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Elsevier

Libros en Ciencias de la Vida

  • Microbes, Microbial Metabolism and Mucosal Immunity

    An Overview
    • 1 Edición
    • Tanima Bose
    • Inglés
    Microbes, Microbial Metabolism and Mucosal Immunity: An Overview presents a concise and well-vetted treatise on the study of microbiome and microbial metabolites. This volume is up-to-date with the most recent developments from the last decade. It encompasses the interaction of immunity and microbes — and their metabolites — from different mucosal organs including gastrointestinal system, lung, oral cavity, eye. Along with the efficiency of the immune system in inhibiting the growth and proliferation of microbes, the volume discusses how the mediators of the immune system can be targeted to develop therapies.This book presents the latest methods, gives broad and systematic coverage of most mucosal systems and diseases, and takes a fresh perspective that looks at the functional aspects of change in the microbiome. The study of microbiome and microbial metabolites and their roles in host mucosal immunology is a rapidly developing area of research. One major way in which the microbiome influences the host is through altered metabolism. Metabolites, readily available to the host, engender significant consequences. Microbial metabolites have been shown to impact the disease processes in both proximal and distal organs, including the brain in several neurocognitive disorders.

  • Endophytic Fungi

    The Full Story of the Untapped Treasure
    • 1 Edición
    • Ahmed M. Abdel Azeem + 2 más
    • Inglés
    Endophytic Fungi: The Full Story of the Untapped Treasure covers the developments in endophytic fungal research from beginning to the end by the eminent researchers involved in the field. It sheds light on the endophytic fungal current research, challenges, and future possibilities, the trending recent topics in the plant-fungal endophytes' biodynamics for sustainable development of bioproducts and its applications are supported in large-scale biosynthesis of industrially and pharmaceutical important biomolecules.Endophy... Fungi: The Full Story of the Untapped Treasure highlights the bioprospecting and applied aspects of endophytic fungal communities from diverse hosts and discusses the practical applications of such endophytes in detail. It also reviews recent strategies on alternative sustainable sources of medicines such as secondary metabolites of fungi instead of over collection of plants under prohibiting of biodiversity conventions. The uniqueness of this book is the inclusion of updated bioinformatics-based strategies and its importance in bioactive molecules produced by endophytic fungi. The book addresses one of the most eminent issues in this field: how to translate the potential that endophytic fungi hold in stable practical application.

  • Food Waste Valorization

    Emerging Trends, Techno-economic and Environmental Considerations
    • 1 Edición
    • Olalere Olusegun Abayomi + 2 más
    • Inglés
    Food Waste Valorization: Emerging Trends, Techno-economic and Environmental Considerations covers bioactive extraction, therapeutic properties and environmental concerns related to food waste conversion to value-added products, along with advanced technological breakthroughs in the field. The book also provides concepts and theories on several facets of agro-food waste valorization and its by-products, as well as opportunities and challenges. Each chapter contains viewpoints from different fields of research such as Basic Science, Agriculture, Food Science and Engineering, Chemical Engineering, Mechanical Engineering, Environmental Science, and more, with each having a unique approach to food waste valorization as it relates to their field. This is an invaluable resource for research and development professionals in post-harvest processing and renewable energy industries, as well as the academicians.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 122
    • Inglés
    Advances in Clinical Chemistry, Volume 122, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists.

  • Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease

    From Basic Science to Clinical Application
    • 1 Edición
    • Asim K. Duttaroy
    • Inglés
    Fatty Acid-Binding Proteins and Their Roles in Human Health and Disease: From Basic Science to Clinical Application presents the latest information on the contributions of different FABPs in physiology and pathophysiology, along with their importance in clinical outcomes. The book is divided into six main sections that cover FABP biology and their role in inflammation and diseases, such as cardiovascular, neurological, and liver diseases, to FABPs and their clinical applications.Each chapter thoroughly reviews current literature, primary research data and clinical cases, providing readers with an overview of the latest information in the expanded field of FABPs. This is an invaluable resource for both researchers and clinicians familiar with and those new to the exciting and everchanging world of fatty acid-binding proteins and clinical disorders.

  • Hematopoietic Stem Cell Transplantation for Neurologic Diseases

    • 1 Edición
    • Volumen 202
    • Inglés
    Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT), Volume 201 provides the latest information on what has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis, and many immune neuropathies. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to new insights on the pathological mechanisms underlying CNS autoimmunity, hence this volume summarizes that research.

  • Hormones and Reproduction of Vertebrates, Volume 4

    Birds
    • 2 Edición
    • David O. Norris + 1 más
    • Inglés
    Hormones and Reproduction of Vertebrates, Volume 4: Birds is the fourth of five second-edition volumes representing a comprehensive and integrated overview of hormones and reproduction in fishes, amphibians, reptiles, birds, and mammals. The book covers endocrinology, neuroendocrinology, physiology, behavior, and anatomy of avian reproduction. It provides a broad treatment of the roles of pituitary, thyroid, adrenal, and gonadal hormones in all aspects of reproduction, as well as descriptions of major life history events. New to this edition is a concluding assessment of the effect of environmental influences on birds.The initial chapters in this book broadly examine sex determination, reproductive neuroendocrinology, stress, and hormonal regulation as they relate to male and female reproductive structure and function. Subsequent chapters examine hormones and reproduction of specific behaviors, including courtship, mating, parental care, and migration.

  • Neuropsychological and Psychosocial Foundations of Neuro-Oncology

    • 1 Edición
    • Herbert B. Newton + 1 más
    • Inglés
    Neuropsychological and Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues. Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as are current practices for rehabilitation and targets for essential future interventions in vulnerable populations.This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology.

  • Hormones and Reproduction of Vertebrates, Volume 3

    Reptiles
    • 2 Edición
    • David O. Norris + 1 más
    • Inglés
    Hormones and Reproduction of Vertebrates, Volume 3: Reptiles is the third of five second-edition volumes representing a comprehensive and integrated overview of hormones and reproduction in fishes, amphibians, reptiles, birds, and mammals. The book covers endocrinology, neuroendocrinology, physiology, behavior, and anatomy of reptilian reproduction. It provides a broad treatment of the roles of pituitary, thyroid, adrenal, and gonadal hormones in all aspects of reproduction, as well as descriptions of major life history events. The initial chapters in this book broadly examine sex determination, reproductive neuroendocrinology, stress, and hormonal regulation as they relate to testicular and ovarian function. Subsequent chapters examine hormones and reproduction of specific taxa, including turtles, crocodilians, lizards, and snakes. The book concludes with an examination of environmental influences on reproduction of reptiles.

  • Smart Food Safety

    • 1 Edición
    • Volumen 111
    • Inglés
    Smart food safety series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Mitochondrial Transplantation and Transfer

    Biology, Methods, Applications, and Disease
    • 1 Edición
    • Gokhan Burcin Kubat + 2 más
    • Inglés
    Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types. Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application.

  • Update on Endocrine Disorders During Pregnancy, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 53-3
    • Maria Papaleontiou + 1 más
    • Inglés
    In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Rachel Pessah-Pollack and Maria Papaleontiou bring their considerable expertise to the topic of Update on Endocrine Disorders During Pregnancy. In recent years, our understanding of endocrine disorders during pregnancy has greatly evolved and changed. In this issue, top experts provide updates on transgender reproductive health, PCOS management during pregnancy, hypertension, diabetes, congenital adrenal hyperplasia during pregnancy, and more.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 125
    • Inglés
    Advances in Parasitology, Volume 125 provides detailed and comprehensive reviews written by experts covering all aspects of parasitology. Chapters in this new release include New directions for malaria vector control using geography and geospatial analysis, PfEMP1 – Still of key importance in Plasmodium falciparum malaria immunity and pathogenesis, and Fish Ectoparasite Detection, Collection and Curation.

  • Quick Guide to Endocrinology

    The Pediatric Version
    • 2 Edición
    • William E. Winter + 2 más
    • Inglés
    Quick Guide to Endocrinology, The Pediatric Version, Second Edition, continues to be an essential resource which focuses on the physiology, diagnostics, and laboratory testing of endocrine (hormone-mediated) disorders encountered in the field of endocrinology with expanded coverage of pediatric endocrinology. The guide is for laboratory scientists and technicians, as well as trainees and clinicians in the field of pediatrics and pediatric endocrinology including fellows, residents, medical students, nursing students, and advance practice providers and students. It is presented in an easy to read, quick format, the physiology and method of measurement for hormones essential to many bodily processes and how their dysregulation results in disease. The characteristics of such diseases and diagnostic testing including up-to-date molecular testing is addressed.

  • Melatonin

    A Ubiquitous Pleiotropic Molecule
    • 1 Edición
    • Sheikh Mansoor + 3 más
    • Inglés
    Melatonin: A Ubiquitous Pleiotropic Molecule equips researchers with an understanding of the molecular biology of melatonin in plants. The book explores the occurrence of melatonin in several plant species, covering key aspects, including its biosynthesis, physiological function in plant growth and development, and signaling pathways. It then discusses the benefits melatonin has for plant and agricultural development, as well as how it can be utilized as a therapeutic in the treatment of human diseases. The role it can play in the oxidative stress response and circadian rhythm modulation are covered, as well as its nutraceutical potential for human health.The book also covers the importance of melatonin in a range of fields, including drug discovery and disease resistance, agriculture, botany, and biotechnology, and is an ideal reference for researchers across these disciplines.

  • Redox Signaling

    • 1 Edición
    • Volumen 162
    • Inglés
    Advances in Cancer Research, Volume 162 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Artificial Intelligence in Microbiology: Scope and Challenges Volume 1

    • 1 Edición
    • Volumen 55
    • Inglés
    Nowadays, the field of microbiology is undergoing a revolutionary change due to the emergence of Artificial Intelligence (AI). AI is being used to analyze massive data in a predictable form, about the behavior of microorganisms, to solve microbial classification-relat... problems, exploring the interaction between microorganisms and the surrounding environment. It also helps to extract novel microbial metabolites which have been used in various fields like medical, food and agricultural industries. As the pace of innovation in Microbiology is accelerating, the use of AI in these industries will be beneficial. AI will not only show its extraordinary potential in expanding the market of antibiotics, food, and agriculture but also offer an eco-friendly, safer, and profitable solution to the respective industries. It would be challenging to search out specific features and discuss future research on AI in microbiology with a wide perspective.

  • Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications

    • 1 Edición
    • Huseyin Tombuloglu + 1 más
    • Inglés
    Microbial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical, and industrial fields. The book consists of four parts devoted to bacterial, viral, and fungal genomics, as well as their applications in clinical, pharmaceutical, and industrial fields. Chapters are written by experts in their respective disciplines and are tightly organized with an introduction to detailed descriptions, available software implementation, applications, advanced topics, summaries, analytic questions, exercises, and suggested readings. Throughout this book, the latest genomics and biotechnological developments and discoveries as well as open problems and future challenges on microbial genomics are highlighted. Readers will be introduced to state-of-the-art developments and trends of microbial genomics, its clinical, pharmaceutical, and industrial applications.

  • The Rose and Mackay Textbook of Autoimmune Diseases

    • 7 Edición
    • M. Eric Gershwin + 2 más
    • Inglés
    **Selected for 2025 Doody’s Core Titles® with "Essential Purchase" designation in Allergy/Clinical Immunology**The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 128
    • Inglés
    Advances in Applied Microbiology, Volume 128 continues the comprehensive reach of this widely read and authoritative review source in microbiology where users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

  • Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer

    • 1 Edición
    • Ashok Kumar + 3 más
    • Inglés
    Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for the diagnosis, prognosis, and treatment of HNSCC. The book encompasses various miRNA-based point-of-care diagnostics and drug delivery systems for HNSCC, along with information on clinical trials for improved clinical outcomes in HNSCC patients. In addition, it provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. Scientists and clinicians looking to win the battle against HNSCC will benefit from the book's sections on early diagnosis to improve treatment, increase treatment response rates, and reduce mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.

  • The Science and Art of Sensory Processing Sensitivity

    • 1 Edición
    • Bianca P. Acevedo
    • Inglés
    The Science and Art of Sensory Processing Sensitivity provides an up-to-date and novel scientific perspective on the biologically based Sensory Processing Sensitivity (SPS) trait— which is associated with enhanced awareness, depth of cognitive processing, and heightened responsivity to the environment and other individuals. This second volume by B.P. Acevedo, following “The Highly Sensitive Brain,” takes a scientific perspective on its exploration of SPS, but adds to the existing body of literature on high sensitivity by including an enhanced discussion on the proposed mechanisms linking it with depression, anxiety, and burnout.In addition, this second volume explores SPS’ relationship to other relevant personality traits, such as the Big Five, creativity, and sensation seeking; and sheds light on how their varying combinations give rise to different outcomes for highly sensitive persons (HSPs). A unique contribution of this volume is its detailed examination of the role of culture, gender, biology, aging, and the environment (including the workplace) on the expression (or repression) of high sensitivity.Also, unlike previous books, this volume takes a broad perspective on outcomes related to being highly sensitive to shine a light on the non-trivial issue plaguing many HSPs: diminished quality of life, happiness, and well-being. As such, a major contribution of the second volume on the science of SPS, is its extensive description of scientifically-based techniques that might improve the quality of life for those with high SPS.Thus, this volume may appeal to a wide audience, including both HSPs and those in their social network (friends, partners, physicians, parents, educators, and clinicians) who wish to better understand SPS, those with the trait, and how to enhance well-being among the highly sensitive.

  • Alzheimer's Disease Research Guide

    Animal Models for Understanding Mechanisms and Medications
    • 1 Edición
    • Takaomi C. Saido
    • Inglés
    Alzheimer's Disease Research Guide: Animal Models for Understanding Mechanisms and Medications provides researchers with a comprehensive guide, detailing every aspect of Alzheimer's Disease research, including chapters on neuroinflammation, immunotherapy, biomarkers, and animal modeling. This book begins with historical perspectives of both pathological chronology and pathological biochemistry in relation to Alzheimer’s disease. Other chapters review Amyloidogenic AB and Non-Amyloidogenic tau and Metabolism of AB major components to the research and understanding of Alzheimer’s research. The book concludes with specific treatment chapters including how to develop safe, effective, and inexpensive medications and the application of genome editing to the treatment of Familial Alzheimer's Disease.Written by world renowned expert in Alzheimer’s research, this book is a valuable resource for all researchers.

  • Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1

    • 1 Edición
    • Volumen 2
    • Inglés
    Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1 deals with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group.

  • Hormones

    • 1 Edición
    • Volumen 142
    • Inglés
    Hormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechanism with agonist and antagonist, Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies – A Bioinformatics approach, Exploring the Role of Estrogen and Progestins in Breast Cancer: A Genomic Approach to Diagnosis, Structural insights on ER-alpha, ER-Beta, progesterone and their drug-targets interactions in Breast cancer, The predictive ability of myokines in patients with chronic heart failure, and much more.Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more.

  • Case-Based Practical Training of Colposcopy and Cervical Pathology

    With Diagrams and Images
    • 1 Edición
    • Nadereh Behtash + 5 más
    • Inglés
    Case-Based Practical Training in Colposcopy and Cervical pathology: With Diagrams and Images is an illustrated reference to improve theoretical and practical knowledge to understand and perform colposcopy. Cervical cancer screening has advanced a great deal over the last century, and the medical field has come far in detect early pre-cancer and invasive cancer of the cervix though colposcopy and pathology. Anyone in the field of gynecology, pathology, and oncology will find this book useful to better understand the different levels of prevention, including vaccinations and screening and for students to correctly understand colposcopy and cervical pathology through real illustrated case studies. The book’s aim is for for prevention and treatment of anogenital and HPV related -diseases and supports the goal of the World Health Organization to cure cervical cancer by 2030.

  • Bio-organic Amendments for Heavy Metal Remediation

    Water, Soil and Plant Approaches and Technologies
    • 1 Edición
    • Allah Ditta + 3 más
    • Inglés
    Bio-organic Amendments for Heavy Metal Remediation: Water, Soil and Plant Approaches and Technologies focuses on these core continuum media to explore remediation options using microbial, organic, and combined approaches. This volume in the Plant Biology, Sustainability and Climate Change series offers a comprehensive view of techniques and approaches for addressing contamination by heavy metals. It provides a comprehensive view of the challenge, with a focus on the bioremediation of heavy metals contamination using ecotechnological approaches for protecting the soil, water, and plant continuum.As anthropogenic activities increasingly negatively impact natural resources, there has been significant disturbance of the water, soil, and plant continuum due to the accumulation of heavy metals. The bioaccumulation of heavy metals in the food chain could pose life-threatening effects on plants as well as humans, and there is need to find effective and sustainable remediation options. The application of bio-organic amendments could serve as a sustainable solution to this problem.

  • Metabolomics for Personalized Vaccinology

    • 1 Edición
    • Mahbuba Rahman
    • Inglés
    Metabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the development of personalized vaccines, which requires in-depth knowledge of the patient’s health status, particularly the immune system, and on metabolomics, the closest indicator of the disease phenotype. Specifically, the book provides an understanding of how metabolomics might be employed in personalized vaccinology and how the metabolic pathway of the host’s system is altered by vaccine administration.Over the past few years, researchers have published articles on personalized vaccines, but these are sparse. Therefore, compiling information on this topic gives the reader an overview of the progress of the field, despite being at its infancy.Metabolomics for Personalized Vaccinology is ideally suited for researchers and postgraduate students who are interested in clinical and nonclinical studies where metabolites are used for the identification of disease and therapeutic targets.

  • Essentials of Translational Pediatric Drug Development

    From Past Needs to Future Opportunities
    • 1 Edición
    • Elke Gasthuys + 3 más
    • Inglés
    Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population.

  • Quality Assurance Management

    A Comprehensive Overview of Real-World Applications for High Risk Specialties
    • 1 Edición
    • Gayathri De Lanerolle + 3 más
    • Inglés
    Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into ‘building blocks’ that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry.

  • Learning Deep Brain Stimulation Management through Clinical Cases

    • 1 Edición
    • Martijn Beudel
    • Inglés
    Learning Deep Brain Stimulation Management through Clinical Cases reviews the clinical practice of applying deep brain stimulation (DBS) to patients with movement disorders. The book explores the cardinal aspects of applying DBS in diverse movement disorders based on patient’s needs. Every case answers all questions, providing case descriptions and step-by-step procedures for optimal replication. Every chapter includes a clinical decision support system (CDSS) depicted in flowcharts that can be used for reference. Deep Brain Stimulation (DBS) uses electrical stimulation to regulate electrical signals in neural circuits to and from identified areas in the brain to improve movement symptoms.The management of DBS in a movement disorders can be challenging, optimizing patient journeys and grasping all clinical aspects of the highly technological therapy. Hence, this book provides the informaiton necessary to embrace new breakthroughs.

  • Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies

    • 1 Edición
    • Volumen 161
    • Inglés
    Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies, Volume 161 in the Advances in Cancer Research series, covers timely topics such as The Prostate Cancer Tissue N-glycome as a Source of Biomarkers, a Progression from Normal to Metastatic Disease, Multiplexed Targeted Proteomics for Prostate Cancer Biomarker Verification, MRI for the Detection of Clinically Significant Prostate Cancer: Update and Future Directions, Genetic and epigenetic factors for prostate cancer progression, Epigenetic regulation of androgen dependent and independent prostate cancer, Molecular Landscape of Prostate Cancer Bone Metastasis, Future of radioligand Therapy in PC, and more.Additional chapters of note include Advancements in Computer Vision and Pathology: Unraveling the Potential of Artificial Intelligence for Precision Diagnosis and Beyond and Extracellular Vesicles in Prostate Cancer.

  • Circuits, Signals, and Systems for Bioengineers

    A MATLAB-Based Introduction
    • 4 Edición
    • John Semmlow
    • Inglés
    Circuits, Signals, and Systems for Bioengineers: A MATLAB-Based Introduction, Fourth Edition, guides the reader through the electrical engineering principles that can be applied to biological systems. It details the basic engineering concepts that underlie biomedical systems, medical devices, biocontrol, and biomedical signal analysis, providing a solid foundation for students in important bioengineering concepts. Fully revised and updated to better meet the needs of instructors and students, the fourth edition expands on concepts introduced in the previous edition through computational methods that allow students to explore operations, such as correlations, convolution, the Fourier transform, and the transfer function. New medical examples and applications are included throughout the text.

  • Advances in Microbial Physiology

    • 1 Edición
    • Volumen 85
    • Inglés
    Advances in Microbial Physiology, Volume 85 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include The genetic basis of predation by myxobacteria, Vancomycin susceptibility and VISA in Staphylococcus aureus, Cytochrome bd-type oxidases and environmental stressors in microbial physiology, Bacterial heme-containing sensor proteins, Algal hemoglobins, Inter-species interactions in polymicrobial infections, Utilization of Low Methane Concentrations by Methanotrophs, and Role of sulfidogenic members of the gut microbiota in human disease.

  • The Discovery of New Medicines in Academia

    • 1 Edición
    • Volumen 100
    • Inglés
    The Discovery of New Medicines in Academia, Volume 100 highlight examples of discoveries originating in academia that have been successfully translated into promising therapeutics that have advanced into clinical trials. Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more.Additional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery/developmen... of antiviral, anticancer and/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 187
    • Inglés
    Advances in Agronomy, Volume 187, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • Targeted Genome Engineering via CRISPR/Cas9 in Plants

    • 1 Edición
    • Alvina Gul
    • Inglés
    Targeted Genome Engineering via CRISPR/Cas9 in Plants provides in-depth insights into the use of the emerging “CRISPR/Cas9” technology for precise genome editing. This technology has revolutionized plant science research particularly for crop improvement owing to its simplicity and efficiency. The book provides a wide range of CRISPR/Cas9 gene editing techniques for a variety of plants. Chapters include the latest applications of CRISPR/Cas9 system in connection with abiotic stresses, biotic stresses, biofortification, yield improvement, disease modelling and prognosis and molecular diagnosis. Targeted Genome Engineering via CRISPR/Cas9 in Plants also evaluates various regulatory and ethical aspects that must be considered when implementing the CRISPR/Cas9 approach. This book is a valuable resource for professionals and researchers, as it provides effective CRISPR/Cas9-based strategies for sustainable agriculture and treatment of various diseases.

  • The Neurophysiology of Silence (C): Creativity, Aesthetic Experience and Time

    • 1 Edición
    • Volumen 287
    • Inglés
    Neurophysiology of Silence: Consciousness and Self Awareness, Volume 284 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Hormones and Reproduction of Vertebrates, Volume 1

    Fishes
    • 2 Edición
    • David O. Norris + 1 más
    • Inglés
    Hormones and Reproduction of Vertebrates, Volume 1: Fishes is the first of five second-edition volumes representing a comprehensive and integrated overview of hormones and reproduction in fishes, amphibians, reptiles, birds, and mammals. The book includes coverage of endocrinology, neuroendocrinology, physiology, behavior, and anatomy of fish reproduction. It provides a broad treatment of the roles of pituitary, thyroid, adrenal, and gonadal hormones in all aspects of reproduction, as well as descriptions of major life history events. New to this edition is a concluding assessment of the effect of environmental influences on fishes.Initial chapters in this book broadly examine sex determination, reproductive neuroendocrinology, stress, and hormonal regulation as they relate to testicular and ovarian development and function. Subsequent chapters examine hormones and reproduction of specific taxa, especially teleosts, with additional coverage of reproductive cycles of agnathan, chondrichthyan, and sarcopterygian fishes. The book concludes with an examination of the environmental influences on hormones and reproduction of fishes, including endocrine-disrupting chemicals, microplastic particles, and climate change.

  • Diagnosis and Analysis of COVID-19 using Artificial Intelligence and Machine Learning-Based Techniques

    • 1 Edición
    • Mohammad Sufian Badar + 4 más
    • Inglés
    Diagnosis and Analysis of COVID-19 using Artificial Intelligence and Machine Learning-Based Techniques offers new insights and demonstrates how machine learning (ML), artificial intelligence (AI), and (Internet of Things (IoT) can be used to diagnose and fight COVID-19 infection. Sections also discuss the challenges we face in using these technologies. Chapters cover pathogenesis, transmission, diagnosis, and treatment strategies for COVID-19, Artificial Intelligence and Machine Learning, and Blockchain /IoT Blockchain technology, examining how AI can be applied as a tool for detection and containment of the spread of COVID-19, and on the socioeconomic and educational post-pandemic impacts of the disease.This is a multidisciplinary resource for those engaged in researching COVID-19 and how emerging technologies are being used as tools for detection, transmission and treatment strategies.

  • Biophysical Approaches for the Study of Membrane Structure Part B

    • 1 Edición
    • Volumen 701
    • Inglés
    Biophysical Approaches for the Study of Membrane Structure, Part B, Volume 701 explores lipid membrane asymmetry and lateral heterogeneity. A burst of recent research has shown that bilayers whose leaflets differ in their physical properties—such as composition, phase state, or lateral stress—exhibit many fascinating new characteristics, but also pose a host of challenges related to their creation, characterization, simulation, and theoretical description. Chapters in this new release include Characterization of domain formation in complex membranes: Analyzing the bending modulus from simulations of complex membranes, The density-threshold affinity: Calculating lipid binding affinities from unbiased Coarse-Grain Molecular Dynamics simulations, and much more.Additional sections cover Uncertainty quantification for trans-membrane stresses and moments from simulation, Using molecular dynamics simulations to generate small-angle scattering curves and cryo-EM images of proteoliposomes, Binary Bilayer Simulations for Partitioning Within Membranes, Modeling Asymmetric Cell Membranes at All-atom Resolution, Multiscale remodeling of biomembranes and vesicles, Building complex membranes with Martini 3, Predicting lipid sorting in curved bilayer membranes, Simulating asymmetric membranes using P21 periodic boundary conditions, and many other interesting topics.

  • Cannabidiol in Neurology and Psychiatry

    • 1 Edición
    • Volumen 177
    • Inglés
    Cannabidiol in Neurology and Psychiatry, Volume 177 in the International Review in Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topic such as Historical perspective on the therapeutic potential of cannabidiol, Cannabidiol: pharmacodynamics pharmacokinetic, Cannabidiol and Alzheimer’s disease, Cannabidiol on anxiety disorders, Cannabidiol on psychosis, Cannabidiol on autism spectrum disorders, Cannabidiol in Epilepsy, Cannabidiol in Ischemia/stroke, Cannabidiol in Depression, Cannabidiol and Abuse of drugs, and much more.Additional chapters cover Cannabidiol in fear response and PTSD, Cannabidiol and Pain. and Cannabidiol and Parkinson’s disease.

  • Blood-Brain Barrier

    • 1 Edición
    • Volumen 126
    • Inglés
    Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Hormones and Reproduction of Vertebrates, Volume 2

    Amphibians
    • 2 Edición
    • David O. Norris + 1 más
    • Inglés
    Hormones and Reproduction of Vertebrates, Volume 2: Amphibians is the second of five second-edition volumes representing a comprehensive and integrated overview of hormones and reproduction in fishes, amphibians, reptiles, birds, and mammals. The book covers endocrinology, neuroendocrinology, physiology, behavior, and the anatomy of amphibian reproduction. It provides a broad treatment of the roles of pituitary, thyroid, adrenal, and gonadal hormones in all aspects of reproduction, as well as descriptions of major life history events. New to this edition is a concluding assessment of the effect of environmental influences on amphibians.This book is designed to provide a readable, coordinated description of reproductive basics in amphibians, as well as an introduction to the latest trends in reproductive research and a presentation of our understanding of reproductive events gained over the past decade. It may serve as a stand-alone reference for researchers and practitioners in the field of herpetology or as one of five coordinated references aligned to provide topical treatment across vertebrate taxa for researchers, practitioners, and students focused on vertebrate endocrinology.

  • Personalized Epigenetics

    • 2 Edición
    • Trygve Tollefsbol
    • Inglés
    Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

  • Aquaculture Virology

    • 2 Edición
    • Frederick S.B. Kibenge + 1 más
    • Inglés
    In 2018, the International Committee on Taxonomy of Viruses (ICTV) approved significant changes leading to a comprehensive taxonomic scheme, allowing the global organization of the virus world (also known as virus megataxonomy). Aquaculture Virology, Second Edition updates the current knowledge on aquatic animal viruses so that all virus families (including those with many newly discovered aquatic animal viruses and those with previously unclassified aquatic animal viruses that have been now assigned) are available under one cover, increasing the number of book chapters from 37 in the first edition to 44 chapters in the second edition. The aims, philosophy, target audience, focus, and format of this second edition of Aquaculture Virology remain unchanged. Like the first edition, this book is a systematic and concise resource useful to anyone involved with or looking to move into aquaculture and fisheries. Clinical veterinarians, aquaculture disease practitioners, biologists, farmers, and all those in industry, government, or academia interested in aquatic animal virology will find this book extremely useful.

  • Overcoming Cancers Resistant to HER-2 Antibodies

    • 1 Edición
    • Volumen 2
    • Benjamin Bonavida
    • Inglés
    Overcoming Cancers Resistant to HER-2 Antibodies provides general updated information on the resistance of various human cancers to anti-HER2 therapeutic antibodies. The book also discusses the description of various sensitizing agents that can reverse resistance when used in combination with anti-HER2 antibodies. There have been a lot of reports in which the treatment with anti-HER2 antibodies for various cancers has resulted in clinical responses; however, there have been also subsets of cancer patients who did not respond initially, and several responding patients developed resistance following treatments. Sections cover Lapatinib, Ganetespib, Paclitaxel, Celecoxib, Emantasine, Liposomal Doxorubicin, and Kinase Inhibitors.This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of the biomedical field interested in fighting cancer resistance to HER-2 antibodies.

  • Pigmented Grains

    Nutritional Properties, Bioactive Potential, and Food Application
    • 1 Edición
    • Arashdeep Singh + 3 más
    • Inglés
    Pigmented Grains: Nutritional Properties, Bioactive Potential, and Food Application highlights the potential of pigmented grains crops in the human diet and their health benefits due to presences of the rich source of phytochemicals and pigments. Divided into 13 chapters, the book covers the breeding approaches and techniques for producing pigmented grains, the functionality and nutritional properties of wheat, rice, maize, barley, oats and rye, sorghum, millets, and pseudo cereals such as amaranth, quinoa and buckwheat. Others chapters cover the processing of pigmented grains and the effect on their functionality, utilization of pigmented grains and their by-products This is a comprehensive reference written for teachers, scientists, researchers, students, and all others who have interest in pigmented grains their potential nutritional value, utilization in food processing, value addition, and in combating malnutrition and nutritional security.

  • Enzyme Biotechnology for Environmental Sustainability

    • 1 Edición
    • Praveen Dahiya + 2 más
    • Inglés
    Enzyme Biotechnology for Environmental Sustainability discusses recent applications of enzyme biotechnology in various industrial sectors and state-of-the-art information on novel microbial enzyme technologies for a sustainable environment.The book describes in detail the latest developments and modern methods in microbial enzyme biotechnology for wider application in bioremediation, cleaner technology for industries and waste management, green chemistry and pharmaceutical biotechnology, sustainable textiles, food production and biodegradation, and other industries. The chapters cover topics such as genetic engineering, protein engineering, nanotechnological advances of microbial enzymes, computational tools for engineering enzymes, and health risk assessment of enzymes in different sectors. With contributors from an array of experts in the field, Enzyme Biotechnology for Environmental Sustainability is an informative reference for researchers, biotechnologists, microbiologists, environmental scientists, graduate and post-graduate students working in the area of enzyme technology and their biomedical, environmental, and industrial applications.

  • The Immunology of the Dog

    • 1 Edición
    • Ian R. Tizard
    • Inglés
    The Immunology of the Dog is the first readily available, single-source, comprehensive review of the canine immune system. The book discusses all immunologic aspects of diseases of the dog and relates recent basic science to important clinical issues. Sections cover the evolution and domestication of the dog, provide detailed information on immunity to infectious diseases, canine allergic diseases, the top canine autoimmune diseases, and canine immunodeficiencies. This book offers professionals in veterinary research and practice complete information on all aspects of canine immunology in one essential resource.

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