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Elsevier

Libros en Ciencias de la Vida

  • Biochemical and Molecular Pharmacology in Drug Discovery

    • 1 Edición
    • Mithun Rudrapal + 2 más
    • Inglés
    Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches, along with certain key topics related to molecular pharmacology of drugs and therapeutics. The book explains the phenomena of drug-target interactions, considering different biochemical systems and cellular strategies. With the advent of technologies, current advances, and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology in a comprehensive and systematic manner.Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology.

  • Macrophages Biology and Tissue Inflammation in Health and Disease

    • 1 Edición
    • Stuart Goodman + 2 más
    • Inglés
    Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats.

  • Transpathology

    Molecular Imaging-Based Pathology
    • 1 Edición
    • Mei Tian
    • Inglés
    Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It is molecular imaging approach to experimental research and clinical practice which will drive the field forward and improve research outcomes.

  • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

    Platforms
    • 1 Edición
    • Wendy Fantl
    • Inglés
    Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms. Understanding the intricate coordination of highly diverse cell types within healthy tissues and organs is essential for grasping their functionality. This coordination, often disrupted in disease, hinges on proteins—the primary drivers of cellular function. By examining protein abundance and activation states in single cells, researchers can identify key cell populations involved in both healthy and diseased states, including those influencing disease initiation, progression, and therapeutic responses. Single-cell multiplex proteomic platforms have recently emerged as powerful tools for biomedical research. Their strengths lie in revealing cell types that are rare or subtly different and would otherwise go undetected in bulk cellular analyses. This unique capability enables deeper insights into cellular behavior and disease mechanisms.This book offers comprehensive overviews of technologies developed for multiplex single-cell proteomic analyses. It begins with the pioneering work from Professors Scott Tanner, Mitchell Winnick and Garry Nolan resulting in the development and early application of the mass cytometer, (CyTOF). The instrument merges flow cytometry with time-of-flight mass spectrometry and analyzes cells labelled with metal tagged antibodies. These components work together to enable CyTOF to perform highly multiplexed protein analysis at the single-cell level, offering a powerful tool for understanding complex cellular behaviors and interactions.Recogni... that cellular organization is critical for tissue function, subsequent chapters explore advanced multiplex imaging platforms including Imaging Mass Cytometry (IMC), Multiplexed Ion Beam Imaging (MIBI), CODetection by InDExing, and Chip Cytometry. Later chapters present recent advances in these imaging platforms and data analysis approaches - Combined Nucleic Acid and Protein Quantification in situ, Tissue Schematics, and High-definition CODEX for 3D Multiplex Spatial Cell Phenotyping. These techniques integrate deep phenotyping with spatial mapping to provide unprecedented insights into cellular interactions within tissues. The book also highlights computational approaches essential for managing and interpreting the vast datasets generated by these technologies. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms help researchers in many fields, including developmental biology, cancer biology, immunology, neuroscience, and drug discovery gain an understanding about the theories and detailed methodologies behind these technologies. Integrating proteomics with genetic, epigenetic, and transcriptomic platforms, this book aims to inspire new research opportunities, ultimately advancing the development of reliable biomarkers and improving patient outcomes.

  • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

    Applications
    • 1 Edición
    • Wendy Fantl
    • Inglés
    Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: ApplicationsHealthy tissues and organs rely on the precise coordination of diverse cell types, each responding to external and internal signals. Disease disrupts this coordination. Since proteins drive cellular function, analyzing their abundance and activation states in single cells helps identify key cell populations in health and disease. Bulk protein analyses mask critical differences between individual cells. Additionally, the arrangement of cells into neighborhoods through cell-cell interactions is essential for tissue function. Over the last decade, single-cell proteomic phenotyping combined with positional information has become crucial for understanding biology in health and disease. This has led to the development of multiple technology platforms, profoundly impacting fields including developmental biology, cancer biology, immunology, neuroscience, and drug discovery. This book focuses on the application of single-cell multiplex proteomic platforms to various biological systems. These platforms have proved to be essential in biomedical research, advancing our understanding of complex biological systems at the cellular level. Compelling studies where authors use these technologies to answer previously unanswerable questions are featured. Exploring this "Uncharted Biology" opens new avenues for scientific inquiry and clinical translation, covering areas including oncology, immunology, metabolomics, stem cell research, preclinical models, and translational research. The initial chapters discuss incorporating these technologies into core facilities and consortia, providing access for multiple users and integrating datasets from other omics technologies. The following chapters cover applications in diverse areas such as muscle stem cell function in skeletal muscle regeneration, metabolic regulome profiling, translational studies, developing predictive biomarkers for patients receiving immune checkpoint inhibitors, and pre-clinical studies of lung cancer. These applications demonstrate how advanced single cell proteomic technologies are reshaping our understanding of complex biological systems and enhancing clinical translation. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications highlights the transformative benefits of single-cell proteomics, offering insights into cellular mechanisms underlying health and disease and inspiring further exploration into "Uncharted Biology." It is an essential resource for researchers, clinicians, and students aiming to advance biomedical science and improve therapeutic outcomes.

  • On Epigenetics and Evolution

    • 1 Edición
    • Carlos M. Guerrero-Bosagna
    • Inglés
    On Epigenetics and Evolution, a new volume in the Translational Epigenetics series, introduces key themes from current epigenetic evolution research, with contributions from leading scientists around the world that investigate the role of epigenetic mechanisms in evolution from a variety of different angles, with each contribution combining theory, current research overviews, and applications. This book gives researchers, students, and clinicians a better understanding of the origin of genotypic and phenotypic variability, the role of epigenetics in development and inheritance, how epigenetics may affect speciation, and the evolution of epigenetic mechanisms in different taxa, and helps them apply their learnings across new research. Other modalities and subtopics explored include epigenetics in neutral and also adaptive evolution; epigenetic evolution in plants, invertebrates, and vertebrates; and the role of epigenetics in human evolution and its societal impact.

  • Resilient Health

    Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond
    • 1 Edición
    • Judy Kuriansky + 1 más
    • Inglés
    Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond presents game-changing and disruptive technological innovations and social applications in physical and mental healthcare around the world for the post-COVID age and beyond, addressing the urgent need for care. In this first-of-its kind comprehensive volume, experts and stakeholders from all sectors - government and the public and private sectors - offer models and frameworks for policy, programming, and financing to transform healthcare, address inequities, close the treatment gap, and “build back better,” especially for under-resourced vulnerable communities globally, to “leave no one behind” and advance development globally. Contributions from world experts cover 8 essential parts: The context and challenges for resilient health systems to shape the future; developments and directions (AI, VR, MR, IVAs and more); an innovations toolbox, also targeted for special populations and settings (women, youth, ageing, migrants, disabled persons, indigenous peoples, in the workplace); the role of stakeholders (governments, the United Nations bodies, and the public and private sector); forums and networks; innovative financing; resources, lessons learned and the way forward.

  • Enzymatic Processes for Food Valorization

    • 1 Edición
    • Monica L. Chavez Gonzalez + 3 más
    • Inglés
    Enzymatic Processes for Food Valorization describes the most recent research in the field of catalysis for food valorization, revealing the impact of the implementation of enzymatic catalysis in the different stages that make up the production processes. Sections review advances in food processing using enzymes, explore the use of enzymes on by-products for the release of compounds of interest, and show recent trends in biocatalysis and its application in the food industry. Written by a team of international experts, this is an invaluable guide for professionals in the area of enzyme technology applied in the food industry, as well as technicians and scientists involved in the use of enzymes on food waste for the valorization and/or recovery of compounds.

  • Functionality of Plant Proteins

    Properties, Methods of Assessment, Modifications and Applications
    • 1 Edición
    • Janitha P.D. Wanasundara + 2 más
    • Inglés
    Functionality of Food Proteins: Mechanisms, Modifications, Methods of Assessment and Applications provides researchers and users of plant-based proteins with the latest developments on their functionality at the molecular and ingredient level, and in food applications. The book discusses the biological, chemical and physical principles behind the techno-functional and nutritional properties of proteins, existing methods of functionality assessment, and protein modification for functional enhancement. With market demand for protein ingredients, several lesser known sources are being utilized to develop new protein ingredients and products, with some intended to replace, partially or wholly, traditional proteins such as egg, milk, meat, soy and vital gluten.Depending on the source and processing into ingredients, the ability of these proteins to satisfy techno-functional and nutritional requirements in the final food product may differ. Science-based knowledge is needed in the area of protein functionality for making decisions along the value chain, from production on the land to processing and formulation.

  • Executive Brain Vitality

    Achieving Optimal Brain Health and Maintenance: A Practical Manual
    • 1 Edición
    • Michael Hoffmann
    • Inglés
    Executive Brain Vitality: Achieving Optimal Brain Health and Maintenance presents research on the effect of brain exercise as a preventative measure for neurodegenerative diseases and other conditions. This volume examines the neurological impact of such exercises from research to clinical application, offering up-to-date research and practical steps. The current book will be of interest to researchers in neurodegeneration and chronic disease as well as practitioners and clinicians interested in the preventative approach in medicine.

  • Metabolic Steatotic Liver Disease

    Current Knowledge, Therapeutic Treatments, and Future Directions
    • 1 Edición
    • Mindie Nguyen + 1 más
    • Inglés
    Metabolic Fatty Liver Disease: Current Knowledge, Therapeutic Treatments, and Future Directions provides the most updated research findings and defines the current data gaps on metabolic fatty liver disease. The book extensively covers key areas in metabolic fatty liver disease research, including epidemiology (adults and children), economic burden, patient-reported outcome burden, natural history, current treatments, current diagnostic methods, controversies (NAFLD/MAFLD), current guidelines, fatty liver disease in the presence of other liver diseases as well as guidance on future research. This book will provide translational researchers with a current and comprehensive resource dedicated to all aspects of research in metabolic fatty liver disease, identify current gaps in research and make future research recommendations. It also offers clinicians a look at important background information in metabolic fatty liver disease and thoroughly reviews the latest research in this area to inform treatment outcomes.

  • Encyclopedia of Food Allergy

    • 1 Edición
    • Scott H Sicherer
    • Inglés
    **2025 PROSE Award Finalist in Clinical Medicine**Encycloped... of Food Allergy, Three Volume Set organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With intuitive and easily accessible organization of information, the reader can quickly access overviews and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions.Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving lifelong, severe, and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them.

  • Advances in Host Genetics and microbiome in lifestyle-related phenotypes

    • 1 Edición
    • Volumen 111
    • Inglés
    Advances in Host Genetics and Microbiome in Lifestyle-Related Phenotypes, Volume 111 explores the recent discoveries in the interaction between Host Genetics-Microbiome and lifestyle-related phenotypes regarding precision nutrition, physical activity, sports performance, circadian rhythm, sleep, and rest. Chapters in this release include Techniques, procedures, and applications in host Genetic analysis, Techniques, procedures, and applications in Microbiome analysis, Human adaptations to diet: biological and cultural coevolution, Impact of Evolution on Lifestyle in Microbiome, Nutrition and host Genetics: nutrigenetics, Nutrition and Microbiome: microbiome nutrition, Genomic predictors of physical activity and athletic performance, physical activity and Microbiome, Microbiome and Host Genetics in Circadian Rhythm, and more.

  • Biochar Production for Green Economy

    Agricultural and Environmental Perspectives
    • 1 Edición
    • Shiv Vendra Singh + 4 más
    • Inglés
    Biochar Production for Green Economy: Agricultural and Environmental Perspectives addresses the advancements and developments for the efficient diversification of biochar toward achieving improved agricultural and environmental benefits. This comprehensive and cohesive volume is the first to address the potential multi-and transdisciplinary opportunities of effective biochar production and use. Including the potential applicability of not only crop waste biochar but weeds, agroforestry, agroindustry, municipal waste, as well chapters explore surface modified, enriched or tailored biochar for soil amendment, GHGs mitigation, bioremediation of organic, inorganic, metals and other emerging pollutants, as well as soil remediation. It also covers the trending multidisciplinary approaches of nanotechnology, surface chemistry and thermal decomposition advancements being adopted for capacity enhancement and versatile applicability in the field of agriculture, environment science and green energy synthesis. Composition and characteristics of tailored biochar, their interactions, and transformation into the soil and water ecosystem are illustrated. This book is a valuable resource for those pursuing biochar related areas as well as those seeking environmentally sustainable solutions to crop, soil or water issues.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1 Edición
    • Volumen 39
    • Inglés
    Advances in Biomembranes and Lipid Self-Assembly, Volume 39 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Genomic and Molecular Cardiovascular Medicine

    • 1 Edición
    • Dhavendra Kumar + 2 más
    • Inglés
    The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice. In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency.

  • Casein

    Structural Properties, Uses, Health Benefits and Nutraceutical Applications
    • 1 Edición
    • Mamdouh El-Bakry + 1 más
    • Inglés
    Casein: Structural Properties, Uses, Health Benefits and Nutraceutical Applications investigates casein properties, uses, and applications in food and non-food products in addition to exploring its health benefits and uses in manufacturing, such as in cheese products. Sections include in-depth discussions on the future scope, challenges, and market trends of this protein. This book is an excellent reference for food scientists, dairy researchers, pharmaceutical scientists, students and researchers studying related fields.

  • Advances in Food and Nutrition Research

    • 1 Edición
    • Volumen 110
    • Inglés
    Advances in Food and Nutrition Research, Volume 111 provides the latest on highly timely topics, including Understanding the Heterocyclic Aromatic Amine Research: An Overview and Recent Findings, Recent advances and challenges in the analysis of natural toxins, High Pressure Processing Plus Technologies: Enhancing the Inactivation of Vegetative Microorganisms, A discussion on A1-free milk: nuances and comments beyond implications to the health, Bioactive peptides as a novel strategy to prevent alcoholic liver injury, Hemp seed protein-derived short- and medium-chain peptides and their multifunctional properties, Condensed tannins – their content in plant foods, changes during processing, antioxidant and biological activities, and more.

  • Advancement of Phenolic Acids in Drug Discovery

    Fundamentals and Applications
    • 1 Edición
    • Naresh Kumar + 2 más
    • Inglés
    Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book’s final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.

  • African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance

    Part 2. Potent Botanicals to Overcome Cancers and their Chemoresistance
    • 1 Edición
    • Volumen 112
    • Inglés
    African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part Two: Potent Botanicals to Overcome Cancers and their Chemoresistance offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently overcome cancers and their drug resistance. The book identifies and comments on the best cytotoxic African medicinal plants. The book also provides knowledge on ethnomedicinal uses of the identified plants, their pharmacological potency, and their phytochemistry.An overview of the relationship between cancer and other human diseases healed in the traditional health system with the plants documented is also highlighted. The book appears a unique tool for Scientists to have state-of-the-art of the best cytotoxic plants from the African flora.

  • Microbial Biostimulants for Plant Growth and Abiotic Stress Amelioration

    • 1 Edición
    • Puneet Singh Chauhan + 2 más
    • Inglés
    Microbial Biostimulants for Plant Growth and Abiotic Stress Amelioration, the latest release in the Biostimulants and Protective Biochemical Agents series, provides readers with insights into the major role of biostimulants in plant growth and development while under abiotic stress. The term biostimulants is broadly used to reference a group of diverse substances and microorganisms that stimulate life or that promote favorable plant responses. They stimulate natural processes to enhance/benefit nutrient uptake, nutrient efficiency, tolerance to abiotic stress, and crop quality.Many biostimulants improve nutrition and they do so regardless of their own nutrient contents. Further, recently microbe-based biostimulants have emerged as important plant protectors under a range of adverse conditions.

  • Biomechanics of the Aorta

    Modeling for Patient Care
    • 1 Edición
    • T. Christian Gasser + 2 más
    • Inglés
    As biomechanics is fundamental to understanding the normal and pathological functions of the aorta, Biomechanics of the Aorta presents a holistic analysis of aortic physiology, clinical imaging, tissue and blood flow modeling. It investigates a wide range of topics from basic sciences (vascular biology, continuum mechanics, image analysis) to essential knowledge for clinical applications, including diagnostics, aortic rupture prediction, as well as surgical planning. Expert chapter authors describe and present computational studies and experimental benches, to mimic, understand and propose the best treatment of aortic pathologies.Divided into five parts, the book begins with an introduction to the fundamental aspects of the anatomy, biology, and physiopathology of the aorta, and then proceeds to present concepts of imaging and tissue/rheology characterization, tissue modeling and rupture, and flow modeling and algorithms. The final part dives into applications and case studies including transcatheter aortic valve implantation, aortic aneurysm rupture prediction, aortic dissections, and pharmacological treatments.

  • Peptide and Peptide Mimicking Tools: Methods, Synthesis, Design & Applications

    • 1 Edición
    • Volumen 698
    • Inglés
    Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-base... peptide mimicking tools for modulating biology.

  • Human Organs-on-a-Chip Technology

    • 1 Edición
    • P.V. Mohanan
    • Inglés
    Human Organs-on-a-Chip Technology focuses on technology advancement from “organ-on-a-chip”, “multi organs-on-a-chip”, and the newest stage of “human organs-on-a-chip." Chapters investigate the design, simulation studies, device development, and application of microfluidic systems. In addition, they offer expert perspectives on the development of an alternative test system in the biological evaluation of drugs, cosmetics, chemicals, medical devices, and many others. Lastly, the book addresses issues related to the development of microfluidic devices and alternative test systems in biological and biomedical research.

  • African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance

    Part 1. Cancer Chemoresistance, Screening Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products
    • 1 Edición
    • Volumen 111
    • Inglés
    African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products, Volume 111 offers an overview of the potential of African medicinal plants as a source of anticancer agents to overcome with an emphasis on cancer drug resistance. Based on the collected data, the book also offers a rational classification basis for the cytotoxic activity of natural products. The general knowledge of state-of-the-art of cancer drug resistance globally and the screening methods for cytotoxic agents are described.This book clearly identifies the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle cancers and their refractory phenotypes. The book appears a unique tool for Scientists for anticancer drug discovery from the exceptional flora of Africa.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 119
    • Inglés
    Advances in Virus Research, Volume 119, the latest release in this esteemed series, presents the latest research and developments in viruses.

  • Human Neuroanatomy

    • 1 Edición
    • Reha Erzurumlu + 2 más
    • Inglés
    Human Neuroanatomy is a unique resource that presents the neuroanatomy of the central and peripheral nervous systems. This atlas-style reference features human brain sections with radiological correlations and original illustrations accompanying macroscopic and microscopic photographs. Chapters include a large number of illustrations in the form of photographs, Illustrations, and MR imaging, including a human brain atlas. Boxes within each chapter contain clinical information, with tables of topic summaries. Presented along with clinical approaches and analyses, this is a reference for all neuroscientists, neurosurgeons, neurologists, medical students, and all students of neuroscience.

  • Computational and Network Modeling of Neuroimaging Data

    • 1 Edición
    • Kendrick Kay
    • Inglés
    Computational and Network Modeling of Neuroimaging Data provides an authoritative and comprehensive overview of the many diverse modeling approaches that have been fruitfully applied to neuroimaging data. As neuroimaging is witnessing a massive increase in the quality and quantity of data being acquired, this book gives an accessible foundation to the field of computational neuroimaging, suitable for graduate students, academic researchers, and industry practitioners who are interested in adopting or applying model-based approaches in neuroimaging.It is widely recognized that effective interpretation and extraction of information from complex data requires quantitative modeling. However, modeling the brain comes in many diverse forms, with different research communities tackling different brain systems, different spatial and temporal scales, and different aspects of brain structure and function. This book takes a critical step towards synthesizing and integrating across different modeling approaches.

  • The History of Gynecological Treatment of Women’s Pelvic Pain and the Recent Emergence of Pain Sensitization

    • 1 Edición
    • John F. Jarrell
    • Inglés
    **2025 PROSE Award Finalist in Biomedicine and Neuroscience**The History of Gynecological Treatment of Women’s Pelvic Pain and the Recent Emergence of Pain Sensitization is a historical account on how women have been treated for the problems of pelvic pain. It describes the earliest reports of women suffering from pelvic pain that seem to suggest the presence of something beyond any understanding prior to the late twentieth century. This book is for awareness of the condition and will help readers understand the complex presentations of pelvic pain: the shift from episodic to persistent pain, referred pain, pain from a non-painful stimulus (allodynia), and excessive pain from a painful stimulus (hyperalgesia).This is a novel reference that provides a detailed chronology of past treatments and how the absence of awareness of pain sensitization led to some disreputable surgical procedures. In addition, it is an historical analysis on the emergence of central pain sensitization as an explanation for the historical challenges of the past to current developments.

  • Waste Management for Sustainable and Restored Agricultural Soil

    • 1 Edición
    • Vijay Singh Meena + 6 más
    • Inglés
    Waste Management for Sustainable and Restored Agricultural Soil provides a holistic approach to various mechanisms of waste management for plant nutrients, highlighting the importance of improving plant growth, nutrient concentration, and system sustainability for enhancing crop production and achieving desired environmental goals. Covering a broad overview of different kinds of wastes and waste recycling methods and sustainable management for soil health, this book focuses on both basic and applied aspects of waste management for sustainable agriculture and how nutrients are made available through waste. Academics, professionals, researchers and policymakers working in the fields of safe waste management for potential use in agricultural crop production will benefit from this book.

  • Chromatin

    Structure, Function, and History
    • 1 Edición
    • Randall H. Morse
    • Inglés
    Chromatin: Structure, Function, and History brings the reader up to date on the remarkable progress made in chromatin research over the course of the past 50 years. Coverage includes the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights, and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research.

  • Pathogenic Viruses and Armamentarium Design

    • 1 Edición
    • Awanish Kumar + 1 más
    • Inglés
    Pathogenic Viruses and Armamentarium Design covers the latest developments in viral target elucidation and viral control using wet and dry lab strategies. The control and combat strategies and their implementation compiled in this book are invaluable in aiding the understanding of viral disease progression and for designing new strategies against existing and evolving viruses.This important resource is a comprehensive compilation of antiviral approaches designed and devised using computational and other laboratory techniques. This book is a useful reference for scientists, researchers, industry professionals, advanced students, and postgraduates in virology, biotechnology, infection biology, biochemistry, and pharmaceutical sciences who engaged in the study of pathogenic virus and the development of prophylactics and therapeutics against viral infection.

  • Management, Body Systems, and Case Studies in COVID-19

    • 1 Edición
    • Rajkumar Rajendram + 3 más
    • Inglés
    Management, Body Systems, and Case Studies in COVID-19 describes the assessment and treatment of patients infected with the novel coronavirus that causes the varied symptoms of COVID-19. Detailing this multisystem disease and the organs and tissues affected, this volume features chapters on several body systems. Conditions affecting the respiratory, hematological, hepatobiliary, renal, gastrointestinal, nervous, musculoskeletal, and cardiovascular systems are addressed. The fundamental role of telemedicine during the pandemic is also discussed. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.

  • Features, Transmission, Detection, and Case Studies in COVID-19

    • 1 Edición
    • Rajkumar Rajendram + 2 más
    • Inglés
    Features, Transmission, Detection, and Case Studies in COVID-19 examines the effects of the virus on the body, as well as its transmission and clinical profile. This volume begins with an introduction to the virus and its pathogenesis, transmission, and avoidance, followed by sections on pulmonary and cardiovascular effects, obesity, diabetes, the liver, detection issues, and biomarkers. Vaccines and treatment are also discussed. Specific case studies covered include hypoxia, acute kidney injury, pneumonia, and neurological effects. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.

  • Advanced Biophysical Techniques for Polysaccharides Characterization

    • 1 Edición
    • Nirmal Mazumder
    • Inglés
    Advanced Biophysical Techniques for Polysaccharides Characterization offers detailed insights into the cutting-edge techniques available for the identification, quantification, characterization. and structural analysis of polysaccharides. A wide range of techniques are covered, including scanning electron microscopy (SEM), atomic force microscopy (AFM), optical microscopy, non-linear optical microscopy and spectroscopic techniques like Fourier transform Infrared (FTIR), X ray diffraction, light scattering, and nuclear magnetic resonance (NMR). Various polysaccharides are investigated, along with their applications across a range of industries. Each chapter offers a detailed description of the techniques before delving into case studies covering the latest advances.This book provides a one-stop solution to the latest advanced microscopic and spectroscopic techniques for investigating a range of important polysaccharides and is an ideal reference for researchers in the field of biophysics, molecular biology, biochemistry, pharmaceutics, food chemistry and related areas.

  • Medical Geology of Africa

    A Research Primer
    • 1 Edición
    • Theophilus Clavell Davies
    • Inglés
    Medical Geology of Africa: A Research Primer explores the connection between geological materials and processes and human health in Africa. A synopsis on current state of knowledge is given for a selection of some of the more critical issues in African Medical Geology. Gaps in knowledge are exposed, and directions are given for navigating the most recent bibliography of the more pressing Medical Geology issues by future researchers. Guidelines for researching gaps in knowledge are prescribed and are intended for researchers eager to make urgently needed contributions towards an understanding of how judicious exploitation of the interphase between geology and health can help unravel environmental disease causality, especially of those (diseases) of unknown aetiology (DUA) which are so widespread on the African Continent.

  • Animal Models of Disease Part B

    • 1 Edición
    • Volumen 188
    • Inglés
    Animal Models of Disease, Part B, Volume 188 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Using C. Elegans as a model for Neurodegenerative disease: Methodology and Evaluation, Modelo Animal de Esclerosis Multiple: Encefalomielitis Autoimmune Experimental (EAE, New mouse model to study aneurysm development, Spinal Nerve Ligation: An Experimental Neuropathic Pain Model in Rats and Mice, Identifying therapeutic compounds for Autosomal Dominant Optic Atrophy (ADOA) through screening in the nematode C. elegans, Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, and much more.Other chapters cover Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis, Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models, Assessing motor development and function in mouse models of neurodevelopmental disorders, Analysis of Gut Microbiota profile targeted to multi hypervariable regions of 16S rRNA in hypertensive heart failure rat model, and more.

  • Diabetes Digital Health, Telehealth, and Artificial Intelligence

    • 1 Edición
    • David C. Klonoff + 2 más
    • Inglés
    Diabetes Digital Health, Telehealth, and Artificial Intelligence explains how to develop and use the emerging technologies of digital health, telehealth, and artificial intelligence to address this important public health problem to deliver new hardware, software, and processes. The book explores trends in developing and deploying the three most important emerging technologies for diabetes: digital health, telehealth, and artificial intelligence. This book is essential to clinicians, scientists, engineers, industry professionals, regulators, and investors, offering the tools that will be used to create the next generation products to support a precision medicine approach to manage diabetes.According to the CDC, in the US there are 37 million people with diabetes and 96 million people with prediabetes. Diabetes triples the risk of myocardial infarction and stroke and is the leading cause of blindness, end stage renal failure, and amputations. The management of diabetes is becoming increasingly dominated by digital health tools consisting of wearable sensors, mobile applications providing decision support software, and wireless communication tools. Digital health provides new data streams that can be combined to create unique approaches for diabetes based on a precision medicine paradigm.

  • Encyclopedia of Hereditary Cancer

    A Desktop Reference
    • 1 Edición
    • John W. Henson
    • Inglés
    Encyclopedia of Hereditary Cancer: A Desktop Reference gives insights into this young and rapidly expanding field that combines oncology and genetics to achieve risk reduction, early detection, family risk management, and identification targeted treatments. While genetics and oncology are both well-developed knowledge areas, their combination in hereditary cancer yields an opportunity for new works that systemize knowledge for current researchers, practitioners, and students. The book exams 371 topics through the lens of hereditary cancer. There are no similar books that presents information in this manner.This reference work contains a complete list of terms and definitions which can be easily reference by researchers and clinicians working in this field.

  • International and Life Course Aspects of COVID-19

    • 1 Edición
    • Rajkumar Rajendram + 2 más
    • Inglés
    International and Life Course Aspects of COVID-19 describes the nuances and international variations of COVID-19 in different populations and age groups. This volume details those differences in chapters examining the effects of the virus at different life stages, including newborns, children, adolescents, and older populations. Consideration of the age-specific effects of COVID-19 on the brain are a major focus unique to this resource. International observations and global outcomes are also described. This volume is relevant for all clinicians working to ensure the best outcomes for patients with COVID-19 worldwide.

  • Future Food Systems

    Exploring Global Production, Processing, Distribution and Consumption
    • 1 Edición
    • Rickey Y. Yada + 3 más
    • Inglés
    Future Food Systems: Exploring Global Production, Processing, Distribution and Consumption provides an overview of food systems, from farming through to logistics, processing, retail, service and consumption, with the intention of enabling more efficient development of policy and implementation of food related practices. The book presents the considerations which must be understood to develop effective and efficient policies and practices for any level of food system and along the continuum of those systems, with attention being given to the academic, public and private sector challenges, and opportunities for progress, efficiency, effectiveness, and sustainability.Prese... in parts to highlight key aspects of the subject area, the book explores production practices including increasingly important programs in integrated farming systems, vertical agriculture and urban farming, processes, value adding for commodities, agricultural technology, supply chain innovations and consumer considerations. The book provides foundational insights into the underpinnings of today’s food systems, its challenges and its opportunities for the future.

  • Linking Neuroscience and Behavior in COVID-19

    • 1 Edición
    • Rajkumar Rajendram + 3 más
    • Inglés
    Linking Neuroscience and Behavior in COVID-19 examines the effect of both the virus and the pandemic on behavior and mental health. Chapters look at the burden of the COVID-19 pandemic on those with pre-existing conditions, including Parkinson’s disease and multiple sclerosis. The ongoing consequences of the pandemic on the mental health of the broad populace are discussed. As well as the neurological effects of the virus itself, chapters discuss psychological concerns including depression and anxiety. Finally, the chapters also include aspects relevant to managing care and the treatment of conditions. A broad range of conditions preceding, caused by, or emerging for the first time during the pandemic are also detailed.

  • Signal Processing Driven Machine Learning Techniques for Cardiovascular Data Processing

    • 1 Edición
    • Rajesh Kumar Tripathy + 1 más
    • Inglés
    Signal Processing Driven Machine Learning Techniques for Cardiovascular Data Processing features recent advances in machine learning coupled with new signal processing-based methods for cardiovascular data analysis. Topics in this book include machine learning methods such as supervised learning, unsupervised learning, semi-supervised learning, and meta-learning combined with different signal processing techniques such as multivariate data analysis, time-frequency analysis, multiscale analysis, and feature extraction techniques for the detection of cardiovascular diseases, heart valve disorders, hypertension, and activity monitoring using ECG, PPG, and PCG signals.In addition, this book also includes the applications of digital signal processing (time-frequency analysis, multiscale decomposition, feature extraction, non-linear analysis, and transform domain methods), machine learning and deep learning (convolutional neural network (CNN), recurrent neural network (RNN), transformer and attention-based models, etc.) techniques for the analysis of cardiac signals. The interpretable machine learning and deep learning models combined with signal processing for cardiovascular data analysis are also covered.

  • Valorization of Fruit Seed Waste from Food Processing Industry

    Insights on Nutritional Profile, Biological Functions, and Applications
    • 1 Edición
    • Manoj Kumar + 2 más
    • Inglés
    Valorization of Fruit Seed Waste from Food Processing Industry: Insights on Nutritional Profile, Biological Functions, and Applications, Volume Five in the Developments in Food Quality and Safety series, provides comprehensive information regarding different aspects of fruit seed waste which can be of great help to students, research scholars, professors, and food industries for both theoretical and practical work. The book covers the composition of different types of fruit seed waste, including their biological and functional characteristics, applications, and extraction/valorizat... methods for the production of value-added products.This series is the most up-to-date resource covering trend topics such as Advances in the analysis of toxic compounds and control of food poisoning; Food fraud, traceability and authenticity; Revalorization of agrifood industry; Natural antimicrobial compounds and application to improve the preservation of food; Non-thermal processing technologies in the food industry; Nanotechnology in food production; and Intelligent packaging and sensors for food applications.

  • Enhancement of Brain Functions Prompted by Physical Activity Vol 2

    • 1 Edición
    • Volumen 286
    • Inglés
    Enhancement of Brain Functions Prompted by Physical Activity, Volume Two, Volume 286 in the Progress in Brain Research series, highlights new advances, with this updated volume presenting chapters on a variety of timely topics, including Predicting sports performance of elite female soccer players through smart wearable measurement platform, Physical activity and verbal memory performance: mediating effects of resting-state brain activity, Associations between physical activity, body composition, and cognitive performance among female office workers, Grip strength, working memory, and emotion perception in middle aged males, Association of aerobic fitness and grip strength with cognitive and academic performance in Arab children, and much more.

  • Mechanisms of Disease Pathogenesis in Multiple Sclerosis

    • 1 Edición
    • Francisco Javier Quintana
    • Inglés
    Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.

  • Advances in Immunology

    • 1 Edición
    • Volumen 162
    • Inglés
    Advances in Immunology, Volume 162, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Treatment of Breast Cancer with Natural Products

    • 1 Edición
    • Yachana Mishra + 1 más
    • Inglés
    Treatment of Breast Cancer with Natural Based Products is designed to provide a wide spectrum of information and knowledge on phytotherapeutics in breast cancer treatment. With a strong focus on the established research and technology on phytoconstituent-bas... nanocarriers, the book also covers their rapidly emerging aspects and discusses future research directions in the treatment of breast cancer. Users will find insights into breast cancer symptoms, epidemiology, risk factors, screening, treatment, and drugs delivery systems. Other sections cover Curcumin, Paclitaxel, Quercetin, Resveratrol, Sulforaphane, Epigallocatechin-3-G... Allicin, Berberine, and Vinca Alkaloids in the treatment of breast cancer, along with future perspectives.This book presents a groundbreaking opportunity for both academia and industry to reshape contemporary medical and healthcare approaches. With a specific emphasis on various facets of phytoconstituents within the realm of oncology, this publication serves as a precious asset for researchers, as well as graduate and post-graduate students specializing in oncology, pharmaceutical sciences, biotechnology, and related biomedical fields.

  • Immune Landscape of Pancreatic Cancer Development and Drug Resistance

    • 1 Edición
    • Volumen 5
    • Batoul Farran + 1 más
    • Inglés
    Immune Landscape of Pancreatic Cancer Development and Drug Resistance explores advances in immune-based therapies aimed at harnessing the power of the immune system against pancreatic cancer and rewiring tumor microenvironments to eradicate pancreatic cells. With a strong focus on the development of therapeutic methods to improve the survival rates of pancreatic cancer, this book also shows the latest trends in immune targeted approaches for pancreatic cancer treatment. In 12 chapters, the book discusses our current understanding of PC development and its various mutational and immune features and explore some of the new immune-based therapies aimed at targeting pancreatic cancer. This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of advances in immunotherapy in pancreatic cancer.

  • Malabsorptive Surgeries

    Surgical Techniques, Results, and Challenges
    • 1 Edición
    • Jaime Ruiz Tovar
    • Inglés
    Malabsorptive Surgery: Surgical Techniques, Results, and Challenges describes the development of classic and new malabsorptive surgical techniques. Coverage includes the results obtained after the procedures, as well as postoperative complications - including early complications (associated with the difficulty of the operation) and late complications (associated with nutritional sequelae). This book is the perfect reference for basic and translational research focused on the mechanism of action of malabsorptive procedures, that goes beyond the bypassing of intestinal loops, affecting the regulation of hormonal signals. The content is also useful for bariatric surgeons and endocrinologists dealing with the bariatric options and results.Despite the aims of bariatric surgery focusing on performing procedures associated with low postoperative complications rates (mostly restrictive procedures), there is increasing evidence showing mid- and long-term failure of restrictive and mixed procedures in terms of weight regain and recurrence of comorbidities. This has increased the need for revisional surgeries after failed primary procedures, and consequently, increased the popularity of malabsorptive techniques.

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