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Elsevier

Libros en Ciencias de la Vida

  • Proteomics

    A Promising Approach for Cancer Research
    • 1 Edición
    • Shafat Ali + 2 más
    • Inglés
    Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment. The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book's content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice.

  • Precision Medicine in Neurodegenerative Disorders

    Part I
    • 1 Edición
    • Volumen 192
    • Inglés
    Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-split... tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine.

  • Computational Modeling of Infectious Disease

    With Applications in Python
    • 1 Edición
    • Chris von Csefalvay
    • Inglés
    Computational Modeling of Infectious Disease: With Applications in Python provides an illustrated compendium of tools and tactics for analyzing infectious diseases using cutting-edge computational methods. From simple S(E)IR models, and through time series analysis and geospatial models, this book is both a guided tour through the computational analysis of infectious diseases and a quick-reference manual. Chapters are accompanied by extensive practical examples in Python, illustrating applications from start to finish. This book is designed for researchers and practicing infectious disease forecasters, modelers, data scientists, and those who wish to learn more about analysis of infectious disease processes in the real world.

  • Security and Privacy Issues in Internet of Medical Things

    • 1 Edición
    • Rajkumar Buyya + 4 más
    • Inglés
    Security and Privacy Issues in Internet of Medical Things addresses the security challenges faced by healthcare providers and patients. As IoMT devices are vulnerable to cyberattacks, and a security breach through IoMT devices may act as a pathway for hackers to enter hospital networks, the book covers a very timely topic. The incorporation of blockchain in the healthcare environment has given birth to the Internet of Medical Things (IoMT), which consists of a collection of healthcare systems that espouse groundbreaking technologies. Systems consist of inter-linked sensors, wearable technology devices and clinical frameworks that perform explicit, secure machine-to-machine and cloud platform communications. The significance of IoMT in the field of healthcare is undoubtedly a win-win situation for patients through technology enhancements and a collection of analytics that helps in better diagnosis and treatment. Due to higher accuracy levels, IoMT devices are more reliable in reporting and data tracking and help avoid human errors and incorrect reporting.

  • Sex and Cohabitation Among Early Humans

    Anthropological and Genetic Evidence for Interbreeding Among Early Humans
    • 1 Edición
    • Rene J. Herrera + 1 más
    • Inglés
    Sex and Cohabitation Among Early Humans: Anthropological and Genetic Evidence for Interbreeding Among Early Humans explores the available information regarding interbreeding among different ancestral human species. In addition, it reviews evidence in support of cohabitation as well as cultural and technological interactions and exchanges among early humans, particularly Neanderthal-sapiens interactions. The fields of archaeology, anthropology, genetics, linguistics and molecular evolution have provided a wealth of information on the complex processes involved in human evolution. The book will help readers will develop knowledge on the complexity and multiplicity of hominins, including Homo heidelbergensis, Homo sapiens, and Homo floresiensis. Moreover, the book will help them reach a greater understanding of major topics, such as introgression, migration from Africa, the origin, development and extinction of Neanderthals, interbreeding between Neanderthals and humans, and trait continuity.

  • Plant Hormones in Crop Improvement

    • 1 Edición
    • M. Iqbal R. Khan + 2 más
    • Inglés
    Plant Hormones in Crop Improvement examines the signaling pathways and mechanisms associated with phytohormones, with particular focus on stress resilience. The growing population of world and unpredictable climate puts pressure on the agriculture production. Current constraints such as increasing temperatures, drought, salinity, cold, nutrient deficiency, along with biotic interactions trigger exquisitely tuned responsive mechanisms in plants. The main coordinators of all stress-related mechanisms are phytohormones, which can be transported over long distances and play a significant role in controlling physiological, agronomic and growth traits, metabolites and sustained crop productivity. Therefore, understanding the mechanisms influencing the stress responses mediated by phytohormones is crucial to ensure the continuity of agricultural production and food security.　 This book aims to address sustainable agricultural approaches to improve biotic and abiotic stress resilience in crop plants, covering different topics from perception and signaling plant hormones to physiological and molecular changes under different cues. Plant Hormones in Crop Improvement is an essential read for students, researchers and agriculturalists interested in plant physiology, plant genetics and crop yield improvement.

  • Distilled Spirits

    • 1 Edición
    • Annie Hill + 1 más
    • Inglés
    Distilled Spirits is the “go-to” guide for identifying the best practices and options available for distilled spirits product development. The book is a valuable reference for current and prospective distillers, including researchers in distilling and chemical engineering and students brewing and distilling programs. With an increase in the number of new start distilleries, the need for guidance on distilled spirits production has risen dramatically. This book examines the impact of raw materials and production processes on spirit quality, flavor and aroma compounds, and as indicators of poor quality. The book covers the entire production process, derivation of flavor and aroma compounds, definition of spirit quality, and identification of defects for Scotch whiskey, vodka, rum, and gin.

  • Comprehensive Guide to Hepatitis Advances

    • 1 Edición
    • Wai-Kay Seto + 1 más
    • Inglés
    The Comprehensive Guide to Hepatitis Advances provides the most up-to-date information on all types of hepatitis in one resource. Coverage spans hepatitis in all forms (viral, alcoholic, metabolic, drug, autoimmune, etc.), showing the implications of current research in clinical practice and discussing future research directions. Discussions focus on the scientific advancements in understanding the disease process and in the treatment of different groups of hepatitis.This reference is perfect for basic science researchers in the field of hepatology; practicing gastroenterologists and hepatologists as well as primary care physicians attending to liver disease; and medical residents undergoing specialist training in gastroenterology and hepatology.

  • Diabetes Remission, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 52-1
    • Betul Hatipoglu
    • Inglés
    In this issue, guest editors bring their considerable expertise to this important topic.

  • Antimicrobial Dressings

    The Wound Care Applications
    • 1 Edición
    • Raju Khan + 1 más
    • Inglés
    Antimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanoparticles. As numerous applications using proteolytic enzymes for debridement, silver as antibiotic and nanoparticles for enzyme immobilization were developed in the last years, this book explores interdisciplinary information combining nanotechnology, biotechnology and medicine and how it's still in early stages. The book adopts a holistic approach in a lifecycle context to evaluate their final feasibility, including industrial exploitability without disregard of the potential risks of enzymes and nanomaterials to human health and the environment.

  • Substance Use and Addiction Research

    Methodology, Mechanisms, and Therapeutics
    • 1 Edición
    • Alan David Kaye + 3 más
    • Inglés
    Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances. The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.

  • Sustainable and Circular Management of Resources and Waste Towards a Green Deal

    • 1 Edición
    • Marzena Smol + 1 más
    • Inglés
    Sustainable and Circular Management of Resources and Waste Towards a Green Deal highlights the importance of resource recovery, phosphorus management, climate action, clean energy transition, and a circular economy. The world is facing significant challenges, including climate disruption, environmental changes, pollution, and population explosion. Sustainable management of finite natural resources within the carrying capacity of the bio-geo-hydrosphere is the crux of transforming the global economy for a sustainable future. Moreover, keeping raw materials in circulation as long as possible and minimizing the amount of waste generated has grown in significance as a part of transitioning to a circular economy (CE) model.

  • Clinical Decision Support and Beyond

    Progress and Opportunities in Knowledge-Enhanced Health and Healthcare
    • 3 Edición
    • Robert Greenes + 1 más
    • Inglés
    Clinical Decision Support and Beyond: Progress and Opportunities in Knowledge-Enhanced Health and Healthcare, now in its third edition, discusses the underpinnings of effective, reliable, and easy-to-use clinical decision support systems at the point of care as a productive way of managing the flood of data, knowledge, and misinformation when providing patient care. Incorporating CDS into electronic health record systems has been underway for decades; however its complexities, costs, and user resistance have lagged its potential. Thus it is of utmost importance to understand the process in detail, to take full advantage of its capabilities. The book expands and updates the content of the previous edition, and discusses topics such as integration of CDS into workflow, context-driven anticipation of needs for CDS, new forms of CDS derived from data analytics, precision medicine, population health, integration of personal monitoring, and patient-facing CDS. In addition, it discusses population health management, public health CDS and CDS to help reduce health disparities. It is a valuable resource for clinicians, practitioners, students and members of medical and biomedical fields who are interested to learn more about the potential of clinical decision support to improve health and wellness and the quality of health care.

  • Artificial Intelligence in Capsule Endoscopy

    A Gamechanger for a Groundbreaking Technique
    • 1 Edición
    • Miguel Mascarenhas + 2 más
    • Inglés
    Artificial Intelligence in Capsule Endoscopy: A Gamechanger for a Groundbreaking Technique highlights the importance of Artificial Intelligence (AI) application in capsule endoscopy. AI will have a key role in the mid/long-term for gastrointestinal endoscopy and capsule endoscopy. This field is a prime area for the use of AI tools with over 50,000 images per endoscopy capsule video, making video analysis a time and resource consuming task and prone to error. With the application of AI image analysis tools (primarily Convolutional Neural Networks) we can decrease capsule endoscopy video reading time and resources and greatly benefit diagnostic accuracy and patient outcomes. In 15 chapters, this important reference provides a global and comprehensive perspective from the background information of AI, machine learning, deep learning and their implications in GI endoscopy. It showcases AI practical use in lesion detection and in relevant clinical indications (like obscure gastrointestinal bleeding and inflammatory bowel disease), and points to future applications of AI within the field.

  • Comparative Mammalian Immunology

    The Evolution and Diversity of the Immune Systems of Mammals
    • 1 Edición
    • Ian R. Tizard
    • Inglés
    Comparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a comparative viewpoint. This reference encompasses recent work on the immune systems of marine mammals, bats and marsupials in addition to other lesser-known species, with the immune systems of humans and laboratory mice as components of chapters on primates and rodents respectively. The book also makes use of the most recent studies on the genomic sequences of the mammals to identify both common and unique features of each mammal's immune system. The book elucidates the complex, but coordinated and controlled series of interactions involving cells and molecules that has evolved to protect the host against disease. Mammals consist of a highly diverse group of animals in which the immune system has been subjected to a variety of selective pressures. This is reflected in differences in the organization and function of their immune systems, and is especially seen in those gene families characterized by complexity and polymorphism.

  • Laboratory Animal Anaesthesia and Analgesia

    • 5 Edición
    • Paul Flecknell
    • Inglés
    Laboratory Animal Anaesthesia and Analgesia, Fifth Edition provides a basic guide to anesthesia for a very diverse audience involved in animal testing. This has been the go-to resource for current, clear and evidence-based information for over 30 years. The book is divided into four parts that deal with preparation for anesthesia, including definitions, equipment, preparations, anesthetic and analgesic agents, the management and monitoring of anesthesia, including pre-procedural preparations, monitoring and problems and emergencies through the procedure, advanced and specialized techniques, and analgesia and post-operative care, including recovery and the prevention and management of post-operative pain. Final sections cover anesthesia in common laboratory species, specifically: rodents, rabbits, cats, dogs, ferrets, pigs, sheep and goats, primates, reptiles, amphibians and new specific chapters on birds, fish and cephalopods. This edition keeps up with the tradition of bringing a balanced dose of practical advice, foundational content, and current, updated references, drugs and procedures to veterinarians, technicians, researchers and ethics committee personnel.

  • Value-Addition in Agri-Food Industry Waste Through Enzyme Technology

    • 1 Edición
    • Mohammed Kuddus + 1 más
    • Inglés
    Value Addition in Agri-Food Industry Waste through Enzyme Technology, Volume Three explores advances in the production of high value-added products from agri-food industry waste/residues using enzyme technology. Waste materials used in hydrogen production are categorized as agricultural waste, municipal waste, industrial waste, and other hazardous wastes. The book explores advances in value-addition to waste materials and includes utilization of industrial, agricultural and municipal waste for its bioconversion using enzyme technology. This book assembles the novel sources and technologies involved in value-added products formation from specific waste materials, making it an essential reference to professionals, scientists, and academics in agri-food and related industries.

  • Adolescent Psychosis

    Clinical and Scientific Perspectives
    • 1 Edición
    • Ingrid Agartz + 1 más
    • Inglés
    Adolescent Psychosis: Clinical and Scientific Perspectives presents new methodologies and novel scientific findings, with a comprehensive orientation into the genetics, phenomenology, nosology, and long-term outcome of adolescent early-onset psychosis research. This volume discusses recent epidemiological studies, along with co-morbid aspects associated with other neurodevelopmental syndromes and somatic diseases. The book also provides suggestions for future research using a translational perspective, from genes to the clinic to and relevant phenotypes, biomarkers, treatment options and etiological aspects. Topics discussed bring together expert researchers in the field to represent different perspectives and future possibilities.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 178
    • Donald L. Sparks
    • Inglés
    Advances in Agronomy, Volume 178 contains a variety of updates and advances in agronomy, including chapters in this new release that cover Agroecological crop protection for sustainable agriculture, The challenge in estimating soil compressive strength for use in risk assessment of soil compaction in field traffic, Drought, salt, and combined stresses in plants: Effects, tolerance mechanisms, and strategies, Soil inorganic carbon, the other and equally important soil carbon pool: Distribution, controlling factors, and the impact of climate change, and Improving nitrogen use efficiency and reducing nitrogen surplus through best fertilizer nitrogen management in cereal production: The case of India and China.

  • Practical Data Analytics for Innovation in Medicine

    Building Real Predictive and Prescriptive Models in Personalized Healthcare and Medical Research Using AI, ML, and Related Technologies
    • 2 Edición
    • Gary D. Miner + 6 más
    • Inglés
    Practical Data Analytics for Innovation in Medicine: Building Real Predictive and Prescriptive Models in Personalized Healthcare and Medical Research Using AI, ML, and Related Technologies, Second Edition discusses the needs of healthcare and medicine in the 21st century, explaining how data analytics play an important and revolutionary role. With healthcare effectiveness and economics facing growing challenges, there is a rapidly emerging movement to fortify medical treatment and administration by tapping the predictive power of big data, such as predictive analytics, which can bolster patient care, reduce costs, and deliver greater efficiencies across a wide range of operational functions. Sections bring a historical perspective, highlight the importance of using predictive analytics to help solve health crisis such as the COVID-19 pandemic, provide access to practical step-by-step tutorials and case studies online, and use exercises based on real-world examples of successful predictive and prescriptive tools and systems. The final part of the book focuses on specific technical operations related to quality, cost-effective medical and nursing care delivery and administration brought by practical predictive analytics.

  • Cann's Principles of Molecular Virology

    • 7 Edición
    • Edward P. Rybicki
    • Inglés
    **Selected for 2026 Doody's Core Titles as an Essential Purchase in Microbiology**Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work. It discusses the interactions which control the structure of virus particles, the ways viruses infect cells, how viruses replicate themselves, and the consequences and pathogenesis of virus infection for host organisms. This fully updated edition also reflects advances made in the field and includes new content on phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses. With the addition of ancillary resources, Principles of Molecular Virology, Seventh Edition is an essential foundational reference for academics, graduate students, and advance undergraduates in virology, molecular biology, and microbiology as well as researchers entering virology, infectious disease, and immunology research.

  • Behaviour in our Bones

    How Human Behaviour Influences Skeletal Morphology
    • 1 Edición
    • Cara S. Hirst + 3 más
    • Inglés
    Exploring behaviour through bones has always been a fascinating topic to those that study human remains. Human bodies record and store vast amounts of information about the way we move, where we live, and our experiences of health and socioeconomic circumstances. We see it every day, and experience it, but when it comes to past populations, understanding behaviour is largely mediated by our ability to read it in bones. Behaviour in Our Bones: How Human Behaviour Influences Skeletal Morphology examines how human physical and cultural actions and interactions can be read through careful analyses of skeletal human remains. This book synthesises the latest research on reconstructing behaviour in the past. Each chapter is dedicated to a specific region of the human body, guiding the reader from head to toe and highlighting how evidence found on the skull, shoulder, thorax, spine, pelvis, and the upper and lower limbs has been used to infer patterns of activity and other behaviour. Chapter authors expertly summarise and critically discuss a range of methodological, theoretical, and interpretive approaches used to read skeletal remains and interpret a wide variety of behaviours, including tool use, locomotion, reproduction, health, pathology, and beyond.

  • Manual of Chronic Total Occlusion Percutaneous Coronary Interventions

    A Step-by-Step Approach
    • 3 Edición
    • Emmanouil Brilakis
    • Inglés
    Manual of Chronic Total Occlusion Percutaneous Coronary Interventions: A Step-by-Step Approach, Third Edition is a practical reference for coronary chronic total occlusion (CTO) percutaneous coronary interventions (PCI). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and how to troubleshoot tactics. Written to bring a practical approach, this book is perfect for interventional cardiologists, interventional and general cardiology fellows, cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff, industry professionals and everyone else interested in understanding the cutting-edge and rapidly evolving field of CTO PCI. In this new edition, new figures, images and algorithms have been developed to reflect the updates in CTO PCI during the past few years. In addition, this update links to approximately 200 CTO PCI cases that are accessible for free and hosted by the author on YouTube, with monthly updates on new cases. The structure of the book is completely revised to align it with the recently published Manual of Percutaneous Coronary Interventions (published in Oct 2020, also by Dr. Brilakis under the same imprint Academic Press).

  • Effect of High-Pressure Technologies on Enzymes

    Science and Applications
    • 1 Edición
    • Bruno Ricardo de Castro Leite Júnior + 1 más
    • Inglés
    Effect of High-Pressure Technologies on Enzyme: Science and Applications provides a deep, practical discussion of high-pressure processing (HPP) and high-pressure homogenization (HPH) technologies and biochemical approaches, applied across research and industry, with applications ranging from food to pharmaceuticals and commercial enzyme production. Early chapters discuss foundational aspects of HPP and HPH approaches; the science of enzyme modification; and basic aspects of enzyme activity, stability, and structure as studied in biochemical processes. Later chapters consider the effect of HPP and HPH technologies and their mechanisms of controlling enzyme modification to improve enzyme performance for chosen applications. Special attention is paid to the application of HPP and HPH technologies and enzyme modifications in food processing, microbial enzyme modification, drug discovery, and production of other commercial enzymes, as well as the challenges of undesirable enzyme inactivation. The final chapter discusses future directions of the field and technologies, and expanded applications.

  • Current Developments in Biotechnology and Bioengineering

    Membrane Technology for Sustainable Water and Energy Management
    • 1 Edición
    • Xuan-Thanh Bui + 3 más
    • Inglés
    Current Developments in Biotechnology and Bioengineering: Membrane Technology for Sustainable Water and Energy Management covers a variety of advanced technologies for membrane processes, including water/wastewater treatment and reuse, membrane materials, operation and maintenance, fouling control, life cycle assessment, removal of micro/emerging pollutants, and operational cost of membrane processes. Supported by prominent editors and global contributors, this reference contains chapters on membrane treatment strategies for the current pollution of complex organic matters, nutrients, toxic substances, microplastics, membrane fouling control in different water resources, and reusing water resources through promising separation technologies, including reverse osmosis, forward osmosis, and membrane distillation.

  • Targeted Protein Degradation

    • 1 Edición
    • Volumen 681
    • Inglés
    Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each. Each written by an international board of authors.

  • Essential Oils

    Extraction, Characterization and Applications
    • 1 Edición
    • Gulzar Ahmad Nayik + 1 más
    • Inglés
    Essential Oils: Extraction, Characterization and Applications covers sixteen essential oils from different herbal and aromatic plants, including production, composition and extraction techniques such as distillation, chemistry and properties, characterization and applications. The book also presents their safety, toxicity and regulation, alongside trade, storage, stability and transport concepts. Essential oils in plants, extraction and analysis, and current trends in the use of essential oils, like aroma therapy, agro-food and non-food usage are thoroughly explored. Remaining chapters are dedicated to different essential oils, including lavender, peppermint, sandalwood, citrus, eucalyptus, tea tree, clove, ginger, cinnamon, nutmeg, rosewood, juniper and pine, patchouli, clary, and more. Edited by a global team of experts in essential oils, this book is designed to be a practical tool for the many diverse professionals who develop and market essential oils.

  • Aeromicrobiology

    • 1 Edición
    • Mathew Olusoji Ilori + 2 más
    • Inglés
    Aeromicrobiology provides a detailed and systematic analysis of the microbial communities and toxins collectively called bioaerosols that can be found in air. It provides information on the basics of Aeromicrobiology, the fate and transport of microorganisms in air, and the fundamental differences between intramural and extramural Aeromicrobiology. Leaning heavily on the current state of science, detailed information on the sampling and analysis of bioaerosol samples is provided. Subsequent chapters comprehensively discuss various airborne microbial groups and toxins, while the final chapter is dedicated to bioaerosol control strategies, biosafety, and biosecurity. There are limited resources on Aeromicrobiology. In rare instances where there are resources on Aeromicrobiology, they are often restricted to chapters in books or even supplementary materials. The emergence of new airborne pathogens, the aerosolization of microorganisms hitherto believed not to be airborne, and the proliferation of technologies for sampling, analysis, and control of bioaerosols makes it imperative for this title, which streamlines and succinctly presents the new body of knowledge in the field.

  • Basic Biotechniques for Bioprocess and Bioentrepreneurship

    • 1 Edición
    • Arvind Kumar Bhatt + 2 más
    • Inglés
    Basic Biotechniques for Bioprocess and Bioentrepreneurship deals with the entire field of industrial biotechnology, starting from the basic laboratory techniques to scale-up, process development, demonstration, and finally its commercialization. The book compiles currently scattered materials on this topic and updates this information based on practical experience and requirements. The book will be an ideal source for new entrepreneurs who wish to start their own commercial units.

  • Novel Methods and Pathways in Cancer Glycobiology Research

    • 1 Edición
    • Volumen 157
    • Inglés
    Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the ‘Alliance’ is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

  • Introductory Immunology

    Basic Concepts for Interdisciplinary Applications
    • 3 Edición
    • Jeffrey K. Actor
    • Inglés
    **Selected for 2026 Doody's Core Titles in Immunology**Introduc... Immunology: Basic Concepts for Interdisciplinary Applications, 3rd Edition, is a completely updated, revised, and expanded concise, conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis. This expanded version includes the aspects of microbiology and related immune defense mechanisms important in combating disease, as well critical components related to the field of vaccine development.Immunolo... as a subject is no longer confined to the realms of "immunology" or "microbiology" studies. Indeed, the subject matter has become increasingly important to understand complex mechanisms found within a wider range of biological systems. This book aims specifically at educated audiences who do not have a deep understanding of medical, biochemical, or cellular knowledge. The overall text will present concepts that portray a comprehensive picture of the natural defenses to infectious agents as well as provide an introduction to mechanisms that lead to autoimmune dysfunction. In addition, immunological diseases will be detailed, with the goal of allowing the readers to gain sufficient knowledge to make sound choices for clinical decisions to affect treatment outcomes.This new edition expands on the existing chapters, focusing on updating the previous text. It has been expanded to include knowledge on effector mechanisms addressing components inherent within cellular responses that are either newly discovered, or missing from the previous edition. It has an extra emphasis on aspects related to mechanisms important in combating microbial agents and critical sections on how vaccines protect against pathogenic invaders to limit associated pathology.The goal is that Introductory Immunology will become the preferred provider of core knowledge in immunology to build a foundation to explore components of the human immune system that work together to confer and understand dysregulation that causes clinical diseases. This book serves as a basic platform to define therapeutic interventions by: creating appreciation for components of the human immune system to work together to confer lifelong protection;providing a core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease, and defining functional aspects of immunological terms to permit the reader easy access to comprehend specific topics;presenting introduction to complex immunological concepts in a concise and easy manner that relates to clinical disease;breaking down all of immunology into manageable, logically digestible building blocks, and providing a map to explore overlapping mechanisms of immune protective responses;providing a platform to readers without medical, biochemical, or cellular expertise to understand and appreciate how immunology controls homeostasis and protects against pathogens.

  • Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders

    • 1 Edición
    • Volumen 168
    • Inglés
    Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson’s disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders.

  • Oxidative Stress Responses in Plants

    • 1 Edición
    • Volumen 105
    • Inglés
    Oxidative Stress Response in Plants, Volume 105 covers environmental stress conditions and the accumulation of reactive oxygen species (ROS). During many stress conditions such as salt, drought, heat, and pathogen infection, changes in metabolic fluxes and alterations in enzymatic activities result in the accumulation of ROS, a major contributor to loss of growth and productivity. High levels of ROS can lead to oxidative stress which damages proteins and DNA, ultimately resulting in plant cell death. This volume provides comprehensive insights into ROS biology in plants, with a focus on plant growth and development, plant defense responses, and plant acclimation to challenging environments. On the other hand, ROS evolves into potent signaling molecules that play crucial roles in abiotic and biotic stress sensing, integration of different environmental signals, and activation of stress-response networks, thereby contributing to the establishment of improved stress resilience.

  • Radiation Oncology and Radiotherapy Part B

    • 1 Edición
    • Volumen 174
    • Inglés
    Radiation Oncology and Radiotherapy, Part B, Volume 174 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics including CT-assisted focal irradiation of tumors in mice, Methods to preserve correct dosimetry in small animal irradiators, Monitoring TGFbeta signaling in irradiated tumors, Cytofluorometric characterization of the lymphoid compartment of irradiated tumors, Cytofluorometric characterization of the myeloid compartment of irradiated tumors, Mass cytometry to characterize the immune infiltrate of irradiated tumors, Characterization of the immune infiltrate in irradiated mouse tumor by multiplex immunofluorescence, and much more. Other chapters cover Methods to study FOXP3+CD8+ cells in irradiated bone metastases, Luminex-based characterization of cytokine signaling by irradiated tumors, Explant-based assessment of anticancer immunity in irradiated tumors, Pipeline to characterize the TCR repertoire of irradiated tumors, Pipeline to identify tumor neoantigens exposed by radiation, and more.

  • Transcription and Translation in Health and Disease

    • 1 Edición
    • Manoj Garg + 2 más
    • Inglés
    Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.

  • Joint and Bone

    From Bench to Bedside
    • 1 Edición
    • Deming Jiang + 1 más
    • Inglés
    Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside. Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.

  • Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC

    • 1 Edición
    • Volumen 19
    • Anthony Faber
    • Inglés
    Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer.

  • Human Histology

    A Text and Atlas for Physicians and Scientists
    • 1 Edición
    • Bertalan Dudas
    • Inglés
    Visually engaging and easy to use, Human Histology: A Text and Atlas for Physicians and Scientists covers the normal histology of every organ in the human body. This book presents full-page high-definition photomicrographs for organs and tissues, followed by a compact and simple-to-read description of the structures identified on the micrographs, offering a clear, visual understanding of this complex subject. With over 300 outstanding images, this reference is an invaluable resource for every clinical researcher and pathologist in need of easily accessible, relatively simple but detailed enough information on normal histology of different organs systems. Due to its compact, but detailed layout, the volume is an excellent tool for medical board review and can be recommended for medical students and histology course directors.

  • Biochemical Pathways and Environmental Responses in Plants: Part B

    • 1 Edición
    • Volumen 680
    • Inglés
    Biochemical Pathways and Environmental Responses in Plants, Part B, Volume 682 in the Methods in Enzymology series, highlights advances in the field with this new volume presenting chapters on MIE 681/682: Biochemical pathways and environmental responses in plants, Structure, function, and engineering of plant polyketide synthases, A sensitive LC-MS/MS assay for enzymatic characterization of methylthioalkylmalat... synthase involved in glucosinolate side-chain elongation, Assaying formate-tetrahydrofo... ligase with monoglutamylated and polyglutamylated substrates using a fluorescence-HPLC based assay, An Approach to Nearest Neighbor Analysis of Pigmented Protein Complexes by Using Chemical Crosslinking in Combination with Mass Spectrometry, Biochemical characterization of plant aromatic aminotransferases, and much more. Other chapters focus on Functional Analysis of Phosphoethanolamine N-methyltransferase (PMT) in Plants and Parasites, A structure-guided computational screening approach for predicting plant enzyme-metabolite interactions, Plant metacaspase: an example of microcrystal structure determination and analysis, Biocatalytic system for comparative assessment of functional association of cytochrome P450 monooxygenases with their redox partners, Dirigent Protein Family Function and Structure, and more.

  • Advanced Microbial Techniques in Agriculture, Environment, and Health Management

    • 1 Edición
    • Satish Chandra Pandey + 3 más
    • Inglés
    Advanced Microbial Techniques in Agriculture, Environment, and Health Management provides current perspectives on the fields of agriculture, the environment and health. This important reference presents recent advancements in applied microbial technology, compiling it in a comprehensive manner and transferring applied microbial technology from laboratory conditions to field level. In 20 chapters, the book focuses on microbial interventions for all-inclusive, cost-effective environmental management tactics while also linking the cumulative microbial services involved in the up-gradation of agriculture, environment and health. In addition, the book offers detailed information on emerging environmental issues and proposes ways of controlling their consequences using different approaches to treatment.

  • Problem-Based Learning Approach in Microbiology

    • 1 Edición
    • Khalid Mubarak Bindayna + 1 más
    • Inglés
    Problem-based Learning Approach in Microbiology, is an organ-based study of microbiology and infectious diseases using real patient problems (cases) and cases edited for educational purposes. This approach uses case studies to stimulate interactive learning and to facilitate basic knowledge for clinical training. In seven sections, each problem in each section begins with a clinical case scenario and is followed by the learning objectives of the case. The “Question-and-answer... section facilitates student-tutor interaction, thereby resulting in a problem-solving approach. The etiological agent is then described in complete detail comprising the epidemiology and pathogenicity of the agent, and the host immune response, clinical manifestations, diagnostic, and therapeutic measures. This book includes a wide-spectrum of commonly encountered infectious diseases, emerging infectious diseases, and immunological diseases. This book caters to the need for fundamental knowledge through an alternative approach achieved by dividing the book into sections. This book facilitates a more effective learning process thereby ensuring better information retention, correlation with real-life scenarios, and better applicability of the concepts.

  • Computational Approaches in Drug Discovery, Development and Systems Pharmacology

    • 1 Edición
    • Rupesh Kumar Gautam + 2 más
    • Inglés
    Computational Approaches in Drug Discovery, Development and Systems Pharmacology provides detailed information on the use of computers in advancing pharmacology. Drug discovery and development is an expensive and time-consuming practice, and computer-assisted drug design (CADD) approaches are increasing in popularity in the pharmaceutical industry to accelerate the process. With the help of CADD, scientists can focus on the most capable compounds so that they can minimize the synthetic and biological testing pains. This book examines success stories of CADD in drug discovery, drug development and role of CADD in system pharmacology, additionally including a focus on the role of artificial intelligence (AI) and deep machine learning in pharmacology. Computational Approaches in Drug Discovery, Development and Systems Pharmacology will be useful to researchers and academics working in the area of CADD, pharmacology and Bioinformatics.

  • Enzymes Beyond Traditional Applications in Dairy Science and Technology

    • 1 Edición
    • Y.S. Rajput + 1 más
    • Inglés
    A volume in the series on Foundations and Frontiers of Enzymology, Enzymes Beyond Traditional Applications in Dairy Science and Technology presents the applications of enzymes in dairy science and technology. Broken into four sections, this book provides a brief account of traditional applications of indigenous milk enzymes, the actions of exogenous enzymes on milk proteins for generating bioactive peptides and lactose for value addition, and methods and approaches for ensuring milk quality or cleaning milk plants.　 This book is an excellent resource for postgraduate students, academics, food scientists, and dairy professionals engaged in milk processing.

  • Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

    • 1 Edición
    • Elena L. Paley
    • Inglés
    Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.

  • Gene-Environment Interactions in Birth Defects and Developmental Disorders

    • 1 Edición
    • Volumen 152
    • Inglés
    Gene-Environment Interactions in Birth Defects and Developmental Disorders, Volume 152, covers the multifactorial etiology of a variety of developmental disorders, including orofacial clefts, fetal alcohol spectrum disorders, autism, and others. The causes of individual cases of most common birth defects are unknown but likely involve a combination of genetic predisposition and environmental exposures. How these risk factors interact in the genesis of these conditions is still largely unknown and readers will find the latest information and ideas on these disorders, along with discussion of the challenges and opportunities for furthering knowledge in this area.

  • Antioxidants

    • 1 Edición
    • Volumen 121
    • Gerald Litwack
    • Inglés
    Antioxidants, Volume 121 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Principles of Genomics and Proteomics

    • 1 Edición
    • Rakeeb Ahmad Mir + 2 más
    • Inglés
    Principles of Genomics and Proteomics is the perfect reference for graduate students and researchers in these areas to understand its principles and execute precise and reproducible experiments. Following an introductory chapter, the book dives into proper research, including genome mapping. Experiments covered in the book span from Sangers Sequencing, Shotgun sequencing, SAGE analysis, DNA footprinting, Gel retardation, ChIP, and protein resolution methods, including PAGE, 2D gel electrophoresis and isoelectric focusing. Biophysical techniques are also described in detail, including ultraviolet and visible light spectroscopy, fluorescence spectroscopy, NMR and X-ray diffraction.A final proteome analysis is dedicated to functional analysis. Other chapters cover applications of omics technologies broadly. This book is the perfect reference for genetics labs around the world. Graduate students will benefit from the structured and detailed coverage of methods and established researchers will benefit from the book for staff training in research and may find it particularly helpful in enhancing reproducibility of experiments.

  • G Protein-Coupled Receptors - Part B

    • 1 Edición
    • Volumen 195
    • Inglés
    G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 119
    • Inglés
    Hybridisation in Parasites: Disease Evolution by Saltation, Volume 119 in the Advances in Parasitology: Disease Evolution by Saltation, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history.

  • Healthcare Systems Design of Intelligent Testing Centers

    Latest Technologies to Battle Pandemics such as Covid-19
    • 1 Edición
    • Tawanda Mushiri + 1 más
    • Inglés
    Healthcare Systems Design of Intelligent Testing Centers: Latest Technologies to Battle Pandemics such as Covid-19 highlights the importance of designing intelligent testing centers requiring no human intervention during sample collection and testing of the Covid-19 virus and all similar viruses. This book introduces the background, medical requirements, and new research on medical robotics applications, including general Covid-19 testing techniques, development considerations for intelligent testing booths, kinematic and dynamic modeling, design specifications and optimization, numerical verifications, actuators, and sensors in medical applications of artificial intelligence and robotics systems.

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