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Elsevier

Libros en Ciencias de la Vida

  • Secondary Metabolites in Stress and Disease Management

    A Natural Alternative
    • 1 Edición
    • Amrita Srivastava + 1 más
    • Inglés
    Secondary Metabolites in Stress and Disease Management: A Natural Alternative details the sources and diversity of microbial and plant secondary metabolites, the methods used for their detection and extraction, their novel applications in disease management, and inclusion in mainstream therapy. Organized into three main sections, the book begins by discussing the potential of microbes, plants, microalgae, and cyanobacteria as valuable sources of secondary metabolites, their role and mechanisms of action in symbiotic and competitive interactions, extractions and purification strategies, and the means to maximize their production. The book goes on to explore the utility of secondary metabolites in mitigating plant stress and their therapeutic impact on human health management. With contributions from experts in the field, Secondary Metabolites in Stress and Disease Management is a useful interdisciplinary resource for researchers, professors, graduate and postgraduate students, and industry professionals studying applied microbiology, biotechnology, biochemistry, pharmacology, and plant science.

  • Artificial Intelligence-Driven Precision Medicine for Triple Negative Breast Cancer

    Innovations and Insights in TNBC Management
    • 1 Edición
    • Sachin Namdeo Kothawade + 1 más
    • Inglés
    Artificial Intelligence-Driven Precision Medicine for Triple-Negative Breast Cancer: Innovations and Insights in TNBC Management is a groundbreaking exploration into the transformative role of artificial intelligence in revolutionizing the management of triple-negative breast cancer (TNBC). In 19 chapters, this comprehensive guide navigates the intersection of cutting-edge technology and healthcare, offering insights that bridge the gap among medical professionals, researchers, and individuals affected by TNBC. Diving into the complexities of TNBC, this book unveils the potential of artificial intelligence (AI) in enhancing diagnostic accuracy, personalizing treatment strategies, and reshaping the landscape of breast cancer care. From radiomics and genomic data analysis to predictive modeling and patient engagement, each chapter unveils the latest innovations and provides the practical applications of AI to empower healthcare practitioners and improve patient outcomes. This book is a timely and valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge in the allied field.

  • Medical Robotics and Intelligent Healthcare Technologies

    AI Applications to Improve Healthcare in Developing Countries
    • 1 Edición
    • Jacky Baltes + 3 más
    • Inglés
    Medical Robotics and Intelligent Healthcare Technologies: AI Applications to Improve Healthcare in Developing Countries is an essential reference for professionals and researchers in fields such as biomedical engineering, health informatics, bioelectronics, medical electronics, physiology, and robotics. This book presents the latest advancements in AI and machine learning-based robotics applications, enabling readers to quickly grasp effective methods and compare various approaches. Addressing critical research areas that directly impact human life and health fills a significant market gap, providing valuable insights into AI, deep learning, machine learning, and big data analytics methods as they relate to emerging robotics research models in the biomedical and healthcare domains.It offers a comprehensive understanding of the concepts, themes, and tools in medical robotics, IoT-based applications, edge computing, and artificial intelligence. With a specific focus on developing countries, this book catalyzes healthcare progress by showcasing the potential of medical robotics and intelligent healthcare technologies. It aims to empower researchers and practitioners to harness these state-of-the-art technologies to improve healthcare systems worldwide.

  • Heart Failure in the Child and Young Adult

    From Bench to Bedside
    • 2 Edición
    • Joseph Rossano + 5 más
    • Inglés
    Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.

  • Biomarkers in Kidney Transplantation

    Clinical Aspects and Laboratory Determinations
    • 1 Edición
    • Dr Smita Pattanaik + 1 más
    • Inglés
    Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.

  • Interaction of Food Macromolecules

    The Matrix of Future Foods
    • 1 Edición
    • Ibrahim Khalifa + 2 más
    • Inglés
    Interaction of Food Macromolecules: The Matrix of Future Foods provides a detailed understanding on why biological macromolecules, i.e., proteins, lipids, and carbohydrates with ligands interactions are essential to understanding biology at the molecular level. The book aims to create a multidisciplinary forum of discussion on the interaction between macromolecules and ligands, providing an understanding on how biological macromolecules with ligands interactions are central to facilitating the discovery, design, and development of future, functional foods. In addition, it outlines information available on the macromolecules-ligan... interaction that happens inside the food matrixes and inside our bodies.Knowing about the mechanisms responsible for the macromolecules-ligan... recognition and binding facilitates the discovery, design, and development of future and functional foods.

  • Myasthenia Gravis, Part B

    • 1 Edición
    • Volumen 183
    • Inglés
    Myasthenia Gravis, Part B, Volume 183 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Typical and Atypical Clinical Presentations, Diagnosis and Differential Diagnosis, Clinical Evaluation, Myasthenia Gravis in Women, Fatigue and Myasthenia Gravis, Clinical and Electrophysiologic Outcomes, Standard Treatment and Different Geographical Approaches, Rescue Treatments, Novel Treatments for Myasthenia Gravis, Measuring Treatment-Related Side Effect Burden in Myasthenia Gravis, Exercise and Myasthenia Gravis, The Social and Personal Impact of Myasthenia Gravis, and Future Perspectives.

  • Machine Learning in Drug Development: Part 1

    • 1 Edición
    • Volumen 64
    • Inglés
    Machine Learning in Drug Development: Part One, Volume 64 in the Annual Reports on Medicinal Chemistry series, highlights new advances in the field. Chapters in this release include Artificial Intelligence in Small Molecule and Nucleic Acid Research: A Review, AI-aided Drug Development for Protein Degraders: Design, Lead Identification, and Optimization, AI-aided Drug Development for Protein Degraders: Biology Validation, Disease-association, Drug Repurposing, Transforming Modern Drug Discovery with Machine Learning, Artificial Intelligence in the Development of Antiviral Drugs: Progress and Applications, Artificial Intelligence for Drug Target Identification, and Machine Learning in Proteomic Biomarker Discovery.

  • Harnessing Quorum Quenching for Disease Management

    • 1 Edición
    • Arpita Roy + 2 más
    • Inglés
    Harnessing Quorum Quenching for Disease Management explores the process of quorum quenching in disrupting bacterial cell communication and how this mechanism can be utilized in the medical field. This book provides a detailed overview of quorum quenching and quorum sensing, delving into the key aspects of this process including the enzymatic mechanisms and methods available to study these. It covers quorum quenching applications, including the regulation of virulence factors, antimicrobial resistance and disease treatment, and the use of quorum quenching bacteria for medical intervention. It also considers genetically modified organisms to produce quorum quenching enzymes, nanomaterials for optimizing quorum quenching, in silico technology and the impact of synthetic biology, closing with a discussion of the current limitations and future prospects for this field. This book is an ideal reference for researchers and advanced students with an interest in quorum quenching and quorum sensing working across a range of fields, including microbiology, cell biology, biomedicine, biochemistry, biotechnology and related areas.

  • Bladder Cancer Breakthroughs

    A Global Perspective on Diagnosis, Treatment, and Patient Care
    • 1 Edición
    • Bhupendra G. Prajapati + 2 más
    • Inglés
    Bladder Cancer Breakthroughs: A Global Perspective on Diagnosis, Treatment, and Patient Care is a groundbreaking scientific resource that delves into the latest advancements in the diagnosis and treatment of bladder cancer, a prevalent malignancy affecting hundreds of thousands worldwide. This meticulously curated volume brings together contributions from leading scientists and healthcare professionals from around the globe, providing a comprehensive overview of contemporary understanding and innovative strategies in managing this complex disease. Bladder Cancer Breakthroughs: A Global Perspective on Diagnosis, Treatment, and Patient Care is not merely a collection of research findings; it is a vital resource that fosters a holistic perspective on patient-centered care. By synthesizing clinical expertise and evidence-based practices, this book aims to empower healthcare providers with the knowledge and tools needed to improve outcomes for individuals living with bladder cancer, ultimately contributing to the global fight against this challenging disease. This book serves as an essential guide for healthcare providers, including physicians, oncologists, immunologists, pharmacists, and physical therapists, striving to enhance patient care and treatment outcomes

  • Encyclopedia of Immunobiology

    • 2 Edición
    • Paul Kaye
    • Inglés
    Encyclopedia of Immunobiology, Second Edition, Five Volume Set covers the full range of Immunology, presenting topics logically and making extensive use of "hot links" to refer the reader to related content. The new edition is not just an update of the original title; it vastly expands fields like immunotherapy, immunity to viral infection, vaccine development, inflammatory responses, and high throughput analyses. Containing 350 chapters written by world-leading experts, this edition integrates all concepts coherently and logically to paint a comprehensive picture of the evolving field of Immunology.The immune system, complex and multi-layered, has evolved to differentiate between "self" and foreign pathogens, providing protection against infections while dysregulation can cause diseases like autoimmunity, allergies, and inflammatory disorders. This understanding has led to numerous therapeutic interventions crucial for human health improvement.

  • Hazardous Chemicals in Medical Devices

    Safety, Risk Analysis, and Regulations
    • 1 Edición
    • Prakash Srinivasan Timiri Shanmugam + 1 más
    • Inglés
    Hazardous Chemicals in Medical Devices: Safety, Risk Analysis, and Regulations provides a comprehensive overview of the hazardous chemicals used in medical device manufacturing. The book discusses the basics of these chemicals, their presence in various components, and the regulations that govern their use. It also delves into the processes involved in manufacturing and the added chemicals during these stages. With a focus on risk assessment and analysis, the book emphasizes the importance of safety in medical devices and outlines the types of hazards associated with these substances.The book further explains the regulatory classification of hazardous chemicals and the labeling and safety data sheet requirements. It includes a list of notified bodies that discuss hazardous substance data, aiding in risk assessment and toxicological profiling. Additionally, it underscores the critical understanding of toxicological profiles of materials used in medical devices, ensuring that readers are well-informed about the safety measures and regulations in place to protect both manufacturers and users.

  • Soil Microorganisms for Plant Growth Promotion and Soil Health

    • 1 Edición
    • Gustavo Santoyo
    • Inglés
    Soil Microorganisms for Plant Growth Promotion and Soil Health provides readers with an overview of plant growth-promoting microorganisms and their molecular mechanisms to improve plant growth and soil health. Students and researchers in soil science will gain a comprehensive understanding of soil microbiota diversity and functions, along with insights into the mechanisms by which plant growth, including molecular processes involved in nutrient acquisitions and defense mechanisms work. In addition, the book provides a noteworthy emphasis on fungi.A soil beneficial microbe cannot only be the living cells, but also their components, such as molecules or enzymes produced by this beneficial microbiota. Molecules like microbial phytohormones can be excellent promoters or regulators of plant growth, as well as proteins and other compounds like volatiles, which might elicit a systemic resistance response against pathogenic threats. Therefore, plant growth promoters living in soil, associated with plant roots, could act through direct beneficial interactions with the plant, by stimulating or regulating growth responses to environmental conditions, or indirectly by inhibiting the growth of potential microbial pathogens and herbivore pests.

  • Oral Delivery of Insulin

    • 2 Edición
    • T.A. Sonia + 1 más
    • Inglés
    Oral delivery of Insulin, Second Edition is a complete reference on non-invasive insulin delivery systems, focusing on the prospect of oral delivery of peptides. The chapters in the revised edition present a comprehensive evaluation of the insulin therapy approaches, with an emphasis on insulin delivery strategies and current advances in engineered insulin delivery systems such as nano/microcarriers and hydrogels. Chapters provides an overview of diabetes mellitus, cover technological innovations, explore artificial intelligence and machine learning approaches to manage diabetes, explore a wide range of non-invasive and alternative routes of insulin administration, and much more.Other chapters cover challenges and strategies in oral insulin delivery, the experimental techniques used to develop oral insulin carriers, the use of polymeric nano and microparticles for insulin delivery, and the use of lipids and inorganic nanoparticles in insulin delivery. The final chapter provide an overview of current clinical trials on insulin delivery and future perspectives in the area. Clinicians can benefit from this information to develop a clear understanding about the research carried out worldwide in the field of oral delivery of insulin, including those in the clinical phase.

  • Lipases

    Foundations, Applications, and Perspectives
    • 1 Edición
    • Eliane Pereira Cipolatti + 2 más
    • Inglés
    Lipases: Foundations, Applications, and Perspectives, a new volume in the Foundations and Frontiers of Enzymology series, offers a practical, in-depth discussion of lipases and instruction in their use across research and industry. Here, global experts in the field introduce readers to basic lipase biology and the history of the field, interfacial activation and lipase lids, evolving analytical techniques and technology for studying lipases, and a range of lipase applications, from health and drug discovery to biofuels, food, cosmetics, and waste treatment. Lipase sources and production methods discussed include mammalian lipases, microbial lipase production, biomass lipase production, immobilized lipases, and tailor-made recombinant lipases, among other approaches.

  • Nitrogen Heterocycles in Cancer Therapy

    • 1 Edición
    • Sanjeev Kumar Sahu + 1 más
    • Inglés
    Nitrogen Heterocycles in Cancer Therapy explores the vast array of recently discovered nitrogen-containing heterocyclic compounds utilized in combating cancer. This comprehensive work not only highlights the fundamentals of oncology but also explains the intricacies of designing, synthesizing, and understanding the anticancer mechanisms of these compounds. Spanning across 10 chapters, the book explores the principles underlying the design, synthesis, and anticancer mechanisms of nitrogen-containing heterocyclic compounds, drawing from the latest research findings. Its scope extends beyond molecular targeting to encompass the exploration of newly identified heterocyclic compounds with potential anticancer properties. A significant emphasis is placed on crucial evaluation techniques such as in-vitro cell culture and in-vivo animal models, providing insights into the performance of these compounds in combating cancer. Particularly noteworthy is the inclusion of clinical study reports detailing the efficacy of various drug candidates across different cancer conditions, coupled with an analysis of their global market impact and pharmacoeconomics. Offering profound insights, this book emerges as an indispensable resource for researchers, clinicians, and students alike.

  • Nervonic Acid and Brain Health

    • 1 Edición
    • Xianyang Chen + 2 más
    • Inglés
    Nervonic Acid and Brain Health is a comprehensive guide for professionals and researchers seeking in-depth knowledge about nervonic acid. This book meticulously delves into its functions, sources, synthesis, and therapeutic applications. Readers will find valuable information on the connections between nervonic acid, brain health, and neurological conditions, presenting data that is currently scarce in other publications. The book emphasizes evidence-based research findings, making it an essential resource for understanding the impact of nervonic acid on cognitive development and its potential therapeutic benefits.In addition to exploring nervonic acid's role in brain health, the book addresses its significance in infant and toddler brain development, the consequences of deficiency during pregnancy, and its inclusion in infant formula and cognitive health products. The association with neurological conditions such as Alzheimer's disease, multiple sclerosis, and cerebral ischemia is thoroughly examined, providing practical insights for medical professionals and caregivers. This text bridges the gap between scientific research and consumer interests, offering real-world relevance and application.

  • Future of Internet of Bio-Nano Things in Personalized Healthcare

    Applications and Challenges
    • 1 Edición
    • Jayachitra Sekar + 3 más
    • Inglés
    Future of Internet of Bio-nano Things in Personalized Healthcare: Applications and Challenges explores the core principles of nanomaterials and the sensing paradigms essential for medical devices based on nano-sensors technology, examining the latest theoretical and practical developments in Internet of Bio-nano Things (IoBNT) for health applications. This book explores how IoBNT facilitates the detection and treatment of diseases within the human body through communication between an in-body network of nanodevices and an external control unit. Readers will discover the transformative benefits of IoBNT, which integrates information and communication technologies with medical and nano-bio sensor devices to enhance patient care. The book highlights advances in telemedicine, including highly functional electronic medical devices like implantable and wearable devices engineered through nanotechnology. It details real-time case studies on smart drug delivery, edge computing, and personalized healthcare applications to provide valuable insights into optimizing network performance and utilization in personalized healthcare. The comprehensive exploration of machine learning algorithms and communication protocols further equips readers with the knowledge to design and implement end-to-end IoBNT solutions.

  • Polyamines-Phytohormones-Nutrients Network

    Nexus in Plant Responses to Abiotic Stresses
    • 1 Edición
    • Asim Masood + 3 más
    • Inglés
    Polyamine-Phytohormo... Network: Nexus in Plant Responses to Abiotic Stresses presents the latest global research on key tools for improving physiological and biochemical mechanisms that enhance plant health and productivity.Exposur... of plants to abiotic stresses is inevitable, often leading to impaired growth, metabolism, and productivity. However, plants are naturally equipped with endogenous chemicals including intracellular messengers and signalling molecules that counteract potential stress impacts, protect cellular functions, and promote healthy growth and production. Polyamines (PAs) are low-molecular-weight... nitrogen-containing compounds with aliphatic polycationic properties. Beyond their role in growth and development, PAs enhance plant tolerance to abiotic stresses. Given their connection with phytohormones and mineral nutrients, understanding their interactions—whether synergistic or antagonistic—could shed light on their potential to mitigate these stresses.Written by a team of expert contributors, this volume in the Plant Biology, Sustainability, and Climate Change series focuses on the interactions among PAs, phytohormones, and mineral nutrients that are crucial for regulating nutrient assimilation, carbon fixation, and secondary metabolic pathways.

  • Isothermal Titration Calorimetry in Enzymology

    Techniques and Applications
    • 1 Edición
    • Anthony Mittermaier + 1 más
    • Inglés
    Isothermal Titration Calorimetry in Enzymology: Techniques and Applications provides a thorough, practical overview of ITC as a productive and powerful tool for quantifying enzyme catalysis and interactions with substrates, products, cofactors, and inhibitors. Here, global experts in the methodology discuss the full capabilities of ITC and how it may be applied in research, medicine, and industry and offer a basis to continue leveraging ITC as its uses expand and evolve. This book bridges the gap between research and application by giving extensive technical details on cutting edge ITC techniques across a wide swath of both ITC kinetics measurements and ITC thermodynamic measurements, alongside case studies illustrating the depth of knowledge that can be obtained. Applications discussed include measuring binding kinetics by ITC, analyzing ITC kinetic data, in vivo enzyme kinetics by ITC, analyzing enzyme kinetics in crowded solutions, studying catalysis of biological substrates, interpreting ITC binding curves, ITC in drug discovery, ITC in the development of cancer therapeutics, ITC analysis of aminoglycoside resistance enzymes, studying enzyme interactions with toxic metals, using ITC to study ubiquitination, and ITC studies of glycoside hydrolases, among others.

  • Handbook of Melatonin-Based Therapy and its Applications

    • 1 Edición
    • Alejandro Romero Martínez + 2 más
    • Inglés
    Handbook of Melatonin-Based Therapy and its Applications provides pharmaceutical researchers and health professionals with a comprehensive reference on the applications of melatonin in the therapeutic setting. Succinct, meticulously organized, and expertly written, this book addresses all essential aspects. It starts with an overview of safe use of melatonin, translational aspects, and its prospection. The next section of the book covers a variety of clinical applications, including dosage, pharmacokinetics and pharmacodynamic profiles, toxicity, and principles of action. The chapters in this section cover applications to both adults and pediatric patients suffering from conditions like skin cancers, GI issues, psychiatric, hepatic and ocular conditions.This is a comprehensive resource for pharmaceutical scientists and health professionals involved in developing therapies and applying them to patients. Researchers in the fields of medicine, biology, neuroscience, and pharmacology conducting studies related to melatonin-based will benefit from insights into the latest research findings, clinical trials, and therapeutic approaches.

  • Maternal-Fetal and Neonatal Endocrinology

    Physiology, Pathophysiology, and Clinical Management
    • 2 Edición
    • Christopher S. Kovács + 1 más
    • Inglés
    Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management, Second Edition continues to systematically examine the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This new edition expands coverage of specific disorders and diseases beyond the current endocrinology content on the market making it the go-to reference for translational and clinical research scientists to appreciate the research gaps that require further investigation. It’s comprehensive coverage of pathophysiology, diagnosis, and treatments, will help readers better understand how various diseases present differently in pregnancy and lactation and how to respond to related complications.

  • Sleep and Cancer

    • 1 Edición
    • Maria Paola Mogavero + 3 más
    • Inglés
    Sleep and Cancer compiles novel information on the interactions between sleep and cancer. The book highlights how prevention and treatment of sleep disturbances in clinical cancer practice helps prevent the onset of tumors and their comorbidities, both short- and long-term. It analyzes how sleep disorder treatment improves the response to antitumor therapy in the long term, presenting procedures regarding cognitive-behavioral therapy of sleep disorders that are often overlooked in the oncological field.In addition, the book suggests new therapeutic approaches in oncology that are based on the knowledge of sleep mechanisms, such as chronotherapy, use of melatonin as an adjuvant in chemo- and radiotherapy, and orexinergic drugs.

  • Fundamentals of Brain Organoids for Neurological Diseases

    • 1 Edición
    • Balachandar Vellingiri + 1 más
    • Inglés
    Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.

  • Biopharmaceutical Ecosystems

    A Comparative Study of U.S. and European Systems
    • 1 Edición
    • David R. Williams
    • Inglés
    The ecosystem perspective on organizations and economic settings is relatively new. It expands on work that looks at bio-clusters, concentrating on the relationship between human and financial capital. The perspective takes an expansive view of biopharmaceuticals in relation to stakeholders and the social, political, and economic landscape, including other life science companies, academia, non-profits, government entities, and health systems. The biotechnology and pharmaceutical industries have been merging for some time, with biotechnology often portrayed as a disruptive innovation to the pharmaceutical industry. A fuller description of this activity put into the greater context of the ecosystem perspective is warranted.Biopharmac... Ecosystems: A Comparative Study of U.S. and European Systems puts forward a picture of biopharmaceutical ecosystems in the USA and Europe. It examines and expands current thinking on the development of the ecosystem perspective on biopharmaceuticals. The title considers multiple locations, with countries in the top 15 of biopharmaceutical exporters selected. It pays particular attention to shifts in the political and economic landscape, and how such changes affect ecosystems. The underlying aim of biopharmaceutical ecosystems is to further the development of new drugs, reduce time to market, and lower costs. In explaining ecosystems, the book applies a quadruple helix model - academia; consumer/society; government; and industry - to each region and country in light of this triple aim.

  • Functional Connectivity of the Human Brain

    From Mechanisms to Clinical Applications
    • 1 Edición
    • Maria A. Rocca + 1 más
    • Inglés
    Functional Connectivity of the Human Brain: From Mechanisms to Clinical Applications is a comprehensive review of mechanisms and analysis of methods of functional connectivity to map brain organization in healthy individuals and sick patients. Providing full coverage of the discipline for a wide audience of different research and clinical specialists, this volume begins with descriptions of mechanisms of functional connectivity and methodological approaches to quantify it, followed by a focus on how functional connectivity has been used to describe brain function in healthy people and to characterize network disruption in diseased conditions. This practical balance in book structure is suitable for readers with a technical or clinical orientation, providing background that is easy to approach for clinicians or scientists. Chapters examine fMRI and electrophysiological techniques, brain maturation, aging, and cognitive neurosciences, as well as functional connectivity in neuroinflammatory, neurodegenerative, and neuropsychiatric conditions. Future perspectives look forward to functional connectivity in multimodal analysis, artificial intelligence, and more. This book will be of use to a wide audience working on functional connectivity experiments, as well as any courses on the topic.

  • Sustainable Advances in Biopolymer-Based Packaging for Food Shelf-life Extension

    • 1 Edición
    • Mihir Kumar Purkait + 2 más
    • Inglés
    Sustainable Advances in Biopolymer-Based Packaging for Food Shelf-life Extension offers readers sustainable solutions for enhancing food shelf-life. It covers topics such as bio-based packaging materials, modification techniques, edible coatings, biodegradable packaging, nanotechnology, hydrogels, and intelligent packaging. Readers will be able to make informed decisions and implement sustainable solutions for enhancing food shelf-life while reducing reliance on traditional non-biodegradable packaging materials. The book begins by exploring the basics of bio-based food packaging materials, covering origins, characteristics, and varieties such as plant, animal, microbial, and waste materials.Subsequent chapters explain emerging bio-based materials, including intelligent packaging and edible coatings. Extraction technologies, modification techniques, and applications for sustainable and eco-friendly food packaging are also discussed. The potential of biopolymers, including those from plant extracts, to improve the nutritional content of packaged foods is highlighted. Through country-specific case studies from the EU, Asia, and North America, the book discusses the global regulatory landscape for bio-based food packaging and offers insights into challenges and future trends.

  • Entomopathogenic Fungi in Insects

    From Physiological Effects to Applications
    • 1 Edición
    • Arash Zibaee + 2 más
    • Inglés
    Entomopathogenic Fungi in Insects: From Physiological Effects to Applications explores the complex relationships between entomopathogenic fungi and insects. This interdisciplinary book delves into the physiological, immunological, and behavioral responses elicited by fungi in insects, offering insights for sustainable development. It assesses the potential applications of these fungi as biopesticides against harmful insects while considering their impact on non-target populations. This comprehensive work is invaluable for researchers and professionals in agroecosystems, insect pathology, biocontrol, plant protection, and crop health, as well as graduate students focused on sustainability.In addition, the book examines the mutualistic roles fungi can play in insect physiology, such as aiding in digestion. These fungi, prevalent in insect habitats, can serve as microbial pest control agents by infecting and weakening insect hosts. The book emphasizes the importance of mitigating potential harm to non-target insect populations, ensuring a balanced approach to biocontrol in agricultural practices.

  • Vestibular Schwannomas

    • 1 Edición
    • Volumen 212
    • Inglés
    Vestibular Schwannomas covers multiple facets of vestibular schwannomas, including advancements in surgical techniques, radiological innovations, long-term patient outcomes, and implications for hearing preservation. It serves as a comprehensive guide for clinicians and researchers aiming to enhance diagnostic accuracy and therapeutic strategies in managing these complex tumors which are benign, slow-growing tumors that originate from the Schwann cells that line the vestibular nerve. They are the most prevalent neoplasms found in the cerebellopontine angle (CPA), the critical junction between the cerebellum and the brainstem.Their incidence, clinical presentation, and impact on surrounding neurological structures make them a focal point of research and medical intervention. Understanding their etiology, diagnosis, and treatment options requires an interdisciplinary approach bridging neurology, otology, and radiology.

  • Theranostics in Cancer Management

    Integrating Diagnostics and Therapeutic Strategies
    • 1 Edición
    • Kuttiappan Anitha + 2 más
    • Inglés
    Theranostics in Cancer Management: Integrating Diagnostics and Therapeutic Strategies introduces a transformative paradigm in clinical oncology, heralding a new era of precision and personalized cancer care. This comprehensive guide empowers clinicians by seamlessly integrating advanced diagnostics with targeted therapeutic approaches. The book provides an extensive exploration of theranostics across diverse clinical scenarios, ensuring that healthcare professionals are equipped with the knowledge to navigate the complexities of cancer management effectively. Beyond the introductory insights, the book delves into several types of cancer and the utilization of Artificial Intelligence in cancer detection tools.Comprising 15 chapters, it offers an invaluable resource for health professionals, scientists, researchers, practitioners, and students who seek to expand their understanding in this evolving field. The emphasis on practical applications and emerging technologies makes it a timely addition to the field of oncology.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 129
    • Inglés
    Unveiling the Proteolytic Networks of Parasites, Volume 129 in the Advances in Parasitology series, presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms. Top researchers in the field conduct multifaceted examinations, shedding light on the distinct roles of these proteases within significant parasite groups, including malaria, trematodes, nematodes, and blood-feeding arthropods. Chapters in this new release include The roundworm Ascaris: recent advances and progress towards elimination, Genetically modified helminths as pharmaceutical bio-factories, Epithelial cytokines in helminth infections, Schistosoma eggs: from conception to eggs-creation, Helminth extracellular vesicles: roles in and beyond parasite-host communication, and more.

  • Advances in Immunology

    • 1 Edición
    • Volumen 167
    • Inglés
    Advances in Immunology, Volume 167, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Recent Advances in Antifungal Immunity, Neuroimmunology beyond the CNS: nerve-macrophage interactions in peripheral tissues, Regulatory T cell functions in peripheral tissues, Alarmins in mucosal tissues and how they regulate health and disease, Ontogeny and function of microglia and nerve-associated macrophages, and Modulation of humoral immunity by γδ T cells.

  • Advancements in the Treatment and Prevention of Breast Cancer

    • 1 Edición
    • Dileep Kumar
    • Inglés
    Advancements in the Treatment and Prevention of Breast Cancer highlights the significance of early detection, risk assessment, and comprehensive care in mitigating the burden of breast cancer within communities. It not only offers insights into the genetic basis of breast cancer susceptibility, familial risk assessment, and emerging genetic testing technologies but also empowers patients and their families with knowledge about available treatment options, clinical trials, and support resources.In 14 chapters this book provides an in-depth analysis of translational research focusing on understanding the etiology of breast cancer, elucidating potential avenues for primary prevention strategies. It offers a comprehensive overview of recent breakthroughs in understanding the molecular mechanisms underlying breast cancer development and discussing novel targeted treatment approaches derived from these advances but also discusses strategies for minimizing treatment-related toxicity in breast cancer management, including supportive care measures and personalized treatment approaches. This book is a valuable resource for anyone interested in the latest developments in breast cancer care and provides clear explanations of complex scientific topics and will offer insights that can help improve patient care and outcomes.

  • AI Technologies for Crop Breeding

    • 1 Edición
    • Jen-Tsung Chen
    • Inglés
    AI Technologies for Crop Breeding offers the latest insights into the use of artificial intelligence models to improve plant health and production. Presenting applications of AI technologies in plant biology, biotechnology, and crop breeding, it explores practices for the mitigation of biotic and abiotic stressors as well as other plant growth challenges.AI-based technologies are expected to advance approaches to plant functional genomics and multiple omics, resulting in smarter and more efficient crop breeding for next-generation agriculture helping to address the challenges of the increasing human population and the globally changing climate. AI tools such as machine learning, particularly deep learning, have been applied to predict chief players in complicated biological networks, increasing the understanding of in-depth mechanisms of plant-pathogen and plant-environment interactions. Additionally, responses of plants facing stress can be modeled using AI technologies, and the resulting data are valuable not only to plant stress physiology but also for stress-resilient and disease-resistant crop breeding.This book introduces AI technologies for studying plant biology, focusing on machine learning and deep learning models for integrating multiple omics approaches and revealing the knowledge of plant functional genomes. Technological advancements and emerging applications of machine learning and deep learning in genomic selection, genome-wide association study (GWAS), phenotyping and constructing phenomics, and transcriptomics are also featured in this book.AI Technologies for Crop Breeding is an ideal reference for researchers, academics, and advanced-level students and professors in the fields of plant sciences, plant stress physiology, bioinformatics, systems biology, and crop breeding.

  • Climate Change and Disability

    A Collaborative Approach to a Sustainable Future
    • 1 Edición
    • Marcalee Alexander + 2 más
    • Inglés
    Until recently, little attention has been paid to the concerns of people living with disabilities during extreme weather events and long-term climate changes. Climate Change and Disability: A Collaborative Approach to a Sustainable, Inclusive Future for All delineates the general and specific risks of climate change for people living with disabilities and how we can use accessible approaches to mitigate, adapt, and control these risks, while maximizing opportunities for people living with disabilities. The book opens with an introduction on how we got here. The book continues with sections on actions and research, the physiologic impact of different disabilities, and discussions of specific continents and countries, where issues related to climate change exist. Education and advocacy are covered in detail, and the book wraps up with a section on action and research, detailing how to respond to extreme weather events including how various types of disabilities are impacted by different events.Climate Change and Disability: A Collaborative Approach to a Sustainable, Inclusive Future for All serves as a guide for a broad audience at the crossroads of environmental adaptation and human health. Physicians, as well as nurses, physical and occupational therapists, and other allied health professionals will find it valuable for tailoring care for people living with disabilities due to climate change. Advocates and individuals living with disabilities will gain insight into advocacy for inclusive policies and personal preparedness. Scientists and clinicians interested in the health and societal impacts of climate change will find it useful in informing their research and practice. Policymakers and politicians can utilize this resource to develop equitable climate strategies, ensuring that environmental justice concerns are inclusive.

  • Ketamine

    Fundamentals, Applications, Pharmacology, and Clinical Aspects
    • 1 Edición
    • Albert Dahan + 1 más
    • Inglés
    Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.

  • Data-Driven Diagnostics and Disease Prediction with AI Optimization

    • 1 Edición
    • Shailendra Pratap Singh + 3 más
    • Inglés
    Data-Driven Diagnostics and Disease Prediction with AI Optimization provides useful insights into model creation, data preparation, and ethical issues for healthcare applications. The book covers all the conventional and non-conventional methods related to this domain. It also discusses AI-based optimization techniques, Machine Learning models, and Advanced AI, offering practical insights, case studies, and optimization strategies to help data scientists and researchers efficiently employ AI in diagnostics and illness prediction in a world where precise diagnostics and early illness prediction may save lives and healthcare resources.

  • Artificial Metalloproteins

    • 1 Edición
    • Volumen 720
    • Inglés
    Artificial Metalloproteins covers artificial metalloproteins (ArMs) and how they have emerged as powerful vehicles with which to control, implement, and leverage the unique reactivity and spectroscopic properties of their bound metal ions. Chapters in this release include Incorporating Non-Native Cofactors into Heme Proteins, Designing 4-Helix Bundles to Bind Porphyrin/Porphyrin-... Cofactors, Cobalt-Substituted Hemoprotein Expression, Rationally designed directed evolution of cytochrome P450 enzymes, De novo design of a switchable a-helical hemoprotein, Primary Coordination Sphere Part B: Unnatural Metal-Binding Sites Beyond the Heme, and more.Other sections cover Unnatural Amino Acid Incorporation for Creating Artificial Metalloenzymes, Development of a PQQ-Dependent Artificial Metalloprotein, Evolutionary Engineering of a Rhodium Complex-Linked Artificial Metalloenzyme, Design and Application of Nonheme Iron Enzymes, Part C: Secondary Sphere Modulation for Metallocofactor Activation, Designing Artificial Metalloenzymes by Engineering the Primary and Secondary Coordination Sphere in Native Protein Scaffolds, and much more.

  • Fungal and Protozoan Carbonic Anhydrases

    • 1 Edición
    • Volumen 57
    • Inglés
    Fungal and Protozoan Carbonic Anhydrases, Volume 57 in The Enzymes series, explores recent advancements in the study of fungal and protozoan carbonic anhydrases (CAs). This volume presents a comprehensive collection of chapters covering various aspects of these enzymes, including an overview of fungal and protozoan CAs (genetics, molecular biology, and phylogenetics), the structure and function of fungal α-carbonic anhydrases, and an in-depth look at β-carbonic anhydrases in Saccharomyces cerevisiae, Candida spp., and Cryptococcus neoformans.Additiona... chapters delve into the Malassezia spp. and Sordaria macrospora CAs, as well as protozoan CAs from Plasmodium falciparum, Trypanosoma cruzi, Leishmania spp., Toxoplasma gondii, and Entamoeba histolytica. The volume also addresses the challenges in developing selective fungal and protozoal CA inhibitors as anti-infective agents, providing insights into their potential biomedical applications.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 129
    • Inglés
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advanced Cancer Research Protocols

    • 1 Edición
    • Volumen 198
    • Inglés
    Advanced Cancer Research Protocols, Volume 198 is a comprehensive and cutting-edge resource dedicated to the latest methodologies and protocols in the field of cancer research. Topics in this new release include Introduction to Cancer Biology and Current Research Trends, Cell Culture Techniques for Cancer Research, Practical Approaches to Advanced Molecular Biology Techniques, High-throughput sequencing Technologies for Cancer Genomics, Epigenetic Analysis in Cancer Research, Proteomics and Metabolomics in Cancer Biomarker Discovery, In vivo Cancer Modeling Using Mouse Models, and much more.Other sections highlight advances in Advanced Imaging Techniques for Cancer Research, Cancer Stem Cell Analysis and Targeting, Immunotherapy and Cancer Vaccine Development, Gene Editing Techniques in Cancer Research, Single-Cell Analysis in Cancer Research, Liquid Biopsy and Circulating Tumor Cell Analysis, and Exploring the Tumor Microenvironment in Solid Cancer: From Biology to Therapy.

  • Temperate Tree Fruits and Nuts

    • 1 Edición
    • George Manganaris
    • Inglés
    Temperate Tree Fruits and Nuts serves as a comprehensive resource, providing up-to-date knowledge about economically significant temperate fruit crops. This textbook covers the history, genetic improvements, and growth physiology of these crops. It details orchard establishment, management practices, and harvest considerations, making it a standalone guide to sustainable fruit crop production in temperate climates. Targeted toward undergraduate and postgraduate students, as well as professionals in pomology, horticulture, and related fields, the book is essential for researchers, farmers, consultants, and agribusiness professionals.Each chapter, authored by an expert, provides an introduction, botany, orchard management, propagation, rootstocks, cultivars, and disease and pest management. It also covers ripening, harvest criteria, postharvest physiology, and technology, complemented by high-quality illustrations and a question bank for instructors.

  • Enzymatic Production of Oligosaccharides

    From Basic Research to Industrial Production
    • 1 Edición
    • Carlos Vera + 2 más
    • Inglés
    Enzymatic Production of Oligosaccharides: From Basic Research to Industrial Production, a volume in the Foundations and Frontiers of Enzymology series, covers the enzymes used for the extraction, synthesis, or modification of oligosaccharides, the biochemical properties of those enzymes, and potential technological applications. The book is divided into three parts, the first of which shares the fundamentals on the enzymatic synthesis of oligosaccharides. The book then explores the enzymatic production of oligosaccharides, considering a range of different oligosaccharides and production processes. Final sections cover the technological properties of oligosaccharides and potential applications across the chemical, biochemical, biotechnology, and food industries.This is a useful reference for researchers working with oligosaccharides across biochemistry, enzymology, biotechnology, food chemistry and related fields.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 123
    • Inglés
    Advances in Virus Research, Volume 123 in this esteemed series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections in this new release include Transcriptional Regulation of Human Endogenous Retroviruses in Cancer, Nomenclature for vertically transmitted plant, Modelling of vertically transmitted viruses, Vertical transmission of tomato viruses, and more.

  • Functional RNAs in Plants

    Developing Climate-Resilient and Stress-Resistant Crops
    • 1 Edición
    • Jen-Tsung Chen
    • Inglés
    Functional RNAs in Plants explores the rapidly advancing field of plant RNA biology and its transformative role in modern agriculture. Covering microRNAs, small interfering RNAs, long noncoding RNAs, circular RNAs, and CRISPR-associated RNAs, the book explains their identification, design, structural and functional analysis, and applications in crop improvement.Chapters address both abiotic and biotic stresses, highlighting how functional RNAs regulate tolerance to climate-driven challenges as well as plant–microbe interactions and disease resistance. Technical sections detail progress in bioinformatics, integrated multi-omics, spatial and single-cell approaches, and high-throughput transcriptomics, which together provide new insights into RNA networks underlying plant stress responses. The book also discusses artificial small RNAs, secondary metabolism, and competing endogenous RNA systems, connecting mechanistic understanding with applied breeding strategies.Practical guidance is offered on integrating RNA knowledge into smart breeding, sustainable agriculture, and CRISPR-based innovations, with emphasis on designing and delivering functional guide RNAs for crop improvement. By combining foundational concepts with emerging applications, this volume serves as a valuable reference for academics, researchers, and advanced-level students in plant molecular biology and agricultural biotechnology.

  • Role of Gut Microbiome in Neurodegenerative Disorders

    • 1 Edición
    • Mukesh Kumar Yadav + 1 más
    • Inglés
    Role of Gut Microbiome in Neurodegenerative Disorders provides an overview of the gut microbiota and its interactions with the gut and the central nervous system. This book reviews the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS). Various chapters discuss the effects of gut derived particles in various parts of brain and the targeting pathways leading to protein deposition in brain.

  • Cancer Theranostics, Second Edition

    • 2 Edición
    • Xiaoyuan Chen + 2 más
    • Inglés
    Cancer Theranostics, Second Edition provide updates on new molecular imaging probes and techniques for early detection of cancer and describes molecular imaging-guided cancer therapy. Discussions also include nanoplatforms, incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. New to this edition is the inclusion of recent developments and a streamlined structure that leads the reader through the content more intuitively, from problem to solution. More illustrations of different forms of cancer theranostics​ are included, and this edition also contains completely new content on DNA and RNA theranostics. In addition, new case studies are featured.This new edition is published in time to meet the needs of medical researchers in a comprehensive manner, encompassing diagnostics, in vivo imaging and its use for image-guided therapy, and a variety of other miscellaneous subjects. This book is a must-have for all research scientists, medical physicists, and physician scientists in cancer experimental therapeutics and molecular imaging.

  • Edible Oil Blends

    Chemistry, Functionality, and Health Aspects
    • 1 Edición
    • Mohamed Fawzy Ramadan
    • Inglés
    Edible Oil Blends: Chemistry, Functionality and Health Aspects, gives readers insight into the advantages of blending traditional and non-traditional oils for optimal nutrition and enhanced product development. The book sheds light on how the intricate concoctions of triacylglycerol, phospholipids, carotenoids, antioxidants and fatty acids can improve nutrition and contemporary food applications.Edible Oil Blends: Chemistry, Functionality and Health Aspects, demonstrates how blended oils stemming from olive, coconut, sunflower, soybean, sesame, grapeseed and more, can alter an oil's' chemical composition for increased cooking stability, enhanced sensory characteristics and more desirable ratios of saturated, mono-and poly-unsaturated and essential fatty acids. Each chapter highlights a specific oil and discusses the bioactive compounds, physiochemical properties, biological properties and the economic value of each.

  • Bioprospecting of Natural Pigments in Human Health

    • 1 Edición
    • Siva Ramamoorthy + 1 más
    • Inglés
    Bioprospecting of Natural Pigments in Human Health provides a comprehensive overview of the therapeutic potential of these compounds. Covering the main pigment classes sourced from plants, algae, and microbes, the book is organized around the applications to specific diseases and conditions. With chapters on the anti-cancer, antidiabetic, anti-microbial, anti-inflammatory, anti-aging effects, cardioprotective and neuroprotective agents, the book covers the molecular biology principles of action, as well as bioavailability and structure. This is the ideal reference for academic researchers interested in natural products pharmacology. It is also beneficial for the academic and corporate researchers in food sciences and the nutraceutical industries.

  • Kratom

    History, Science and Therapeutic Potential
    • 1 Edición
    • Jack E. Henningfield + 2 más
    • Inglés
    Kratom: History, Science and Therapeutic Potential is the first book to address the unregulated, widespread availability of kratom, with its weak opioid and stimulant effects, coupled with limited awareness of it by healthcare professionals. Kratom has great therapeutic utility and medicinal potential, but more study, caution, and possible regulation is needed. It discusses geographical sourcing, historical uses, current worldwide uses, and potential for treatment of other medical conditions. Most exciting for healthcare professionals will be the implications of this substance's potential for treatment of diseases like depression, ADHD, PTSD, and substance-use disorder, particularly opioid use disorder (OUD).Moreover, kratom and its active alkaloid mitragynine are getting remarkable attention at federal and local governments as more than eight million Americans consume this product annually. Yet, the paucity of information for researchers and clinicians is troublesome.

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