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Elsevier

Libros en Ciencias de la Vida

  • Toxic Phosphorus Esters

    Chemistry, Metabolism, and Biological Effects
    • 1 Edición
    • Richard D. O'Brien
    • Inglés
    Toxic Phosphorus Esters: Chemistry, Metabolism, and Biological Effects aims to become a source book on organophosphate research and show how the understanding of the events following organophosphate poisoning of animals can be understood in terms of events at the molecular level. The manuscript first offers information on nonenzymic reactions and the reaction with cholinesterase in vitro. Discussions focus on hydrolysis, isomerization, oxidation, phosphorylation of the enzyme, and selectivity for different cholinesterases. The text then examines enzymic degradation and activation in vitro, effects in mammals, and effects on isolated whole tissues. The publication ponders on the effects in insects and plants, including results of poisoning, metabolism, resistance, antagonism and synergism, and phytotoxicity. The text also reviews selective toxicity, as well as excretion and storage, metabolism, design of new selective compounds, and nature of the target. The manuscript is a dependable reference for readers interested in the composition, reactions, and effects of toxic phosphorus esters.

  • Biotechnology and Food Quality

    Proceedings of the First International Symposium
    • 1 Edición
    • Shain-dow Kung + 2 más
    • Inglés
    Biotechnology and Food Quality focuses on the potential of biotechnology in quantitatively and qualitatively modifying agriculture. The selection first offers information on the benefits of agricultural biotechnology on developed and developing countries, food quality education, and food quality, biotechnology, and the food company. Discussions focus on consumer concerns, demographic and social changes, scope and future role of food quality, and improvement of agricultural raw materials and processed foods. The manuscript then underscores how to make technology transfer work and the regulatory considerations of biotechnology. The text examines the characterization and modification of maize storage proteins; genetic modification of traits of interest to consumers and processors; and omega-3 fatty acid improvements in plants. Topics include genetic engineering of fatty acid biosynthesis, cellular genetics, molecular biology, application of technology to food products, and genetic engineering of lysine-containing alpha zeins. Cell wall dynamics, prospects for the use of genetic engineering in the manipulation of ethylene biosynthesis and action in higher plants, and molecular interactions of contractile proteins are also elaborated. The selection is a highly recommended source of data for biotechnologists, agriculturists, and food experts.

  • Cell Culture

    • 1 Edición
    • P. Michael Conn
    • Inglés
    Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.

  • Marijuana

    Effects on Human Behavior
    • 1 Edición
    • Loren L. Miller
    • Inglés
    Marijuana: Effects on Human Behavior attempts to synthesize much of the existing experimentation concerning the acute and chronic effects of marijuana and its derivatives on human behavior. The book opens with a chapter on the strategies for conducting research on marijuana. It also describes a clinical study at the University of British Columbia. The next chapter discusses the issues that have beclouded the question of legalization of marijuana in the United States. This is followed by separate chapters on the effects of marijuana on motor and mental performance; marijuana-memory research; a model of attention which can be used to describe the effects of marijuana use on cognition; and the effects of marijuana on neuropsychological functioning and learning. Subsequent chapters examine the behavioral actions of cannabis in man; compare the behavioral actions of cannabinoids in humans with those found in infrahumans, with special reference to acquisition and retention processes, timing behavior, state-dependent learning, and attention; and investigate the long-term effects of cannabis use.

  • Drugs in Cerebral Palsy

    Based on a Symposium Held at Dallas, 24-26 November, 1963
    • 1 Edición
    • Eric Denhoff + 2 más
    • Eric Denhoff
    • Inglés
    Clinics in Developmental Medicine No. 16: Drugs in Cerebral Palsy: Based on a Symposium held at Dallas, 24-26 November, 1963 is a collection of papers of the 1963 Symposium on Drugs in Cerebral Palsy, arranged by the American Academy. This book is composed of nine chapters that cover the various components and treatment options involved in cerebral palsy. This text begins with a presentation of the many problems of drug evaluation, with an emphasis on the issue that human responses to a drug cannot be predicted from those of animals and that the response of one human to a drug may differ quite sharply from that of another. The next chapters deal with the historical developments and pharmacology of drugs in cerebral palsy, as well as the two aspects of drug evaluation, namely, the immediate or direct effects of the drug on patients and the double-blind test. The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. The last chapter considers the possible toxic drug reactions, which are the result of individual idiosyncrasy and may occur regardless of drug dosage. This book will be of value to pharmacologists, neurologists, clinicians, and researchers who are interested in drug evaluation in cerebral palsy.

  • Genesis and Evolutionary Development of Life

    • 1 Edición
    • A. I. Oparin
    • Inglés
    Genesis and Evolutionary Development of Life discusses the present state of thought on the origin and development of life. The book contains six chapters and begins with a brief history of attempts to solve the problem of the origin of life. This is followed by separate chapters the discuss the following events: the initial stages in the evolution of carbon compounds; formation of the "primitive soup"; origin of prebiological systems; evolution of "protobionts" and the origin of the first organisms; and the further evolution of the first organisms.

  • Advances in Drug Delivery Systems, 6

    Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21-24, 1993
    • 1 Edición
    • James M. Anderson + 2 más
    • Inglés
    Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

  • Progress in Chemical Toxicology

    Volume 3
    • 1 Edición
    • Abraham Stolman
    • Inglés
    Progress in Chemical Toxicology, Volume 3 explores the developments in methods and instrumentation for toxicological analyses. This book is composed of eight chapters, and begins with a description of the pharmacologic and physiologic effects of aliphatic alcohols. The succeeding chapter deals with the methods of analysis of various volatile poisons, such as halogenated aliphatic compounds, aromatic hydrocarbons, and acid compounds. A chapter focuses on the methods of determination and classic procedures for carbon monoxide analysis in breath and blood. These topics are followed by discussions on the development of spectrochemical methods chemical and radiochemical methods of determination of radionuclides in human bones and tissues; and the toxic effects of combined drug action. The last chapter examines the poison residue occurrence in human tissues. This book is of great value to toxicologists and public health workers and researchers.

  • Development of Responsiveness to Steroid Hormones

    Advances in the Biosciences
    • 1 Edición
    • Alvin M. Kaye + 1 más
    • Inglés
    Development of Responsiveness to Steroid Hormones is a collection of papers presented at the Bat-Sheva Seminar of the same name which was held in Rehovot, Israel, on October 18-26, 1978 and sponsored by the Bat-Sheva de Rothschild Foundation for the Advancement of Science in Israel in cooperation with The Weizmann Institute of Science. Contributors explore how the steroid receptor complex modulates transcription of RNA and cover topics ranging from the sequential acquisition of responsiveness to estrogen in the rat uterus to the ontogeny of steroid receptors in the guinea pig. This book is comprised of 29 chapters and begins with a review of estrogen and estrogen effects in rat uterus and pituitary in culture. The embryonic chick Müllerian duct and several fetal guinea pig organs are then considered, followed by discussions on mammalian and chick liver, multi-hormonal control in rat liver; progesterone and decidualization; and rat mammary gland in culture. Glucocorticoids in developing pancreas, lung, and liver are examined, along with ecdysteroids in both locusts and Drosophila. Refractoriness is exemplified by gonadotropin action in the ovary. The remaining chapters deal with the role of steroid hormone receptors in brain development; the neural trigger for ovulation; aromatization and development of responsiveness of the brain to gonadal steroids; and neuroendocrine correlates of female-offspring interaction in maternal rats. This monograph will be of value to physiologists, biologists, and biochemists.

  • Clinical Neuroendocrinology

    • 1 Edición
    • G. M. Besser + 1 más
    • Inglés
    Clinical Neuroendocrinology, Volume II discusses neuroendocrine science and its application to the analysis of human physiology and behavior. This book stresses the importance of the interrelationships between central and peripheral signals, neurotransmitters and neuromodulators, and target glands and peripheral tissues to ensure coordination of somatic and behavioral development and function. The ""centralist"" concepts of the importance of brain hormones are revised in this text, emphasizing that neurohumoral factors isolated from brain tissues, and initially considered to be primarily involved in the central nervous system regulation of the endocrine system, also exist outside the brain and spinal cord. This volume is valuable to neuroendocrinologist... but is also a good source for those involved in basic and clinical research and patient management.

  • Fats in Animal Nutrition

    • 1 Edición
    • J. Wiseman
    • Inglés
    Fats in Animal Nutrition provides a useful text containing information from many diverse disciplines that discuss the nutritional utilization of lipids of domesticated animals. The book is divided into seven parts. Part I covers the chemistry and biochemistry of animal and plant fats and their nutritional importance; Part II discusses the general principles involved in the transport and absorption of fats and how this process is facilitated in ruminant and non-ruminant animals. The book also deals with the role of essential fats in the nutrition of different animals, as well as the protective functions of fat-soluble vitamins . Part IV discusses the use of fats as an energy source for animals; Part V deals with the inclusion of fats in animal feeds and their uses. The deposition of fat in different meats and the practical applications of fat utilization in animals are covered as well. The text is recommended for agriculturists, veterinarians, and zoologists who would like to know more about the importance of the inclusion of fats in animal diets.

  • Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

    • 1 Edición
    • T.E. Gram
    • Inglés
    Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

  • Contributions to Thermal Physiology

    Satellite Symposium of the 28th International Congress of Physiological Sciences, Pécs, Hungary, 1980
    • 1 Edición
    • Z. Szelényi + 1 más
    • Inglés
    Advances in Physiological Sciences, Volume 32: Contributions to Thermal Physiology is a collection of papers that details the advances in the understanding of the thermal aspects of physiology. The first part of the title presents articles about central nervous control of body temperature, while the second part covers papers about fever. Next, the selection deals with brain cooling, along with thermoregulation and sleep. The fifth part covers phylogenic aspects of temperature regulation, while the sixth part tackles acclimation. Next, the selection talks about age-related difference in temperature regulation and the peripheral effector mechanisms. The text also covers the brown adipose tissue and the relevance of exercise in regulating body temperature. The book will be of great interest to students, researchers, and practitioners of medicine and biology.

  • Principles and Practice of Restorative Neurology

    Butterworths International Medical Reviews
    • 1 Edición
    • Robert R Young + 1 más
    • Inglés
    Principles and Practice of Restorative Neurology is a collection of topics in clinical neurology where progress through research has brought concepts of patient management. The collection emphasizes research done clinically and in experimental laboratories and attempts to discuss restorative neurology in the larger context, encompassing biology, neurobiology, and rehabilitative engineering. The book discusses the concept that neurology should be more therapeutic instead of being just diagnostic because of advances in techniques and drugs. An epidemiology of disability and the evaluation of restorative neurology are explained. The text also presents the developments in the pharmacotherapy of major neurological disorders, such as Parkinson's disease, dementia, and stroke. The use of biomechanical or rehabilitation engineering to treat impaired or lost functions in a patient is compared; the feedback mechanisms and the kinds of treatment including microsurgery, nuerostimulation methods, surgery, and molecular genetics that are applied to specific disorders are discussed extensively. The book also reviews the approaches of gene correction for disorders in the central nervous system. Finally, the future needs of neurology in terms of diagnosis and treatments are dealt with as more research, techniques, and drugs are being discovered and proved useful. The collection is intended for neurologists, neurologists in training, and other physicians whose work lies with neurological disorders. The book can also prove useful for practitioners and academicians in the fields of neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

  • The Molecular Biology of Neurological Disease

    Butterworths International Medical Reviews
    • 1 Edición
    • Roger N. Rosenberg + 1 más
    • Inglés
    The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

  • Structure-Function Properties of Food Proteins

    • 1 Edición
    • Lance G. Phillips
    • Steve L Taylor
    • Inglés
    The functional properties of food proteins affect behavior in food systems and influence the quality attributes, structure, texture, mouth-feel, and flavor of the final product. These attributes are precisely those with which food engineers and technologists are concerned when developing new products. This innovative book provides an overview of the physical properties of proteins and how dynamic changes in conformation, structural changes, and protein-protein interactions are involved in the performance of particular functional properties such as gelation, emulsification, and foaming properties. Models used include B-Lactoglobulin, soy, and meat proteins.

  • Parasitic Protozoa

    Volume 9
    • 2 Edición
    • Julius P. Kreier
    • Inglés
    Updated and much expanded, the Second Edition of Parasitic Protozoa is designed to be useful to physicians, veterinarians, and research scientists concerned with diseases caused by protozoa in man, and in domestic and wild animals including fish, mollusks and insects, as well as the more commonly considered vertebrate animals. Each section contains information on disease pathogens, treatment, diagnosis, and epidemiology of the diseases caused by the various protozoans. The book is not limited to these medically-oriented subjects, but treats taxonomy, morphology, and metabolism of the organisms in such a way as to be of interest to scientists and graduate students working in the field of protozoology. The entire edition, published in ten volumes, is arranged so that subjects of common interest occupy individual volumes.

  • An Agricultural Geography of Great Britain

    The Commonwealth and International Library: Geography Division
    • 1 Edición
    • D. W. Gilchrist Shirlaw
    • W. B. Fisher
    • Inglés
    An Agricultural Geography of Great Britain is a comprehensive account of Great Britain's agricultural geography. The relationship between agriculture and geography is highlighted, with emphasis on the points of contact between them, including soils, geology, climate, and systems of farming. The farming systems of Great Britain are described, along with the agriculture of Scotland and the border country as well as the agricultural regions of England and Wales. This book is divided into four sections and begins with an overview of the factors affecting the choice of a farming system, including economic circumstances, soil, climate, topography, disease, and the personal preference and individual skills of the farmer. The next section is devoted to Great Britain's farming systems, which include hill sheep farming and hill sheep with cattle; stock rearing and fattening; dairy farming; horticulture and market gardening, often with some livestock; and pigs and poultry. The agriculture of Scotland and the border country is then considered, followed by a discussion on the agricultural regions of England and Wales. This monograph is intended primarily for agriculturists and geographers as well as students of agricultural geography.

  • The Anatomy of Aging in Man and Animals

    • 1 Edición
    • Warren Andrew
    • Inglés
    The Anatomy of Aging in Man & Animals presents a critical review of the characteristics of invertebrates. It discusses the physical features and parts of fishes, amphibians, reptiles, and birds. It also addresses the characteristics and physiology of mammals as well as the organization of the nervous system. Some of the topics covered in the book are the descriptions and species of protozoa; description of porifera, coelenterate, and kinds of rotifer; parts and functions of mollusca; description and reproduction of annelida; types of crustacea; studies on drosophila; analysis of nutrition, temperature, and aging; and development of the nervous system of a bee. The structures of flatworms and the development of roundworms and echinodermata are discussed. An in-depth analysis of the classes of echinoidea is provided. The characteristics of thymus in an adult amphibian are also presented. A chapter is devoted to the description of changing appearance of human skin. The book can provide useful information to scientists, biologists, students, and researchers.

  • Poulsson's Text-Book of Pharmacology and Therapeutics

    • 1 Edición
    • Stanley Alstead
    • Inglés
    Poulsson’s Text-Book of Pharmacology and Therapeutics, Second English Edition covers the considerable progress in understanding the basic principles, applications, and classifications of drugs and other organic compounds of therapeutic interest. This text is divided into six chapters, each dealing with a specific classification of drugs. The first chapter describes the so-called protoplasmic poisons, which are organic substances that are characterized by their specific effects after absorption on the nervous and muscular systems, while local effects are altogether absent or insignificant. The second chapter examines the organic remedies that principally act locally, such as at the point of application, while the action after absorption is unimportant or is not utilized in medicine. The third and fourth chapters explore the main groups containing the inorganic bodies. These chapters demonstrate that the inorganic compounds differ from the organic, whose activity is due to the unchanged entire molecules, and they are subjected to dissociation. The fifth chapter considers the digestive ferments and foodstuffs, while the sixth chapter is concerned with antitoxins and bacterial products. This book will be of value to pharmacologists, pharmacists, researchers, and pharmacology and pharmacy students.

  • Oxygen in the Animal Organism

    Proceedings of a Symposium Held Under the Joint Auspices of the International Union of Biochemistry and the International Union of Physiological Sciences, London, 1963
    • 1 Edición
    • Frank Dickens + 1 más
    • Inglés
    Oxygen in the Animal Organism is a compilation of papers presented during the symposium on Oxygen in the Animal Organism, jointly sponsored by the International Union of Biochemistry and the International Union of Physiological Sciences, held at Bedford College, London in September 1963. The book provides a multidisciplinary approach to the study of the subject of oxygen in the animal organism. The papers presented cover a wide range of facts and hypotheses on the subject. Topics discussed include studies in the transport of oxygen; the fundamental physics and chemistry of oxygen; the diffusion of oxygen from the capillaries to the mitochondria; the neural and humoral components to the regulation of ventilation; and the evolution of biochemical pathways for oxygen. Biologists, biochemists, biophysicists, physiologists, and researchers will find the text informative and insightful.

  • Progress in Neurology and Psychiatry

    An Annual Review
    • 1 Edición
    • E. A. Spiegel
    • Inglés
    Progress in Neurology and Psychiatry: An Annual Review, Volume 22 covers the significant advances in the understanding of neurophysiology, neuro-ophthalmology, and psychiatry. This volume is organized into four sections encompassing 33 chapters that also deal with the neurological aspects of pain and motor disorders. The first part discusses the fundamentals of neuroanatomy, general and regional neurophysiology, neuropathology, and the pharmacological aspects of the central nervous system. The second part examines the diagnosis, symptoms, and clinical features of neurological disorders. This part also explores the anatomical aspects of neuro-ophthalmology, otoneurology, and pediatric neurology. The third part reviews the surgical treatments for various neuro-related problems, including trauma, brain tumors, pain, and motor disorders. The fourth part considers the application of clinical psychiatry to the diagnosis and treatment of mental and emotional disorders, both in children and adults. This book will prove useful to neurologists, clinicians, pediatricians, and psychiatrists.

  • Controlled Breeding in Farm Animals

    • 1 Edición
    • I. Gordon
    • Inglés
    This textbook provides a detailed view of the different ways in which reproduction in cattle, sheep, pigs and horses can be controlled and manipulated. It is primarily of interest to students of animal science and veterinary medicine, but will also be of use to those who are concerned with the practical aspects of reproduction control, whether in an advisory capacity or in applying techniques on the farm itself. A major objective of the book is to draw attention to information which may be used directly to increase the efficiency of the livestock industry.

  • Charles Darwin

    The Founder of the Theory of Evolution and Natural Selection
    • 1 Edición
    • Gerhard Wichler
    • Inglés
    Charles Darwin: The Founder of the Theory of Evolution and Natural Selection provides a comprehensive coverage of the whole spectrum of the theory of evolution. The title presents the historical accounts and conceptual basis that leads to the foundation of the theory of evolution. The text first covers the history of the theory of evolution; the book also details the early form of the theory up to the point of the theories acceptance. Next, the selection discusses the basis and development of theory of evolution. The book will be of great interest to anyone who wants to investigate in great depth the theory of evolution.

  • Recent Advances in Acarology

    Volume II
    • 1 Edición
    • J. G. Rodriguez
    • Inglés
    Recent Advances in Acarology, Volume II, had its inception in the V International Congress of Acarology held at Michigan State University in August 1978. This two-volume work includes the contents of the symposia and a selection of contributions to the workshops and submitted paper sessions. These volumes examine subjects such as strategies in pest management of mites and ticks, topics encompassing pheromone communication, resistance of mites and ticks to acaricides, nonchemical control of ticks, new acaricides, nutritional ecology/control, and biological control. This book is devoted primarily to medical and veterinary acarology: biology, ecology, management, disease transmission, and pheromonal communication. It also contains a section covering systematics, morphology, and evolution; and a section on the evolution of hosts and their parasites. Management strategies for medical and veterinary acari are dependent on sound investigations of biology and ecology. Such investigations, beginning with contributions on the biology of spotted fever ticks, are discussed. It sets forth appropriate methodology for ecological studies, describes the zoogeography and biological adaptations of one species, and reviews the ecological associations of the two.

  • The Molecular Properties and Evolution of Excitable Cells

    International Series of Monographs in Pure and Applied Biology
    • 1 Edición
    • C. J. Duncan
    • G.A. Kerkut
    • Inglés
    The Molecular Properties and Evolution of Excitable Cells describes the theoretical aspects in which excitable cells, such as nerves, muscles, and sense organs, operate. This book develops a hypothesis regarding the evolution and characteristics of excitable cells. This monograph focuses on the properties of the bounding membrane and its complex permeability system, which starts the excitation state. Sense organs, as the input component in both vertebrates and invertebrates, are then discussed. The text then briefly describes the ways that the ionic permeability of the excitable membrane can both be modified and controlled. The book points out that since ions pass through standard sizes of the pores in an excitable membrane, their passage is determined by the dimensions of the pore and by the existing charge found on its walls. The book then explains the application of a mechanical stimulus to a mechanoreceptor that will cause deformations in the membrane. This deformation leads to enzyme activity and produces alteration in the rate at which ATP is supplied to the lateral borders of the cell. The text discusses a hypothesis that invokes enzyme activity by propagating action potential along the axon, and other input systems, such as adrenaline, amino acids, and y-amino-butyric acid (GABA). The book also explains the hypothesis that living organisms are composed of an ordered system of protein-enzymes forming on phospholipid-protein membranes. This monograph will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 2
    • 1 Edición
    • E. J. Ariëns
    • Inglés
    Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of cholinesterases. The text also describes the design of reactivators for irreversibly blocked acetylcholinesterase... drug design based on the inhibition of protein synthesis in the context of susceptible enzymic reactions; as well as the role of enzymes and their synthesis as a target for antibiotic action. The rational design of antiviral agents; the design of penicillin; the design of peptide hormone analogs; as well as the advances in the design of diuretics are also considered. The book further tackles the design of biologically active steroids; the rational elements in the development of superior neuromuscular blocking agents; and the design of tumor-inhibitory alkylating drugs. Pharmacologists, chemists, and people involved in drug design will find the book invaluable.

  • An Atlas of the Commoner Skin Diseases

    With 139 Plates Reproduced by Direct Colour Photography from the Living Subject
    • 3 Edición
    • Henry C. G. Semon
    • Inglés
    An Atlas of the Commoner Skin Diseases presents a collection of illustrations of dermatoses from the living subject in natural color. This 139-chapter text discusses the methods of treatment of the covered diseases. Considerable chapters are devoted to the differential diagnosis and treatment of numerous skin diseases, including acne, chilblains, dermatitis artefacta, generalized exfoliative dermatitis, psoriasis, gumma syphilis, lupus vulgaris, rosacea, scabies, and varicose ulcer. Other chapters describe the physical appearance of acne, alopecia areata, dermatitis artefacta, varicose, and herpes zoster. The remaining chapters tackle the diagnosis and clinical manifestations of other skin diseases. The book can provide useful information to the dermatologists, doctors, students, and researchers.

  • Analysis of Welded Structures

    Residual Stresses, Distortion, and Their Consequences
    • 1 Edición
    • Koichi Masubuchi
    • D. W. Hopkins
    • Inglés
    Analysis of Welded Structures: Residual Stresses, Distortion, and their Consequences encompasses several topics related to design and fabrication of welded structures, particularly residual stresses and distortion, as well as their consequences. This book first introduces the subject by presenting the advantages and disadvantages of welded structures, as well as the historical overview of the topic and predicted trends. Then, this text considers residual stresses, heat flow, distortion, fracture toughness, and brittle and fatigue fractures of weldments. This selection concludes by discussing the effects of distortion and residual stresses on buckling strength of welded structures and effects of weld defects on service behavior. This book also provides supplementary discussions on some related and selected subjects. This text will be invaluable to metallurgists, welders, and students of metallurgy and welding.

  • A Synopsis of Respiratory Diseases

    • 1 Edición
    • J. Smart
    • Inglés
    A Synopsis of Respiratory Diseases discusses the concept of pulmonary physiology and its diseases. This book is composed of 10 chapters that address the development and treatment of tuberculosis. Some of the topics covered in the book are the essential function of the lungs; transfer of gases; blood gas analysis; definition of acute respiratory failure; different diseases of the nose; ailments of the larynx; conditions of spasm or obstruction of the larynx; types of ventilators; control of respiration; and differential lung function. Other chapters describe the physiological instances leading to carbon dioxide narcosis and some diseases of the trachea. The discussion then shifts to the etiology, histology, and bacteriology of chronic bronchitis. The concluding chapters are devoted to the definition and treatment of emphysema, as well as the diagnosis of tumors of the bronchus. The book can provide useful information to doctors, students, and researchers.

  • Advances in Pharmacological Research and Practice

    Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985
    • 1 Edición
    • J. Knoll + 1 más
    • Inglés
    Advances in Pharmacological Research and Practice, Volume 1: Pharmacological Protection of the Myocardium presents the proceedings of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the development in the fields of pharmacological protection of the myocardium and the pharmacology of the vascular system. Organized into two sections encompassing 70 chapters, this volume begins with an overview of the ischemic biochemical changes with emphasis on the role of cAMP and the protein kinase system. This text then explores the cellular electrophysiological disorders seen in acute myocardial ischemia as well as their pharmacological modification. Other chapters consider the prevention of primary ventricular fibrillation that includes measures aimed at maintaining electrical stability. The final chapter deals with drugs affecting beneficially the pathological lipoprotein levels. This book is a valuable resource for cardiologists and pharmacologists.

  • Environmental Soil Chemistry

    • 1 Edición
    • Donald L. Sparks
    • Inglés
    As the author states in his Preface, this book is written at a time when scientific and lay communities recognize that knowledge of environmental chemistry is fundamental in understanding and predicting the fate of pollutants in soils and waters, and in making sound decisions about remediation of contaminated soils. Environmental Soil Chemistry presents the fundamental concepts of soil science and applies them to environmentally significant reactions in soil. Clearly and concisely written for undergraduate and beginning graduate students of soil science, the book is likewise accessible to all students and professionals of environmental engineering and science. Chapters cover background information useful to students new to the discipline, including the chemistry of inorganic and organic soil components, soilacidity and salinity, and ion exchange and redox phenomena. However, discussion also extends to sorption/desorption, oxidation-reduction of metals and organic chemicals, rates of pollutant reactions as well as technologies for remediating contaminated soils. Supplementary reading lists, sample problems, and extensive tables and figures make this textbook accessible to readers.

  • Human Actinomycosis

    What the General Practitioner Ought to Know About
    • 1 Edición
    • V. Zachary Cope
    • Inglés
    What the General Practitioner Ought to Know about Human Actinomycosis focuses on infectious bacterial diseases caused by actinomyces species. This book discusses the tissue reaction to the actinomyces; microscopical appearance of the lesions; clinical pathology of actinomycosis; and cervico-facial actinomycosis. The orbital actinomycosis; diagnosis of visceral actinomycosis; ano-rectal actinomycosis; and prevention of actinomycosis are also elaborated. This text also describes the infection of actinomyces to certain parts of the body such as the tongue, stomach, intestines, colon, kidney, genital tract, liver, chest, bone with special reference to vertebral involvement, and skin. This publication is a good reference for medical practitioners and students intending to acquire knowledge of the diseases caused by actinomyces.

  • Bioreduction in the Activation of Drugs

    Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25-26 July 1985
    • 1 Edición
    • P. Alexander + 2 más
    • Inglés
    Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.

  • Metal Toxicology

    Approaches and Methods
    • 1 Edición
    • Robert A. Goyer
    • Inglés
    Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time.

  • The Biology of the Mollusca

    • 2 Edición
    • R. D. Purchon
    • G. A. Kerkut
    • Inglés
    Reviews the most important literature on the functional morphology and natural history of molluscs over a period of half a century, from 1925 to the present day, and draws extensively upon authoritative papers published mostly in the English language in a large number of international journals during this period. By these means it is hoped to provide an anthology of what is most interesting in the literature in a number of selected topics. Appendices give some practical assistance for the dissection of selected examples

  • Recent Progress in Hormone Research

    Proceedings of the 1974 Laurentian Hormone Conference
    • 1 Edición
    • Roy O. Greep
    • Inglés
    Recent Progress in Hormone Research, Volume 31 covers the proceedings of the 1974 Laurentian Hormone Conference held in Mount Tremblant, Quebec, Canada, on August 25-30, 1974. The book discusses the relationship between catecholamines and other hormones; the hormone receptor complexes and their modulation of membrane function; and receptors for insulin, NSILA-s, and growth hormone. The text also describes the mechanism of action of pituitary growth hormone; hormonal regulation of ovalbumin synthesis in the chick oviduct; and studies on the hepatic glucocorticoid receptor and on the hormonal modulation of specific mRNA levels during enzyme induction. The endocrine neurons; the formation of estrogens by central neuroendocrine tissues; and the operating characteristics of the hypothalamic-pituita... system during the menstrual cycle and observations of biological action of somatostatin are also considered. The book further tackles somatostatin; the relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in human; and the genetic approaches to the study of the regulation and actions of vasopressin. The identification and actions of gastric inhibitory polypeptide; the studies on the pathogenesis of Graves' ophthalmopathy, and qualitative and quantitative gonad-pituitary feedback is also looked into.

  • Basic Gastro-Enterology

    Including Diseases of the Liver
    • 1 Edición
    • J. M. Naish + 1 más
    • Inglés
    Basic Gastro-Enterology: Including Diseases of the Liver covers the nervous system and the gastro-intestinal tract. This book consists of 25 chapters that evaluate the diseases of the buccal mucous membranes, the control of acid secretion by parietal cells, and the causes of hematemesis and melaena. Some of the topics covered in the book are the diseases of salivary glands; gastric carcinoma; neoplastic diseases of the oesophagus; causes of dysphagia; gastric motility and emptying; problem of recurrent ulceration; and complications related to gastrectomy. Other chapters deal with the acute reactions due to drugs and poisons, the lesions of the hepatic artery, and the clinical varieties of cirrhosis. The diagnosis of anorectal disease is provided. The concluding chapters are devoted to the management and treatment of ulcerative colitis. The book can provide useful information to doctors, pathologists, students, and researchers.

  • Mycobacteria

    Institute of Medical Laboratory Sciences Monographs
    • 1 Edición
    • Maureen V. Chadwick
    • F. J. Baker
    • Inglés
    Mycobacteria covers some aspects of mycobacterial identification. The book starts by describing a historical review of tuberculosis, including topics about searching for its causes and cure and about the use of chemotherapy for treating tuberculosis. The text describes the different species of Mycobacteriaceae, including Mycobacterium tuberculosis, M. africanum, M. bovis, M. microti, and M. ulcerans. Safety precautions in pathology laboratories; the preparation of good culture media and sensitivity test media; and the treatment of specimens are also considered. The book further tackles sensitivity testing of Mycobacteria using the resistance ratio method, the proportional method and the absolute concentration method, and methods of identifying mycobacteria. The text also describes assay methods for anti-tuberculosis drugs. Pathologists, medical technologists, and other people working in pathology laboratories will find the book useful.

  • The Value of Agricultural Land

    • 1 Edición
    • Colin Clark
    • Inglés
    The Value of Agricultural Land is concerned with the value of agricultural land and covers topics ranging from land rents, transport costs, and land use as well as land prices and agricultural rents. This book has seven chapters; the first of which discusses the principles underlying the value of agricultural land, with emphasis on rent and the views of David Ricardo. The next chapter focuses on Von Thünen’s theory of rents, transport costs, and land use. In particular, it examines Von Thünen’s argument that transport costs were the cause, and rents the consequence, of important differentiations of agricultural, dairy, and forest production, according to distance from the market. The use of production functions and programming to estimate the marginal productivity of land is then explained, along with agricultural rents actually paid in different countries and periods. This book concludes with an analysis of prices of land in relation to ""residual incomes."" Agricultural economists and policymakers will find this book extremely helpful.

  • Progress in Chemical Toxicology

    Volume 4
    • 1 Edición
    • Abraham Stolman
    • Inglés
    Progress in Chemical Toxicology, Volume 4 covers the capabilities of paper and thin-layer chromatography to separate closely resembling drugs and some of their metabolites. The book discusses the use of interfering compounds and artifacts in the identification of drugs in autopsy material; paper and thin layer chromatographic techniques for separation and identification of barbiturates and related hypnotics; and the forensic chemical detection of digitalis glycosides. The text also describes the applications of atomic absorption spectrometry to trace metal analyses of toxicological materials; and the toxicology of insecticides, rodenticides, herbicides, and phytopharmaceutical compounds. The combined action of drugs with toxicological implications is also considered. Chemists, toxicologists, biochemists, and forensics will find the book invaluable.

  • The Biology and Control of Weeds in Sugarcane

    • 1 Edición
    • Volumen 4
    • S.Y. Peng
    • Inglés
    Offering much new information on the subject, this volume discusses the problems of weed control in sugarcane against the background of world-wide cultivation, with emphasis on Taiwan's intensive pattern of crop farming. After a brief botanical description of sugarcane and its cultivation in relation to weed control, the weeds themselves are studied. Chemical control of weeds, problems of crop tolerance and responses of weed species to chemicals are examined. Techniques for evaluating new herbicides, research and practices of chemical weed control in the leading industries of the world, and the application of techniques and equipment are all described in detail.The author has served the Taiwan sugar industry for more than 30 years and many of his techniques and approaches have been adopted by industries in other countries. To his own extensive experience, he has added a large amount of information published in recent years to compile this treatise which is both a contribution to the field of weed science, and a valuable practical manual for agronomists in general.

  • Culture, Health and Illness

    An Introduction for Health Professionals
    • 1 Edición
    • Cecil Helman
    • Inglés
    Culture, Health and Illness: An Introduction for Health Professionals covers basic ideas and research in medical anthropology. The book starts by discussing the scope of medical anthropology and the cultural definitions of anatomy and physiology, including the body structure and its functions. The text describes the clinical significance of food in diet and nutrition, social and cultural aspects of medical pluralism and health care. Doctor-patient interactions; social, psychological and cultural factors associated with pain; and non-pharmacological influences of medication, in relation to placebos, psychotropic and narcotic drugs, alcohol, and tobacco are also considered. The book then covers the type of rituals that relate to health and illness and the management of misfortune. The text also encompasses transcultural psychiatry, the cultural aspects of stress, and cultural factors in epidemiology. The selection is useful to health professions (doctors, nurses, midwives, health visitors, medical social workers, and nutritionists); those involved in health education or foreign medical aid; undergraduate students taking up these disciplines; and those studying anthropology or sociology.

  • In Vitro Biological Systems

    Methods in Toxicology, Vol. 1
    • 1 Edición
    • Charles A. Tyson + 1 más
    • Inglés
    Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. The text also describes liver slices; liver hepatocytes; other liver cell systems; proximal tubule fragments; kidney cell culture; reproductive and developmental systems; immune system; and skin. Pharmacologists, toxicologists, cell biologists, physiologists, immunotoxicologists, and molecular toxicologists will find the book invaluable.

  • Good Living

    A Philosophy of Health
    • 1 Edición
    • A. T. Todd
    • Inglés
    Good Living: A Philosophy of Health presents a critical review of the meaning of life and living. It discusses the anatomy and dynamics of digestion. It addresses the different parts that make up the ingestion of food. Some of the topics covered in the book are the components of digestion; energy, appetite, cooking, make-up of meals, and kinds of food; care of the circulatory system; type of breathing exercise; duration of exercise; type of aerobic exercises; health hazards of smoking; care of the nose; and house cleansing and health. The proper way of cooking food is covered. The relationship between sex and health and proper care of the mind is also discussed. The book can provide useful information to the general reader.

  • The Influence of Teeth, Diet, and Habits on the Human Face

    • 1 Edición
    • D. M. Davies
    • Inglés
    The Influence of Teeth, Diet, and Habits on the Human Face discusses the relation between dental health, diet, and habits to the facial characteristics of humans. The book is comprised of 12 chapters that cover the various aspects of the relationship of the said variables. The text first compares the facial traits of primitives and civilized peoples, and then proceeds to differentiating the characteristics of primitive and modern diets. The next chapter discusses disparity between meat and vegetable diet. The next five chapters deal topics related to dental health, such as tooth diseases among primitive tribes, establishing racial links through analyzing teeth, and some unusual dental customs. The remaining three chapters present the conclusion, review of related literature, and methodology of the study. The book will be of great interest to dentists, physicians, anthropologists, and sociologists.

  • Neurogenic Heart Lesions

    • 1 Edición
    • I. S. Zavodskaya + 2 más
    • Inglés
    Neurogenic Heart Lesions reviews the main publications concerned with the problem of neurogenic lesions of the heart. The book describes the methods for producing experimental neurogenic lesions, as well as the pharmacological analysis of the participation of the sympathetic nervous system and its transmitters in the development of neurogenic lesions of the myocardium. The text also discusses the changes in energy metabolism and in functional conditions of the myocardium caused by neurogenic lesions; and the pharmacoprophylaxis and pharmacotherapy of the biochemical changes produced by neurogenic lesions of the myocardium. Pharmacologists, pathologists, and other clinicians and physicians concerned with the new achievements in the field of cardiology will find the book invaluable.

  • Anatomy and Human Movement

    Structure and Function
    • 1 Edición
    • Nigel Palastanga + 2 más
    • Inglés
    Anatomy and Human Movement: Structure and Function describes the musculoskeletal structures of the human body and the biomechanics behind their movements. The book provides anatomical descriptions of bone and muscle groups with emphasis on the joints; enumeration of common traumatic or pathological problems affecting the musculoskeletal structures; and the use of palpation through intact skin to describe the structures, as well as how movements can be tested and analyzed with respect to joint movement, muscle work and function. Chapters on embryology; the skin and its appendages; terminologies used in the book; and an account of the structure and function of the nervous system are included as well. Students of anatomy will find the text a valuable reference material.

  • Ultrastructural Pathology of the Cell and Matrix

    A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components
    • 3 Edición
    • Feroze N. Ghadially
    • Inglés
    Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume I present a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the physiological analysis of the nucleus; nuclear matrix, interchromatin, and perichromatin granules; structure and function of centrioles; characteristics of mitochondria; Golgi complex in cell differentiation and neoplasia; and degranulation of rough endoplasmic reticulum. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, scientists, students, and researchers.

  • Advances in Enzymic Hydrolysis of Cellulose and Related Materials

    Including a Bibliography for the Years 1950–1961
    • 1 Edición
    • Elwyn T. Reese
    • Inglés
    Advances in Enzymic Hydrolysis of Cellulose and Related Materials documents the proceedings of a symposium held in March 1962. This book emphasizes the interests of contributors actively engaged in production and properties of the enzymes and cellulose decomposition. Despite the significance of enzymes, relatively little work has been done on this group of enzymes, which include cellulases, hemicellulases, xylanases, disaccharidases, and glycosidases. This compilation aims to have the biological aspects of celluloses and hemicelluloses recognized under the cellulose field, and the cellulases to be considered in future books about cellulose and wood. Other topics discussed in this selection include structural features of cellulose that influence its susceptibility to enzymatic hydrolysis; purification of cellulase and related enzymes; endwise degradation of cellulose; and applications for cellulases. This publication is beneficial to students and researchers conducting work on enzymes and cellulose decomposition.

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