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Elsevier

Libros en Ciencias de la Vida

  • Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

    • 1 Edición
    • Michael Fehlings + 3 más
    • Inglés
    Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.

  • Hormones, Regulators and Hippocampus

    • 1 Edición
    • Volumen 118
    • Gerald Litwack
    • Inglés
    Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more.

  • Digestive System Malignancies

    • 1 Edición
    • Constantine P. Spanos
    • Inglés
    Digestive System Malignancies provides an up-to-date overview on the most relevant diagnostic techniques, staging of malignancies, and current therapeutic modalities for digestive system malignancies. With coverage from esophageal, gastric and pancreatic cancers, to colon, anal and peritoneal surface, this reference offers a wide-ranging guide to malignancies throughout the digestive system. The use of engaging infographics provides an "at-a-glace" perspective on the subject, allowing users to retain a large amount of information without scrolling through large text or complex algorithms. This is an important reference for clinicians, surgeons, medical students and scientists that need a quick reference on digestive system malignancies.

  • The Lung in Autoimmune Diseases

    • 1 Edición
    • Volumen 17
    • Fabiola Atzeni + 2 más
    • Inglés
    The Lung in Autoimmune Diseases, Volume Seventeen identifies and describes the role of the lung in the most common systemic autoimmune diseases. From disease patterns, prognosis and risks to treatment, this book provides a comprehensive approach for the role of the lung in autoimmune diseases and the influence of autoimmune disease on the lung’s functionality. In recent years, there is increasing knowledge in the field, including lung infection in early disease stages, mechanisms involved in lung damage, and new treatments. Recognition of lung involvement and implementation of some specific therapies is an important issue for clinicians dealing with systemic autoimmune diseases.

  • Diabetic Neuropathy

    • 1 Edición
    • Mitra Tavakoli
    • Inglés
    Diabetic Neuropathy identifies the most accurate early biomarkers of nerve damage to better understand pathophysiology and diagnose diabetic neuropathy in the clinical care of patients, and in particular, permit an accurate evaluation of future therapies in clinical trials. This succinct reference focuses on the current data and research on diabetic neuropathy and is essential reading for researchers in endocrinology, neurology and pharmacology, along with clinicians that need to better understand the novel pathogenetic pathways leading to diabetic neuropathy and the treatments.

  • Elements of Marine Ecology

    • 5 Edición
    • Frances Dipper
    • Inglés
    Elements of Marine Ecology, Fifth Edition focuses on marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. The text reflects ecological groupings such as the pelagic lifestyle vs. the benthic lifestyle. In addition, background oceanographic material, previously in various chapters, is consolidated in the first chapter. The broad definition of ecology is the study of organisms in relation to their surroundings. This book presents marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. This new edition has been thoroughly revised and updated to meet the needs of today’s courses and now includes worldwide examples, all thoroughly updated with brand new chapters.

  • Rhizosphere Engineering

    • 1 Edición
    • Ramesh Chandra Dubey + 1 más
    • Inglés
    Rhizosphere Engineering is a guide to applying environmentally sound agronomic practices to improve crop yield while also protecting soil resources. Focusing on the potential and positive impacts of appropriate practices, the book includes the use of beneficial microbes, nanotechnology and metagenomics. Developing and applying techniques that not only enhance yield, but also restore the quality of soil and water using beneficial microbes such as Bacillus, Pseudomonas, vesicular-arbuscular mycorrhiza (VAM) fungi and others are covered, along with new information on utilizing nanotechnology, quorum sensing and other technologies to further advance the science. Designed to fill the gap between research and application, this book is written for advanced students, researchers and those seeking real-world insights for improving agricultural production.

  • Deep Learning for Medical Applications with Unique Data

    • 1 Edición
    • Deepak Gupta + 3 más
    • Inglés
    Deep Learning for Medical Applications with Unique Data informs readers about the most recent deep learning-based medical applications in which only unique data gathered in real cases are used. The book provides examples of how deep learning can be used in different problem areas and frameworks in both clinical and research settings, including medical image analysis, medical image registration, time series analysis, medical data synthesis, drug discovery, and pre-processing operations. The volume discusses not only positive findings, but also negative ones obtained by deep learning techniques, including the use of newly developed deep learning techniques rarely reported in the existing literature. The book excludes research works with ready data sets and includes only unique data use to better understand the state of deep learning in real-world cases, along with the feedback and user experiences from physicians and medical staff for applied deep learning-based solutions. Other applications presented in the book include hybrid solutions with deep learning support, disease diagnosis with deep learning focusing on rare diseases and cancer, patient care and treatment, genomics research, as well as research on robotics and autonomous systems.

  • Herbal Medicines

    A Boon for Healthy Human Life
    • 1 Edición
    • Hifzur Rahman Siddique + 1 más
    • Inglés
    Herbal Medicines: A Boon for Healthy Human Life provides a comprehensive overview of the role of herbal medicines for treating a broad variety of human diseases, from neurological disorders to cancer and major disorders such as infectious diseases, metabolic disorders, and more. Each chapter summarizes the current state and future direction of the use of herbal medicines against multiple diseases from a translational point-of-view, making this reference a valuable source of information for a large audience, including researchers and healthcare providers interested in the field of herbal remedies.

  • Applications of Computational Intelligence in Multi-Disciplinary Research

    • 1 Edición
    • Ahmed A. Elngar + 3 más
    • Inglés
    Applications of Computational Intelligence in Multi-Disciplinary Research provides the readers with a comprehensive handbook for applying the powerful principles, concepts, and algorithms of computational intelligence to a wide spectrum of research cases. The book covers the main approaches used in computational intelligence, including fuzzy logic, neural networks, evolutionary computation, learning theory, and probabilistic methods, all of which can be collectively viewed as soft computing. Other key approaches included are swarm intelligence and artificial immune systems. These approaches provide researchers with powerful tools for analysis and problem-solving when data is incomplete and when the problem under consideration is too complex for standard mathematics and the crisp logic approach of Boolean computing.

  • Molecular Biology and Clinical Medicine in the Age of Politicization

    • 1 Edición
    • Volumen 188
    • Inglés
    Molecular Biology and Clinical Medicine in the Age of Politicization, Volume 188 provides readers with an appreciation of the practical effects of the politicization of science on their work. Topics covered in the volume include Shattered Silos: Politicization of Science through Changing Research Norms, Moralized Science Communication (with applications for molecular biologists), Vax Attacks: How Conspiratorial Thinking and Misinformation Undermines COVID-19 Vaccine Uptake, Effects of Politicized Media Coverage: Experiment Evidence on Mammography, HPV, and Covid-19, Communicating CRISPR: Challenges and Opportunities in Engaging the Public, Strategic Communication and Engagement for the Biomedical Sciences, and more. Additional chapters cover The Great and Powerful Oz: On the Authority and Misuse of Science, The Gateway-Belief Model and the Politicization of Climate Science, Effects of Politicization on the Practice of Science, When Politics Trumps Science, The Effect of Media Framing and Politics on Covid-19 Vaccine Hesitancy, and more.

  • Antimicrobial Peptides

    • 1 Edición
    • Volumen 663
    • Inglés
    Antimicrobial Peptides, Volume 663 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Unifying the classification of antimicrobial peptides in the Antimicrobial Peptide Database, Optimizing peptide library creation for PepSAVI-MS (RP libraries, etc.), Discovery of novel Antimicrobial peptides using BioProspecting, Screening for cysteine-stabilized scaffolds for developing protelytic-resistant AMPs, Exploring synergy and its role in antimicrobial peptide biology, Colorimetric assays for the rapid and high-throughput screening of antimicrobial peptide activity against diverse bacterial pathogens, and much more. Other chapters cover Liquid chromatography-mass spectrometry-based analysis of naturally occurring neuropeptide diastereomers, Multiplexed Quantitative Neuropeptidomics via DiLeu Isobaric Tagging, In vitro evaluation of antibiotic resistance via proteomics, Molecular networking-based strategies in mass spectrometry, Development of Macrocyclic antimicrobial peptides and peptoids, and a host of other timely topics.

  • Roadmap to Successful Digital Health Ecosystems

    A Global Perspective
    • 1 Edición
    • Evelyn J.S. Hovenga AM + 1 más
    • Inglés
    Roadmap to Successful Digital Health Ecosystems: A Global Perspective presents evidence-based solutions found on adopting open platforms, standard information models, technology neutral data repositories, and computable clinical data and knowledge (ontologies, terminologies, content models, process models, and guidelines), resulting in improved patient, organizational, and global health outcomes. The book helps engaging countries and stakeholders take action and commit to a digital health strategy, create a global environment and processes that will facilitate and induce collaboration, develop processes for monitoring and evaluating national digital health strategies, and enable learnings to be shared in support of WHO’s global strategy for digital health. The book explains different perspectives and local environments for digital health implementation, including data/information and technology governance, secondary data use, need for effective data interpretation, costly adverse events, models of care, HR management, workforce planning, system connectivity, data sharing and linking, small and big data, change management, and future vision. All proposed solutions are based on real-world scientific, social, and political evidence.

  • Processed Cheese Science and Technology

    Ingredients, Manufacture, Functionality, Quality, and Regulations
    • 1 Edición
    • Mamdouh El-Bakry + 1 más
    • Inglés
    Processed Cheese Science and Technology: Ingredients, Manufacture, Functionality, Quality, and Regulations details the most recent developments and updates regarding processed cheeses and cheese products. It offers comprehensive information on all aspects of processed cheese, including manufacturing, types, ingredients, flavors, colors, preservatives, functionality (texture and rheology), analyses, quality, microbiology, regulations and legislations. Structured into 16 chapters, the book begins with an introduction that provides a general overview of processed cheese, followed by a detailed description of the ingredients used in manufacturing, such as using cheeses as ingredients, vegetable-originated ingredients, salts, and more. In addition, low sodium and low-salt processed cheeses are discussed, highlighting the potential benefits for human health. Technological aspects of processed cheese are also covered, followed by an outline of special types of processed cheeses. The book then goes on to examine techniques for end-product characterization, as well as the quality aspects including the microbiology of processed cheese. The last chapter discusses the applications, current challenges, and market trends of processed cheese. Processed Cheese Science and Technology: Ingredients, Manufacture, Functionality, Quality, and Regulations is an excellent resource aimed at food scientists, researchers in academia, and individuals working in the food industry and the commercial sector with a focus on processed cheeses and their end-products.

  • The Lymphatic System in Colorectal Cancer

    Basic Concepts, Pathology, Imaging, and Treatment Perspectives
    • 1 Edición
    • Wim Ceelen
    • Inglés
    The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects. Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain.

  • Reproductive and Developmental Toxicology

    • 3 Edición
    • Ramesh C. Gupta
    • Inglés
    **Selected for Doody’s Core Titles® 2024 in Toxicology**Reproduc... and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlifeWith a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.

  • MCB: CAR T Cells: Development, Characterization and Applications

    • 1 Edición
    • Volumen 167
    • Lorenzo Galluzzi + 1 más
    • Inglés
    MCB: CAR T Cells: Development, Characterization and Applications, Volume 167 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including High-efficiency of genetic modification using CRISPR/Cpf1 system for engineered CAR T-cell therapy, Determination of the Biodistribution of Chimeric Antigen Receptor-Modified T Cells against CD19 in NSG Mice, Generation of CAR-T cells using lentiviral vectors, Generation of CAR T-cells using γ-retroviral vector, Flow cytometry detection and quantification of CAR T cells into solid tumors, Evaluation of CAR-T Cell Cytotoxicity: Real-Time Impedance-Based Analysis, and much more.

  • Ensuring Global Food Safety

    Exploring Global Harmonization
    • 2 Edición
    • Aleksandra Martinovic + 2 más
    • Inglés
    Ensuring Global Food Safety: Exploring Global Harmonization, Second Edition, examines the policies and practices of food law which remain top contributors to food waste. This fully revised and updated edition offers a rational and multifaceted approach to the science-based issue of "what is safe for consumption?" and how creating a globally acceptable framework of microbiological, toxicological and nutritional standards can contribute to the alleviation of hunger and food insecurity in the world. Currently, many laws and regulations are so stringent that healthy food is destroyed based on scientifically incorrect information upon which laws and regulations are based. This book illuminates these issues, offering guidelines for moving toward a scientifically sound approach to food safety regulation that can also improve food security without putting consumers at risk.

  • Multi-Objective Combinatorial Optimization Problems and Solution Methods

    • 1 Edición
    • Mehdi Toloo + 2 más
    • Inglés
    Multi-Objective Combinatorial Optimization Problems and Solution Methods discusses the results of a recent multi-objective combinatorial optimization achievement that considered metaheuristic, mathematical programming, heuristic, hyper heuristic and hybrid approaches. In other words, the book presents various multi-objective combinatorial optimization issues that may benefit from different methods in theory and practice. Combinatorial optimization problems appear in a wide range of applications in operations research, engineering, biological sciences and computer science, hence many optimization approaches have been developed that link the discrete universe to the continuous universe through geometric, analytic and algebraic techniques. This book covers this important topic as computational optimization has become increasingly popular as design optimization and its applications in engineering and industry have become ever more important due to more stringent design requirements in modern engineering practice.

  • Microbial Syntrophy-mediated Eco-enterprising

    • 1 Edición
    • Raghvendra Pratap Singh + 3 más
    • Inglés
    Microbial Syntrophy-Mediated Eco-enterprising summarizes and reviews possible microbial applications for eco-industrial sustainability. The book emphasizes a wide spectrum of experimental and theoretical contributions from eminent researchers in the field. In 13 chapters, there is a focus on the microbial intrusions for remediating sites by accumulated pesticides, heavy metals, polyaromatic hydrocarbons, and other industrial effluents. Moreover, the potentiality and key mechanisms used by microorganisms for sustainable environmental management and their prospects are also considered in this new release. The term syntrophy for nutritional interdependence is often used in microbiology to describe the symbiotic relationship between bacterial species. Understanding such interactions can be of considerable interest when we come to manipulate microbes to our own benefit, such as by disrupting pathogenic communities with antibiotics or by promoting efficiency in communities that produce energy or break down waste.

  • Fertility, Pregnancy, and Wellness

    • 1 Edición
    • Diana Vaamonde + 2 más
    • Inglés
    Fertility, Pregnancy, and Wellness is designed to bridge science and a more holistic approach to health and wellness, in particular, dealing with female-male fertility and the gestational process. Couples seeking to solve fertility issues for different reasons, whether failed assisted reproductive techniques or the emotional impact they entail, economic or moral reasons, are demanding more natural ways of improving fertility. This book explores the shift in paradigm from just using medications which, in the reproductive field, can be very expensive and not accessible to the entire population, to using lifestyle modifications and emotional support as adjunctive medicine therapies. This must-have reference brings together the current knowledge – highlighting the gaps – and delivers an important resource for various specialists and practitioners.

  • Practical Stress Management

    A Comprehensive Workbook
    • 8 Edición
    • John A. Romas + 1 más
    • Inglés
    Practical Stress Management, Eighth Edition emphasizes a positive approach to stress management, covering topics such as relaxation techniques, coping with anxiety, managing anger, communication skills, exercise and nutrition. In this edition, the authors cover the latest advances in stress management, as well as stress related to the use of technology in education. The context of disasters, such as the COVID-19 pandemic, is also incorporated throughout. The workbook describes some of the surreptitious meditation techniques from India not described before in any text. Worksheets and Thoughts for Reflection boxes help users determine their own level of stress to apply effective stress management techniques.

  • Environmental Contaminants and Medicinal Plants Action on Female Reproduction

    • 1 Edición
    • Alexander V. Sirotkin + 1 más
    • Inglés
    Environmental Contaminants and Medicinal Plants Action on Female Reproduction discusses the problem of environmental pollution, medicinal and food plants, and their impact on reproduction. The book describes the mechanisms of environmental contaminants' action, outlines the key causes of their harmful impact on reproduction, and explores what regulatory substances and processes should be targeted due to the negative effect of pollutants on reproduction. Furthermore, it describes the provenance, properties, physiological and therapeutic effects, and possible areas of application of the known medicinal and functional food plants and their constituents with a focus on female reproductive processes. This book will be a useful resource for reproductive biologists, specialists in assisted reproduction, animal production and phytotherapy, toxicologists, pharmacologists, pharmaceutical scientists, endocrinologists, medicinal and natural product chemists, nutritionists and others engaged in the study of environmental contaminants and medicinal and functional food plants.

  • Microneedles

    • 1 Edición
    • Kevin Ita
    • Inglés
    Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study.

  • Allosteric Modulation of G Protein-Coupled Receptors

    • 1 Edición
    • Robert Laprairie
    • Inglés
    Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies.

  • Pharmacokinetics and Toxicokinetic Considerations - Vol II

    • 1 Edición
    • Rakesh K. Tekade
    • Inglés
    Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.

  • Artificial Intelligence-Based Brain-Computer Interface

    • 1 Edición
    • Varun Bajaj + 1 más
    • Inglés
    Artificial Intelligence-Based Brain Computer Interface provides concepts of AI for the modeling of non-invasive modalities of medical signals such as EEG, MRI and FMRI. These modalities and their AI-based analysis are employed in BCI and related applications. The book emphasizes the real challenges in non-invasive input due to the complex nature of the human brain and for a variety of applications for analysis, classification and identification of different mental states. Each chapter starts with a description of a non-invasive input example and the need and motivation of the associated AI methods, along with discussions to connect the technology through BCI. Major topics include different AI methods/techniques such as Deep Neural Networks and Machine Learning algorithms for different non-invasive modalities such as EEG, MRI, FMRI for improving the diagnosis and prognosis of numerous disorders of the nervous system, cardiovascular system, musculoskeletal system, respiratory system and various organs of the body. The book also covers applications of AI in the management of chronic conditions, databases, and in the delivery of health services.

  • Bacterial Bioflocculant for Multifunctional Features

    • 1 Edición
    • S. Sivaramakrishnan + 1 más
    • Inglés
    Bacterial Bioflocculant for Multifunctional Features highlights research findings on the production and characterization of self-assembling bioflocculant from bacterial consortium (encompassing Bacillus subtilis, Enterococcus faecalis and Proteus mirabilis). The book describes the various high-throughput techniques for characterization of wastewater at microbiological and molecular level. Sections cover pharmaceutical compounds, macromolecular compounds and other contaminants, the biotoxicity exhibited cellular and nuclear abnormalities in the zebra fish, and high-throughput techniques used for evaluating the flocculating efficiency of the bacterial bioflocculant to remove the contaminants in different other applications. Bacterial Bioflocculant for Multifunctional Features will help users undertake further advanced research in bacterial bioflocculant for bioremediation technology and environmental prospectives. In addition, it will also inspire readers to understand bioflocculation and its functions.

  • Liquid Biopsy in Urogenital Cancers and its Clinical Utility

    • 1 Edición
    • Seyed Mohammad Kazem Aghamir
    • Inglés
    Liquid Biopsy in Urogenital Cancers and Their Clinical Utility presents updated information on liquid biopsy techniques and their utility for diagnosing urological cancers. As a promising and recent diagnostic method, these techniques can be used for identifying tumors at initial stage, thus greatly improving treatment outcomes and survivorship. Chapters provide an overview of liquid biopsy as a new tool for diagnosis, monitoring and personalized medicine in urogenital cancers and explain its applicability in different cancer types, including bladder, prostate, kidney and testis tumors, female genital tract and pediatric urogenital tumors. This is a valuable resource for cancer researchers, oncologists, graduate students, urologists and biomedical researchers who need to understand more about liquid biopsy and its use for urogenital cancers.

  • RAS: Past, Present, and Future

    • 1 Edición
    • Volumen 153
    • Inglés
    Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable” RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

  • Lipids in Plants and Algae: From Fundamental Science to Industrial Applications

    • 1 Edición
    • Volumen 101
    • Inglés
    Lipids in Plants and Algae: From Fundamental Science to Industrial Applications, Volume 101 provides in-depth reviews on the most important aspects of the field. Topics in this volume encompass the most recent data about the physical properties of membrane lipids, lipid biosynthesis and metabolism (including glycerolipids, fatty acids, sterols, N-acylethanolamines, prostaglandins, phytoprostane), lipid storage, acyl flux, the dynamic and transport of glycerolipids, and the conversion of fatty acids into hydrocarbons. Lipid metabolism and lipidomics in plants and algae are one of the most challenging areas in biology, not only for fundamental research but also for the sustainable production of valuable molecules for green chemistry, including biofuel and health.

  • Handbook on Opium

    History and Basis of Opioids in Therapeutics
    • 1 Edición
    • Vasanth Kumar
    • Inglés
    Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 172
    • Donald L. Sparks
    • Inglés
    Advances in Agronomy, Volume 172, the latest release in this leading reference on the topic, contains a variety of updates and highlights new advances in the field, with each chapter written by an international board of authors.

  • Selenoprotein Structure and Function

    • 1 Edición
    • Volumen 662
    • Inglés
    Selenoprotein Structure and Function, Volume 662 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Identification of Selenoprotein O substrates using a biotinylated ATP analog, Selenium-encoded isotopic signature targeted profiling, Designing tRNASec variants for efficient selenocysteine incorporation using Sec-specific reporters, Preparation of selenoprotein S by chemical ligation, Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells, SecMS analysis of selenoprotein with selenocysteine insertion sequence and beyond, Selenocysteine substitutions in thiyl radical enzymes, and much more. Additional chapters cover Recombinant selenoprotein expression in E. coli based upon the redefinition of a UAG codon in an RF1-depleted host strain, Metabolic labeling with radioactive selenium in zebrafish, Low pH isoTOP-ABPP to identify selenocysteines, Expression of selenoproteins via genetic code expansion in mammalian cells, Alpha-methyl selenocysteine as a tool for the study of selenoproteins, Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications, and much more.

  • Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

    • 1 Edición
    • Volumen 187
    • Inglés
    Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more.

  • Multiple Biological Activities of Unconventional Seed Oils

    • 1 Edición
    • Abdalbasit Adam Mariod
    • Inglés
    Multiple Biological Activities of Unconventional Seed Oils brings detailed knowledge concerning the biological properties of oils (antioxidant, antimicrobial, antidiabetic, antitumor, anti-inflammatory, etc.), the content of individual substances with health-promoting properties, methods for biological properties assay, the influence of raw material quality and technological processes on the quality of oils, and possible raw materials and oil contaminants with adverse health effects. The book's chapters also highlight the unique properties of new oils, along with their biological activities. Less than a decade ago, the vegetable oils on grocery store shelves were derived from conventional oil seeds e.g., cotton, groundnut, sesame, corn sunflower and soybean. However, as consumers began to understand how fat intake affects overall health, researchers, plant growers and food manufacturers started to produce oils from unconventional sources. This book highlights what we've learned in the process.

  • Sensory Analysis for the Development of Meat Products

    Methodological Aspects and Practical Applications
    • 1 Edición
    • José Manuel Lorenzo + 3 más
    • Inglés
    Sensory Analysis for the Development of Meat Products: Methodological Aspects and Practical Applications highlights the application of sensory analysis in the development of meat products. It presents the background and historical aspects of sensory evaluation on the characterization and development of meat products. Divided into two sections, the book discusses fundamental concepts, methodological approaches, statistical analysis, innovative methods, and presents case studies using these approaches. Chapter include definitions, applications, literature reviews, recent developments, methods and end of chapter glossaries. Researchers in sensory analysis and meat processing, as well as new product developers, will benefit from this comprehensive resource on the topics discussed.

  • High-Quality Transesophageal Echocardiography

    • 1 Edición
    • David T. Linker
    • Inglés
    High-Quality Transesophageal Echocardiography presents a step-by-step approach aimed to help readers understand how to perform a high-quality transesophageal echocardiogram. The book explains the steps, tips, tricks, and troubleshooting tactics for performing a transesophageal echocardiogram effectively and with highest diagnostic utility, while ensuring patient safety and comfort. High-Quality Transesophageal Echocardiography is suitable for a wide audience from early learners of the technique who want to accelerate their progress and boost their confidence to those already qualified in the procedure who want to pick up tips to increase the quality and effectiveness of their practice.

  • Tissue Engineering

    Current Status and Challenges
    • 1 Edición
    • Chandra P. Sharma + 3 más
    • Inglés
    Tissue Engineering: Current Status and Challenges bridges the gap between biomedical scientists and clinical practitioners. The work reviews the history of tissue engineering, covers the basics required for the beginner, and inspires those in the field toward future research and application emerging in this fast-moving field. Written by global experts in the field for those studying and researching tissue engineering, the book reviews regenerative technologies, stem cell research and regeneration of organs. It then moves to soft tissue engineering (heart, vascular, muscle and 3D scaffolding and printing), hard tissue engineering (bone, dental myocardial and musculoskeletal) and translational avenues in the field.

  • Processing Contaminants in Edible Oils

    MCPD and Glycidyl Esters
    • 2 Edición
    • Shaun MacMahon + 1 más
    • Inglés
    Fully revised and updated, Processing Contaminants in Edible Oils, 2nd edition, presents the latest research on monochloropropanedio... (MCPD) and glycidyl esters in edible oils. These potentially harmful contaminants are formed during the industrial processing of food oils during deodorization. A number of advancements in understanding these have been made since the publication of the first edition. These important changes, which impact industrial mitigation, analytical methods, toxicology and regulation, are highlighted for up-to-date reference. The mechanisms of formation for MCPD and glycidyl ester contaminants, as well as research identifying possible precursor molecules are reviewed, as are strategies which have been used successfully to decrease the concentrations of these contaminants. From the removal of precursor molecules before processing, modifications of deodorization protocol, to approaches for the removal of these contaminants after the completion of processing, methods of mitigating and eliminating contaminants are presented.

  • Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B

    • 1 Edición
    • Volumen 366
    • Inglés
    Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections cover Genetic and Sex predisposition to MPN, Transcriptional configurations of Myeloproliferative Neoplasms, Inhibitors and therapeutic targets of MPN, Mutational landscape of blast-phase myeloproliferative neoplasm (MPN-BP) and antecedent MPN, and Lessons from Mouse model of MPN, Lab tests for MPN.

  • Aphasia

    • 1 Edición
    • Volumen 185
    • Argye Elizabeth Hillis + 1 más
    • Inglés
    Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

  • Cardiovascular Pathology

    • 5 Edición
    • L. Maximilian Buja + 1 más
    • Inglés
    Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

  • Debulking in Cardiovascular Interventions and Revascularization Strategies

    Between a Rock and the Heart
    • 1 Edición
    • On Topaz
    • Inglés
    Debulking in Cardiovascular Interventions and Revascularization Strategies: Between a Rock and the Heart aims to provide a comprehensive overview on the diagnostic and therapeutic aspects of resistant lesions as well as tailored debulking processes in revascularization strategies. Cardiovascular interventionalists and surgeons alike frequently encounter technical challenges and increased risk when attempting to diagnose and treat resistant cardiovascular lesions, bio-tissues and vessels. Calcified plaques, fibrotic or thrombotic lesions, total occlusions, degenerative plaques, complex lesions and vessels impose morphologic obstacles to the safe and effective delivery and deployment of balloons and stents. In such instances, a debulking strategy involving the actual drilling and extraction of the targeted plaque/bio-tissue constitutes a unique option that ensures safe and efficacious subsequent balloon dilatations and stenting.A range of topics is included in the book, from the characteristics and constituents of various resistant targets and bio-tissues, to the corresponding options of debulking methods, and finally the technologic and pharmacologic means available for application.The book also provides an up-to-date description of related management solutions and tools, exploring the medical issues pertaining to the patients with these targets; procedural results and clinical outcomes as related to debulking strategies and associated diagnostic and therapeutic technology and revascularization options.

  • Microbiome Under Changing Climate

    Implications and Solutions
    • 1 Edición
    • Ajay Kumar + 2 más
    • Inglés
    Microbiome Under Changing Climate: Implications and Solutions presents the latest biotechnological interventions for the judicious use of microbes to ensure optimal agricultural yield. Summarizing aspects of vulnerability, adaptation and amelioration of climate impact, this book provides an important resource for understanding microbes, plants and soil in pursuit of sustainable agriculture and improved food security. It emphasizes the interaction between climate and soil microbes and their potential role in promoting advanced sustainable agricultural solutions, focusing on current research designed to use beneficial microbes such as plant growth promoting microorganisms, fungi, endophytic microbes, and more. Changes in climatic conditions influence all factors of the agricultural ecosystem, including adversely impacting yield both in terms of quantity and nutritional quality. In order to develop resilience against climatic changes, it is increasingly important to understand the effect on the native micro-flora, including the distribution of methanogens and methanotrophs, nutrient content and microbial biomass, among others.

  • David A. Robinson’s Modeling the Oculomotor Control System

    • 1 Edición
    • Volumen 267
    • Inglés
    Modelling: The Oculomotor Systems, Volume 269 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics including The function and phylogeny of eye movements, The behavior of motoneurons, Statics of plant mechanics, Dynamics of plant mechanics, The functional operation of the vestibulo-ocular reflex, Basic framework of the vestibulo-ocular reflex, Oculomotor signals, Signal processing in the vestibulo-ocular reflex, Plasticity and repair of the vestibulo-ocular reflex, The behavior of the optokinetic system, Models of the optokinetic system, Neurophysiology of the optokinetic system, and much more.

  • Gene Regulatory Mechanisms in Development and Evolution: Insights from Echinoderms

    • 1 Edición
    • Volumen 146
    • Inglés
    Sea urchins and other echinoderms, which have been studied intensively by developmental biologists for more than a century, are currently among the most prominent models for elucidating the genomic regulatory processes that control embryogenesis and the evolution of those processes. This volume contains reviews from the world’s leading researchers who are using echinoderms to address these questions. Chapters focus on gene regulatory networks that drive the differentiation and morphogenesis of major embryonic tissues such as the skeleton, muscle, nervous system, immune system, pigment cells, and germ line, and on evolutionary insights from comparative studies of these networks across echinoderms and other taxa. Other chapters comprehensively review the architecture and evolution of the cell signaling pathways that establish the early embryonic axes and on recent evolutionary changes in gene networks that have led to dramatic changes in the life history modes of echinoderms. This volume provides a comprehensive, current picture of exciting research at the interface between developmental genomics and evolution from one of the research communities leading this work.

  • Recent Advances and Controversies in Gamma Knife Neurosurgery

    • 1 Edición
    • Volumen 268
    • Inglés
    Recent Advances and Controversies in Gamma Knife Neurosurgery, Volume 268, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume presenting interesting chapters on the latest in Dosimetry, Radiobiology, Evolving Gamma Knife Technology, Imaging, Arteriovenous Malformations, Dural A-V Fistulae, Cavernous Malformations, Vestibular Schwannoma, Other Schwannoma, Meningiomas, Pituitary Adenomas, Craniopharyngiomas, Metastases, Glioma Low Grade, Glioma High Grade, Glomus Tumors, Less Common Tumors, Orbital Indications, Trigeminal Neuralgia, Epilepsy, Movement, Psychosurgery, and Future Trends.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 106
    • Gregory S. Makowski
    • Inglés
    Advances in Clinical Chemistry, Volume 106, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Advances in ADAMTS biomarkers, Advances in fibrosis biomarkers in nonalcoholic fatty liver disease, Metabolomics of Peripheral Artery Disease, Molecular and cellular functions of long non-coding RNAS in prostate and breast cancer, Myostatin: Basic Biology to Clinical Application, and Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer.

  • Clinical Applications of Noncoding RNAs in Cancer

    • 1 Edición
    • Subash Gupta + 1 más
    • Inglés
    Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types.

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