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Elsevier

Libros en Ciencias de la Vida

  • Immunotherapeutic Strategies for the Treatment of Glioma

    • 1 Edición
    • Christopher Jackson + 1 más
    • Inglés
    Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward.The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics.This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma.

  • Connectomic Deep Brain Stimulation

    • 1 Edición
    • Andreas Horn
    • Inglés
    Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.

  • Brain Seizure Detection and Classification Using EEG Signals

    • 1 Edición
    • Varsha K. Harpale + 1 más
    • Inglés
    Brain Seizure Detection and Classification Using Electroencephalograp... Signals presents EEG signal processing and analysis with high performance feature extraction. The book covers the feature selection method based on One-way ANOVA, along with high performance machine learning classifiers for the classification of EEG signals in normal and epileptic EEG signals. In addition, the authors also present new methods of feature extraction, including Singular Spectrum-Empirical Wavelet Transform (SSEWT) for improved classification of seizures in significant seizure-types, specifically epileptic and Non-Epileptic Seizures (NES). The performance of the system is compared with existing methods of feature extraction using Wavelet Transform (WT) and Empirical Wavelet Transform (EWT). The book's objective is to analyze the EEG signals to observe abnormalities of brain activities called epileptic seizure. Seizure is a neurological disorder in which too many neurons are excited at the same time and are triggered by brain injury or by chemical imbalance.

  • Chromatin and Genomic Instability in Cancer

    • 1 Edición
    • Volumen 364
    • Inglés
    Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associ... DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology.

  • Application of Polyphenols in Foods and Food Models

    • 1 Edición
    • Volumen 98
    • Inglés
    Phenolic compounds are secondary metabolites found in legumes, grains, fruits, algae, leaves and many other dietary sources. However, the abundance and differences in chemical structure, solubility, toxicological safety and, therefore, bioactivity and functional effects in humans. This book covers the basic chemical composition and structure of phenolic compounds and focus on their technological applications in food models and products: nondairy and dairy beverages, bakery, and meat-based foods. Additionally, food preservation aspects, including the effects of polyphenols additions on the product’s shelf-life, processing and recovery of polyphenols from plant materials, antioxidant and antiproliferative aspects of polyphenol-rich extracts are considered and holistically debated.

  • Practical Aspects of Vaccine Development

    • 1 Edición
    • Parag Kolhe + 1 más
    • Inglés
    Practical Aspects of Vaccine Development provides an academic and industry perspective on vaccine development and manufacturing. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and challenges being encountered. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges. Vaccines include a wide range of components including proteins, polysaccharides, protein-polysacchari... conjugates, adjuvants, and more. The container closure system may also be unique, and the product may require freezing storage or lyophilization based on the stability of the vaccine components. Based on the route of delivery, novel technologies and devices may be required. Covering formulation development, manufacture, and delivery considerations of vaccine production, this book is essential to formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students.

  • Encyclopedia of Respiratory Medicine

    • 2 Edición
    • Sam Janes
    • Inglés
    Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management. The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders such as asthma and COPD to rarer lung diseases such as cystic fibrosis, interstitial lung diseases and pulmonary hypertension. Written in at a time when the globe is in the grip of respiratory pandemic, lung disease has never been so prominent in the public and political conscious. This new edition will provide new researchers in respiratory medicine with a solid foundation in unfamiliar topics and will update more experienced researchers seeking to step outside their core areas of research to put their work into a broader context.

  • Spatiotemporal Modeling of Stem Cell Differentiation

    Partial Differentiation Equation Analysis in R
    • 1 Edición
    • William E. Schiesser
    • Inglés
    Spatiotemporal Modeling of Stem Cell Differentiation: Partial Differentiation Equation Analysis in R covers topics surrounding how stem cells evolve into specialized cells during tissue formation and in diseased tissue regeneration. As the process of stem cell differentiation occurs in space and time, the mathematical modeling of spatiotemporal development is expressed in this book as systems of partial differential equations (PDEs). In addition, the book explores important feature of six PDE model which can represent, for example, the development of tissue in organs. In addition, the book covers the computer-based implementation of example models through routines coded (programmed) in R. The routines described in the book are available from a download link so that example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the stem differentiation models, such as changes in the PDE parameters (constants) and the form of the model equations.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 2 Edición
    • Paul I. Dargan + 1 más
    • Inglés
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology, Second Edition provides readers with a comprehensive examination on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." The book covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance and a discussion of their associated acute and chronic harm and toxicity. This second edition addresses drugs new to the scene, with completely updated and revised chapters. Written by international experts in the field, this multi-authored book is an essential reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

  • Encyclopedia of Behavioral and Cognitive Neuroscience

    • 2 Edición
    • Sergio Della Sala
    • Inglés
    Behavioral Neuroscience is a relatively recent discipline which unifies different fields encompassing Cognitive Psychology, Cognitive Science, Clinical Neurology, Neuroanatomy, and Neurophysiology. Encyclopedia of Behavioral Neuroscience, Three Volume Set is a comprehensive, multidisciplinary work written by the best experts in the field, addressing the relationship between the neurological and biological basis of behavior and models of cognition, spanning from perception to memory and covering phenomena that occur in human and other animals. Published in 2010, it comprised 212 articles and was a unique and essential resource for students and professionals in several fields including neuroscience, psychology, neurology, psychiatry, and cognitive science. It was by far the most comprehensive reference work available addressing the advances in all the field of behavioral neuroscience. It does however, now need revising with the latest science. The new edition will again cover the relationship between brain and behavior, both in humans and other animals, as well as mental and brain disorders. This new edition spans accross three volumes, 250 chapters and approximately 2000 pages. It will build on the foundations of the first edition by thoroughly updating all current articles with the latest research that has developed in the last decade. In addition, 40 brand new articles on the hottest topics within behavioral neuroscience will be added, covering areas such as advances in behavioral genetics and epigenetics, cognitive ageing, neuroepidemiology, social neuroscience, as well as the upsurge of new technologies like diffusion tensor imaging or transcranial direct current stimulation. The result will be an all-encompassing one-stop interdisciplinary major reference work on how the brain and its disorders influence behavior, perfect for neuroscience students, clinicians and scientists interested in knowing more about behavior from a biological perspective.

  • Biology and Management of Problematic Crop Weed Species

    • 1 Edición
    • Bhagirath Chauhan
    • Inglés
    Weeds are the main biological constraint to crop production throughout the year. Uncontrolled weeds could cause 100% yield loss. In Australia, the overall cost of weeds to Australian grain growers was estimated at AU$ 3.3 billion annually. In terms of yield losses, weeds amounted to 2.7 million tonnes of grains at a national level. In the USA, weeds cost US$ 33 billion in lost crop production annually. In India, these costs were estimated to be much higher (US$ 11 billion). These studies from different economies suggest that weeds cause substantial yield and economic loss. Biology and Management of Problematic Weed Species details the biology of key weed species, providing vital information on seed germination and production, as well as factors affecting weed growth. These species include Chenopodium album, Chloris truncata and C. virgate, Conyza bonariensis and C. canadensis, Cyperus rotundus, and many more. This information is crucial for researchers and growers to develop integrated weed management (IWM) strategies. Written by leading experts across the globe, this book is an essential read to plant biologists and ecologists, crop scientists, and students and researchers interested in weed science.

  • Inflammation and Oral Cancer

    From Bench to Bedside
    • 1 Edición
    • Hiroyuki Tomita
    • Inglés
    Inflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translational research that helps in the optimization of clinical management strategies. The book discusses topics such as chronic inflammation and cancer in oral cavity, the role of HPV in oral inflammation and cancer, rodent models of oral cancer, and epigenetics in oral inflammation and cancer. This is a valuable resource for cancer researchers, oncologists and members of biomedical field who are interested in learning more about the diverse aspects of inflammation and oral cancer. Inflammation in oral mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it can have fundamental clinical consequences, the principal of which can be premalignant lesions throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for oral cancer - therefore it is very important to understand these interactions in detail.

  • Molecular Players in iPSC Technology

    • 1 Edición
    • Alexander Birbrair
    • Inglés
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Molecular Players in iPSC Technology, Volume 12 addresses the molecular players underlying induced pluripotent stem cell (iPSC) generation, maintenance, expansion, and differentiation. The discovery of iPSCs revolutionized biomedical research. iPSC technology involves multiple molecular mechanisms. This volume covers exosomal microRNAs, auxiliary pluripotency-associa... genes, inducible caspase-9 suicide gene, cell cycle proteins, ion channels, Notch signaling, kinase signaling, SOCS3/JAK2/STAT3 pathway, NANOG, Krüppel-like factors, H1FOO, and much more in iPSCs. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine and is contributed by world-renowned authors in the field.

  • Alzheimer's Disease

    Understanding Biomarkers, Big Data, and Therapy
    • 1 Edición
    • Ahmed Moustafa
    • Inglés
    Nearly 44 million people have Alzheimer’s or related dementia worldwide, according to the Alzheimer’s Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer’s and other forms of dementia.First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer’s disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer’s disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer’s diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer’s disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer’s disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

  • Nonfood Sensory Practices

    • 1 Edición
    • Anne-Marie Pense-Lheritier + 2 más
    • Inglés
    Sensory evaluation is applied in very diverse and sometimes unexpected sectors. Nonfood Sensory Practices aims to show how sensory professionals from sectors other than food have embraced sensory evaluation methods for product development and communication of their products’ sensory properties. This book is thus intended as a first assessment of what is happening in nonfood sectors. It will open perspectives to those sensory professionals who wish to apply and adapt their expertise in food sensory science to other types of products, as well as to those working in nonfood sectors but with lesser background in sensory evaluation. Many nonfood products are intrinsically complex. They can be used in diverse ways, often in strong interaction with context and – unlike food – over several hours, days or months. This book shows how sensory professionals have adapted to these specificities, not to mention specific needs in terms of panel management and different ways to deal with consumers, users, customers or even sometimes with patients. First chapters present general methodological principles that will allow readers to fully apprehend the use of sensory practices. Then, contributions from many professionals in nonfood sectors will help to realize and promote the potential added value of sensory evaluation to their own field of application.

  • Phytochemical Profiling of Commercially Important South African Plants

    • 1 Edición
    • Alvaro Viljoen + 4 más
    • Inglés
    Phytochemical Profiling of Commercially Important South African Plants comprises a carefully selected group of plant species that are of interest to researchers and industry partners who would like to investigate the commercialization of plant species. The book presents 25 botanicals selected based on commercial relevance. For each of the species, the following topics are covered: botanical description and distribution, phytochemistry (including chemical structures), HPTLC fingerprint analysis, UPLC analysis, and GC analysis (the latter only in the case of essential oil-bearing species). Using standard methodology, high-level chromatographic fingerprints have been developed for better understanding. Different methods are succinctly summarized allowing for the rapid identification of botanical raw materials and formulated consumer products. This book will be extremely valuable to researchers in the field who wish to rapidly identify the constituents and for those who want to prepare formulations of plant material for commercial applications. This work will also be a valuable resource in the field of pharmacognosy.

  • Laboratory Fish in Biomedical Research

    Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Cavefish, Stickleback, Goldfish and Danionella Translucida
    • 1 Edición
    • Livia D'Angelo + 1 más
    • Inglés
    Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 104
    • Gregory S. Makowski
    • Inglés
    Advances in Clinical Chemistry, Volume 104, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

  • The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

    • 1 Edición
    • Elizabeth Head + 1 más
    • Inglés
    The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.

  • Child Neurology

    Its Origins, Founders, Growth and Evolution
    • 2 Edición
    • Stephen Ashwal
    • Inglés
    Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition updates the first biographical study of important contributors to the field of child neurology, consisting of over 250 biographical sketches written by over 100 physicians specializing in neurology, child neurology, pediatrics and obstetrics. Organized chronologically into six chapters, beginning before 1800 and continuing to the present, Child Neurology traces the emergence of child neurology as a separate specialty from its roots in pediatrics and neurology. With a definitive historical introduction by the editor, Dr. Stephen Ashwal. This new edition will feature a new section on The Dynamic Growth and Expansion of Child Neurology: The Late Twentieth Century (1960 to 2000+) and features about 138 new biographical sketches of leaders in the field during this recent time frame. Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition will be published on behalf of the Child Neurology Society, a professional society that strives to foster recognition and support for children with neurological disorders and to promote and exchange national and international scientific research, education, and training in the field of neurology.

  • The Fovea

    Structure, Function, Development, and Tractional Disorders
    • 1 Edición
    • Andreas Bringmann + 1 más
    • Inglés
    The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described. Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye.

  • Neurological Care and the COVID-19 Pandemic

    • 1 Edición
    • Ahmad Riad Ramadan + 1 más
    • Inglés
    Offering a comprehensive review of the neuropathology of SARS-CoV-2, Neurological Care and the COVID-19 Pandemic provides up-to-date coverage of the wide array of the pathogen’s neurological symptoms and complications. Drs. Ahmad Riad Ramadan and Gamaledin Osman discuss the neuropathology of SARS-CoV-2, its neurological manifestations, and the impact the pandemic has had on the care of patients with pre-existing neurological conditions. The authors also offer an overview of emerging treatments and vaccines, as well as ways healthcare systems have reorganized in order to respond to the pandemic.

  • A Centum of Valuable Plant Bioactives

    • 1 Edición
    • Muhammad Mushtaq + 1 más
    • Inglés
    During last couple of decades, a great deal of research has explored what exactly plants contain (bioactives) and how these molecules may interact with human physiology at the molecular level. It is extremely important to know what happens to plant bioactives or their biological activities when processed or isolated under various reaction conditions. Huge numbers of extraction or food manufacturing methodologies are adversely affecting the quality of these phytonutrients so there is a prompt need to highlight these processes/methods and replace them with more novel, efficient, green, or eco-friendly ones. A Centum of Valuable Plant Bioactives is a comprehensive resource on the top 100 plant bioactives available. Chapters are grouped together by bioactives, with sections on carotenes, xanthophylls, terpenoids, steroids, polyphenols and more. This is an essential guide for botanists, food technologists and chemists, nutritionists and pharmacists.

  • Medical Epigenetics

    • 2 Edición
    • Volumen 29
    • Inglés
    **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine.This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs.

  • Twentieth Century Mouse Genetics

    A Historical and Scientific Review
    • 1 Edición
    • Robert P. Erickson
    • Inglés
    Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.

  • Epigenetics and Metabolomics

    • 1 Edición
    • Volumen 28
    • Paban K. Agrawala + 1 más
    • Inglés
    Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.

  • Engineering Technologies and Clinical Translation

    Volume 3 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy
    • 1 Edición
    • Mansoor M. Amiji + 1 más
    • Inglés
    Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy　discus... biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

  • Valorization of Agri-Food Wastes and By-Products

    Recent Trends, Innovations and Sustainability Challenges
    • 1 Edición
    • Rajeev Bhat
    • Inglés
    Valorization of Agri-Food Wastes and By-Products: Recent Trends, Innovations and Sustainability Challenges addresses the waste and by-product valorization of fruits and vegetables, beverages, nuts and seeds, dairy and seafood. The book focuses its coverage on bioactive recovery, health benefits, biofuel production and environment issues, as well as recent technological developments surrounding state of the art of food waste management and innovation. The book also presents tools for value chain analysis and explores future sustainability challenges. In addition, the book offers theoretical and experimental information used to investigate different aspects of the valorization of agri-food wastes and by-products. Valorization of Agri-Food Wastes and By-Products: Recent Trends, Innovations and Sustainability Challenges will be a great resource for food researchers, including those working in food loss or waste, agricultural processing, and engineering, food scientists, technologists, agricultural engineers, and students and professionals working on sustainable food production and effective management of food loss, wastes and by-products.

  • Pandemic Outbreaks in the 21st Century

    Epidemiology, Pathogenesis, Prevention, and Treatment
    • 1 Edición
    • Viswanath Buddolla
    • Inglés
    In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective. Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience.

  • Abiotic Stress and Legumes

    Tolerance and Management
    • 1 Edición
    • Vijay Pratap Singh + 5 más
    • Inglés
    Abiotic Stress and Legumes: Tolerance and Management is the first book to focus on the ability of legume plants to adapt effectively to environmental challenges. Using the -omic approach, this book takes a targeted approach to understanding the methods and means of ensuring survival and maximizing the productivity of the legume plant by improving tolerance to environmental /abiotic stress factors including drought, temperature change, and other challenges.The book presents a comprehensive overview of the progress that has been made in identifying means of managing abiotic stress effects, specifically in legumes, including the development of several varieties which exhibit tolerance through high yield using transcriptomic, proteomic, metabolomic and ionomic approaches. Further, exogenous application of various stimulants such as plant hormones, nutrients, sugars, and polyamines has emerged as an alternative strategy to improve productivity under these environmental challenges.Abiotic Stress and Legumes: Tolerance and Management examines these emerging strategies and serves as an important resource for researchers, academicians and scientists, enhancing their knowledge and aiding further research.

  • Epigenetics in Psychiatry

    • 2 Edición
    • Jacob Peedicayil + 2 más
    • Inglés
    Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

  • Field Crop Arthropod Pests of Economic Importance

    • 1 Edición
    • Peter A. Edde
    • Inglés
    Field Crop Arthropod Pests of Economic Importance presents detailed descriptions of the biology and ecology of important arthropod pest of selected global field crops. Standard management options for insect pest control on crops include biological, non-chemical, and chemical approaches. However, because agricultural crops face a wide range of insect pests throughout the year, it can prove difficult to find a simple solution to insect pest control in many, if not most, cropping systems. A whole-farm or integrated pest management approach combines cultural, natural, and chemical controls to maintain insect pest populations below levels that cause economic damage to the crop. This practice requires accurate species identification and thorough knowledge of the biology and ecology of the target organism. Integration and effective use of various control components is often enhanced when the target organism is correctly identified, and its biology and ecology are known. This book provides a key resource toward that identification and understanding. Students and professionals in agronomy, insect detection and survey, and economic entomology will find the book a valuable learning aid and resource tool.

  • Systemic Drug Delivery Strategies

    Volume 2 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy
    • 1 Edición
    • Mansoor M. Amiji + 1 más
    • Inglés
    Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

  • Advancements and Technologies in Pig and Poultry Bacterial Disease Control

    • 1 Edición
    • Neil Foster + 2 más
    • Inglés
    Advancements and Technologies in Pig and Poultry Bacterial Disease Control provides the most up-to-date knowledge on the tools and technologies used in the economics, prevention, monitoring and control of the most important bacterial diseases in these two important livestock species. Written by international experts in veterinary medicine, veterinary science, agricultural economics and environmental monitoring, this book provides state-of-the-art information regarding the application of technology to the prevention and control of bacterial disease in pigs and poultry. It presents the most up-to-date information on the major bacterial pathogens, why they are important, their epidemiology, pathogenesis and molecular basis of their virulence. Additional sections examine how genomic sequencing addresses the development of disease biomarkers for faster and highly specific diagnosis and how next generation sequencing can identify good and bad microflora. This book will be a valuable resource for veterinarians, epidemiologists, animal scientists, technologists, and researchers studying precision livestock farming. Students in veterinary, animal science and bio-science courses will also find it useful for its coverage of diseases and monitoring tools.

  • Hormones, Regulators and Viruses

    • 1 Edición
    • Volumen 117
    • Gerald Litwack
    • Inglés
    Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors

  • Microbes in Land Use Change Management

    • 1 Edición
    • Jay Shankar Singh + 3 más
    • Inglés
    Microbes in Land Use Change Management details the various roles of microbial resources in management of land uses and how the microbes can be used for the source of income due to their cultivation for the purpose of biomass and bioenergy production. Using various techniques, the disturbed and marginal lands may also be restored eco-friendly in present era to fulfil the feeding needs of mankind around the globe. Microbes in Land Use Change Management provides standard and up to date information towards the land use change management using various microbial technologies to enhance the productivity of agriculture. Needless to say that Microbes in Land Use Change Management also considers the areas including generation of alternative energy sources, restoration of degraded and marginal lands, mitigation of global warming gases and next generation -omics technique etc. Land use change affects environment conditions and soil microbial community. Microbial population and its species diversity have influence in maintaining ecosystem balance. The study of changes of microbial population provides an idea about the variation occurring in a specific area and possibilities of restoration. Meant for a multidisciplinary audience Microbes in Land Use Change Management shows the need of next-generation omics technologies to explore microbial diversity.

  • Emerging Horizons in Neuromodulation: New Frontiers in Brain and Spine Stimulation

    • 1 Edición
    • Volumen 159
    • Inglés
    International Review of Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Oncological Functional Nutrition

    Phytochemicals and Medicinal Plants
    • 1 Edición
    • Maira Rubi Segura Campos + 1 más
    • Inglés
    Oncological Functional Nutrition: Phytochemicals and Medicinal Plants presents the anticancer activities, metabolism, mechanism of action, doses, and sources of various phytochemicals and medicinal plants. Broken into five parts, this book addresses cancer epidemiology, molecular and therapeutic bases of cancer, macro and micronutrients in cancer prevention and treatment, phytochemicals in the cancer treatment, and medical plants as potential functional foods or resources for the obtention of metabolites with anticancer activity. Written for nutritionists, food scientists, health professionals, oncologists, endocrinologists, natural product chemists, ethnobotanists, chemists, pharmacists, biochemists, and students studying relating fields, Oncological Functional Nutrition: Phytochemicals and Medicinal Plants will be a useful reference for those interested in learning more about functional nutrition and cancer.

  • Microbial Extremozymes

    Novel Sources and Industrial Applications
    • 1 Edición
    • Mohammed Kuddus
    • Inglés
    Microbial Extremozymes: Novel Sources and Industrial Applications is a unique resource of practical research information on the latest novel sources and technologies regarding extremozymes in bioremediation, waste management, valorization of industrial by-products, biotransformation of natural polymers, nutrition, food safety and diagnosis of disease. The book's broad knowledge and varying applications are useful to the food industry, dairy industry, fruit and vegetable processing, and baking and beverages industries, as well as the pharmaceutical and biomedical industries. This is a concise, all-encompassing resource for a range of scientists needing knowledge of extremozymes to enhance and research. Furthermore, it provides an updated knowledge of microbial enzymes isolated from extreme environments (temperatures, etc.) and their biotechnological applications. It will be useful to researchers, scientists and students in enzyme research. In addition, users from the dairy and baking industries will benefit from the presented content.

  • Biochemistry of Lipids, Lipoproteins and Membranes

    • 7 Edición
    • Neale Ridgway + 1 más
    • Inglés
    Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences. As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.

  • Twin and Family Studies of Epigenetics

    • 1 Edición
    • Volumen 27
    • Shuai Li + 1 más
    • Inglés
    Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.

  • Scientific Principles of Adipose Stem Cells

    • 1 Edición
    • Lauren Kokai + 2 más
    • Inglés
    Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells.

  • Cancer Immunology and Immunotherapy

    Volume 1 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy
    • 1 Edición
    • Mansoor M. Amiji + 1 más
    • Inglés
    Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

  • Pathogenesis, Treatment and Prevention of Leishmaniasis

    • 1 Edición
    • Mukesh Samant + 1 más
    • Inglés
    Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis.

  • Pandemic of Diabetes and Prediabetes: Prevention and Control, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1 Edición
    • Volumen 50-3
    • K M Venkat Narayan
    • Inglés
    Provides in-depth, clinical reviews on diabetes and prediabetes prevention and control, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

  • Fundamentals of Pediatric Imaging

    • 3 Edición
    • Lane F. Donnelly
    • Inglés
    Fundamentals of Pediatric Imaging, Third Edition presents the foremost techniques of pediatric medical image analysis and processing. It includes advanced imaging techniques, neuro applications, and highlights basic anatomy needed to understand this complex specialty. The book introduces the theory and concepts of pediatric digital image analysis and newly revised information on quality and safety topics, imaging modalities, imaging applications, and new discoveries in diseases and treatments. The newly revised edition provides updates in areas of expertise including neurologic, musculoskeletal, cardiac, chest, and GU imaging. Edited by Lane F. Donnelly, MD, recipient of the Society of Pediatric Radiology’s 2009 Singleton-Taybi Award, this book is sure to be a prime reference in pediatric medical imagining.

  • Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms

    • 1 Edición
    • Xinyu Liu + 1 más
    • Inglés
    Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanic... systems (MEMS) and microfluidic devices to robotic micro-nanomanipulati... systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.

  • Recent Advancement in Microbial Biotechnology

    Agricultural and Industrial Approach
    • 1 Edición
    • Surajit de Mandal + 1 más
    • Inglés
    The rapid increase in microbial resources along with the development of biotechnological methods has revolutionized the field of microbial biotechnology. Genome characterization methods and metagenomic approaches further illustrate the role of microorganisms in various fields of research. Recent Advancement in Microbial Biotechnology: Agricultural and Industrial Approach provides an overview on the recent application of the microorganisms in agricultural and industrial improvements. The purpose of this book is to integrate all these diverse areas of research in a common platform. Recent advancement in Microbial Biotechnology targets researchers from both academia and industry, professors and graduate students working in molecular biology, microbiology and biotechnology.

  • Advances in Botanical Research

    Past, Current and Future Topics
    • 1 Edición
    • Volumen 100
    • Inglés
    Advances in Botanical Research: Past, Current and Future Topics, Volume 100 in the Advances in Botanical Research series, celebrates a remarkable achievement as 100 volumes have now been published, with several others being prepared. New chapters in this monumental release include Editorial activities for Advances in Botanical Research, Revisiting ABR editing in the period 2006-2012: An exciting experience with Jean-Claude Kader, A tribute to the scientific contributions of Pierre Gadal and his laboratory, Evolution of Bacterial Phototrophy, Algae for Global Sustainability, Genomics of cyanobacteria: New insights and lessons for shaping our future, An overview of the root-knot-nematode compatible interaction, and more.

  • Endocrine-Disrupting Chemicals

    • 1 Edición
    • Volumen 92
    • Inglés
    Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

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