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Elsevier

Libros en Ciencias de la Vida

  • Principles of Translational Science in Medicine

    From Bench to Bedside
    • 3 Edición
    • Martin Wehling
    • Inglés
    Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields.

  • Advances in Probiotics

    Microorganisms in Food and Health
    • 1 Edición
    • Dharumadurai Dhanasekaran + 1 más
    • Inglés
    Advances in Probiotics: Microorganisms in Food and Health highlights recent advances in probiotic microorganisms, commercial probiotics, safety aspects of probiotics, preparation and commercialization, microbiome therapy for diseases and disorders, and next generation probiotics. This is a comprehensive resource of developments of new formulations and products for probiotic and prebiotic food with focus on the microorganisms to enable effective probiotic delivery. The book deliberates contemporary trends and challenges, risks, limitations in probiotic and prebiotic food to deliver an understanding not only for research development purposes but also to benefit further standardize industrial requirements and other techno-functional traits of probiotics. At present there is no solitary volume to describe the probiotics and prebiotics properties, Advances in Probiotics: Microorganisms in Food and Health provides novel information to fill the overall gap in the market. It presents the most current information on probiotic and prebiotics for the food industry. This book is a valuable resource for academicians, researchers, food industrialists, and entrepreneurs.

  • Mitochondrial Dysfunction and Nanotherapeutics

    Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine
    • 1 Edición
    • Marcos Roberto de Oliveira
    • Inglés
    Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Relat... Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Relat... Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.

  • Ocean Acidification and Marine Wildlife

    Physiological and Behavioral Impacts
    • 1 Edición
    • Guangxu Liu
    • Inglés
    Ocean Acidification and Marine Wildlife: Physiological and Behavioral Impacts provides comprehensive knowledge on how decreases in the pH of the world’s oceans is affecting marine organisms. The book synthesizes recent findings about the impacts of ocean acidification (OA) on marine animals, covering the physiological and behavioral effects upon marine invertebrates and vertebrates, the potential physiological and molecular mechanism affects, and interactions of OA with other environmental factors. Written by international experts in this research field, this book summarizes new discoveries of OA effects on fertilization, embryonic development, biomineralization, metabolism, immune response, foraging, anti-predation, habitat selection, and the social hierarchy of marine animals. This is an important resource for researchers and practitioners in marine conservation, marine wildlife studies, and climate change studies. In addition, it will serve as a valuable text for marine biology and animal science students.

  • Mitochondrial Physiology and Vegetal Molecules

    Therapeutic Potential of Natural Compounds on Mitochondrial Health
    • 1 Edición
    • Marcos Roberto de Oliveira
    • Inglés
    Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others. Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle.

  • Teleneurology

    Complete Guide to Implementing Telemedicine and Telebehavioral Health into Your Practice
    • 1 Edición
    • Randall Wright
    • Inglés
    In today’s changing medical climate, more physicians than ever before are incorporating telemedicine into their clinical practice. Teleneurology provides comprehensive, practical answers to the many questions clinicians have on implementing and growing a teleneurology practice. Covering everything from historical perspectives to future possibilities in this evolving field, it provides the information you need to successfully use this promising new option in providing optimal and adaptable patient care.

  • Marine Neurotoxins

    • 1 Edición
    • Volumen 6
    • Inglés
    Marine Neurotoxins, Volume Five provides comprehensive information on marine toxins present in the human food chain and the affecting targets relevant for the functioning of the brain and our nervous system, covering all the information available on their action on the physiology of neurons and glial cells, both "in vivo" or "in vitro." New sections in this release include Guanidinium Toxins: Evolution, Mode of Action and Chemical Ecology, Amnesic: Domoic Acid, Neurotoxic: Ciguatoxin and Brevetoxin, Neurotoxic: Cyclic Imines, Potentially Neurotoxic: Okadaic acid and analogues, Potentially Neurotoxic: Palytoxin, and Methods for assessing the presence of marine neurotoxins.

  • Epigenetics of Exercise and Sports

    Concepts, Methods, and Current Research
    • 1 Edición
    • Volumen 25
    • Stuart M Raleigh
    • Inglés
    Epigenetics of Exercise and Sports: Concepts, Methods, and Current Research explains fundamental epigenetic processes and how these are altered by exercise and sports. After a brief review of fundamental epigenetic biology, this all-new volume in the Translational Epigenetics series offers step-by-step instruction in how epigenetic factors are investigated for their influence over exercise related traits of human physiology, disease, and injury. The current state of knowledge in the field and recent findings are discussed in-depth, illuminating how exercise and sports performance may epigenetically modify our physiology, disease and injury risks, and how this knowledge can be applied in personalized exercise approaches, diagnostics, and treatment. This book also explores the shortcomings of explaining exercise related phenomena using only genomics and traditional biochemical techniques, setting the scene for a paradigm shift in exercise biology. In addition, over a dozen international specialists contribute chapters on exercise and sports epigenetics, and their influence over metabolism, obesity, aging, immunity, and neurological disease, as well as the epigenetic impacts of concussions and sports doping. A concluding chapter discusses ongoing themes in the field and outlooks for future research.

  • Forest Microbiology

    Volume 1: Tree Microbiome: Phyllosphere, Endosphere and Rhizosphere
    • 1 Edición
    • Fred O Asiegbu + 1 más
    • Inglés
    Forest Microbiology, Volume One: Tree Microbiome: Phyllosphere, Endosphere and Rhizosphere places an emphasis on the microbiology of leaves, needles, stems, roots, litter and soil. This comprehensive title is split into five sections, including the phyllosphere microbiome, endosphere, rhizosphere, archaea, viruses in forest ecosystem and microbiota of forest nurseries and tree pests, challenges and potentials. Microbial communities associated with various host trees and different tree tissues are compared, and generalists and specialists among tree-associated microbes are identified. In addition, biotic and abiotic factors determining the composition and the structure of forest tree microbial communities are presented, along with the concept of microbial ‘hubs.' Together, the book's editors have 25 years’ worth of experience teaching and conducting research on forest microbiology, making this an essential read for any scientist interested in the forest microbiome.

  • Pediatric Neurology, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 39-3
    • Gary Clark + 1 más
    • Inglés
    This issue of Neurologic Clinics, guest edited by Drs. Gary D. Clark and James J. Riviello, will cover key topics in Pediatric Neurology. This issue is one of four selected each year by our series consulting editor, Dr. Randolph W. Evans. Topics discussed in this issue will include: The State of Child Neurology; The Financial Power of Neurology in a Major Children’s Hospital; Neurology in a Pandemic; Education: Training the Next Generation of Child Neurologists and Neurodevelopmental Disability Doctors, Student Education and Recruitment; Genetic Testing and Counseling in Child Neurology; Novel Treatments and Clinical Research in Child Neurology; Epilepsy: Novel Surgical Techniques and Monitoring; Epilepsy: Genetics; Epilepsy: Treatment of Epileptic Syndromes; Neuromodulation for Pediatric Epilepsy; Inflammatory Diseases of the Nervous System; Neurooncology; Neurocritical Care and Brain Monitoring; The Brain and Heart Disease in Children; Neurology of Sleep; and Evidence Based Protocols. 　 　 　

  • Thyroid and Parathyroid Imaging, An Issue of Neuroimaging Clinics of North America

    • 1 Edición
    • Volumen 31-3
    • Salmaan Ahmed + 1 más
    • Inglés
    In this issue of Neuroimaging Clinics, guest editors Salmaan Ahmed and J. Matthew Debnam bring their considerable expertise to the topic of Thyroid and Parathyroid Imaging.

  • Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease

    • 1 Edición
    • Asim K. Duttaroy
    • Inglés
    Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease explores a wide range of studies from clinical investigations to mechanistic research, covering the actions of bioactives on specific tissues and cells in intestinal, neurological, immunological and cardiovascular health and disease, including cancers. The book also focuses on metabolism, mechanisms of actions, tissue-specific effects, and the structure–function relationships between clinical trial, ex vivo and in vitro data. Written for nutrition researchers, clinical researchers, dieticians, and others working in and studying health-related fields, this book highlights the concepts surrounding the preventive and therapeutic impacts of bioactive foods.

  • Inter-Organellar Ca2+ Signaling in Health and Disease - Part A

    • 1 Edición
    • Volumen 362
    • Inglés
    Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, Volume 362, the latest release in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Genes and Endocrine Signalling in Development and Homeostasis

    • 1 Edición
    • Volumen 60
    • Inglés
    Advances in Insect Physiology Volume 60 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including The Steroid, Ecdysis Triggering Hormone, Juvenile Hormone Signaling Triad in Development and Reproduction, A Decade of Teasing Apart the Juvenile Hormone Receptor, Evolutionary Physiology of Peptidergic Signaling, Recent Advances in Neuroendocrine Regulation of Insect Excretory Systems, Recent Advances in Ecdysteroid Research in Insects, and Regulation and Mechanisms of Sleep in Drosophila.

  • Biopharmaceutics and Pharmacokinetics Considerations

    • 1 Edición
    • Inglés
    Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce.

  • Alcohol

    Neurobiology of Addiction
    • 1 Edición
    • Volumen 3
    • George F. Koob + 3 más
    • Inglés
    A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/antici...

  • The Human Hypothalamus

    Neuropsychiatric Disorders
    • 1 Edición
    • Volumen 182
    • Dick F. Swaab + 4 más
    • Inglés
    The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

  • Methods in Microbiology

    • 1 Edición
    • Volumen 49
    • Inglés
    The book Methods in Silkworm Microbiology is the first ever publication that provides in-depth reviews on the latest progresses about silkworm –pathogen interactions, diseases and management practices for sustainable development of sericulture. Different molecular and immunodiagnostic methods for the detection of pathogens have been comprehensively addressed. Most recent advancements on the role of Micro RNAs in silkworm and pathogen interactions are provided with suitable illustrations. Recent technological advances and emerging trends in exploring silkworm gut microbial communities towards translation research, particularly to understand microbiome functions have been highlighted. Information on various immune mechanisms of silkworm against invading pathogens is summarized. The book further highlights the silkworm gut microbiota as a potential source for biotechnological applications.

  • Stereotaxic Brain Atlas of the Egyptian Fruit Bat

    • 1 Edición
    • Raya Eilam-Altstadter + 3 más
    • Inglés
    The Stereotaxic Brain Atlas of the Egyptian Fruit Bat provides the first stereotaxic atlas of the brain of the Egyptian fruit bat (Rousettus aegyptiacus), an emerging model in neuroscience. This atlas contains coronal brain sections stained with cresyl violet (Nissl), AChE, and Parvalbumin – all stereotaxically calibrated. It will serve the needs of any neuroscientist who wishes to work with these bats – allowing to precisely target specific brain areas for electrophysiology, optogenetics, pharmacology, and lesioning. More broadly, this atlas will be useful to all neuroscientists working with bats, as it delineates many brain regions that were not delineated so far in any bat species. Finally, this atlas will provide a useful resource for researchers interested in comparative neuroanatomy of the mammalian brain.

  • The Human Hypothalamus

    Neuroendocrine Disorders
    • 1 Edición
    • Volumen 181
    • Dick F. Swaab + 4 más
    • Inglés
    The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders.

  • Safety and Regulatory Issues of Nanoencapsulated Food Ingredients

    • 1 Edición
    • Volumen 7
    • Inglés
    Safety and Regulatory Issues of Nanoencapsulated Food Ingredients, a volume in the Nanoencapsulation in the Food Industry series, discusses the safety and toxicity potential of food-relevant and edible nanostructures, along with legislation issued by different countries and organizations governing their safety. The book's chapters cover safety issues of nanocapsules in food matrices, their possible toxicity effects, and in vitro and in vivo assays which are explored to underline their impact. Authored by a team of global experts in the fields of nano and microencapsulation of food, nutraceutical and pharmaceutical ingredients, this title is of great value to those engaged in fields surrounding nanoencapsulation.

  • The Human Hypothalamus

    Middle and Posterior Region
    • 1 Edición
    • Volumen 180
    • Dick F. Swaab + 4 más
    • Inglés
    The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.

  • Immortal

    Our Cells, DNA, and Bodies
    • 1 Edición
    • David Goldman
    • Inglés
    In recent times, the boundary between living and non-living has been blurred by advances in genomics, cell biology, and molecular neuroscience, whereby humans are repaired, enhanced, or made anew. Scientists and physicians are now able to keep cells, organs, and bodies alive indefinitely and can return cells or DNA to our bodies and make new cells for the purpose of treating disease or growing new tissue. Meanwhile, transhuman technologies create illusions of immortality. Immortal: Our Cells, DNA, and Bodies synthesizes what we know about life and death from a genetic, molecular, and cellular perspective, demarcates limits of knowledge, and poses new questions. Award-winning researcher and writer David Goldman examines in-depth three keys to understanding the nature and continuity of life: 1) epigenetic (ephemeral) vs genetic (durable) transgenerational memory; 2) life’s cellular nature, and the ability to make bodies from cells; and 3) the distinction between bodies and persons. Grounded in recent scientific evidence and real-life cases that test our historical understanding of life and death, Goldman probes the nature of molecular continuity in the face of mortal extinction, encompassing how changes to the DNA code can be both long-lasting and transgenerational, and the continuous nature of cellular and molecular information transmission. In tying these themes together, Immortal asks us to apply fresh scientific concepts to examine, for ourselves, the continuity of being in the face of mortality.

  • Monitoring Vesicular Trafficking in Cellular Responses to Stress

    • 1 Edición
    • Volumen 164
    • Inglés
    Monitoring Vesicular Trafficking in Cellular Responses to Stress, Volume 164 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

  • Neuromuscular Disorders

    Treatment and Management
    • 2 Edición
    • Tulio E. Bertorini
    • Inglés
    Offering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools and strategies for minimizing disability and maximizing quality of life. Dr. Tulio Bertorini, an expert in clinical neuromuscular care, and a team of world-renowned contributors cover all management and therapeutic considerations regarding the full range of neuromuscular disorders and resulting complications.

  • Principles and Labs for Deep Learning

    • 1 Edición
    • Shih-Chia Huang + 1 más
    • Inglés
    Principles and Labs for Deep Learning provides the knowledge and techniques needed to help readers design and develop deep learning models. Deep Learning techniques are introduced through theory, comprehensively illustrated, explained through the TensorFlow source code examples, and analyzed through the visualization of results. The structured methods and labs provided by Dr. Huang and Dr. Le enable readers to become proficient in TensorFlow to build deep Convolutional Neural Networks (CNNs) through custom APIs, high-level Keras APIs, Keras Applications, and TensorFlow Hub. Each chapter has one corresponding Lab with step-by-step instruction to help the reader practice and accomplish a specific learning outcome. Deep Learning has been successfully applied in diverse fields such as computer vision, audio processing, robotics, natural language processing, bioinformatics and chemistry. Because of the huge scope of knowledge in Deep Learning, a lot of time is required to understand and deploy useful, working applications, hence the importance of this new resource. Both theory lessons and experiments are included in each chapter to introduce the techniques and provide source code examples to practice using them. All Labs for this book are placed on GitHub to facilitate the download. The book is written based on the assumption that the reader knows basic Python for programming and basic Machine Learning.

  • Zika Virus Impact, Diagnosis, Control, and Models

    Volume 2: The Neuroscience of Zika Virus
    • 1 Edición
    • Colin R. Martin + 3 más
    • Inglés
    Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barré syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

  • The Neuroscience of Aging

    • 1 Edición
    • Colin R. Martin + 2 más
    • Inglés
    Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer’s, stroke, and multiple sclerosis. Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease.

  • Zika Virus Biology, Transmission, and Pathways

    Volume 1: The Neuroscience of Zika Virus
    • 1 Edición
    • Colin R. Martin + 3 más
    • Inglés
    Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers’ understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.

  • Epigenetic Regulation in Overcoming Chemoresistance

    • 1 Edición
    • Volumen 16
    • Chunfu Wu + 1 más
    • Inglés
    Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers.

  • Environmental and Health Management of Novel Coronavirus Disease (COVID-19)

    • 1 Edición
    • Mohammad Hadi Dehghani + 2 más
    • Inglés
    Environmental and Health Management of Novel Coronavirus Disease (COVID-19) examines mitigation measures that can be adopted at the time of a novel coronavirus outbreak to lessen environmental contamination and impacts on human health. The book discusses origin, structure and pathogenesis, epidemiology, environmental transmission and the potential spread routes of COVID-19 via surfaces, air, water, wastewater, medical waste and food products. It also covers guidelines and protocols for setting safety conditions to provide adequate health care and reduce the risk of infection in health and non-healthcare settings, along with preventative measures and disinfection technologies. In addition, the book discusses challenges, opportunities and future perspectives, the global crisis, and global consequences on the environment and health. With contributions from experts, this book presents a multidisciplinary reference resource for virologists, microbiologists, public health professionals, environmental health managers and others engaged in the study and mitigation of the environmental and health impacts of the virus.

  • Prostate Cancer Metabolism

    From Biochemistry to Therapeutics
    • 1 Edición
    • Tomas Koltai + 3 más
    • Inglés
    Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-orient... approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside.

  • Advances in Immunology

    • 1 Edición
    • Volumen 150
    • Frederick W. Alt
    • Inglés
    Advances in Immunology, Volume 150, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

    • 1 Edición
    • Volumen 15
    • Ramasamy Paulmurugan + 1 más
    • Inglés
    Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.

  • mRNA 3’ End Processing and Metabolism

    • 1 Edición
    • Volumen 655
    • Inglés
    mRNA 3’ End Processing and Stability, Volume 655 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 103
    • Gregory S. Makowski
    • Inglés
    Advances in Clinical Chemistry, Volume 103, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

  • Foodborne Infections and Intoxications

    • 5 Edición
    • J. Glenn Morris Jr. + 1 más
    • Inglés
    Foodborne Infections and Intoxications, Fifth Edition brings together up-to-date, relevant interdisciplinary expertise of 70 authors presenting foodborne disease pathogens and toxins, microbiology, disease diagnosis and treatment, epidemiology, and disease prevention in the context of public health and food safety regulation. Beginning with the estimation of foodborne disease burden at the international scale, this book dives deep in foodborne disease outbreak investigation, food safety risk assessment, and molecular analysis, together with detailed descriptions of the major bacteria, viruses, parasites, and toxins associated with foodborne illness. This new edition also emphasizes development of risk-based approaches to food safety and safety regulation implementation. This book is a valuable scientific resource for understanding causes and management of foodborne diseases. The new edition offers the latest knowledge and updates on foodborne infections and intoxications and food safety for multiple generations of students, investigators, public health workers, food scientists, and food safety practitioners.

  • Inoculating Cities

    Case Studies of Urban Pandemic Preparedness
    • 1 Edición
    • Rebecca Katz + 1 más
    • Inglés
    Inoculating Cities: Case Studies of Urban Pandemic Preparedness begins with a brief historical description of infectious disease outbreaks in cities as well as an overview of infectious disease outbreaks since 2000 that hold profound implications for cities and urban environments – such as severe acute respiratory syndrome (SARS) in 2003, H1N1 influenza in 2009, Ebola virus in 2014, Zika virus in 2015, and more recently, COVID-19 in 2020. Each of these outbreaks affected different geographies of the world and underscored the importance of urban pandemic preparedness or urban health security as a means of mitigating the threats posed by infectious diseases. This book describes several of the characteristics of cities that make them uniquely vulnerable to infectious disease threats which include, but are not limited to, their population density, population diversity, internal and external population movements, and inequalities in cities. Finally, the book discusses frameworks and capacities that are essential for preparing cities to prevent, detect, and respond to infectious disease outbreaks. With contributions from experts and researchers with first-hand experiences with infectious disease outbreaks, their impact on the management of disease, and pandemic preparedness in progressively urban societies, Inoculating Cities addresses the unique threats infectious diseases pose to urban environments and surveys innovative models that cities are using to combat these threats.

  • Biomedical Signal Analysis for Connected Healthcare

    • 1 Edición
    • Sridhar Krishnan
    • Inglés
    Biomedical Signal Analysis for Connected Healthcare provides rigorous coverage on several generations of techniques, including time domain approaches for event detection, spectral analysis for interpretation of clinical events of interest, time-varying signal processing for understanding dynamical aspects of complex biomedical systems, the application of machine learning principles in enhanced clinical decision-making, the application of sparse techniques and compressive sensing in providing low-power applications that are essential for wearable designs, the emerging paradigms of the Internet of Things, and connected healthcare.

  • Advanced Drug Delivery Systems in the Management of Cancer

    • 1 Edición
    • Kamal Dua + 5 más
    • Inglés
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  • Successes and Challenges of NK Immunotherapy

    Breaking Tolerance to Cancer Resistance
    • 1 Edición
    • Benjamin Bonavida + 1 más
    • Inglés
    Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers.

  • Curing Genetic Diseases through Genome Reprogramming

    • 1 Edición
    • Volumen 182
    • Inglés
    Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome.

  • Biostimulants for Crops from Seed Germination to Plant Development

    A Practical Approach
    • 1 Edición
    • Shubhpriya Gupta + 1 más
    • Inglés
    Biostimulants for crops from seed germination to plant development focuses on the effects and roles of natural biostimulants in every aspect of plant growth development to reduce the use of harmful chemical fertilizers and pesticides. Biostimulants are a group of substances of natural origin that offer a potential to reduce the dependency on harmful chemical fertilizers causing environmental degradation. While there is extensive literature on biostimulants, there remains a gap in understanding how natural biostimulants work and their practical application. This book fills that gap, presenting the ways in which biostimulants enhance seed vigor and plant productivity by looking into their mode of action, an area still being researched for deeper understanding. Exploring the roles of seed germination, pollen tube formation, pollen-pistil interaction, flower and fruit setting, to plant pigments, rhizospheric and soil microorganisms, the book also sheds light on the challenges and realistic opportunities for the use of natural biostimulants.

  • Polymeric Supports for Enzyme Immobilization

    Opportunities and Applications
    • 1 Edición
    • Alka Dwevedi
    • Inglés
    Enzyme immobilization has been approached for finding solutions for various critical problems associated with industries, medicine, environment, agriculture, etc. Especially since last decades, several innovative researches have come up to look for enhancing catalytic efficiency, reusability of immobilized enzyme and longer stability by introducing range of immobilizing supports, supports modifiers through introduction of several chemical agents (non-toxic) and adopting innovative enzyme immobilization methods. In the present book, polymeric supports have been focussed for enzyme immobilization, especially due to their versatility in immobilizing different enzymes for different large scale enzyme reactors to be used for several applications. Especially, polymers can be modified according to applications and enzyme properties which have made it supports of choice for all several enzyme based applications. Polymeric Supports for Enzyme Immobilization: Opportunities and Applications offers in-depth discussions of known polymeric enzyme support materials, reaction processes, and optimized methods to enhance enzyme immobilization. Case-based chapters examine methods of enzyme immobilization onto various polymeric supports, their surface chemistry and physical morphology followed by implementation of polymers based immobilized enzymes in various applications, viz. medicine, environment, industries, clean energy, disease diagnosis, drug delivery etc. This book has prime focus to allow several researchers across the world to provide updated technological details and incite to contribute more innovative work in coming years to find solutions to several critical problems.

  • Engineering Principles of Unit Operations in Food Processing

    Unit Operations and Processing Equipment in the Food Industry
    • 1 Edición
    • Seid Mahdi Jafari
    • Inglés
    Engineering Principles of Unit Operations in Food Processing, volume 1 in the Woodhead Publishing Series, In Unit Operations and Processing Equipment in the Food Industry series, presents basic principles of food engineering with an emphasis on unit operations, such as heat transfer, mass transfer and fluid mechanics.

  • Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders

    • 1 Edición
    • Volumen 264
    • Inglés
    Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Volume 264 presents the latest updates on recent techniques used to examine the potential treatment of psychiatric and neurological disorders in adults. In this special issue, the book's authors and contributors provide a unique focus on the potential effects of non-invasive brain stimulation. Topics cover a range of reviews, opinions, methodologies, original research articles, and suggestions on how to better translate scientific knowledge into practice. This new release will help guide basic research and the development of therapeutic interventions for children and adolescents who suffer from neurodevelopmental disorders.

  • The Inductive Brain in Development and Evolution

    • 1 Edición
    • Nelson R Cabej
    • Inglés
    The Inductive Brain in Development and Evolution provides readers with a substantial biological education on animal nervous systems and their role in the development, adaptation, homeostasis, and evolution of species. The book begins by delving into the embryonic development of the brain and then discusses epigenetic information and neural activity post-birth. It then analyzes the inductive brain’s neural and brain control of such factors like myogenesis, bone development, sensory organs, metamorphosis in vertebrates and invertebrates, and wing development in insects. The book closes with an examination of phenotypic evolution in neural control, mechanisms, and drivers of animal brains. The Inductive Brain in Development and Evolution will offer evolutionary biologists, specifically those researching development, adaptation, and evolution of animals, a comprehensive text that covers a variety of valuable topics.

  • Generative Adversarial Networks for Image-to-Image Translation

    • 1 Edición
    • Arun Solanki + 2 más
    • Inglés
    Generative Adversarial Networks (GAN) have started a revolution in Deep Learning, and today GAN is one of the most researched topics in Artificial Intelligence. Generative Adversarial Networks for Image-to-Image Translation provides a comprehensive overview of the GAN (Generative Adversarial Network) concept starting from the original GAN network to various GAN-based systems such as Deep Convolutional GANs (DCGANs), Conditional GANs (cGANs), StackGAN, Wasserstein GANs (WGAN), cyclical GANs, and many more. The book also provides readers with detailed real-world applications and common projects built using the GAN system with respective Python code. A typical GAN system consists of two neural networks, i.e., generator and discriminator. Both of these networks contest with each other, similar to game theory. The generator is responsible for generating quality images that should resemble ground truth, and the discriminator is accountable for identifying whether the generated image is a real image or a fake image generated by the generator. Being one of the unsupervised learning-based architectures, GAN is a preferred method in cases where labeled data is not available. GAN can generate high-quality images, images of human faces developed from several sketches, convert images from one domain to another, enhance images, combine an image with the style of another image, change the appearance of a human face image to show the effects in the progression of aging, generate images from text, and many more applications. GAN is helpful in generating output very close to the output generated by humans in a fraction of second, and it can efficiently produce high-quality music, speech, and images.

  • Volatiles and Metabolites of Microbes

    • 1 Edición
    • Joginder Singh Panwar + 2 más
    • Inglés
    Volatiles and Metabolites of Microbes compiles the latest research and advancement in the field of volatiles, metabolites synthesized from the microbial strains such as actinomycetes, bacteria, cyanobacteria, and fungal species and their potential applications in the field of healthcare issue and sustainable agriculture. There is an urgent need to explore new and advanced biological methods for health industries and sustainable agriculture and to protect the environment from environmental pollution or contaminates, global warming, and also control the health of human beings from the side effects of various pharmaceuticals products. Focusing all these factors, Volatiles and Metabolites of Microbes explores new aspects of microorganism in terms of volatiles, enzymes, bioactive compounds synthesized from the microbes and their potential applications in the field of sustainable agriculture and health-related issues

  • Mosby's Pharmacy Technician - Text and Workbook/Lab Manual Package

    Principles and Practice
    • 6 Edición
    • Elsevier Inc + 2 más
    • Inglés

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