Advances in Protein Chemistry and Structural Biology

    • 1 Edición
    • Volumen 94
    • Inglés
    This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

  • The Role of 5-HT Systems on Memory and Dysfunctional Memory

    Emergent Targets for Memory Formation and Memory Alterations
    • 1 Edición
    • Alfredo Meneses
    • Inglés
    Drugs acting through 5-HT (5-hydroxytryptamine... or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.

  • Reconstituting the Cytoskeleton

    • 1 Edición
    • Volumen 540
    • Inglés
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cytoskeletal structure, including such topics as rotational movement of formins studied by fluorescence polarization microscopy, in vitro assembly assays for bacterial actin filaments, and modulators of microtubule plus end growth.

  • From an Antagonistic to a Synergistic Predator Prey Perspective

    Bifurcations in Marine Ecosystem
    • 1 Edición
    • Tore Johannessen
    • Inglés
    From an Antagonistic to a Synergistic Predator Prey Perspective: Bifurcations in Marine Ecosystems is a groundbreaking reference that challenges the widespread perception that predators generally have a negative impact on the abundance of their prey, and it proposes a novel paradigm — Predator-prey Synergism — in which both predator and prey enhance abundance by their co-existence. Using this model, the text explains a number of issues that appear paradoxical in the case of a negative predator-prey relationship, including observed ecosystem bifurcations (regime shifts), ecosystem resilience, red tides in apparently nutrient depleted water, and the dominance of grazed phytoplankton over non-grazed species under high grazing pressure. This novel paradigm can also be used to predict the potential impact of global warming on marine ecosystems, identify how marine ecosystem may respond to gradual environmental changes, and develop possible measures to mitigate the negative impact of increasing temperature in marine ecosystems. This book approaches the long-standing question of what generates recruitment variability in marine fishes and invertebrates in an engaging and unique way that students and researchers in marine ecosystems will understand.

  • Starch Polymers

    From Genetic Engineering to Green Applications
    • 1 Edición
    • P. Halley + 1 más
    • Inglés
    This book focuses on starch polymers including starch genetics, biotechnological and chemical modification, nanostructures, processing, characterization, properties and applications. This books topic is in a cutting edge and emerging technology area of biomaterials, nanomaterials and renewable materials, and will involve international experts in diverse fields from genetic engineering to applications.

  • Erectile Dysfunction as a Cardiovascular Impairment

    • 1 Edición
    • Robert Fried
    • Inglés
    Erectile Dysfunction as a Cardiovascular Impairment organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.

  • Pattern Recognition and Signal Analysis in Medical Imaging

    • 2 Edición
    • Anke Meyer-Baese + 1 más
    • Inglés
    Medical imaging is one of the heaviest funded biomedical engineering research areas. The second edition of Pattern Recognition and Signal Analysis in Medical Imaging brings sharp focus to the development of integrated systems for use in the clinical sector, enabling both imaging and the automatic assessment of the resultant data. Since the first edition, there has been tremendous development of new, powerful technologies for detecting, storing, transmitting, analyzing, and displaying medical images. Computer-aided analytical techniques, coupled with a continuing need to derive more information from medical images, has led to a growing application of digital processing techniques in cancer detection as well as elsewhere in medicine. This book is an essential tool for students and professionals, compiling and explaining proven and cutting-edge methods in pattern recognition for medical imaging.

  • Aging

    Oxidative Stress and Dietary Antioxidants
    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging.

  • Side Effects of Drugs Annual

    A worldwide yearly survey of new data in adverse drug reactions
    • 1 Edición
    • Volumen 35
    • Jeffrey K Aronson
    • Inglés
    The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

  • Cancer

    Oxidative Stress and Dietary Antioxidants
    • 1 Edición
    • Victor R. Preedy
    • Inglés
    Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

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