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Elsevier

Libros en Ciencias de la Vida

  • Factors Affecting Neurodevelopment

    Genetics, Neurology, Behavior, and Diet
    • 1 Edición
    • Colin R. Martin + 2 más
    • Inglés
    Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems.

  • Signal Transduction in Cancer and Immunity

    • 1 Edición
    • Volumen 361
    • Inglés
    Signal Transduction in Cancer and Immunity, Volume 361 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

  • Encyclopedia of Mycology

    • 1 Edición
    • Oscar Zaragoza + 1 más
    • Inglés
    Encyclopedia of Mycology, Two Volume Set provides a broad and multidisciplinary overview of a subject whose importance in an ecosystem is becoming more and more universally accepted with its close links to botany, microbiology, biotechnology and medicine. While there are many subject-specific works available on the topics presented, from a multidisciplinary point-of-view it is difficult to find a reliable and updated source such as this one. This work is unique in that it is a one-stop-shop on every topic area of this exciting field.

  • Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment

    Results from the European Graduate School for Interdisciplinary Tinnitus Research
    • 1 Edición
    • Volumen 263
    • Inglés
    Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Heterogeneous Contributions to Numerical Cognition

    Learning and Education in Mathematical Cognition
    • 1 Edición
    • Wim Fias + 1 más
    • Inglés
    Arithmetic disability stems from deficits in neurodevelopment, with great individual differences in development or function of an individual at neuroanatomical, neuropsychological, behavioral, and interactional levels. Heterogeneous Contributions to Numerical Cognition: Learning and Education in Mathematical Cognition examines research in mathematical education methods and their neurodevelopmental basis, focusing on the underlying neurodevelopmental features that must be taken into account when teaching and learning mathematics. Cognitive domains and functions such as executive functions, memory, attention, and language contribute to numerical cognition and are essential for its proper development. These lines of research and thinking in neuroscience are discussed in this book to further the understanding of the neurodevelopmental and cognitive basis of more complex forms of mathematics – and how to best teach them. By unravelling the basic building blocks of numerical thinking and the developmental basis of human capacity for arithmetic, this book and the discussions within are important for the achievement of a comprehensive understanding of numerical cognition, its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills.

  • Cytogenomics

    • 1 Edición
    • Thomas Liehr
    • Inglés
    Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping... and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists.

  • Advances in Clinical Chemistry

    • 1 Edición
    • Volumen 102
    • Gregory S. Makowski
    • Inglés
    Advances in Clinical Chemistry, Volume 102, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the most up-to-date technologies related to the field of clinical chemistry. Chapters in this new release cover Advances in immunosensor technology, Extracellular Vesicles: Roles and Applications in Drug-Induced Liver Injury, Oxidative stress biomarkers in the preterm infant, Translational biomarkers in the era of precision medicine, Metabolomics applications in coronary artery disease personalized medicine, Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers.

  • Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences

    • 1 Edición
    • Navneet Sharma + 3 más
    • Inglés
    Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful.

  • Data Science for COVID-19 Volume 1

    Computational Perspectives
    • 1 Edición
    • Utku Kose + 3 más
    • Inglés
    Data Science for COVID-19 presents leading-edge research on data science techniques for the detection, mitigation, treatment and elimination of COVID-19. Sections provide an introduction to data science for COVID-19 research, considering past and future pandemics, as well as related Coronavirus variations. Other chapters cover a wide range of Data Science applications concerning COVID-19 research, including Image Analysis and Data Processing, Geoprocessing and tracking, Predictive Systems, Design Cognition, mobile technology, and telemedicine solutions. The book then covers Artificial Intelligence-based solutions, innovative treatment methods, and public safety. Finally, readers will learn about applications of Big Data and new data models for mitigation.

  • Food Losses, Sustainable Postharvest and Food Technologies

    • 1 Edición
    • Charis M. Galanakis
    • Inglés
    The urgent need for sustainability within the food producing industries and agriculture has turned the interest of research to investigate new non-thermal technologies, nanotechnologies and other practices in postharvest treatment of crops and fruits. Subsequently, there is a need for a new guide covering the latest developments in this particular direction. Food Losses, Sustainable Postharvest and Food Technology provides solutions to postharvest treatment technologies. It explores modern non-thermal technologies, focusing on postharvest losses and quality of fresh-cut products. In addition, it discusses the implications for postharvest technology research, policies and practices. It also focuses on the most recent advances in the field, while it explores the potentiality and sustainability of already commercialized processes and products. Aimed at professionals working in the food industry and agriculture, it could also be utilized as a handbook for anyone dealing with sustainability issues of food production in spite of postharvest treatment.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 112
    • David Rollinson + 1 más
    • Inglés
    Advances in Parasitology, Volume 112, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Taking the strain out of onchocerciasis: a reanalysis of blindness and transmission data does not support the existence of a savanna blinding strain of onchocerciasis in West Africa, Enterocytozoon bieneusi of animals, Taenia solium taeniasis/cysticerco... Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in eukaryotic pathogens, HTLV-I and Strongyloides: the worm lurking beneath, and more.

  • Global Emergency of Mental Disorders

    • 1 Edición
    • Jahangir Moini + 2 más
    • Inglés
    Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource.

  • Thermal Ablation Therapy

    Theory and Simulation
    • 1 Edición
    • Amira S. Ashour + 2 más
    • Inglés
    Thermal Ablation Therapy: Theory and Simulation includes detailed theoretical and technical concepts of thermal ablation therapy in different body organs. Concepts of ablation technology based on different thermal ablation methods are introduced, along with changes in the tissues’ mechanical properties due to thermal denaturation. The book emphasizes the mathematical and engineering concepts of RF and MW energy propagation through tissues and where high heating rates produced by MW systems can overcome the heat-sink effects from nearby vessels. The design and tuning of the MW antennas to deliver energy efficiently to specific organ systems such as the liver or lung is also covered. Other sections cover the computational modeling of radiofrequency ablation and microwave ablation procedures for developing and implementing new efficient ablation in clinical systems, numerical simulations for different scenarios of different organs with different size using RF and MW ablation systems with different antennas’/probes design and configurations, and numerical techniques for temperature profile in tissues.

  • Diseases of the Nervous System

    • 2 Edición
    • Harald Sontheimer
    • Inglés
    The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.

  • Drug Discovery and Development

    Technology in Transition
    • 3 Edición
    • Raymond G Hill + 1 más
    • Inglés
    Essential insight into drug development and the pharmaceutical industry With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape. Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.

  • Chemical Biology of the Genome

    • 1 Edición
    • Siddhartha Roy + 1 más
    • Inglés
    Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs.

  • Stress Tolerance in Horticultural Crops

    Challenges and Mitigation Strategies
    • 1 Edición
    • Ajay Kumar + 4 más
    • Inglés
    Stress Tolerance in Horticultural Crops: Challenges and Mitigation Strategies explores concepts, strategies and recent advancements in the area of abiotic stress tolerance in horticultural crops, highlighting the latest advances in molecular breeding, genome sequencing and functional genomics approaches. Further sections present specific insights on different aspects of abiotic stress tolerance from classical breeding, hybrid breeding, speed breeding, epigenetics, gene/quantitative trait loci (QTL) mapping, transgenics, physiological and biochemical approaches to OMICS approaches, including functional genomics, proteomics and genomics assisted breeding. Due to constantly changing environmental conditions, abiotic stress such as high temperature, salinity and drought are being understood as an imminent threat to horticultural crops, including their detrimental effects on plant growth, development, reproduction, and ultimately, on yield. This book offers a comprehensive resource on new developments that is ideal for anyone working in the field of abiotic stress management in horticultural crops, including researchers, students and educators.

  • Fluorescent Probes

    • 1 Edición
    • Volumen 48
    • Inglés
    Fluorescent Probes, Volume 48 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics, including Hydrogel microarray technology as a tool for clinical diagnostics, The use of probes and bacteriophages for bacteria detection, Probes used with point-of-care microfluidic devices for pathogen detection, Methods for combining FIB/SEM with three-dimensional fluorescence microscopy using CLEM approaches, Probes and Microbes, Microbial signatures associated with cancers, Fluorescent Aptamers for Detection and Treatment of Pathogenic Bacteria and Cancer, Labelled and Unlabeled Probes for Pathogen Detection with Molecular Biology Methods and Biosensors, and much more.

  • Translational Bioinformatics in Healthcare and Medicine

    • 1 Edición
    • Inglés
    Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice.

  • Advances in Immunology

    • 1 Edición
    • Volumen 149
    • Frederick W. Alt
    • Inglés
    Advances in Immunology, Volume 149, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Endocrine Emergencies

    • 1 Edición
    • Alexander L. Shifrin
    • Inglés
    Endocrine emergencies are often potentially life-threatening and can be easily overlooked in patients with no history of endocrine disease. Endocrine Emergencies is a practical guide to identification and treatment for today’s clinicians, offering essential coverage of common and serious emergencies related to endocrine metabolic conditions of the thyroid, parathyroid, pituitary, and adrenal glands.

  • Nematode Models of Development and Disease

    • 1 Edición
    • Volumen 144
    • Inglés
    Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more. Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans.

  • Biochemical and Molecular Basis of Pediatric Disease

    • 5 Edición
    • Edward C.C. Wong + 3 más
    • Inglés
    Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases.

  • Autonomous Robot-Aided Optical Manipulation for Biological Cells

    • 1 Edición
    • Mingyang Xie
    • Inglés
    Autonomous Robot-Aided Optical Manipulation for Biological Cells gives a systematically and almost self-contained description of the many facets of modeling, sensing, and control techniques or experimentally exploring emerging trends in optical manipulation of biological cell in micro/nanorobotics systems. To achieve biomedical applications, reliability design, modeling, and precision control are vitally important for the development of engineering systems. With the advances in modeling, sensing, and control techniques, it is opportunistic to exploit them for the benefit of reliability design, actuation, and precision control of micro/nanomanipulati... systems to expanding the applications of robot at the micro and nano scales, especially in biomedical engineering. This book presents new techniques in reliability modeling and advanced control of robot-aided optical manipulation of biological cells systems. The book will be beneficial to the researchers within robotics, mechatronics, biomedical engineering, and automatic control society, including both academic and industrial parts.

  • Cultured Microalgae for the Food Industry

    Current and Potential Applications
    • 1 Edición
    • Tomas Lafarga + 1 más
    • Inglés
    Cultured Microalgae for the Food Industry: Current and Potential Applications is a comprehensive reference that addresses the current applications and potential uses of microalgae and microalgae-derived compounds in the food industry. The book explores the different steps of the subject, from strain selection and cultivation steps, to the assessment of the public perception of microalgae consumption and the gastronomical potential of this innovative resource. Readers will find coverage of microalgae biology, common and uncommon algae species, cultivation strategies for food applications, novel extraction techniques, safety issues, regulatory issues, and current market opportunities and challenges. This title also explores the gastronomic potential of microalgae and reviews current commercialized products along with consumer attitudes surrounding microalgae. Covering relevant, up-to-date research as assembled by a group of contributors who are experts in their respective fields, the book is an essential reading for advanced undergraduates, postgraduates, and researchers in the microbiology, biotechnology, food science and technology fields.

  • Visceral Leishmaniasis

    Therapeutics and Vaccines
    • 1 Edición
    • Awanish Kumar
    • Inglés
    Visceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidates and amastigote-based vaccination strategies for Leishmania. The book provides a precise view on VL, Leishmania parasite culture, host immunity and immunomodulation, natural compounds effective against VL, animal models for VL, and methodologies available for anti-leishmanial drug screening procedures against VL, as well as vaccine and vaccination-related information on Leishmaniasis. Readers will find concrete information on past and current hurdles facing vaccine development for Leishmania, along with scientific opportunities and the potential impact of vaccines, including problems encountered. The book is designed to increase the understanding of vaccines, particularly in VL, for students and researchers. Although vaccines are now available for many diseases, there are still challenges ahead for a vaccine for VL. The ideal vaccine must be safe and able to induce an immune response that is strong and effective. In a nutshell, a combination of chemotherapy (drugs) and immunoprophylaxis (vaccine) would be ideal to win the battle against VL.

  • Neurologic Emergencies, An Issue of Neurologic Clinics

    • 1 Edición
    • Volumen 39-2
    • Joseph D. Burns + 1 más
    • Inglés
    This issue of Neurologic Clinics, guest edited by Drs. Joseph D. Burns and Anna M. Cervantes-Arslanian, will focus on Neurologic Emergencies. This issue is one of four selected each year by series consulting editor, Dr. Randolph W. Evans. Topics include—but are not limited to—Coma and depressed level of alertness; Post-arrest Neuroprotection; Headache Emergencies; Acute dizziness, vertigo, and unsteadiness; Neuro-ophthalmologic emergencies; Intracerebral hemorrhage; Acute ischemic stroke; Seizures and status epilepticus; Movement disorders emergencies; Neuromuscular respiratory failure; Neuroinfectious disease emergencies; Severe traumatic brain injury; Acute myelopathy; Neuro-oncologic emergencies; Autoimmune neurologic emergencies; Brain herniation and intracranial hypertension; Aneurysmal subarachnoid hemorrhage; Anesthesiology considerations in neurological emergencies; Neurological emergencies during the COVID pandemic; Neurocritical care and the COVID pandemic; and Neurologic Emergencies during Pregnancy.

  • Problems of Living

    Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science
    • 1 Edición
    • Dan J. Stein
    • Inglés
    Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.

  • Human Aging

    From Cellular Mechanisms to Therapeutic Strategies
    • 1 Edición
    • Calogero Caruso + 1 más
    • Inglés
    Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.

  • Biotechnological Strategies for the Treatment of Gluten Intolerance

    • 1 Edición
    • Mauro Rossi
    • Inglés
    Biotechnological Strategies for the Treatment of Gluten Intolerance provides a comprehensive overview of a wide range of biotechnological approaches that will further research and upon implementation improve the quality of life of this population. Gluten intolerance is a heterogeneous condition with varying levels of sensitivity that have typically been treated with a gluten free diet, but this book provides new and exciting biotechnological approaches that affect diet as well as non-dietary approaches. The reference describes the varying levels of sensitivity and explores symptoms beyond the intestines for a complete overview of the spectrum of sensitivity. The impact of diversity of wheat species, gluten quality and the nutritional values of gluten free products are extensively discussed. This reference is perfect for researchers and clinicians that want to further treatment options for those suffering from gluten sensitivity.

  • Cell Sources for iPSCs

    • 1 Edición
    • Alexander Birbrair
    • Inglés
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. Cell Sources for iPSCs, Volume 7 teaches readers about current advances in the field. It shares up-to-date comprehensive overviews of current advances in the field. This book describes the derivation of iPSCs from different sources in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. The authors focus on the modern state-of-art methodologies and the leading-edge concepts in the field of stem cell biology. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. Thus, this book is an attempt to describe the most recent developments in iPSCs biology, which is one of the rising hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on how we derive iPSCs from distinct sources. Ten chapters written by experts in the field summarize the present knowledge about different cell sources for iPSCs. This volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

  • Evidence-Based Vascular Neuroimaging, An Issue of Neuroimaging Clinics of North America

    • 1 Edición
    • Volumen 31-2
    • Ajay Malhotra + 1 más
    • Inglés
    This issue of Neuroimaging Clinics focuses on Evidence-Based Vascular Neuroimaging and is edited by Drs. Ajay Malhotra and Dheeraj Gandhi. Articles will include: Unruptured Intracranial Aneurysms: Duration, Frequency and Modality Used for Surveillance; Vasospasm: Role of Imaging in Detection and Monitoring Treatment; Extracranial Vascular Disease: Carotid Stenosis and Plaque Imaging; Subarachnoid Hemorrhage: Distribution and Role of Imaging; Acute Ischemic Stroke: MRI-based Paradigms; Imaging of Intracranial Hemorrhage (Non-subarachnoid Hemorrhage); Brain Arteriovenous Malformations: The Role of Imaging in Treatment Planning and Monitoring Response; Intracranial Vascular Disease and Vessel Wall Imaging; Acute Ischemic Stroke: CT/CTA/CTP and Their Role; Imaging for Treated Aneurysms (including clipping, coiling, stents, flow-diverters); and more!

  • Actin Cytoskeleton in Cancer Progression and Metastasis – Part C

    • 1 Edición
    • Volumen 360
    • Inglés
    Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more.

  • Clinical Chemistry, Immunology and Laboratory Quality Control

    A Comprehensive Review for Board Preparation, Certification and Clinical Practice
    • 2 Edición
    • Amitava Dasgupta + 1 más
    • Inglés
    Clinical Chemistry, Immunology and Laboratory Quality Control: A Comprehensive Review for Board Preparation, Certification and Clinical Practice, Second Edition presents core topics and 70 case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This succinct reference offers practical examples of how things function in the pathology clinic with useful lists, key points, case studies and a bullet point format ideal for quick pre-board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this book is designed to educate senior medical students, residents and fellows on how tests are performed. This second edition successfully helps pathology residents gain command of clinical chemistry, toxicology, immunology, and laboratory statistics in an effort to help them prepare for the American Board of Pathology examination. Clinical chemistry is a topic in which many senior medical students and pathology residents face challenges.

  • Frontiers in Plant–Soil Interaction

    Molecular Insights into Plant Adaptation
    • 1 Edición
    • Tariq Aftab + 1 más
    • Inglés
    Plants face a wide range of environmental challenges, which are expected to become more intense as a result of global climate change. Plant–soil interactions play an important role in the functioning of ecosystems. Soil properties represent a strong selection pressure for plant diversity and influence the structure of plant communities and biodiversity. The complexity of plant–soil interactions has recently been studied by developing a trait-based approach in which responses and effects of plants on soil environment are quantified and modelled. This fundamental research on plant–soil interaction in ecosystems is essential to transpose knowledge of functional ecology to environmental management.Frontiers in Plant-Soil Interaction: Molecular Insights into Plant Adaptation will address topics that provide advances in understanding plant responses to soil conditions through the integration of genetic, molecular, and plant-level studies of diverse biotic and abiotic stresses under field and laboratory conditions. This book will be beneficial to students and researchers working on stress physiology and stress proteins, genomics, proteomics, genetic engineering and other fields of plant-soil interactions. Frontiers in Plant-Soil Interaction will also help scientists explore new horizons in their area of research.

  • Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions

    • 1 Edición
    • Volumen 109
    • Inglés
    Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 in the Advances in Virus Research series, highlights state-of-the art mass spectrometry techniques to elucidate the tight interplay of vertebrate viruses and their host cells. The volume includes chapters on Spatio-temporal resolution of host protein complexes during virus entry, Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis, Applications of Mass Spectrometry Imaging in Virus Research, Mapping surfaceome dynamics during viral infection, Characterization of proteolytic events in virus-host interactions, Dynamic protein network modulation upon viral infection, and much more.

  • Nutritional and Health Aspects of Food in the Balkans

    • 1 Edición
    • Alina-Ioana Gostin + 2 más
    • Inglés
    Nutritional and Health Aspects of Food in the Balkans s introduces and analyzes traditional foods from the Balkans. Beginning with the eating habits in Balkans, this book unfolds the history of use, origin, compositions and preparation, ingredient origin, nutritional aspects, and the effects on health for various foods and food products of the region. Nutritional and Health Aspects of Food in the Balkans also addresses local and international regulations and provides suggestions on how to harmonize these regulations to promote global availability of these foods. A volume in a series co-produced with Global Harmonization Initiative, Nutritional and Health Aspects of Food in the Balkans is sure to be a welcomed reference for nutrition researchers and professionals, including nutritionists, dieticians, food scientists, food technologists, toxicologists, regulators, and product developers as well as educators, and students.

  • Advances in Applied Microbiology

    • 1 Edición
    • Volumen 114
    • Inglés
    Advances in Applied Microbiology, Volume 114 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on recent advances in the biosynthesis of isoprenoids in the engineered Saccharomyces cerevisiae.

  • Probiotic Beverages

    • 1 Edición
    • Sandeep K. Panda + 2 más
    • Inglés
    Probiotic Beverages is an essential reference guide to traditional, emerging and unique probiotic beverage products throughout different regions of the world. The book includes in-depth knowledge by local authors on indigenous and commercially produced probiotic beverages and related products. Examining current advancements in probiotic beverages and consumer health relationships, with a focus on large-scale beverage technology, sections cover starter cultures, regulatory challenges, genetic engineering, quality and safety. From practical issues of developing probiotic beverages, to the marketing of these drinks to the consumer, the full product lifecycle of a probiotic beverage is discussed.

  • Advances in Agronomy

    • 1 Edición
    • Volumen 167
    • Donald L. Sparks
    • Inglés
    Advances in Agronomy, Volume 167, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

  • Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B

    • 1 Edición
    • Volumen 180
    • Inglés
    Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas.

  • iPSCs for Modeling Central Nervous System Disorders, Volume 6

    • 1 Edición
    • Alexander Birbrair
    • Inglés
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into　Induced pluripotent stem cells　by the expression of specific transcription factors. These cells　are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field.

  • Apoptosis in Health and Disease - Part A

    • 1 Edición
    • Volumen 125
    • Rossen Donev
    • Inglés
    Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed.

  • Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus

    • 1 Edición
    • Volumen 262
    • Inglés
    Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus, Volume 262, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on current topics such as Cochlear implantation for patients with tinnitus – a systematic review, Event Related Potentials to Assess the Tinnitus complaint during drug treatment, The difference in post-stimulus suppression between residual inhibition and forward masking, Sleep, sleep apnea and tinnitus, A Bayesian brain in imbalance: medial, lateral and descending pathways in tinnitus and pain, Tinnitus features according to caffeine consumption, and much more.

  • Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

    • 1 Edición
    • Moyra Smith
    • Inglés
    Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

  • Transdisciplinary Case Studies on Design for Food and Sustainability

    • 1 Edición
    • Sonia Massari
    • Inglés
    Transdisciplinary Case Studies on Design for Food and Sustainability, a volume in the Consumer Science and Strategic Marketing series, analyzes the interconnectivity of sustainability, food, and design, demonstrating the presence of food design in various food-related fields of study. Broken into six parts, the book begins with the theory behind food and design. The following five sections include several case studies highlighting the different forms and applications of food design, including the use of food design in production and distribution, in food and restaurant businesses, in territory-identity, in social food design, and with regard to post-consumption. Using a case study approach to meet the needs of both academics and practitioners, Transdisciplinary Case Studies on Design for Food and Sustainability includes practical examples to illustrate food system challenges, to explain phenomena, and to build theory.

  • Remodeling Forensic Skeletal Age

    Modern Applications and New Research Directions
    • 1 Edición
    • Bridget F.B. Algee‐Hewitt + 1 más
    • Inglés
    Remodeling Forensic Skeletal Age: Modern Applications and New Research Directions presents a comprehensive understanding of the analytical frameworks and conceptual approaches surrounding forensic age estimation and the current state of the field. The book also includes a series of recommendations of best practice through chapter-examples that offer theory and guidance for data acquisition, technique and/or model development, and the assessment of impact of the adopted approaches. Written by leading, international experts, the book's contributors provide an introduction, conceptual understanding and taxonomy of statistical frameworks and computational approaches, including the Bayesian paradigm and machine learning techniques for age estimation.

  • Atlas of the Pig Gut

    Research and Techniques from Birth to Adulthood
    • 1 Edición
    • Romuald Zabielski + 1 más
    • Inglés
    Atlas of the Pig Gut: Research and Techniques from Birth to Adulthood examines the development of the gastrointestinal tract in swine. It focuses on changes occurring during the developmental phase, with an emphasis on the gut that is reflected in alterations of the intestinal mucosa architecture. Led by leading experts in pig digestion research, the book contains descriptions and microphotographs of the most updated research. The changes occurring in the intestine are presented in a comprehensive order, from small magnifications of tissue structures to high magnifications of fragments of epithelium-building cell structures. Additionally, the book highlights the replacement mechanism of epithelial cells during the development of the small intestinal mucosa. This book is the ideal resource for animal science researchers and practitioners. In addition, swine veterinarians and academics will also find it useful due to its helpful, detailed graphics and organized structure.

  • Non-Canonical Autophagy

    Mechanisms and Pathophysiological Implications
    • 1 Edición
    • Giulia Petroni + 1 más
    • Inglés
    Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies.

  • Cyclospora and Cyclosporiasis

    Epidemiology, Diagnosis, Detection, and Control
    • 1 Edición
    • Long Zhang + 3 más
    • Inglés
    Cyclospora cayetanensis is a microscopic parasite that can be transmitted via food or water sources and causes intestinal disease (Cyclosporiasis) in humans. Cyclospora and Cyclosporiasis: Epidemiology, Diagnosis, Detection, and Control reviews 22 species of Cyclospora and discusses C. cayetanensis infection in humans. This book offers comprehensive coverage that includes taxonomy and biology, molecular characteristics, and transmission of the parasite. It also provides researchers, clinicians, public health officials, and food safety officials with basic data for the epidemiology of the Cyclospora spp. or C. cayetanensis, as well as strategies to monitor large-scale outbreaks of Cyclospora spp. or C. cayetanensis. The book further covers clinical symptoms, diagnostic methods, and means of treatment and prevention of this disease and informs readers of the hazards of the parasite, common means of transmission, and self-protection measures.

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